#tnbc analysis

[thetownwecallhome]

TNBC showerthought #10: Sally is her own Doll

((OOC: So I saw because of @tnbc-thoughtsandheadcanons that there's a new comic coming out that's a 'what if' if Sally had been the one to find the holiday doors and not Jack. I'll admit the idea intrigues me...but I'm a little cautious.

Now's not the time to go into it but I get a little peeved with how Disney is utilizing fan-fic ideas and concepts like AUs and mecha crossovers in their spinoff material. But, besides that fear, I'm cautious for another reason. I'm noticing a lot more stuff trying to feature Sally more and more. While I like that, I'm also kind of annoyed with it.

Among the many problems I have with "Long Live the Pumpkin Queen", one of them is I feel like they're trying to make Sally more of a female alt to Jack, rather than her own unique character. LLTPQ had to retcon Sally into being a princess from another kingdom the way Jack is already a 'King'. Which, to ME is deeply insulting.

Part of what makes Sally impressive is that she is 'just' a ragdoll. She was created, not born or 'died', and she also happens to be smarter than her creator and even the king of her town. There doesn't need to be some explanation for her being the way she is and that's what's cool about her. It's very, Ozian, for lack of a better word. It's such a cute idea of an inanimate-object-brought-to-life becoming a ruler and being thought of as their own person. It's cute and even a little empowering in a way.

While I'm not scared that this new comic will retcon anything like LLTPQ did (really, it's supposed to, given that it's an AU), I'm still worried that this new comic will give Sally the exact same reaction Jack has to Christmas and have the plot of the movie try and go on but with Sally in Jack's place...and I really hope that's not what happens.

Sally is not Jack. That's what's adorable about her. That's what we the audience love about her and that's what Jack falls in love with her at the end for. Sally wouldn't do the things Jack does with Christmas because Sally is her own person and her situation and social status is different than Jack.

AUs of this kind really kind of put into perspective the kind of characters you're working/messing with. The whole reason the story of TNBC happens at all is because Jack is the kind of person he is while he finds Christmas; extroverted, peppy, self-absorbed, ostentatious and manic depressive. Jack is the king and everybody wants his approval and attention even if he thinks no one actually listens to him. The only reason Halloween ends up doing Christmas at all is because Jack is the king and is used to doing what he wants and getting his citizens in on his plans.

If Sally finds Christmas Town or any other holiday world and comes to her own self-discovery, she better not go back and try and tell the people of Halloween about it. Sally's whole deal in the first half of the movie is she doesn't want to live with Dr. Fink; she's trying to escape. She'd probably stay in the Holiday worlds because she has no one back home desperately looking for her besides Dr. Fink. She wants to be away. If anything she has a way better reason than Jack or anyone else in town to run away. And, if Dr. Fink did make a big deal and ask people to help him look and then THAT's how Halloween first finds Christmas-- that would be something. I'd really like to see an alt. Jally-romance take that direction; Jack starts a search party for Dr. Fink's missing secretary he's seen once or twice, he follows a party personally to the outskirts of Halloween land, finds the doors and Sally and SHE'S the one to introduce HIM to the other holiday worlds. That'd be so cool!

tl;dr: I hope the 'what if' comic has Sally functionally going on her own journey and being a different character and not her functionally going through the beats of the story Jack did but just Sally in place of Jack. Sally is not Jack.

))

[hanafubukki]

Malleus being in the TNBC and Endless Halloween event has me rather intrigued.

His connection with ghosts is interesting when you think about it.

In fact, Lilia’s connection also adds into it. Lilia went to the spiritual realm before returning.

And now we have Malleus’s connection to them.

In Endless Halloween, it was about letting the ghosts enjoy more time in twst.

In TNBC, it was about a past character meeting the present cast. About someone who so tied into his olden ways being changed.

Makes you wonder, if a ghost from the past will come and haunt the narrative in main story.

Someone so stuck in olden times who will need to change. Because they can’t move past it.

And in a way, we already have that don’t we. Meleanor hated humans and didn’t change her views even until her death. Humans feared the fae and wanted their lands which led to wars for centuries even though some wanted change it wasn’t the right time for it.

But now through Lilia’s teachings, we see how Malleus and Silver are trying to bridge that gap during present times. Sebek is also an example of how that gap has been bridged.

But it’s interesting, how we have literal ghosts haunting the narrative. Tactile ones nonetheless. No matter how temporary.

