#signal transduction

[simonh]

Protein Modules In Signal Transduction: A Lecture by National Library of Medicine Via Flickr: Series Title(s): NIH director's Wednesday afternoon lecture series Contributor(s): Pawson, T. National Institutes of Health (U.S.). Medical Arts and Photography Branch. Publication: [Bethesda, Md. : Medical Arts and Photography Branch, National Institutes of Health, 1998] Language(s): English Format: Still image Subject(s): Signal Transduction, Gene Expression Regulation -- physiology, Eukaryotic Cells -- physiology Genre(s): Posters Abstract: Black, orange, and red poster with a visual representing signal transduction. Details of the event are also given. Extent: 1 photomechanical print (poster) : 71 x 41 cm. Technique: color NLM Unique ID: 101456172 NLM Image ID: C02937 Permanent Link: resource.nlm.nih.gov/101456172

[medicomunicare]

Geraniolo: l'alcol di molti aromi naturali e la sua azione protettiva contro la demenza senile

Nonostante le malattie cardiovascolari, il diabete e i tumori hanno ancora la loro alta prevalenza, l’aspettativa di vita nel 21° secolo è in aumento con conseguente aumento delle malattie legate all’età, come le malattie neurodegenerative quali il Parkinson e la demenza di Alzheimer. Una modalità di simulare in laboratorio l’invecchiamento del corpo, incluso quello cerebrale, è quello di…

[tenth-sentence]

The heat shock response appears to be mediated by one or more signal transduction pathways, one of which involves a specific set of transcription factors, called heat shock factors, that regulate the transcription of HSP mRNAs.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[whats-in-a-sentence]

A diagram of the possible early events in the sensing of abiotic stress and the signal transduction and acclimation pathways activated by these events is presented in Figure 24.8.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[izvmimi]

mimiloves!! in the mimidoriyaverse, do you have a quirk?

yup! in some aus i'm quirkless but in most of them i have a quirk and it's like 80% of the time the same quirk

[themanwhomadeamonster]

me: i should standardise my usernames so it's easy for ppl to reach me

also me: call me map kinase kinase kinase

[realdonsteve1]

ROLE OF MEMBRANE COMPONENTS IN MODULATING SIGNAL TRANSDUCTION ACROSS THE MEMBRANE

Membrane components play a crucial role in the modulation of biological processes, including signal transduction across the membrane. The cell membrane is composed of a lipid bilayer that surrounds the cell and regulates the passage of molecules in and out of the cell. Within this bilayer, there are various types of membrane components, such as phospholipids, proteins, and cholesterol, which work…

[sleeplesssmoll]

Cellular Activity Lore and Theories

"Signal transduction is the transmission of molecular signals from a cell's exterior to its interior. Signals received by cells must be transmitted effectively into the cell to ensure an appropriate response." (source)

This could explain why Vertin's skills take more Moxie every time you use her skills like Grand Orchestra or First Melody. The capacity for signal transduction decreases, meaning it takes longer for the cells to respond and react to the message. In her case, she must need to recharge often since she canonically sucks at arcanum. Timekeeper's running on Picrasma candy and the power of friendship.

It also explains Round Limits from a lore perspective. The more you use arcanum, the less control you have over it and you'll need to recharge. Long battles are not ideal and you want to end them quickly.

Another thing of note, there are biological reactions happening within arcanists when they use arcanum skills. This is important because it makes the widens the divide between humans and arcanists. It also explains why mixed blood arcanists are weaker than pure bloods. Pure-bloods are literally built different.

This also gives new context to chapters 2 and 3 but I won't delve into that until I can form a complete thought instead of fragments.

[ghor-dranas]

Teletheric Transduction Pocket Guide - Table of Contents!

So, the appendix for Season 3 Episode 2 of Midst [link] is a pocket book, opened to its introductory pages, but I noticed that if you look closely, you can see the text on the previous and next pages! It's a little hard to read [to say the least], but @captainofthetidesbreath quickly flipped and edited the image which made it much easier!

And to make things even easier still, I am going to give you a full transcript.

