#agrp

[dougielombax]

Just leaving this here.

Feel free to reblog.

[ahblab]

AGRP Peptide: Innovative Dental Care Solution for Repairing Gingival Recession

Oral health is integral to overall well-being, and maintaining healthy gums is a crucial aspect of it. Repair Gingival Recession, where the gum tissue pulls back and exposes more of the tooth, can lead to sensitivity, increased risk of decay, and even tooth loss. Traditional treatments for gingival recession include deep cleaning and surgical procedures, but recent advancements in peptide technology offer a less invasive, effective solution. One such breakthrough is the AGRP peptide, a promising dental care innovation for repairing gingival recession.

Understanding Gingival Recession

Gingival recession can be caused by various factors, including:

Poor Oral Hygiene: Inadequate brushing and flossing can lead to plaque buildup, which can cause gum disease and recession.

Aggressive Brushing: Overly vigorous brushing can wear down gum tissue.

Genetics: Some people are more prone to gum recession due to genetic factors.

Periodontal Disease: Chronic gum inflammation can lead to the destruction of gum tissue and bone.

Hormonal Changes: Hormonal fluctuations, especially in women, can make gums more sensitive and prone to recession.

The Role of Peptides in Dental Care

Peptides are short chains of amino acids that act as building blocks for proteins. In dental care, certain peptides can promote healing, reduce inflammation, and stimulate the regeneration of gum tissue. This makes them highly effective for treating conditions like gingival recession.

Introducing AGRP Peptide

AGRP (Agouti-Related Peptide) is an innovative peptide that has shown promising results in dental care, particularly in the repair of gingival recession. AGRP peptide works by:

Stimulating Gum Tissue Regeneration: AGRP promotes the growth of new gum tissue, helping to cover exposed roots and reduce sensitivity.

Reducing Inflammation: AGRP has anti-inflammatory properties that help to calm inflamed gum tissue, creating a healthier environment for regeneration.

Enhancing Overall Oral Health: By promoting gum health, AGRP supports overall oral hygiene and reduces the risk of further gum recession and dental issues.

Benefits of Using AGRP Peptide for Gingival Recession

Non-Invasive Treatment: Unlike surgical procedures, using AGRP peptide is non-invasive and can be easily incorporated into a regular dental care routine.

Promotes Natural Healing: AGRP supports the body’s natural ability to heal and regenerate gum tissue.

Reduces Sensitivity: By covering exposed roots, AGRP can help reduce tooth sensitivity, making it easier to enjoy hot and cold foods and drinks.

Improves Gum Health: Regular use of AGRP peptide can improve overall gum health, reducing the risk of periodontal disease and further recession.

How to Incorporate AGRP Peptide into Your Dental Care Routine

1. Consult with Your Dentist

Before starting any new treatment, it’s essential to consult with your dentist. They can provide guidance on the appropriate use of AGRP Peptide and how it fits into your overall dental care plan.

2. Use as Directed

Follow the usage instructions provided by the manufacturer or your dentist. Consistent application is key to achieving the best results.

3. Maintain Regular Oral Hygiene

AGRP peptide should be used alongside regular oral hygiene practices, including brushing, flossing, and routine dental check-ups. This ensures a comprehensive approach to oral health.

4. Monitor Progress

Regularly monitor the condition of your gums and report any changes or concerns to your dentist. This helps in adjusting the treatment plan if necessary and ensures optimal results.

Conclusion

The AGRP Peptide represents a significant advancement in dental care, offering an effective, non-invasive solution for repairing gingival recession. By promoting gum tissue regeneration, reducing inflammation, and supporting overall oral health, AGRP peptide can help maintain a healthy, resilient smile. Always consult with your dental professional to determine the best approach for incorporating this innovative treatment into your dental care routine. Embrace the future of oral health with AGRP peptide and enjoy the benefits of healthier gums and a more confident smile.

