#hypercholesterolemia

[medicomunicare]

Lipoproteins and cardiovascular risk: how t manage

What are lipoproteins? Dietary lipids are digested within the gastrointestinal tract, following which they enter the intestinal mucosa to become chylomicrons, transporting triacylglycerols from food into the blood. Chylomicron breakdown in muscle or fat tissue yields chylomicron remnants for excretion by liver cells. Lipoproteins consist of lipids that are chemically attached to protein…

[trendingarticles]

Dizziness as a Potential Symptom of Hypercholesterolemia

What it is Cholesterol? Cholesterol or hypercholesterolemia refers to a medical condition characterized by high levels of cholesterol in the blood. Cholesterol is a type of lipid (fat) that is essential for various bodily functions, including the formation of cell membranes, production of certain hormones, and synthesis of vitamin D. However, when cholesterol levels exceed the normal range, it…

[berryblogg]

Managing Ehlers-Danlos Syndrome: Lifestyle Modifications and Treatment Options

[iconhub2023]

Lipid Control Plus Cholesterol

Lipid Control Plus is a multi-ingredient food supplement designed for people who want to take comprehensive care of their cholesterol levels, liver health and cardiovascular system. The product has been created on the basis of 8 natural ingredients. Take control of your cholesterol!

Regular use of Lipid Control Plus helps to take care of the lipid profile. The product supports detoxification and the flow of digestive juices. Lipid Control Plus also prevents the accumulation of fats and improves their removal by the liver. Consumers will appreciate that the product supports heart health and supports proper liver function. 7 benefits of taking Lipid Control Plus!

Lipid Control Plus is a multi-tasking food supplement sought after by informed consumers. Reach new customers with your offer - promote Lipid Control Plus Comprehensive support for the body Product Ingredients!

[jppres]

Effect of Lissachatina fulica chitosan on the antioxidant and lipid profile of hypercholesterolemic male Wistar rats

Image: Flickr Article published in J. Pharm. Pharmacogn. Res., vol. 10, no. 6, pp. 995-1005, November-December 2022. DOI: https://doi.org/10.56499/jppres22.1468_10.6.995 Umarudin1,2, Sri Widyarti1, Warsito3, Sri Rahayu1* 1Department of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya, Malang 65145, East Java, Indonesia. 2Department of Pharmacy, Diploma III…

[cannondisabledcharacters]

Today’s disabled character of the day is Anita Sánchez from The Book of Life, who is a wheelchair user and has hypercholesterolemia

[Image Description: 3D model of a woman knitting dark brown fabric. He has long with hair tied in a bun and light brown eyes. She is wearing glasses, black long sleeve dress, and white tear drop earrings. She is sitting in a wooden wheelchair.]

[bommagoni]

Homozygous Familial Hypercholesterolemia Treatment Market

[headspace-hotel]

I forget why, but I was on the Wikipedia page for polycystic ovarian syndrome, and I started researching hirsutism in women, and I learned the following things in this order:

there's a diagnostic criteria used to evaluate how hairy a woman is

This is important because being too hairy is a diagnostic criteria of most disorders that cause hyperandrogenism

Disorders that cause hyperandrogenism can be diagnosed by...measuring how hairy you are (this is the main and most important diagnostic criterion for PCOS)

Disorders that cause hyperandrogenism are important because they are correlated with obesity, infertility, and...being too hairy?

I think to myself, wait, what is a normal range for testosterone in women? I find this article...which set reference ranges for "normal" testosterone levels in women...EXCLUDING WOMEN WITH PCOS?

Quote: "Polycystic ovary syndrome (PCOS) is another notable condition in genetic (XX) females, which is characterized by excessive ovarian production of androgens. This condition is included for comparison with DSD, as the affected females with PCOS are genetic and phenotypic females. The elevated levels of testosterone in these females can lead to hyperandrogenism, a clinical disorder characterized variably by hirsutism, acne, male-pattern balding, metabolic disturbances, impaired ovulation and infertility. PCOS is a common condition, affecting 7%-10% of premenopausal women."

So: the study claims to demonstrate a clear distinction between the normal range of hormone levels in "Healthy" men and "healthy" women...with "healthy" being defined in the study as...having hormones within the "normal" range.......................

