#prion diseases

[tinpot64]

this shouldve been done like 5 months ago but blehhhh x3

[iliterallydecepticanteven]

listen. i can't explain why i find this section of the wikipedia article on kuru hilarious. i just do.

[nonbinaryboss]

made a silly little thing

[badolmen]

Not to ‘humans are space orcs’ in the year of our Lord 2024 but I was just thinking about how fucked up and terrifying prion diseases are for us I can’t imagine how horrifying it would be to other life forms. What do you mean your planet doesn’t have biological proteins capable of turning normal biological proteins into spaghetti? Fuck rabies and mind controlling fungus the scariest thing from Earth isn’t even debatably alive it’s a fucking protein molecule that will 100% kill you.

[aliasblackbird]

Prion

[darkmodepls]

Prion diseases are terrifying because if your body is really bad at molecular origami, you become afflicted with HORRIBLE ZOMBIE DISEASE and there is nothing nothing that can be done to cure it.

[paskuda-lynx]

I made this dubious meme A WHILE ago. And I still laugh at it like a madman. So I figured I should share it

[trash-and-trash-accessories]

Chronic wasting disease was confirmed in ungulates in my region. It's so fucking over for us. Chronic wasting disease is highly contagious, incurable, and can't be killed or treated because it's a prion disease. Not a living thing, a folded protein. Can't be destroyed once it's in the body. It spreads via all parts of an animal, not just the brain. It's in mucus and saliva. Meat and blood. It remains infectious in soil and dead plant matter for years.

It can and it will infect humans. There is no reason to think it can't and won't. Such optimism is a lie or a delusion to prevent panic. This is far worse than mad cow. Far more infectious, impossible to contain, faster-acting.

We are fucked.

[oh-yes-i-did-not]

Okay so for those either too young to remember or who were alive during but it never really affected them based on where they lived, Mad Cow Disease

Mad Cow Disease was thing in the late 80′s and the entire 90′s, all the way to early 00′s and it was an international scare. Like, we had disinfecting stations on international airports because of it.

It was a virus passed from animals to humans and this didn’t happen somewhere random in Asia, where, idk, bats and pigs interact and infect the food chain, but in Europe. In UK to be precise.

It affected only cows at first and only agriculture paid any attention, since any animal infected needed to be put down. Like no shit, those animals couldn’t even walk with how bad they were shaking and if you want to google this, be prepared. It doesn’t look nice, it looks ugly and horrifying and it will likely traumatize someone.

And the mode of transfer was not evident. There are videos and photos, showing cow carcasses being burned and someone trying to claim that was early days but that was very much not the reality in the beginning. In fact, all the research showed it is not possible for Mad Cow Disease to infect humans. In fact2, a similar disease was already known in lambs for decades and that one could not infect humans, so it was a no brainer to say, a similar disease in cows can also NEVER infect humans, so no precautions with the carcass needed.

But the thing is, how we processed meat had changed drastically between the lambs being a stable, grown at home meat, and then cows, or beef, becoming dominant with supermarkets. This is basically the “you see this, this is animal paste from a teletubby machine” video, except the paste wasn’t fed to humans. It’s known as meat and bone meal and it was all the leftover stuff from abattoirs, ground up and fed back to the animals as valuable protein.

You might see where this is going.

So let’s talk about prion diseases.

Well, as much as I, a random person know about them. Prions are proteins and proteins are not DNA or RNA, which are most likely familiar to anyone who has googled Covid, or any novel corona viruses in general. They’re the viruses a vaccine is made for.

Prion diseases are, in fact, mostly known because of cannibalism. Kuru is a famous disease among one specific tribe on Pacific Islands, caused by their tradition of consuming their relatives flesh after death. In fact, I just fact checked on which ocean and was told that the Kuru was mainly affecting kids and women because the men ate limbs and muscles and women and kids got the brain and basically all the best, fatty parts. Which, ironically, carried the disease.

And yes, in any survivalist culture fat, innards, and cartilage and the “bad parts” are the best because they contain the most nutrients so no, you do no get to twist this into the men taking the best, so fuck of terfs. This post is not for you.

Creutzfeldt-Jakob Disease was already known by the time of Mad Cow Disease, it was a brain destroying disease affecting the elderly population. Mad Cow became variant Creutzfeldt-Jakob Disease, or vCJD and was picked up because it mainly affected the young.

And in case you didn’t get it already, the link was infected cow carcasses being processed to meat and bone meal to be fed back to cows, because infected prion diseases spread through cannibalism. Or more specifically, spine and brain stem.

(so you’re relatively safe eating just the thigh or any muscle tbh)

So in the end, Mad Cow Disease didn’t kill that many people, only few hundreds, if I recall correctly.

But the thing that was found out about the prion diseases because of Kuru was that while some people exhibited symptoms and died really early, most had an incubation period of DECADES, aka 50 years. So the inevitable conclusion about vCJD is that it has only claimed it’s first victims and that majority are still waiting to appear and die.

Because the thing about prion diseases? There is currently no cure. And the fact that no one seems to remember this and that there is no awareness of it is not helping.

[existennialmemes]

I act like I'm fine, but I'm not

I am constantly afraid of Prion Diseases

You can't detect them

You can't kill them

They get inside your Brain and they REFOLD YOUR PROTEINS

Honestly they are way too overpowered, it's unfair to the others diseases

Nature needs to fix this in its next update

[ma-39]

who up misfolding they brain proteins

[moonlight-alphafemale]

Prion disease is so weird... It's like, one day a protein is like "nah, I wanna be different" 😭😭

[org4n-failur3]

Can!balism

The psychology and history. INFO POST!!