[massispost]

New Post has been published on https://massispost.com/2024/02/ararat-eskijian-museum-research-center-and-the-promise-armenian-institute-launch-vahakn-n-dadrian-archive-project/

Ararat-Eskijian Museum Research Center and The Promise Armenian Institute Launch Vahakn N. Dadrian Archive Project

LOS ANGELES — The Ararat-Eskijian Museum Research Center (AEMRC) and the Armenian Genocide Research Program (AGRP) within The Promise Armenian Institute at UCLA have announced the launch of the Vahakn N. Dadrian Archive Project. Professor Vahakn N. Dadrian (1926–2019) was a preeminent scholar of the Armenian Genocide and instrumental in establishing the larger field of genocide studies. He lectured and published widely in the field, leading to greater international recognition of the Armenian Genocide. His unique collection of archival materials and books is of extraordinary value to those researching the origins of the Armenian Genocide, the Genocide itself and its…

[jhavelikes]

Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out physiological energetic state and elicit feeding, but the regulation of these neurons across daily timescales is poorly understood. Using a combination of neuron dynamics measurements and timed optogenetic activation in mice, we show that daily AgRP-neuron activity was not fully consistent with existing models of homeostatic regulation. Instead of operating as a ‘deprivation counter’, AgRP-neuron activity primarily followed the circadian rest–activity cycle through a process that required an intact suprachiasmatic nucleus and synchronization by light. Imposing novel feeding patterns through time-restricted food access or periodic AgRP-neuron stimulation was sufficient to resynchronize the daily AgRP-neuron activity rhythm and drive anticipatory-like behavior through a process that required DMHPDYN neurons. These results indicate that AgRP neurons integrate time-of-day information of past feeding experience with current metabolic needs to predict circadian feeding time.

AgRP neurons encode circadian feeding time | Nature Neuroscience

[jhave]

Study shows that AgRP neurons encode circadian feeding time in mice

[leedsomics]

Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety

Liraglutide and other agonists of the glucagon-like peptide 1 receptor (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. GLP-1RAs inhibit hunger-promoting Agouti-related peptide (AgRP) neurons of the arcuate hypothalamus (Arc) but only indirectly, implicating synaptic afferents to AgRP neurons. To investigate, we developed a method combining rabies-based connectomics with single-nuclei transcriptomics. Applying this method to AgRP neurons in mice predicts 21 afferent subtypes in the mediobasal and paraventricular hypothalamus. Among these are Trh+ Arc neurons (Trh Arc), which express the Glp1r gene and are activated by the GLP-1RA liraglutide. Activating Trh Arc neurons inhibits AgRP neurons and decreases feeding in an AgRP neuron-dependent manner. Silencing Trh Arc neurons increases feeding and body weight and reduces liraglutide's satiating effects. Our results thus demonstrate a widely applicable method for molecular connectomics, reveal the molecular organization of AgRP neuron afferents, and shed light on a neurocircuit through which GLP-1RAs suppress appetite. http://dlvr.it/SyMyqT

[myfeeds]

Dieting: Brain amplifies signal of hunger synapses

“People have looked mainly at the short-term effects after dieting. We wanted to see what changes in the brain in the long term,” explains Henning Fenselau, a researcher at the Max Planck Institute for Metabolism Research, who led the study. To this end, the researchers put mice on a diet and assessed which circuits in the brain changed. In particular, they examined a group of neurons in the hypothalamus, the AgRP neurons, which are known to control the feeling of hunger. They were able to show that the neuronal pathways that stimulate AgRP neurons sent increased signals when the mice were on a diet. This profound change in the brain could be detected for a long time after the diet. Preventing the yo-yo effect The researchers also succeeded in selectively inhibiting the neural pathways in mice that activate AgRP neurons. This led to significantly less weight gain after the diet. “This could give us the opportunity to diminish the yo-yo effect,” says Fenselau. “In the long term, our goal is to find therapies for humans that could help maintaining body weight loss after dieting. To achieve this, we continue to explore how we could block the mechanisms that mediate the strengthening of the neural pathways in humans as well.” “This work increases understanding of how neural wiring diagrams control hunger. We had previously uncovered a key set of upstream neurons that physically synapse onto and excite AgRP hunger neurons. In our present study, we find that the physical neurotransmitter connection between these two neurons, in a process called synaptic plasticity, greatly increases with dieting and weight loss, and this leads to long-lasting excessive hunger,” comments co-author Bradford Lowell from Harvard Medical School.

[ear-worthy]

NYT “First Person” Podcast: How Do We Treat Obesity?

Interview podcasts are as common as hidden fees in today’s world. Think about it. They’re cheap to produce, easier to set up than on-location recording, and enable the guest to fill in most of the script with their comments and observations.

