#enzyme art

[janasojka]

just night.

[charseraph]

Spidersona Crown pls

[isabelopaque]

WEIRD SCIENCE!!!

[fauxpapillons]

Luciferin......

[poeticalyx]

Oh my hollow spine,

Despite the decline,

Swallow me before nine,

And let me stay at your shallow,

As i float as an enzyme.

[gio-goose]

I don't get how the fuck GAP turns into glucose AND EVERYTHING I FIND GETS MORE CONFUSING

(yes, this is about photosynthesis)

[proxentauri]

the second half to the collab i did with the fantastic @sophios-draws!! this time i did the sketch/lineart and they did the colouring; check out the other version here!

the characters are my designs of a humanized version of the EcoRI (right) and FokI restriction enzymes, based on soph's original designs! i'll post refs for them at some point, probably (explaining how their character designs correspond to the enzymes' method of action)...check out soph's blog for other cool bio humanizations!!

[dementia7]

enzymes.gif

[pinkbat5]

the human enzyme galactokinase

[everythingaboutbiotech]

Common Restriction Enzymes

I help researchers increase engagement with their work. Together we will transform your ideas into unique and intuitive graphics with my reliable process: 1-Pinpoint your goals 2-Sketch and prototype 3-Discuss and iterate 4-Goal accomplished . 𝐇𝐈𝐑𝐄 𝐌𝐄 (DM Your Projects) . 💎Here to HELP You: ✔️Graphical Abstract Design ✔️Journal Figures Design ✔️Scientific Illustration ✔️Flyer and Poster Design ✔️Infographic Design ✔️Slides Design

[biotechstudentlife]

Nucleic Acid MCQ 279 Link in bio ☝️ for more mcqs recommendations . . #mcqueen #mcq #mcqs #mcqbiology #biologymcq #csirnet #enzyme #enzimjsr #biologia #bio #upscmcqs #art #biotech #biotechnology #biotechnologystudent #biotechnologist #instagram #instagood #inspiration #note #notes (at Los Angeles, California) https://www.instagram.com/p/Cp5GCrbvtFV/?igshid=NGJjMDIxMWI=

[jcmarchi]

Illuminating a critical step in initiating DNA replication in eukaryotes - Technology Org

New Post has been published on https://thedigitalinsider.com/illuminating-a-critical-step-in-initiating-dna-replication-in-eukaryotes-technology-org/

Illuminating a critical step in initiating DNA replication in eukaryotes - Technology Org

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to better understand how DNA replication is initiated in eukaryotes. Using Vanderbilt’s state-of-the-art instrumentation in the Center for Structural Biology’s Cryo-Electron Microscopy Facility, Eichman, Chazin, and their colleagues provided detailed visualizations of a multi-functional protein in action, which sheds light on how DNA replication is initiated in humans.

Cryo-EM structures of polα–primase reveal a remarkable range of motion between two sub-complexes.

Eichman and Chazin shared reflections on this research, newly published in Nature Structural & Molecular Biology:

What issue does your research address?

We are interested in the molecular details of human DNA replication, one of the most fundamental processes of life; it is repeated millions of times each day as we make new cells. The new copies of DNA are synthesized by polymerases, which read the sequence of an existing DNA strand one nucleotide at a time and add the complementary nucleotide to the nascent DNA strand. Specific polymerases perform the bulk of DNA synthesis but cannot function without first having a short “primer” segment of the new strand.

This work addresses the molecular mechanisms of DNA polymerase α–primase (polα–primase), the enzyme responsible for synthesizing the primers. Polα–primase is an essential enzyme as it is the only polymerase that can initiate DNA synthesis by generating the primers that the other polymerases need to duplicate the genome.

Despite polα–primase being the first human polymerase discovered, the way it synthesizes very specific lengths of RNA and DNA in a single strand remained unclear for more than fifty years. How does it know that it has synthesized a specific number ofnucleotides of RNA before transitioning to DNA synthesis? How does it transition between the two modes? How does it know that it has synthesized a certain number of nucleotides of DNA before stopping?