Makes you wonder if we’ll be seeing other literal ghosts again? And if they are playing a part in the story.

(We already had one in book 7, haven’t we? For all intents and purposes, KOD is one. And then we also see how similar Malleus’ OB dragon is to his mother…and of course, there’s the senate…)

The role of ghosts are interesting to me, there seems to be more to them through the little hints twst shows us.

And we know that ghosts can posses bodies…makes you wonder, has any of the cast been possessed? And is it limited to living people only? Because Silver’s ring is not a person nor “living”

It just adds onto the story’s mysteries. Are the OBs, in any way, possessed? Anyone else in the cast?

When the haunting of the narrative becomes literal 😅😂

[random-dragon-exe]

So I've been thinking about Oogie Boogie, but mostly his shadow and how it works.

Going by the beginning of the movie, the "shadow on the moon at night" is like an extension of him he uses to terrorize people in their dreams to fill them to "the brim with fright".

Now, given Disney's track record with shadows, I'd wager it works similar to them.

An animated shadow of his but he can willingly detach it (somehow) to screw with people in their dreams.

Since its implied that it's also him, (or at least has the same voice and personality), I'm willing to bet he has full control over it, unlike Dr. Facilier and Peter Pan's shadows.

Which are just separate entities with their own personalities when you watch their respective movies.

Idk, this is just my analysis based on what I'm observing in the movies. Pretty sure this is what the intention was, but I still wanted to get my thoughts out there.

[velvet-vox]

Although I'm always kind of saddened by the fact that we never got the plot twist of Doctor Finkelstein secretly being the Oogie Boogie, I feel like it was also for the best, probably?

In a way, the character became more iconic due to him not having any twists attached; if the original idea would have gone through, I doubt Oogie would have popped up as much in other Disney media, as the extra layer of complexity provided by him also being the alter-ego of the Doctor would have created issues when translating the character:

Oogie Boogie is a pretty easy villain to slap on whatever the hell you want and still be functional and charming; his simplicity makes him incredibly versatile to whatever the story needs him to do, you need to look no further than Kingdom Hearts to see what I mean.

Plus, Oogie already functions pretty well as a foil to Jack, being someone who overindulges in his interests and desires (similar to Jack, but way more overtuned), lacking the comprehension skills to understand what others are talking about (like Jack), as how is evidenced in his song, and so on and so forth.

At least, you can say that in the end the original idea for Oogie Boogie was reutilized in Wreck-It Ralph, where it was much more fitting anyway.

[thewitfire]

Immunotherapy in Triple-Negative Breast Cancer (TNBC): An In-Depth Analysis

1Amit Kumar, *Usaman Khan1ResearchScholar, Anand College of Pharmacy*Research Scholar, Anand College of Pharmacy Immunotherapy in Triple-Negative Breast Cancer (TNBC) Article Details Title: Immunotherapy in Triple-Negative Breast Cancer (TNBC): An In-Depth Analysis Authors: Amit Kumar, Usaman Khan Published in: Witfire Volume/Issue: 2(1) Pages: 1-12 Publication Date: 18/01/2024 DOI:…

[rainyducktiger]

Oncology Market Size Share and Demand Analysis to 2033

Oncology Market – Industry Trends and Forecast to 2032

The global oncology market is at the forefront of healthcare innovation, driven by increasing cancer prevalence, technological advancements, evolving treatment paradigms, and growing investment in research and development. As we look toward 2032, the oncology market is expected to experience substantial transformation, shaped by emerging therapies, personalized medicine, and greater accessibility to advanced treatments across the globe.

Market Overview

In 2024, the global oncology market was valued at approximately USD 217 billion, and it is projected to surpass USD 450 billion by 2032, growing at a compound annual growth rate (CAGR) of 8.5% during the forecast period. The market includes pharmaceutical drugs, diagnostics, treatment devices, and services dedicated to preventing, diagnosing, and treating various forms of cancer.

Cancer remains one of the leading causes of mortality worldwide, responsible for nearly 10 million deaths annually. The increasing burden of cancer, along with the growing geriatric population, is accelerating demand for novel oncology solutions, particularly in high-burden regions such as North America, Europe, and Asia-Pacific.