Most interview podcasts market themselves as having culturally relevant conversations on topics of social importance. The reality, however, is far different from the hype.

Interview shows like Something You Should Know and The Jordan Harbinger Show are solid interview podcasts with interesting guests a host that knows how to ask probing questions, then listen to the response and follows up.

The New York Times’s interview podcast, First Person, is one of the best in the genre. The show’s tagline is: “Every opinion starts with a story. Intimate conversations about the big ideas shaping our world, hosted by journalist Lulu Garcia-Navarro. From New York Times Opinion.”

Garcia-Navarro has Ira Glass-level interviewing skills, and the topics chosen resonate with listeners. Consider some of the recent episodes.

Why Does Big Tech Make It So Hard to Fix Your Devices? — The C.E.O. of iFixit is fighting for your right to stop shopping and start repairing.

Veteran Outing Domestic Extremists — Veterans are valuable recruits for far-right groups. Kris Goldsmith wants them to fight back.

A Librarian Spoke Against Censorship. Dark Money Came For Her. — Now she’s fighting back.

In the most recent episode of First Person, host Lulu Garcia-Navarro speaks to Dr. Fatima Cody Stanford, a professor at Harvard Medical School and Obesity Medicine Specialist at Massachusetts General Hospital.

When Dr. Stanford entered medical school in the early 2000s, obesity medicine was not part of the curriculum, even though obesity rates in the United States have been steadily rising since the 1980s.

Since then, she’s spent her career pushing for changes in the way the medical establishment thinks about and treats obesity, calling for interventions that recognize the condition as a disease, not simply a failure of willpower.

And one of those interventions is medication. As new weight loss drugs like Ozempic and Wegovy enter the market, Dr. Stanford finds herself at the forefront of a larger cultural debate about weight loss, body image and the role of medication in it all.

You can listen to this episode of First Person on Apple, Spotify, Google or wherever you get your podcasts. The full transcript of the interview can be found here, with highlights below:

Fatima Cody Stanford

“A lot of people believed that obesity was just a consequence of other diseases as opposed to a cause of the 200 plus diseases that obesity does cause. That was one of the arguments. A lot of people pointed to a lot of the behavioral studies that did demonstrate for some people that they had achieved success in interventions like Weight Watchers, like you mentioned earlier, or community level interventions. And so there was this pushback against this being a disease characterized by pathophysiology in the body. And a lot of that, I would say, came from the public health space, this idea that we can fix it if we just work harder.”

Lulu Garcia-Navarro

“Dr. Stanford, let me ask you this. What does that mean? When you say you began to see that obesity is a disease, what is it a disease of? I mean, do we know what causes obesity?”

Fatima Cody Stanford

“So I’m going to say it’s a disease of the brain. And the reason why I’m going to say it’s a disease of the brain is because the brain regulates how the body stores fat. The brain is the central operating system.”

Fatima Cody Stanford

“If the brain’s not there, the rest of the body doesn’t work. So let’s explain what happens. There are two primary pathways by which the brain will regulate weight. There is the pathway that tells us to eat less and store less, what we call the POMC or proopiomelanocortin pathway, or AGRP pathway, which is the agouti-related peptide pathway, which tells us to eat more and store more.”

Fatima Cody Stanford

“And we don’t choose. And this is where the willpower issue goes away. My organs, my genetics, my environment, all of these things can play a role in whether I signal down the more desirable pathway or less desirable pathway. And so this comes the complexity of this disease that is obesity. Why do certain people signal one way and other people signal another way?”

Lulu Garcia-Navarro

“Well, help me understand this. Our genetics haven’t completely changed in the past 40 years. Yet, we’ve seen this huge increase in the number of people living with obesity. So what’s changed? I mean, are there environmental factors at play?”

Fatima Cody Stanford

“Absolutely. So we’ve placed our bodies inside of what we call this obesogenic environment. And this gets into those environmental factors and how they play a role.”

Fatima Cody Stanford

“How has diet quality changed? How has our sleep quality changed? Our screen time, how does that disrupt or affect our circadian rhythm? We’re supposed to rise when it’s bright outside and go to sleep when it’s dark outside.”