Table of Contents Actual Adventure is All Around - 4 Transducer History - 6 Priathic Impulses - 7 Tele-Aetherics - 7 Transduction - 8 Bocular Energy Transference - 8 The Stymie Prototype - 9 Teletheric Transduction: The Modern Standard - 9 Building and Tuning Teletheric Transducers - 10 Building a Teletheric Transducer - 10 Recommended Retailers and Parts List - 10 Tuning - 11 Where to Buy Teletheric Equipment - 12 Common Models - 12 How to Evaluate Controls and Material - 13 Teletheric Science - 14 Broadcast Standards - 16 Upper Un Signal Boost Equipment - 16 Forbidden Broadcasting - 18 Safe Harbor Hours - 19 Teletheric Licensing - 20 License Tradition - 20 Study Guide - 21 Index of License Posts - 22 Shorthand Signals - 24 Teletheric Communication Codes - 28 Distance and Signal Strength Maps and Overlays - 32

The other page shows a variety of signals, with the only text reading "FIG. C: SIGNAL STRENGTH IN IDEAL CONDITIONS"

[residancylog]

September 16th | Signal transduction | 26 days.

Dear Lenin,

I’ve finally gathered the courage to share these subtle updates with you. Truth be told, I was hesitant to document even a fragment of this still-undefined/ undifferentiated journey! — like a trembling bird in my palms, waiting to take flight.

Yesterday, I sat at my desk, not feeling grumpy for once, and immersed myself in clinical oncology. I pinned a few notes to the wall—I had never done that before intentionally you believe that? then I worked through a quiet decent number of questions, and they felt manageable. I tried to keep the momentum going, by diving into blood diseases but found myself wandering through the winding paths of pathology and oncogenesis. I didn’t quite finish, but today, if Allah wills, I will.

Pray for me, will you! I’ll tell you about my last week soon enough, but for now, did you know already that tissue is, indeed, the issue?

Kindley yours.

[medicomunicare]

Cancer kills by lactate: how cellular junk becomes a signal to acquire more fuel

Cachexia is a complex metabolic syndrome associated with rapid loss of body weight, mainly loss of fat and lean muscle. Patients with cancer cachexia often develop anemia, fatigue, asthenia and anorexia, which worsen their quality of life and reduce their tolerance to anticancer therapies. As a result, cachexia accounts for approximately 20% of patients with cancer-related deaths. To date,…

[captainofthetidesbreath]

I've been thinking about teletherics and mica, especially since the appendices for 3.02 is a pocket guide to telethric transduction.

Teletherics is an Un-based technology, and teletheric waves aren't Fold-safe; the appendices for 1.05 mention that they need to be converted for rebroadcast into the Fold along cables for that reason. So, you can't transmit teletheric waves through the Fold. This is also suggested by the fact that Kozma's agenda lists all her teletheric calls after she leaves Midst; she can't have done it before then, in the Fold.

Apparently, teletherics can involve mica. The art of Backpack and her teletheric equipment includes a parabolic dish that uses a shard of mica as a feed antenna. Seeing as teletheric receivers, such as Ginsberg's in the icon for 1.03 and Hieronymous's in art for 3.02, don't feature visible mica, I presume then that her equipment is using it for transmission. If teletheric waves are transmitted using mica, that may explain why they're not Fold-safe. Teletheric signals are, of course, created using specially-boculated electric currents. A mica antenna would interact with that, then radiate it to a receiving teletheric transducer.

As a sidebar, the breakdown of the word teletheric is also very interesting to me: tele- + aetheric. I wonder if the Un is as empty as it seems to be when in compared to the Fold. Perhaps there is some stuff out there in the Un that they have not yet learned to measure. Or, perhaps teletheric is aetheric in the sense of aether theory and the transmission of waves through a medium. Or, in the sense of luminiferous aether and old theories on the movement of light. Or, perhaps in the sense of the mythological personification of the bright upper sky.