𝗗𝗼𝘄𝗻𝗹𝗼𝗮𝗱 𝗮 𝗙𝗿𝗲𝗲 𝗦𝗮𝗺𝗽𝗹𝗲 𝗥𝗲𝗽𝗼𝗿𝘁:-https://tinyurl.com/35fyjwev

Key Market Drivers

Rising Cancer Incidence

The primary driver of the oncology market is the rising global cancer burden. Factors such as aging populations, sedentary lifestyles, poor dietary habits, pollution, and tobacco consumption are contributing to increased cancer incidence. According to the World Health Organization (WHO), the number of new cancer cases is projected to rise to 30 million annually by 2040, up from 19.3 million in 2020.

Advances in Drug Development

In the past decade, the oncology drug development pipeline has expanded exponentially. Targeted therapies, immunotherapies, monoclonal antibodies, and combination treatments have redefined cancer care. With breakthroughs in areas such as CAR-T cell therapy and checkpoint inhibitors, the industry is witnessing a paradigm shift from conventional chemotherapy to more personalized, precision-based treatments.

Technological Innovations in Diagnostics

Early and accurate diagnosis significantly improves cancer prognosis. Technological advancements in imaging (such as PET-CT and MRI), liquid biopsies, and genomic testing are enabling earlier detection and better characterization of tumors. The rise of artificial intelligence (AI) in pathology and radiology is also enhancing diagnostic accuracy and efficiency.

Growth in Personalized Medicine

Personalized or precision medicine is transforming oncology by tailoring treatment to an individual’s genetic makeup and tumor profile. Next-generation sequencing (NGS) and biomarker discovery are allowing oncologists to prescribe therapies that are most likely to benefit the patient, thus increasing treatment efficacy and minimizing side effects.

Government and Private Sector Investment

Substantial investment from governments and private stakeholders in oncology research, infrastructure, and public awareness programs has fueled market growth. Initiatives like the U.S. Cancer Moonshot and global collaborations such as the International Cancer Genome Consortium (ICGC) are accelerating innovation.

Market Segmentation

By Cancer Type

Lung Cancer Lung cancer remains the most commonly diagnosed cancer and the leading cause of cancer death. The segment dominates the oncology market due to high prevalence and recent approvals of targeted drugs like osimertinib and immunotherapies like nivolumab.

Breast Cancer Breast cancer has overtaken lung cancer in terms of new cases globally. Innovations in hormone therapy, HER2-targeted therapies, and triple-negative breast cancer (TNBC) treatment are expanding the therapeutic landscape.

Colorectal Cancer The third most common cancer globally, colorectal cancer treatment is being revolutionized by biologics, immunotherapy, and screening programs.

Prostate Cancer A common cancer in men, especially in developed countries, prostate cancer is being addressed through hormone therapies, novel radiopharmaceuticals, and genetic testing.

Other Cancers Including leukemia, lymphoma, melanoma, and rare cancers – each with unique treatment pathways and significant research attention.

By Therapy Type

Chemotherapy While chemotherapy remains a mainstay of cancer treatment, its market share is slowly declining due to the rise of targeted therapies and immunotherapies.

Targeted Therapy Drugs that block specific molecules involved in tumor growth are now integral to modern oncology care. Examples include tyrosine kinase inhibitors (TKIs) and HER2 inhibitors.

Immunotherapy Immune checkpoint inhibitors (e.g., pembrolizumab, atezolizumab) and adoptive cell therapies are reshaping the treatment landscape. The immunotherapy segment is projected to grow at the fastest pace during the forecast period.

Hormone Therapy Used primarily in breast and prostate cancers, hormone therapies continue to be widely prescribed and are witnessing advancements like selective estrogen receptor degraders (SERDs).

Radiotherapy and Surgical Interventions Advanced radiation technologies (proton therapy, stereotactic radiosurgery) and minimally invasive surgery remain critical for comprehensive cancer care.

Regional Insights

North America

North America, led by the United States, holds the largest share of the oncology market. Strong R&D infrastructure, favorable regulatory policies, and high cancer incidence drive market dominance.

Europe

Europe follows closely, with major contributions from countries like Germany, France, and the U.K. Supportive healthcare policies and access to innovative drugs contribute to the region’s growth.

Asia-Pacific

The Asia-Pacific region is poised for the fastest growth due to increasing healthcare access, rising cancer burden, and growing medical tourism. Countries like China and India are investing heavily in oncology infrastructure.

