#Cancer development

[andrewjhonson1234]

A recent review published in Cancers highlights the significant role of progranulin in cancer development. The growth factor has been found to promote tumor growth by enhancing cancer cell proliferation, migration, and resistance to chemotherapy. It also influences the tumor microenvironment and immune surveillance. Despite these findings, the molecular mechanisms behind progranulin’s oncogenic role are not yet fully understood. Researchers from the Sbarro Health Research Organization and Temple University suggest that further exploration of progranulin could lead to novel therapeutic strategies, including its potential as a diagnostic and prognostic marker for cancer.

[newsepick]

Study finds how fever promotes increased activity, mitochondrial dam

Researchers at Vanderbilt University Medical Centre discovered that elevated body temperatures during fevers boost immune cell metabolism and activity but also cause mitochondrial stress, DNA damage, and death in certain T cells. Published in *Science Immunology*, the study highlights how these processes could link chronic inflammation to cancer development. While higher temperatures enhance the immune response to infections, they also risk cell viability, particularly in Th1 cells. The findings suggest that while mild fever can be beneficial, prolonged high temperatures may promote tumorigenesis, providing a clearer understanding of cellular responses to inflammation and temperature changes.

[kangals]

some of my fave pieces of Great Dog Advice I’ve seen people give include:

-You do not need to impose exercise restrictions on an injured or post-surgical dog, because dogs will never over-exert themselves.

-only deworm your dog on a full moon.

-dogs will only eat food that is good for them; they naturally know to avoid toxins

-dogs should be allowed to breed freely because they will only mate with the most fit partners.

-some dogs simply should never have their hair groomed or cut because it will make them feel bad about how they look.

[oifaaa]

I have a fun new game I'm playing where anytime I find out something good a vaccine has done I share that news with my deeply anti vax mother I know it won't change her mind but it makes me happy anyway today I learned that the HPV vaccination programme the UK started in 2008 has managed to cut down the amount of cervical cancer cases by 90% in England

[mvrdermeharder]

EVIL BOYFRIENDS

naaaaah had to redownload this app for 2 seconds to say this bc HUHHHHHH?!??!?

i love them sm tho they’re so toxic

[on-a-lucky-tide]

just woke up and my dumbass read your tags as "Brothers Karamazov" and went "heh. Nice book" haha BUT. Makarov? I'm interested 👁️👁️

Nik had bypassed the security and snuck in through one of the bedroom windows. There was no one waiting for him in a van outside. No Watcher, no Bravo Six. This was something he had to do alone. Something he should have done many, many years ago.

It had been too simple, which meant Makarov knew he was coming. Wanted him to come. But Nik had no choice. John had lost a man; his heir, his protegé. He would stop at nothing now, risking even his own life in pursuit of revenge.

Makarov didn't look up as Nik opened the door to the study. He didn't even flinch, the white of his arm sling stark against his black military fatigues. He must have broken it in his escape.

"You are getting sloppy in your old age," Makarov murmured. Nik clocked the sidearm on the table near his hand, and the AK propped up against the nearby wall.

"I know your traps."

"And yet you walk into it willingly. That can only mean you are here on behalf of your favourite whore."

Nik swallowed down the flare of rage that burned behind his eyes, fingers twitching at his sides. "Your obsession with him ends tonight."

"Obsession? Hardly. But it was always... entertaining, seeing how far a man like Price could be pushed before he broke." Makarov ran gloved fingers over the paperwork on the desk before him; maps, stolen intel. Impossible to tell. "And yet, he never did. You have to admire that. It's why he’s still alive... for now."

"You still see him as the biggest thorn in your side. Why? What makes him so special to you? You have killed so many... What is one more?"

Makarov looked to the side sharply, bringing Nik into his periphery for the first time. "It’s not about killing him. It’s about breaking him. Price is a symbol—of everything I despise. The British... the Americans... they think they can control the world with their petty morals and weak ideals." Makarov chuckled; a low, humourless sound in the back of his throat. "Price represents that. He stands against everything I want to achieve. And I won’t rest until I’ve shattered him, piece by piece."

Nik clenched his teeth, fingers flexing against his palms. "You are delusional. Price is no different than you or me. He does what he thinks is right. But in the end, he is just another soldier."