History

In history it’s been used since humans were made many did it since they thought theyd gain strength. Multiple tribes also did it as a ritual, most famously the tribe of Fore. However the tribe has had 30+ cases of a mystery disease being called Kuru (more about that later). Some k!lers also did it some for a feeling of control or power, many can!bals are lonely so it gives the feeling of not being alone

Causes

Many can!bals have had schizophrenic disorders (IF YOU HAVE ONE IT DOES NOT MEAN YOU ARE A CAN!BAL!!!) or personality disorder.

And of course a famous can!bal being Jeffery Dahmer who had a schizophrenic disorder as well as BPD (correct if wrong) and again with Albert Fish who gained a s3xual satisfaction.

Kuru

Zuru is a neurodegenerative disease caused by eating the infected brain of another human. The disease is highly rare now but still has no cure.The infected being caused by Prions. Prions are misfolded proteins lacking instructional nucleic acids. The disease is rapid with d3ath occurring usually after 1-2 years. The symptoms are loss of coordination and muscle spasms as well as uncontrollable laughter. Prions also cause madcow disease which is found in well cows. Eating infected cow meat can cause you to get a prion disease.

—

I could go into SO MUCH detail about the subtypes and about prions in general. TELL ME IF YOU WANT MOREEE!!

-Vivi

[didanawisgi]

Emergence of a New Creutzfeldt-Jakob Disease: 26 Cases of the Human Version of Mad-Cow Disease, Days After a COVID-19 Injection

Jean-Claude Perez Biomathematics; Luc Montagnier Foundation https://orcid.org/0000-0001-6446-2042

Claire Moret-ChalminNeurology; Luc Montagnier Foundation

Luc Montagnier Virology; Discoverer of the Human Immunodeficiency Virus (HIV) and Nobel Laureate 2008

Abstract

Creutzfeldt-Jakob Disease, the formerly rare but universally fatal prion disease in humans, normally progresses over several decades before it leads to death. In the Appendix to this paper, we highlight the presence of a prion region in the spike protein of the original SARS-CoV-2, and in all the “vaccine” variants built from the Wuhan virus. The prion region in the spike of SARS-CoV-2 has a density of mutations eight times greater than that of the rest of the spike, and, yet, strangely that entire prion region disappears completely in the Omicron variant. In the main body of our text, we present 26 cases of Creuzfeldt-Jacob Disease, all diagnosed in 2021 with the first symptoms appearing within an average of 11.38 days after a Pfizer, Moderna, or AstraZeneca COVID-19 injection. Because the causal progression, the etiopathogenesis, of these atypical and new cases of human prion disease — cases of what is apparently a totally new form of rapidly developing Creuzfeldt-Jacob Disease — we focus on the chronology of the symptomatic development. We consider it from an anamnestic point of view — one in which we compare the typical development of pre-COVID cases of Creuzfeldt-Jacob Disease to the extremely accelerated development of similar symptoms in the 26 cases under examination. By such an approach, we hope to work out the etiopathogenesis critical to understanding this new and much more rapidly developing human prion disease. By recalling the sequential pathway of that the formerly subacute and slowly developing disease followed in the past, and by comparing it with this new, extremely acute, rapidly developing prion disease — one following closely after one or more of the COVID-19 injections — we believe it is correct to infer that the injections caused the disease in these 26 cases. If so, they have probably also caused a many other cases that have gone undiagnosed because of their rapid progression to death. By late 2021, 20 had died within 4.76 months of the offending injection. Of those, 8 died suddenly within 2.5 months confirming the rapid progression of this accelerated form of Creuzfeldt-Jacob Disease. By June 2022, 5 more patients had died, and at the time of this current writing, only 1 remains still alive.

[stainlesssteellocust]

I can’t believe I’m looking into the biochemistry of prion diseases for this one fanfic

I paid extortionate amounts of money to do this for several years of my life I can’t believe I’m heading back to it as part of a fucking hobby

(the question is: Could you plausibly have one that hits quickly but leaves you symptomatic and yet stable for many years, slowly declining or staying metastable before a sudden collapse? I mean I can invoke sci-fi suspension of disbelief rules and Just Do It if I need, but that has knock-on effects about how much I should talk science about it. If you couch your sci-fi ideas in genuine science you’re going to be held to a higher standard in getting said science right than if you wrote a squishy-soft space opera, after all)

[cj33333]

Plague Inc. has done more to teach me about diseases than school ever has.

Go learn about prion diseases, they're terrifying, and if they had an easy way to spread and weren't as elusive and rare as they are, millions would die

Getting a prion protein folded abnormally in your brain is guaranteed death (eventually) and it's incurable

We know little about how they actually work and they are incredibly hard to track and discover. The particles that cause them are nonliving, persistent, and can fly under the radar by taking extremely long to incubate, giving them another chance to spread through their niche methods before we can take action. Prion diseases are more of an issue with certain other animals like cows and deer, and they're not a direct threat to humans unless we enter them into our food chain by eating infected animals and/or exhibit a general level of typical human stupidity (cough cough Mad Cow Disease). Like in humans, it's still 100% fatal and incurable in other animals as well

I never knew these existed before Plague Inc. when I started playing it in middle school and I've still never known anything about them until I started playing again recently