Latin America, Middle East & Africa

These regions are still developing oncology infrastructure but represent untapped potential. Market growth will depend on improved healthcare funding and public health initiatives.

Key Players and Strategic Developments

Major players in the oncology market include:

Roche Holding AG

Bristol-Myers Squibb

Merck & Co., Inc.

Pfizer Inc.

AstraZeneca

Novartis AG

Amgen Inc.

Johnson & Johnson

Gilead Sciences

Eli Lilly and Company

Strategic Trends:

Mergers and Acquisitions: Pharma giants are acquiring biotech firms to bolster their oncology portfolios.

Collaborations: Partnerships with academic institutions and tech companies are accelerating drug discovery.

Clinical Trials: A surge in late-stage trials and FDA fast-track approvals is helping novel therapies reach the market faster.

Challenges in the Oncology Market

Despite rapid progress, the oncology market faces several challenges:

High Treatment Costs: Many cancer therapies, especially biologics and cell therapies, remain unaffordable for a large segment of the population.

Regulatory Hurdles: Varying approval standards across regions can delay global market entry for new drugs.

Resistance to Therapies: Tumor mutations often lead to resistance, necessitating combination therapies or novel approaches.

Access to Care: In low-income regions, limited diagnostic and treatment capabilities hinder cancer outcomes.

Future Outlook: Trends Shaping the Oncology Market Through 2032

AI and Big Data in Oncology: AI will enhance predictive modeling, diagnostics, drug discovery, and patient monitoring.

Liquid Biopsies: These minimally invasive tests will revolutionize early cancer detection and treatment monitoring.

Cancer Vaccines: Therapeutic cancer vaccines and preventive vaccines for HPV-related cancers will gain traction.

Digital Health Integration: Tele-oncology, wearable monitoring devices, and patient-centric digital platforms will become more widespread.

Global Expansion of Clinical Trials: More diverse populations will be represented, improving drug efficacy across demographics.

Conclusion

The oncology market is entering an exciting era of transformation. With the convergence of cutting-edge science, data-driven precision medicine, and growing global collaboration, the fight against cancer is becoming more targeted and effective than ever before. However, to truly capitalize on these advancements, stakeholders must address challenges related to access, affordability, and healthcare disparities. As we move toward 2032, the global oncology market will not only expand in size but also in its potential to change millions of lives for the better.Read Full Report:-https://www.uniprismmarketresearch.com/verticals/healthcare/oncology

[tnbc-thoughtsandheadcanons]

Hiii, I'm sorry if you have already answer this question but what happend to the Vehemente because some time I tend to go through all your fanfic of tnbc since I live and breath for sally and jack content and their isn't so much finished.

Anyway sorry again for asking I also love your analysis and headcanons. Sorry for any mistakes english is not my first language hi from Argentina (also if you haven't done you should watch the movie in spanish I always LOVED their voices)

Hi there! My 18+ TNBC fanfic, 'Vehement', was taken down on all fanfic sites some time ago, AO3 being the last it was on. I was just never really happy with the fic to begin with, and a review at the time reminded me of all of its issues and that's when I decided to finally take it off its last site. I don't plan on re-publishing it anytime soon, but I'd like to rewrite the story at some point.

If you *reeaaallyy* want to read it again, you can DM me and I'll give you a link to the story, all I ask is that you DON'T share it around. This applies to my followers and anyone who's interested in reading it -- if I find it's been shared or posted anywhere then I'll stop sharing the link, but so far everything's been good.

Also, I really need to watch TNBC in other languages! I'm particularly interested in the French and Italian versions. I'll check out the Spanish one while I'm at it!

[delveinsight12]

PARP Inhibitors Market to Witness Upsurge in Growth During the Study Period, Assesses DelveInsight | Key Companies to Look Out - TakaraBio, Merck, ShanghaiSunwayBiotech, SillaJen

The PARP Inhibitors market size is anticipated to increase in the study period due to a direct consequence of an increase in R&D activity in the 7MM. Additionally, the competitive landscape is relatively sparse and the regulatory pathway for approval will likely involve extensive clinical trials to demonstrate safety and efficacy.

DelveInsight’s PARP Inhibitors Market Insights report includes a comprehensive understanding of current treatment practices, emerging PARP Inhibitors, market share of individual therapies, and current and forecasted PARP Inhibitors market size from 2019 to 2032, segmented into 7MM [the United States, the EU-4 (Italy, Spain, France, and Germany), the United Kingdom, and Japan].

