#long covid treatment

[pandemic-info]

by Hannah E. Davis, Lisa McCorkell, Julia Moore Vogel & Eric J. Topol

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Fig. 1: Long COVID symptoms and the impacts on numerous organs with differing pathology

Fig. 3: Hypothesized mechanisms of long COVID pathogenesis

There are several hypothesized mechanisms for long COVID pathogenesis, including immune dysregulation, microbiota disruption, autoimmunity, clotting and endothelial abnormality, and dysfunctional neurological signalling. EBV, Epstein–Barr virus; HHV-6, human herpesvirus 6; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

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Table summarizing candidate treatment options for different components of long Covid / view in full here: https://www.nature.com/articles/s41579-022-00846-2/tables/1

[longhaulerbear]

Following perispinal etanercept administration there was immediate neurological improvement. At 24 hours there were remarkable reductions in chronic post-COVID-19 fatigue and depression, and significant measureable improvements in cognition, executive function, phonemic verbal fluency, balance, gait, upper limb coordination and grip strength. Cognition, depression and fatigue were examined at 29 days; each remained substantially improved.

Conclusion

Perispinal etanercept is a promising treatment for the chronic neurologic dysfunction that may persist after resolution of acute COVID-19, including chronic cognitive dysfunction, fatigue, and depression. These results suggest that long COVID brain neuroinflammation is a potentially reversible pathology and viable treatment target. In view of the increasing unmet medical need, clinical trials of perispinal etanercept for long COVID are urgently necessary. The robust results of the present case suggest that perispinal etanercept clinical trials studying long COVID populations with severe fatigue, depression and cognitive dysfunction may have improved ability to detect a treatment effect. Positron emission tomographic methods that image brain microglial activation and measurements of cerebrospinal fluid proinflammatory cytokines may be useful for patient selection and correlation with treatment effects, as well as provide insight into the underlying pathophysiology.

[healthbuyerclub]

What is Chronic Fatigue? Can it be cured?

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. People with ME/CFS are often not able to do their usual activities and enjoy their life. People with chronic fatigue syndrome (CFS) usually have tremendous difficulty doing the things that many of us take for granted. We usually don’t think twice about getting dressed or driving to some place provided we had enough rest. However, this is not the case for someone who is chronically fatigued. Sometimes ME/CFS can even confine a person to bed. People with ME/CFS have severe fatigue and sleep problems.

Chronic fatigue syndrome occurs more commonly in women. The cause of this condition is unknown, but may include environmental or genetic factors. The main symptom is fatigue for over 6 months. The fatigue often worsens with activity and does not improve with rest. There is not one Chronic fatigue syndrome treatment that fits all. Latest news on Chronic Fatigue Syndrome compares it to Long Covid.

How long does chronic fatigue last?

For some it can be shorter. Unfortunately, for most it can last for long periods of time and they are unable to recover. However, some symptoms can be treated or managed to provide relief. New treatments for chronic fatigue syndrome include: Targeted supplementation with products that increase ATP and energy that can help reduce fatigue. Brands such as; Bodybio, Biopure, Cellcore, and Quicksilver Scientific offer supplements like glutathione, minerals, and fatty acids that help improve the cell membrane function and fatigue. There is a product called Oxaloacetate made by Benegene that has some great clinical studies showing improvement in energy and lowered fatigue.

Is there a test for Chronic Fatigue Syndrome?

Currently there are no tests to determine if someone has CFS. New tests are being developed but they are not commercially available. Many patients look for top chronic fatigue doctors. It can be extremely expensive and hard to get appointments with CFS specialists. This condition can be very frustrating for many reasons. First, rest does little to nothing to suppress CFS symptoms. Second, the causes of chronic fatigue syndrome are not well known (though a weakened immune system, hormonal imbalances, viral infections, and stress may contribute). HealthBuyerClub.com was created to help those dealing with this chronic illness, along with many others, afford the treatments and medical devices they need. We offer up to 40% in savings on over 55 physician formulas brands and technology. We also have a referral program. Join our club today for FREE and start saving today!