If mica is capable of transmitting teletheric waves, how do teletheric signals interact with the mica fields of the Un? Radio engineering is not as simply as any old piece of metal can act as an antenna, there's electric currents and what-not, but in this fantasy world in which our understanding of teletherics and mica is limited, it is a question. (And who is to say that things don't work slightly differently in the cosmos.) Do teletheric signals interact with mica bergs at all? Does wild mica bounce those signals across the Un?

If mica transmits signals, waves, does it have resonance then? Does it vibrate? Do mica bergs make sound as they float through the Un, and is it audible? Or, does it resonate a tone that is below the typical threshold of human hearing, like the third sound of a superfluid?

Hell, while I'm asking questions. Can someone end up with the opposite of what Lark has with the Fold, where they can hear mica resonating through the Un? Is there some soul out there, cosmos whispering to them, who can hear its crystalline tones resonating out across the Un, or the sound of lightning in the Delta or unships passing through the upper Un bouncing off the bergs, or teletheric signals transmitting out through the mica?

But, I'm getting ahead of myself: mica and teletherics and the transmission of sound. I think about teletherics and the shapes of all associated with it. Priathic notation reminds me of neumes, or even modern notation with beams but no stems. The impulses are tonal and have harmonics. Teletheric transducers uses fluted pipes, and those pipes make them look like small pipe organs. With that—

Does mica sing? Can you hear it if you tune in just right?

[whats-in-a-sentence]

Plant signal transduction mechanisms may be relatively rapid or extremely slow (Figure 15.1)

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[science-lover33]

Exploring the Marvels of Biological Macromolecules: The Molecular Machinery of Life (Part 3)

Proteins and Enzymes: Catalysts of Molecular Reactions

Proteins are the central players in macromolecular interactions. Enzymes, a specialized class of proteins, catalyze biochemical reactions with remarkable specificity. They bind to substrates, facilitate reactions, and release products, ensuring that cellular processes occur with precision.

Protein-Protein Interactions: Orchestrating Cellular Functions

Proteins often interact with other proteins to form dynamic complexes. These interactions are pivotal in processes such as signal transduction, where cascades of protein-protein interactions transmit signals within cells, regulating diverse functions such as growth, metabolism, and immune responses.

Protein-Ligand Interactions: Molecular Recognition

Proteins can also interact with small molecules called ligands. Receptor proteins, for instance, bind to ligands such as hormones, neurotransmitters, or drugs, initiating cellular responses. These interactions rely on specific binding sites and molecular recognition.

Protein-DNA Interactions: Controlling Genetic Information

Transcription factors, a class of proteins, interact with DNA to regulate gene expression. They bind to specific DNA sequences, promoting or inhibiting transcription, thereby controlling RNA and protein synthesis.

Membrane Proteins: Regulating Cellular Transport

Integral membrane proteins participate in macromolecular interactions by regulating the transport of ions and molecules across cell membranes. Transport proteins, ion channels, and pumps interact precisely to maintain cellular homeostasis.

Cooperativity and Allosteric Regulation: Fine-Tuning Cellular Processes

Cooperativity and allosteric regulation are mechanisms that modulate protein function. In cooperativity, binding one ligand to a protein influences the binding of subsequent ligands, often amplifying the response. Allosteric regulation occurs when a molecule binds to a site other than the active site, altering the protein's conformation and activity.

Interactions in Signaling Pathways: Cellular Communication

Signal transduction pathways rely on cascades of macromolecular interactions to transmit extracellular signals into cellular responses. Kinases and phosphatases, enzymes that add or remove phosphate groups, play pivotal roles in these pathways.

Protein Folding and Misfolding: Disease Implications

Proteins must fold into specific three-dimensional shapes to function correctly. Misfolded proteins can lead to Alzheimer's, Parkinson's, and prion diseases. Chaperone proteins assist in proper protein folding and prevent aggregation.

References

Voet, D., Voet, J. G., & Pratt, C. W. (2016). Fundamentals of Biochemistry: Life at the Molecular Level. Wiley.

Lehninger, A. L., Nelson, D. L., & Cox, M. M. (2017). Lehninger Principles of Biochemistry. W. H. Freeman.

Berg, J. M., Tymoczko, J. L., & Stryer, L. (2002). Biochemistry. W. H. Freeman