Key Takeaways from the PARP Inhibitors Market Report

As per DelveInsight’s analysis, the PARP Inhibitors market is anticipated to grow at a significant CAGR by 2032.

Leading PARP Inhibitors companies such as TakaraBio, Merck, ShanghaiSunwayBiotech, SillaJen, and others are developing novel PARP Inhibitorss that can be available in the PARP Inhibitors market in the coming years.

Some of the key PARP Inhibitorss include ZEJULA, AKEEGA, LYNPARZA, TALZENNA, RUBRACA, and others. 

Discover which therapies are expected to grab the PARP Inhibitors market share @ PARP Inhibitors Market Report

PARP Inhibitors Overview

PARP inhibitors are a class of drugs that target poly (ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair. These inhibitors have primarily been developed for the treatment of cancers, especially those associated with specific genetic mutations, such as BRCA1 and BRCA2 mutations.

PARP enzymes play a role in repairing damaged DNA. PARP inhibitors work by blocking these enzymes, preventing cancer cells from repairing their DNA effectively.

The concept of using PARP inhibitors is particularly relevant in cancers with deficiencies in the homologous recombination DNA repair pathway, such as those with BRCA mutations.

PARP enzymes play a role in repairing damaged DNA. PARP inhibitors work by blocking these enzymes, preventing cancer cells from repairing their DNA effectively.

The concept of using PARP inhibitors is particularly relevant in cancers with deficiencies in the homologous recombination DNA repair pathway, such as those with BRCA mutations.

PARP Inhibitors Treatment Market 

The market for PARP inhibitors was experiencing growth, driven by their approvals for multiple cancer indications and ongoing research into their efficacy in various settings. However, the market dynamics may have evolved, and it's recommended to check more recent sources for the latest information.

Competition among pharmaceutical companies played a role in shaping the market. New entrants, the development of combination therapies, and ongoing research contributed to the competitive landscape.

Access to PARP inhibitors, as well as pricing considerations, were factors influencing market growth. Discussions around the cost-effectiveness of these therapies, reimbursement policies, and patient access contributed to market dynamics.

The field of PARP inhibitors was dynamic, with ongoing research exploring new compounds, combination therapies, and applications in different stages of cancer treatment.

Learn more about the FDA-approved PARP Inhibitors @ PARP Inhibitors Drugs

Key PARP Inhibitors Therapies and Companies

ZEJULA - GSK - Ovarian cancer, NSCLC, Endometrial cancer

AKEEGA -  JANSSEN BIOTECH - CRPC, HSPC

LYNPARZA - AstraZeneca -  Ovarian Cancer, Breast Cancer (HR+/HER2- and TNBC), Pancreatic Cancer, CRPC

TALZENNA - Pfizer - Breast Cancer (HR+/HER2- and TNBC), CRPC, HSPC

RUBRACA - Pharma& - Ovarian Cancer, CRPC

To know more about PARP Inhibitors clinical trials, visit @ PARP Inhibitors Treatment Drugs 

Scope of the PARP Inhibitors Market Report

PARP Inhibitors Therapeutic Assessment: PARP Inhibitors current marketed and emerging therapies

PARP Inhibitors Market Dynamics: Attribute Analysis of Emerging PARP Inhibitors Drugs

Competitive Intelligence Analysis: SWOT analysis and Market entry strategies

Unmet Needs, KOL’s views, Analyst’s views, PARP Inhibitors Market Access and Reimbursement

Discover more about PARP Inhibitors drugs in development @ PARP Inhibitors Clinical Trials

[leedsomics]

Proteomics Landscape of Triple-Negative Apocrine Breast Carcinoma Reveals Molecular Mechanisms of Tumorigenesis and Characteristics of Chemo-insensitivity