[joseywritesng]

Other viruses offer clues to the mystery of long-term COVID

Other viruses offer clues to the mystery of long-term COVID

August 18, 2022 – Researchers hunt a range of potential culprits in the race to find the causes of long-term COVID. They agree on some things: There will be a number of different causes and the symptoms will vary greatly from case to case. The two leading theories: the persistence of the coronavirus that causes COVID-19, and an overactive immune response. There is some evidence that the…

[clothinglennyco]

Stress hormone cortisol may explain long COVID—and how to treat it, Yale researchers say

Stress hormone cortisol may explain long COVID—and how to treat it, Yale researchers say

Public health officials are scrambling to understand long COVID, the condition in which patients report symptoms like fatigue, muscle weakness and ‘brain fog’ months after infection. A new study released Wednesday shows one way doctors might diagnose who has the chronic condition and indicates a possible way to treat it. Researchers from the Yale School of Medicine and the Icahn School of…

[reportwire]

Long COVID Doubles Risk of Some Serious Outcomes in Children, Teens: Study

Long COVID Doubles Risk of Some Serious Outcomes in Children, Teens: Study

Aug. 4, 2022 – CDC researchers report that children and teenagers with long COVID have about twice the risk of getting serious outcomes, compared to others without COVID. Heart inflammation; a blood clot in the lung; or a blood clot in the lower leg, thigh, or pelvis were the most common bad outcomes in a new study. Even though the risk was higher for these and some other serious events, the…

[puppyeared]

Why are ppl scared to call it what it is and say we’re still going thru covid on top of seasonal illness. Like. That’s pretty important right. I was watching the news and they were like oh yeah we have an unprecedented number of flu cases “as well as other sicknesses” without actually saying Covid. No announcement abt vaccinations or masking or anything. Also if I hear someone joking abt “war flashbacks” for mentioning covid I fucking hate u

[impotsiblelife]

Don't feel bad if you haven't recovered from a condition your doctor says is "very treatable." Doctors and society in general often underestimate how debilitating pain, physical illnesses, and mental health problems can be. Don't listen to anyone who insinuates that you don't want to get better or aren't committed to your treatment because your symptoms haven't improved much. Take as long as you need to heal.

[longhaulerbear]

From May 2022.

Both parasympathetic excess and sympathetic withdrawal are separate and treatable autonomic dysfunctions and autonomic treatment significantly reduces the prevalence of autonomic symptoms. Conclusion. SARS-CoV-2, via its oxidative stress, can lead to P&S (parasympathetic and sympathetic) dysfunction, which, in turn, affects the control and coordination of all systems throughout the whole body and may explain all of the symptoms of long-COVID syndrome. Autonomic therapy leads to positive outcomes and patient quality of life may be restored.

The initial respiratory compromise, due to the COVID-19 virus, on the medullary respiratory control centers (including the pre-Bötzinger complex) [9,10,11] may be so dramatic that P&S symptoms and signs are often overlooked or misunderstood.

Respiratory pacing from the pre-Bötzinger complex involves (1) vagus nerve afferents, among other brainstem structures; (2) feedback from the COVID-19-damaged lung; (3) aortic and carotid chemo-, baro-, and vagal receptors; and (4) medullary chemoreceptors. All involving P&S nerves [9,12]. Brainstem cardiorespiratory centers (e.g., the Nucleus Tractus Solitarius, Dorsal Vagal Motor Nucleus, and Nucleus Ambiguus, all of which are autonomic nuclei) are also implicated in COVID-19 infection [13]. Furthermore, sympathetic involvement in cytokine storms [14,15,16,17] and the angiotensin system [18,19], and parasympathetic involvement in immune function [20,21,22], provides further evidence of P&S compromise in COVID-19 infections. Any resulting damage to these nerves further implicates P&S dysfunction in long-COVID syndrome.

Long-COVID symptoms [23] may be explained by a pro-inflammatory state with oxidative stress and P&S dysfunction.

Long COVID is characterized by parasympathetic excess and alpha-sympathetic withdrawal.

Anti-cholinergic therapy may relieve post-COVID-19 symptoms associated with parasympathetic excess. This is hypothesis generating and further trials are needed.