So I researched what the clinically established "normal" range for testosterone in women is

THERE ISN'T ONE????

Quote from the above article: "Several different approaches have been used to define endocrine disorders. The statistical approach establishes the lower and the upper limits of hormone concentrations solely on the basis of the statistical distribution of hormone levels in a healthy reference population. As an illustration, hypo- and hypercalcemia have been defined on the basis of the statistical distribution of serum calcium concentrations. Using this approach, androgen deficiency could be defined as the occurrence of serum testosterone levels that are below the 97.5th percentile of testosterone levels in healthy population of young men. A second approach is to use a threshold hormone concentration below or above which there is high risk of developing adverse health outcomes. This approach has been used to define osteoporosis and hypercholesterolemia. However, we do not know with certainty the thresholds of testosterone levels which are associated with adverse health outcomes."

What the fuck?

What the fuck?

It's batshit crazy to make a diagnostic criteria for medical disorders by placing arbitrary cutoffs within 2-5% of either end of a statistical distribution. What the actual fuck?

"The results came back, you have Statistical Outlier Disease." "What treatments are available?" "Well, first, we recommend dietary change. You should probably stop eating so many spiders."

Another article which attempted to do this

Quote: "Subjects with signs of hirsutism or with a personal history of diabetes or hypertension, or a family history of polycystic ovarian syndrome (PCOS) were excluded."

"We're going to figure out the typical range of testosterone levels that occur in women! First, we're going to exclude all the women that are too hairy from the study. I am very good at science."

Anyway I got off topic but there are apparently race-specific diagnostic tools for "hirsutism." That's kinda weird on its own but when I looked more into this in relation to race I found this article that straight-up uses the term "mongoloid"

[medicomunicare]

Niacin paradox on the heart shows off: catabolism reveals potential threats on cardiovascular risk

Cardiovascular disease (CVD) is a worldwide health problem, with only a tiny proportion of the risk linked to known risk factors. Despite breakthroughs in therapeutics, the risk of CVD remains high, indicating the presence of other unidentified variables. Niacin (vitamin B3) is critical in CVD treatment but physicians in the past have speculated that niacin lacking could be a predisposing factor…

[munaeem]

Familial Hypercholesterolemia: Understanding the Genetic Cause and Effective Treatment

Familial Hypercholesterolemia (FH) is a genetic disorder characterized by high levels of low-density lipoprotein (LDL) cholesterol in the blood. It is caused by a mutation in the LDL receptor gene, which plays a crucial role in removing LDL cholesterol from the bloodstream. The LDL receptor gene mutation disrupts the normal functioning of the receptor, leading to impaired clearance of LDL…

[drpedi07]

US (MEDPED) Diagnostic Criteria for Familial Hypercholesterolemia (FH) Calculator

The US (MEDPED) diagnostic criteria for Familial Hypercholesterolemia Diagnoses FH by using patient's age range and cut off values of total cholesterol.

[berryblogg]

Do people with uncontrolled diabetes also suffer from hypertension and hypercholesterolemia?

people with uncontrolled diabetes also suffer from hypertension and hypercholesterolemia.

[futuretonext]

The Global Hypercholesterolemia Market is projected to grow at a CAGR of around 3.2% during the forecast period, i.e., 2023-28. The market is driven by the alarming rise in the prevalence of cardiovascular diseases and chronic disorders such as diabetes, obesity, and others worldwide. Elevated levels of non-HDL cholesterol and LDL in the blood may result in life-threatening conditions, including heart disease and stroke. According to WHO, raised total cholesterol is a major cause of disease burden in both the developed and developing world as a risk factor for ischemic heart disease and stroke. Globally, a third of ischaemic heart disease is due to high cholesterol. Overall, raised cholesterol is estimated to cause 2.6 million deaths (4.5% of total) and 29.7 million DALYS, or 2% of total DALYS.

[scienceswitch]

Breakthrough Drug Achieves 65% Reduction in Genetic 'Bad Cholesterol'

For the first time, doctors may soon have a way to lower extremely high levels of a risky type of cholesterol known as lipoprotein(a), or Lp(a). This genetically-influenced cholesterol has long been untreatable, leaving many patients at heightened risk of heart disease. But thanks to a new breakthrough drug called muvalaplin, there is now hope for better controlling this “silent killer.” Lp(a) is…