Triple-negative apocrine breast carcinoma (TNAC) is a rare type of triple-negative breast cancer (TNBC) characterized by apocrine morphology. Due to its low clinical incidence, TNAC has not been well studied at the molecular level in terms of cellular mechanisms of tumorigenesis and treatment response. In this study, we collected formalin-fixed paraffin-embedded samples from 31 patients diagnosed with invasive TNAC. Mass spectrometry analysis and whole-exome sequencing were performed to systematically construct the proteome and mutation landscape of the TNAC. Comparing ductal carcinoma in situ (DCIS), invasive, and adjacent normal tissues, we observed increased cadherin binding and ligase activity during tumorigenesis, heightened extracellular matrix signaling at tumor initiation, and elevated GTPase activity during tumor progression. Besides, we discovered genes such as C3 and COL18A1 enriched in somatic mutations are also significantly dysregulated in invasive TNAC. Additionally, by assessing biopsies before neo-adjacent chemotherapy, we provided molecular evidence supporting clinical observations of chemotherapy insensitivity in TNAC patients. We further identified a protein panel (CAPN1, CORO1B, HK1, RAP1B, and VPS4B) differentiating TNAC from non-apocrine TNBC, which could potentially serve as diagnostic markers. Taken together, this study represents the first large-scale proteomics analysis of TNAC and may provide guidance on decisions regarding the chemotherapy treatment of TNAC patients. http://dlvr.it/TBJLJW

[tumimmtxpapers]

Single-cell and bulk RNA sequencing analysis of B cell marker genes in TNBC TME landscape and immunotherapy

CONCLUSION: This study has established a robust model based on B-cell marker genes in TNBC, which holds significant potential for predicting prognosis and response to immunotherapy in TNBC patients. http://dlvr.it/T0LDCc

[thetownwecallhome]

TNBC Shower Thought: Comparing the worst to best TNBC posters

((OOC:

I know how much you love my pedanticy-pedantics about unimportant TNBC details and reviews. Or, at least, I think you like em and none of you have told me to can it yet...

So I figured in the spirit of that and Christmas season, why not compare some of Nightmare Before Christmas's movie posters? Comparing posters and covers is a fun activity for me. There different kinds of posters and cover art throughout the years for all sorts of things that are great at subtly, creativity, minimalism or just being a good cover overall. One day I hope to compare some of the Walt Disney features' many fantastic poser art for their films, but for now lets stick to Nightmare.

I'm starting from the bottom to work my way up into the GREAT stuff. Lets not waste anymore time...

This is easily the worst cover for the film and what I hate is that it's the most current cover. I already hate when they try to make the clipart we're used to all shaded and three dimensional-like, but just...LOOK AT THIS?!?!

Who thought THIS looked good? Honestly?!? The characters are all way too colorful and smooth and it's plastered on top of the film cel like it fits together...it DOESN'T!!!

Next we have the 2008 DVD cover.

I'll try not too be too harsh on this one in case anyone here grew up with it...but I'm sorry I am so not a fan. It tells you nothing about the film and is more of that '3D-ish take on the og lineart that looks ugly to me.

The 2023 30th anniversary art is...fine?

Like there's nothing WRONG with it, but it feels incrediblly lackluster compared to some of the screen-capped and colored up artwork I've seen on things like T-Shirts and even fan made posters.

Also, and I hope this ISN'T true, it's so basic I worry that it at some point was made by or with AI or at least with an artist who wasn't paid that much in a short amount of time. Like, the composition is all there: Sally and Jack in the forground, Lock, Shock and Barrel under them and above the title, Oogie in the moon behind them all...but I don't know why they didn't do something really cool like make all the intricate purple and blue-shapes into silhouettes of the other characters and other iconic imagery or scenes?

Look at how...ALONE Zero feels off the side there!!

This is another older image I remember on the back of my VHS growing up, though I never knew it was used for an actual cover of the movie.

It does INFINITELY look better than the first shaded-lineart image (this was done in the 90s...how...) but while I love the composition of Jack and Sally and them walking around in Christmas Town, I never liked the colors of the image at all.

I also never got why Lock, Shock and Barrel are there, chillin and watching them like they're Belle and Beast and they're Beasts' servants trying to wingman for him...Where's Zero? Everyone knows HE'S jack's wingman.

This is an image I found on IMDB that took my by surprise. To be honest I have no clue if it's an actual film poster or a fan poster, but I like the composition of it all as a Universal Horror film poster. Doesn't work as well as Frankenweenie, but still...

And now, the classic. The one you most certainly grew up seeing everywhere or around the place regarding this movie in the 90s or 20s. It's the cover to the soundtrack and VHS I had. This is obviously the most famous version.

But there's also this slightly different version with Jack's arms in a different pose 'to receipt Shakespearean quotation'. This is the same version of the cover used on our "The Film, the Art and the Vision" book as well.