Based on their P&S test results, the patients were prescribed therapy, typically for both sympathetic withdrawal (and associated orthostatic dysfunction) and for parasympathetic excess. Therapy for sympathetic withdrawal (after ruling out vascular causes) typically included: (1) 2.5 mg, tid, of Midodrine (ProAmatine, an alpha-adrenergic antagonist); and (2) up to 600 mg, tid, of Alpha-Lipoic Acid (an antioxidant selective for nerves [29,30]). Therapy for parasympathetic excess included: (1) 10 mg, qd, of Nortriptyline (as a low-dose anti-cholinergic), and (2) up to 40 minutes of low-and-slow exercise.

In our findings, long COVID is largely characterized by parasympathetic excess and sympathetic withdrawal. Both potentially contributing to hypoperfusion of the brain and all structures above and around the heart. Pre-COVID-19 infection, patients presented to the clinics with more sympathetic withdrawal (45.7%) than parasympathetic excess (27.0%). Post-COVID-19 infection, these patients presented with that ratio reversed (36.2% and 46.7%, respectively). The etiology of this is not well known; however, parasympathetic excess may be more prominent post-COVID-19, due to an over-active immune system, which the parasympathetics help to control and coordinate and leads to parasympathetic excess.

Orthostatic dysfunction is caused by poor vasoconstriction due to alpha-adrenergic (sympathetic) dysfunction, known as sympathetic withdrawal [5]. Poor perfusion and dysfunction are exacerbated by the effect of COVID-19 on the lungs.

Both parasympathetic excess and sympathetic withdrawal are separate and treatable dysfunctions. As in this study, parasympathetic excess was treated, pharmaceutically, with anti-cholinergics (e.g., Nortriptyline, see the Methods Section) [31] and sympathetic withdrawal was treated, pharmaceutically, with oral vasoactives (e.g., Midodrine, see the Methods Section).

Traditionally, upon COVID-19 infection, there is a marked increase in the resting sympathetic activity and a decrease in anti-inflammatory resting parasympathetic activity [16], causing a high (resting) sympathovagal balance in all patients. However, in post-COVID-19 syndrome patients, after 12 weeks or more, our data shows that there is a significant percentage of patients that develop a parasympathetic dominance as indicated by the low (resting) sympathovagal balance. This is also indicative of increasing and prolonged parasympathetic activity. Parasympathetic activation is meant to be protective; including, since the parasympathetics are anti-inflammatory. However, prolonged and increased parasympathetic activity, especially in response to stressors, seems to exaggerate sympathetic inflammatory activity. Within this cohort, and anecdotally with the vast majority of our patients, anti-cholinergic therapy relieves parasympathetic excess. Further studies are required to elaborate whether anti-cholinergic therapy may relieve post-COVID-19 symptoms.

Further decreases in cerebral perfusion may lead to “adrenaline storms”, which cycle anxiety-like symptoms, including shortness of breath and palpitations which may cause chest pressure or chest pain. The effects of sympathetic withdrawal and orthostatic dysfunction are exacerbated by parasympathetic excess, which may limit or decrease the heart rate and blood pressure, reducing cerebral perfusion. The decrease in BP is also associated with excessive vasodilation from parasympathetic excess.

If the parasympathetics increase in response to a stress (known as parasympathetic excess), the result is a secondary sympathetic excess [5]. Our findings of prolonged parasympathetic excess in long-COVID patients appears to prolong sympathetic excess responses causing more and chronic symptoms, suggesting that this may be a mechanism contributing to long-COVID syndrome.

Pharmaceutical therapy for P&S dysfunction (anti-cholinergics for parasympathetic excess [28] and oral vasoactives for sympathetic withdrawal [39]) needs to be very low to prevent additional symptoms, thereby exacerbating P&S dysfunction.

[moregraceful]

If I do not test negative in the next three days, I will be creating an incident. If I miss the Cuda game on Wednesday I will create such a situation. Yes I caught Covid at either a Sharks or Cuda game, yes I still love them, it's a toxic relationship where everyone loses.

[healthbuyerclub]

What is Chronic Fatigue? Can it be cured?