"No. Price has always been more than that. He’s a man who refuses to accept his fate. He clings to his honour like a fool, and that is what makes him dangerous." Makarov turned, leaning against the desk, his broken arm adjusting against his chest. "And that is why I will break him. Because when he falls, everyone will know the truth. That no one is beyond my reach."

Nik stared at the face he had not seen in person for so many years. Always passing each other at a distance, never crossing. It was like looking through a portal into a mirror universe; Makarov was what he could have been. "Price might be a symbol, but so are you. You just do not see it yet."

Makarov's face warped into a snarl. "I am no symbol. I am the storm that will sweep everything away. And when the dust settles, only my vision will remain. Price... and his ideals, will be nothing but ashes."

"We will see about that."

Makarov tilted his head back and sighed at the ceiling. He moved slowly, lifting the sheathed machete from the table and throwing it to the floor between them. Nik knew what he wanted. How he intended this to end, and the painful memories made his chest ache.

Makarov's nose twisted into a sneer when he saw the pain flash over Nik's face. Even after all this time, Makarov could still read him. He knew how much healing Nik had done in the decades since they had fought in the snow, two shirtless boys, one all skinny, pale limbs and the other grown enough into his manhood to always gain the upper hand. To always be the one to inflict just enough harm to stave off worse.

As they threw punches, executed throws and latched each other in chokeholds, numb fingers scrambling through the ice for the blade, their father had watched with watery eyes, rinsing away his grief with vodka.

Makarov, whose heart had hardened, not healed, showed his teeth in a sharp parody of a smile. "Just like old times, big brother."

[canisalbus]

realistically, i know fur cannot tan. but in my heart i believe vasco would love to sunbathe and would develop an even warmer golden brown from it, while machete would turn pink-red from merely going outside for more than 10 minutes

.

[clexa-surrogacy-au]

It is correct/safe to say that if in few months since Costia died, Lexa and Clarke have developed (apparently) some feelings and a strong atracttion for each other, its because they felt something before? Not that they realized that in that time….

I’ll mark this with a read more since it’s spoilery

I think it’s safe to say they found each other attractive 🤔 both physically and emotionally. They have a sort of competitiveness and intensity to them they don’t have in the same way with other people, an appreciation for how the other works. To say it plainly, they just get each other, seem to wear the same type of weight on their shoulders. Weren’t afraid to call each other out or disagree. They understood each other so there was always a kinship there.

I would say in a way it was less “oh I’m super attracted to her” and more “oh I could be attracted to her…” and a baseline acknowledgment of “she’s exactly my type, but nothing is ever happening 🤷🏽‍♀️” that resulted in them automatically keeping a bit of a distance with each other, something they didn’t feel the need to do with anyone else (and also, at least in the case of one of them, compartmentalizing and trying not to ever think about it). Not necessarily because they let themselves consciously worry that it could develop into something, but because they could both sense something deeper there than was wise to explore. They were friends. Lexa and Costia were happy together, and that was that. Clarke was happy for them. That was how it had always been and they couldn’t imagine that changing.

I think that happens a lot in real life. People don’t magically stop being attracted to other people when they’re in a relationship; it just doesn’t matter, because you choose who you are with and you choose whether or not you let something grow where it shouldn’t. Choosing anything other than loyalty to Costia was never an option for either of them. It likely could and would have been much different, had Clexa somehow spent as much time with each other alone as they are now, but they didn’t.

But when you’re suddenly thrust together on a journey through life—when you’re both grieving together, both scared together, both healing together—well, things can change.