But, for my own PERSONAL favorite cover of the film (even if it's just a simple photoshop), I have to go with the original 'special edition' DVD my sister and I still have.

Somehow Sally just being on the spiral hill next to Jack and holding his hand is so sweet and doesn't feel like the cheap and quick edit it is. I think it's because, despite being a reference to the scene I never saw this cover as directly portraying "Jack's Lament", that this was Jack having a nice moment of peace after the events of the films somehow and waxing his poetics in reference to the film...so somehow the idea of Sally coming up to join him in that with his other arm let out to her is ADORABLE.

Here's a different version on a French DVD.

Lastly, since it does technically count as a poster for the movie itself, I'd be remissed not to mention Nightmare Before Christmas 3D's poster. This this was great back in the day and it's still great now. I'm fairly certain they just photoshopped stills and photos of puppets themselves but y'see kids- THIS vvvv

This is how you photoshop. Everyone has a unique face and pose. Everyone's doing something you think that character would be doing if they were going to MT3K their own film (Sally that's rude!) and they're all drenched in theater accurate lighting. That's more like it!! Besides Oogie being smol, this is the perfect poster to catch the eye of a rerelease!

Hope you enjoyed!

))

[arrangoiz]

Original Molecular Classification of Triple Negative Breast Cancer (TNBC)

Following the description of the main intrinsic breast cancer molecular subtypes based on gene expression analysis: Lehmann et al. demonstrated the complex and heterogeneous nature of TNBCs, and that their definition simply based on interpretation of histopathological features might be of limited efficacy in understanding prognostic behaviour and therapeutic implications They described six…

[weaselbeaselpants]

That's the problem with a lot of bad media analysis.

It's still operating on a "my opinion > everyone else's opinion and perspective", despite claiming to be impartial and accademic, so mouthbreathers use the air of media criticism as a way to tout their fandumb+opinions as fact rather than actually look into the media their engaging with, accepting all truths about it.

Some people have a better eye for this than others; Princess Weekes and Hbomber generally have a better 'clap back' way of stating their opinion but then ALSO stating the objective opinion of their argument....but their imitators are kind of lost in the "#mike-drop" mentality of it all any not only abuse the language needed to make important points, but also use that on anything that threatens their viewpoint. I've felt that way about Ayy Lmao for a long time-

Calling out media or just pointing out the problematicisms in, even stuff you enjoy, isn't going to hurt you. I can be very harsh in regards to Disney, TNBC, Venture Bros and Hadestown, which are all properties I love, and find for you TONS of reviews pointing out what's problematic/badly written/offensive about it. I genuinely want the things I love to be looked and broken down, sometimes on topics I can't even speak for myself like TooManyCrowns' Princess and the Frog analysis, and talked about the good and the bad. Extending that perspective to stuff you love every bit as much as stuff you hate, be it as a fan or critic, should be seen as a positive thing and not an attack in any means.

Anti vs Profandom: Dawn of Justice is a glorified fandom debate among people who really aren't that good at analysis trying to one-up and bury eachother. Sometimes they use the positivity-culture based "end cringe! let people liek things" and sometimes they'll use ernest but harsh media crit to do this- either way, it's cultural elitism, absolutism and fandom apathy all rolled into one. It's killing us and our fandoms.

"As someone who watches horror movies -- and also you know, movies at all -- I always get a laugh out of that one."

Yeah that's the vibe I personally get from a lot of antis (and honestly a lot of people who are chronically online): they don't consume a lot of media, and if they do they do so uncritically. They tend to just stick to the few things they know they like.

- skibidi toilet anon

I seriously think that's what constitutes acceptable media in their eyes...enjoyable and completely, 100% beyond criticism.

[sophieakatz]

Thursday Thoughts: The Jewish Heart of The Nightmare Before Christmas

On a recent episode of the Disney For Scores podcast, Danny Elfman, composer and songwriter for The Nightmare Before Christmas, was asked about his relationship with Halloween and Christmas.

“Since I was a little kid,” Elfman replied, “my least favorite night of the year was Christmas, and my favorite night of the year was Halloween… At Christmas, I was just a lonely Jewish kid in a neighborhood without Jewish friends.”

And I had to pause the podcast and shout, “I KNEW IT!!!”