Understanding the mechanisms behind polα–primase’s ability to “count” the length of the RNA and DNA segments of the primer is important because primers must be kept to a very short length, as they contain RNA in the new DNA strand and the DNA synthesized by polα is littered with mutations. Thus, the primers would be highly detrimental to the cell if they became a substantial part of the new DNA strand that persisted in the genome after replication.

To answer these outstanding questions, we used cryo-electron microscopy to capture snapshots of this multi-functional protein at various stages as it generates a primer. The high-resolution structures we determined illuminated the mechanisms of RNA and DNA counting by polα–primase. They also provide a starting point for design of novel small molecule modulators of polα–primase function that would provide new ways to investigate DNA replication in cells.

What was unique about your approach to the research?

The Eichman and Chazin labs have collaborated for many years to understand how polα–primase works. We visualized some of the first structures of polα–primase bound to nucleic acid substrates. It was the highly strategic design of primer/template substrates that allowed our team to “trap” the enzyme at several specific points along the pathway to synthesizing the primer. Importantly, this research was made possible by access to the state-of-the-art instrumentation in the CSB Cryo-Electron Microscopy Facility.

What were your findings?

Our data directly show that polα–primase holds on to one end of the primer throughout all stages of synthesis. This observation is critical to understanding how the initial RNA-primed template is handed off from the primase active site in one subunit (where RNA synthesis occurs) to the DNA polymerase active site in another subunit (where DNA synthesis occurs). The sustained attachment also serves to increase polα–primase’s ability to remain bound to the template and to regulate both RNA and DNA composition. Importantly, the detailed analysis of the structures revealed how flexibility within this four-subunit complex is critical to being able to synthesize the primer strand across two active sites.

In addition, our research suggests that termination of DNA synthesis is facilitated by reduction polα and primase affinities for the template as more DNA is synthesized.

What do you hope will be achieved with the research results? 

We hope our research findings will illuminate to the field a more complete understanding of replication initiation and contribute to the growing understanding that complex molecular machinery requires flexibility and dynamics to function. The inherent flexibility within this complex, multi-subunit polymerase is essential to primer synthesis and to its ability to dynamically interact with multiple other enzymes present in the replisome (for the handoff of the primer to the replicative polymerase for bulk DNA synthesis, for example).

We also hope that this work will lead to a better understanding of how current polα–primase inhibitors work and more broadly pave the way for future designs of small molecule modulators to serve as tools for studying DNA replication in cells. Tool compounds of this type can also be used to evaluate the therapeutic potential of targeting specific replication proteins with roles in diseases of genome instability.

Source: Vanderbilt University

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[isabelopaque]

we saw you across the bar and HATED your vibes (iggy owned by @princeshilo)

[funsimplethings]

[randomslasher]

Haha so

My psychiatrist wanted me do a genetic test to figure out what meds will help me the most (something something what enzymes does my brain not convert to something else something science something) and I said "I'd love to but I just need to know the price" and she said "Oh, insurance will cover it."

So guess what haha insurance does NOT cover it because apparently the lab is out of network! I now owe them a few hundred bucks that I do not have to spare at the moment.

So...would anyone be interested in a mandala art commission?

Here are the things I can do and prices. At the moment I think I can only afford to ship to the US (sorry :( ) Though if you want me to ship internationally and you're willing to pay the extra for the shipping just let me know.

EDIT: The pieces pictured have all been sold but I can recreate them/do custom colors and whatnot! Just holler at me :)

Rocks: $30 (S&H included)

Coasters: $15 for one, $12 ea if you order more than 1 (S&H included)

Wall Art (plywood circle): $50 (S&H included)

So...yeah if you're interested please send me an ask, please and thank you very kindly for your consideration.

[lenny-link]

um,, engiespy yuri,,,,,,,plez,,,,,,

i love old women yuri <<33

bro the way that i gave up on all the other fanarts i was working on, art requests, art trades, biocomputing homework, enzyme engineering assignments, life projects, studying, eating, breathing since i received this ask a few days ago, because my brain couldn’t stop thinking about these two old gay ladies being in love

i thought engiespy was my otp but femengiespy now thats something else

also the "experiment 08" is obviously a reference for "expiration date" it rhymes lol

(i know its just a single letter changing but idk they all give a different vibe and i just couldnt choose one :p)

edit: you can suggest other names if you wish in the comments! :D