Fatima Cody Stanford

“But I can tell you that most of us don’t follow that as our inherent rhythm. So when we deviate from all of these things, put ourselves in this world that our bodies weren’t really created to be in, it’s going to lead to a greater storage of adipose or fat. It’s stress on the body. And when we have stress, stress increases storage of an organ that has typically helped us out. And that organ is adipose or fat.”

The full transcript of the interview can be found here.

[magitori]

Hello, all!

I’m happy to announce that my indie game, Animal Game: Race Panic!, is now nearly complete! The story, dialogue, and art has all been coded into the game, and now all that’s left is beta-testing. That being said: 

If you are interested in playing the full game as a beta-tester, please send me a message here on tumblr! 

Soon, I will post an announcement about the game’s release. Thank you for your patience!

[herapocalyps]

                                                  DOWN    ,    DOWN     ;       in    a     hole in the ground     There are      G H O S T S       that    never    can    be    found     ---     𝐇𝐎𝐌𝐄     ,    𝐇𝐎𝐌𝐄       𝐈𝐒      𝐈𝐍     𝐓𝐇𝐄     𝐆𝐑𝐎𝐔𝐍𝐃          ,     you're     only    waiting     at     the    end     of    the    road        .          And    nothing's     better    than       BLOOD ON BLOOD      ;       I promise sister    ,    you are safe with us     .            There's        no       telling          what      tomorrow       will    bring     ,        we    have    our    devils    and   OH    !       ---      YOU’VE GOT TO LET THEM SING  !

-----------------          indie    /     private    /     selective     ;      LAURA MOON     of                                      AMERICAN GODS.     headcanon based    &    novel-centric  .  

[healthinnovations]

Researchers show how to shut off hunger craving. Thoughts health innovators? It is known that the brain regulates food intake by processing sensory cues and peripheral physiological signals, however, the neural basis of this integration remains unclear. 

[dougielombax]

Just leaving this here.

Feel free to reblog.

[ahblab]

Exploring the Benefits of Peptide-based Dental Products

The biological roles and potential therapeutic benefits of peptides—short chains of amino acids—have drawn interest in contemporary dentistry. Their appearance in dental products indicates that the industry is moving towards creative approaches to mouth hygiene. As dental care peptide supplier explores various uses, the benefits of peptide-based dental treatments are starting to show. The possibilities for dental health are increased by these items’ many benefits, which span the spectrum from treatment to preventive care.

For More:

[massispost]

New Post has been published on https://massispost.com/2024/01/armenian-genocide-looted-art-and-restitution/

Armenian Genocide Looted Art and Restitution

LOS ANGELES — In the summer of 2023, the Armenian Genocide Research Program (AGRP) spearheaded the Armenian Genocide Looted Art Research Project (AGLARP), a multidisciplinary, collaborative research project aimed at (1) fostering research on Armenian art, cultural heritage, and other cultural objects that were looted, destroyed, or transferred in conjunction with the Armenian Genocide by using several disciplinary methods; and (2) engaging in critical thinking and action on the many dimensions of justice, dialogue, restitution, and repair regarding the losses of Armenian culture arising from the Armenian Genocide. The project is a follow-up to the AGRP’s March 2023 conference at UCLA, What’s Next?: Armenian…

[jhavelikes]

Contrary to theoretical predictions, their findings suggest that AgRP neurons do not work as a homeostat (i.e., firing when energy is low and ceasing their activity once the mice finish eating). "Instead, we found that ups and downs in daily AgRP neuron activity appear to follow recent feeding pattern," Atasoy said. "A yet to be clarified biological clock appears to be synchronized to past mealtimes and turns on and off the activity of AgRP neurons at those mealtimes, This is a clear divergence from 'homeostatic' regulation and more in line with so-called 'allostatic' regulation. Unlike homeostasis, in allostatic regulation, animals do not wait until their energy level drop." The results gathered by Atasoy and their colleagues suggest that AgRP neurons proactively defend the energy levels of mice before they actually feel the need to eat. They seem to achieve this by predicting future energy deficits based on cues learned from the past experiences of mice.

Study shows that AgRP neurons encode circadian feeding time in mice

[herapocalyps-a]

- “ Like my friend Jesus Christ, the only thing you need, dead wife, is RESURRECTION. ”

- “ did you just name drop Jesus Christ like you know a guy who knows a guy? ”