There’s a little more to it than that but for the sake of spoilers, I’ll leave it there ☺️

[trainerdawn]

in the workplace. straight up “touching it”. and by “it”, haha, well. let’s justr say. Ethidium bromide

[starleska]

You know, you seem like the exact kind of person who probably had a crush on hexxus from Ferngully. I mean this positively of course, because I know your type 

hahahahaha...hahaha...yes. yes, you've got me. that seductive hunk of smog gave tiny me (who was veeery obsessed with FernGully: The Last Rainforest) confusing feelings 😳 but then...doesn't every character voiced by Tim Curry? and did they really need to animate Hexxus so...seductively...🫠🫠🫠

[mechatronophilia]

isn't it so neat that WD40 and flame retardants and so many things that make up the inside of The Machine are also so harmful to your fleshy body. you're burning up like dry leaves in the glow of something incomprehensibly divine but it's like, magic smoke giving you a permanent cough. greasy hands stained a little grey forever. vision loss from laser exposure. and missing fingers obviously

[peacherweasel]

Character Thoughts/Notes

(This is just one of those "random 3am thoughts/inspiration" moments) -- Coming from being an Autistic person, who's current fixation is the game Rain World, I've been following peoples' RW Anthro AU's. As a person who likes furry/anthro art & media, I want to develop my own AU, but I've been having issues on where to start. I have some ideas & will post them here, although I am struggling to keep things somewhat realistic yet still somewhat fantasy-themed (as that's just my liking of style in general; semi-realistic & semi-fantasy.) ((thought I should add that my dad is a cancer survivor, so I might ask him for some advice on creating some of these characters)) -- I want to give my versions of some of the Rain World Characters different types of disabilities. So far the characters specifically on my mind are Hunter, Artificer, Looks To The Moon, & Spearmaster. For Artificer in my Anthro AU, I want her to to have her facial scars/ear scars, as well as her missing eye. Not sure if I want to add a loss of hearing to her left ear, considering she's missing her left eye (after an incident) In this AU her pups are alive, but they (might) be missing for some time, before reuniting with their mother. For Hunter in my Anthro AU, I want her (I see Hunter as Female - She/Her) to be a cancer survivor. (Considering sometimes The Rot disease in the game is sometimes called Turbo Cancer) I'm not sure what type of cancerous disease I'm going to write/draw Hunter with, not sure if I'm gonna keep it as "the rot/rotting disease" or something else. For Spearmaster in my Anthro AU, I want to develop them (I've developed my au version of Spearmaster to be born female but soon to identify as non binary, They/It.) & I wanted to incorporate the fact that they can't really eat with a mouth but using the needle/spears they create from canon/in-game. So I've decided they've got a feeding tube, specifically a PEG Tube. My thought process is that Spearmaster is also a cancer survivor (specifically a stomach cancer, & one that requires Spearmaster to need said PEG/Feeding tube to survive, as they can't eat or gain nutrition otherwise.) I also ship the pairing Love Letter (aka Spearmaster x Hunter) so maybe I'll develop a part of their stories (both Spearmaster & Hunter) to be in the same hospital where they're being treated for their cancer types & that's how they meet/connect with each other. For Looks To The Moon in my Anthro AU (Iterators are going to be included in my Anthro AU, however they will still remain as iterators/humanoid robots, & will be developed later) I want to develop her with a memory disability, as well as a disability that makes it difficult for her to walk. Maybe the memory part could be linked to a traumatic brain injury, caused by some accident. I also wanna include Moon having dehydration problems (since in canon/game lore, Moon lost a lot of her water intake & that's one of the reasons/main reasons her superstructure collapsed.) (Maybe the brain injury & the dehydration could be linked? idk I need to do more research on that.) I might also give Moon a part where she needs some sort of crutches or canes to walk more functionally. I still have more to develop/think about/research.

[thekamukuraproject]

Oh to be old (like 30) and be so undeniably in love and changed by your other half that the line of where you begin and where he ends is too blurred to distinguish

[gammaraydeath]

you know taking a radiation biology class has made me like my url a lot more. niche reference to ro's old band name now it's like haha i am killing you with low let particles that penetrate your entire body. i am generating reactive oxygen species and damaging your dna. you will develop cancer in about 30 years

[soulhealingastrologywithamanda]

This week’s (June 2nd-8th) astrology brings BIG energy: Read all about it here ✨ Release fears (Venus-Jupiter) 🌊 Trust or overthink? (Mercury-Nodes) 🌿 Pleasure or numbing? (Venus in Taurus) Your soul’s upgrade starts here��read now! 🔗 #Astrology #Horoscopes #Healing #Growth

[enbyman]

Maybe Ryan didn't really liked Gloria, maybe he just had mommy issues