I love TNBC for a lot of reasons. The music is catchy. The stop-motion animation is amazing. The setting and characters are fascinating, bizarre, lovable, and unforgettable. But the thing I’m happiest to ramble on about when it comes to TNBC is its message.

Last year, I called this film an “Anti-Christmas Movie.” A Christmas movie follows a character who does not value Christmas as they gradually learn to bring Christmas into their life. However, the upshot of TNBC is that despite Jack’s fascination with Christmas, he should NOT bring Christmas into his life. Instead, he should let the Christmas people do their thing, and he should take pride in his own culture, his own people, and his own holiday.

And in my heart, I knew there was no way a movie like this could have been made only by gentiles. Gentiles love Christmas, and they love telling other people that we need Christmas. As a Jewish kid surrounded by non-Jews for most of my life, I know this all too well. When I was in kindergarten, some girls at school told me that if I didn’t believe in Santa (and Jesus and the Easter Bunny), then there would be monsters under my bed forever. That was just the beginning of a long road of well-meaning antisemitism, and at the end of that road, I’m left with a bad taste in my mouth at the very sight of a Christmas tree. To be clear, I don’t care if other people enjoy Christmas – my problem is with people telling me that I should enjoy Christmas.

In my experience, it’s not just religious Christians who were so eager to remind me that I shouldn’t be alone on Christmas. Atheists love Christmas and are very quick to tell me that I should love it, too, even after I politely explain that I don’t need Christmas to be happy. So while I had no idea whether the creators of TNBC were religious Christians, and given that Jesus is not mentioned even once in the film I had a hunch that they were not, I also had a hunch that this movie would not exist without some Jewish person’s contributions.

Now, Tim Burton is not Jewish, despite his clear love for and frequent use of Jewish folklore, imagery, and history. Henry Selick, the often-forgotten director of TNBC, is not Jewish, and I’m pretty sure Caroline Thompson, the screenwriter, is also not Jewish. So that leaves Danny Elfman. The lonely Jewish kid who, to paraphrase him, felt disconnected from the Christian world around him, loved getting to run around in a monster mask at Halloween, and grew gloomy at the sound of Christmas music in the mall. Danny Elfman, who poured his heart and soul into the character of Jack Skellington to the point where his soundtrack demos were often used in the final film instead of the studio recordings.

Sure, you can argue about who really holds the power of storytelling in a film. The characters and basic plot undeniably belong to Tim Burton. But a movie musical truly comes to life in its songs, and in TNBC, the music never stops playing. The music carries us through this world where Christmas isn’t the most important thing, where you don’t need to take on someone else’s culture in order to feel complete, where people love and support you for who you are in all your oddness and uniqueness.

It’s no wonder I love this movie so much, and it’s no wonder that a Jewish man was at the heart of its creation.

[yourlocalsimpsonsandsanriofan]

Here's a disturbing theory i have of Dorit man

Honestly, have you ever wondered why Mayor's spider only has six legs instead of having eight legs like the average spider? Well I have a disturbing theory why. As you can see in the movie, when he gets pissed off, it seems he can get pretty aggressive. My evidence: when Lock Shock and Barrel fling things at him when we first see them for the first time in the movie, he growls in anger, and when his spider dosent stay on his chest, he aggressively puts it back on his chest. He also pushes wolf man aside saying, "Move aside." Agressivly, all while trying to get to his hearse. So he's capable of hurting somebody if something dosent go his way. In this case, Jack being missing. My theory here is that one day, the spider didn't do what he wanted, was stay on his chest (or doing anything to piss him off for that matter), so he got so aggressive that he accidentally ripped two of its legs off, wich resulted in it only having six legs now. And maybe thats why it escaped him in the movie, because its scared of him. Or it could be that the spider is a mutant, wich wouldn't be surprising, because we're talking about the world of Tim Burton where things are always twisted, creepy, and weird. But my theory would work, cuz like I said, he gets aggressive when he gets pissed off. And that could be dangerous. That could also tie into his bipolar personality, Where he can change his mood at the drop of a pin. Like I said, this could be dangerous. There is a chance he could go insane by constantly switching emotions (and faces) back and forth. Thats probably why he overreacts (sound familiar?) when Jack is missing. When things don't go his way, he panics. Wich causes him to be hurt, or potentially hurt somebody else. Which obviously isn't good.

I dunno I thought I'd maybe share my thoughts on this. Its a dumb theory, but I think It could work.

Sorry for posting two times today btw