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. People with ME/CFS are often not able to do their usual activities and enjoy their life. People with chronic fatigue syndrome (CFS) usually have tremendous difficulty doing the things that many of us take for granted. We usually don’t think twice about getting dressed or driving to some place provided we had enough rest. However, this is not the case for someone who is chronically fatigued. Sometimes ME/CFS can even confine a person to bed. People with ME/CFS have severe fatigue and sleep problems.

Chronic fatigue syndrome occurs more commonly in women. The cause of this condition is unknown, but may include environmental or genetic factors. The main symptom is fatigue for over 6 months. The fatigue often worsens with activity and does not improve with rest. There is not one Chronic fatigue syndrome treatment that fits all. Latest news on Chronic Fatigue Syndrome compares it to Long Covid.

How long does chronic fatigue last?

For some it can be shorter. Unfortunately, for most it can last for long periods of time and they are unable to recover. However, some symptoms can be treated or managed to provide relief. New treatments for chronic fatigue syndrome include: Targeted supplementation with products that increase ATP and energy that can help reduce fatigue. Brands such as; Bodybio, Biopure, Cellcore, and Quicksilver Scientific offer supplements like glutathione, minerals, and fatty acids that help improve the cell membrane function and fatigue. There is a product called Oxaloacetate made by Benegene that has some great clinical studies showing improvement in energy and lowered fatigue.

Is there a test for Chronic Fatigue Syndrome?

Currently there are no tests to determine if someone has CFS. New tests are being developed but they are not commercially available. Many patients look for top chronic fatigue doctors. It can be extremely expensive and hard to get appointments with CFS specialists. This condition can be very frustrating for many reasons. First, rest does little to nothing to suppress CFS symptoms. Second, the causes of chronic fatigue syndrome are not well known (though a weakened immune system, hormonal imbalances, viral infections, and stress may contribute). HealthBuyerClub.com was created to help those dealing with this chronic illness, along with many others, afford the treatments and medical devices they need. We offer up to 40% in savings on over 55 physician formulas brands and technology. We also have a referral program.

Join our club today for FREE and start saving today!

[joseywritesng]

Diagnosing children with long-term COVID can be tricky: experts

Diagnosing children with long-term COVID can be tricky: experts

August 15, 2022 – When Spencer Siedlecki contracted COVID-19 in March 2021, he was ill for weeks with extreme fatigue, fever, sore throat, severe headache, nausea and eventually pneumonia. That was scary enough for the then 13-year-old and his parents, who live in Ohio. More than a year later, Spencer still had many of the symptoms and, more alarmingly, the once-healthy teenager had… postural…

[autismserenity]

Hello! I'm here to bring you your breaking medical news from Twitter!

(No lie: I'm sure it depends who you're following, but I get really clear and specific COVID-19 info there.)

In this peer-reviewed, randomized, double-blind, multicentre, parallel group, placebo-controlled phase III clinical trial (which you KNOW I read through before sharing!), people with COVID-19 tested negative much sooner when using nitric oxide nasal spray.

It reduced the virus in their noses, which makes it less contagious AND means the patients get less sick.

(It specifically mentioned symptoms ending sooner, and it looked like a fair number of people on placebo were still having symptoms after 2½ weeks. I really hope that means it will significantly reduce the risk of long COVID, but of course it'll take months to find out for sure.)

And it apparently works on all (or just lots?) of airborne viruses.

More trials are apparently on the way, but you can buy these sprays over the counter - at least online.

[createyourownnarrative]

Fellow Covid Long Hauler, here.

3 years 3 months in this hell

Surfing the internet, for Long Covid news, as usual, since I was “diagnosed” with this condition, and I noticed a few things.

I’m seeing and reading a lot of articles and “news” about Long Covid; not being real, may not be as bad as Influenza, Long Cold might be a thing too, etc.

Pay attention to wording. Words like “likely” “maybe” “may” “if” “yet”.

Long Covid “may” not be real

Flu “might be worse” than Long Covid

Long Cold, exists too, “likely”.

These people don’t sound too sure. Because they have no foundation, no proof. Pure speculation. So next time, fellow Long Hauler, if you see some dismissive piece of shit article, downplaying and invalidating our whole experience, just look at the wording. 🖤

And always always always check. your. sources