Frankly, the biggest reason nobody can figure out how to make a Duke Nukem reboot work is because they think the 90s edgelord bullshit is the main reason that Duke Nukem 3D was such a breakout hit, when the truth of the matter is that it succeeded at least partly in spite of that. Duke Nukem 3D legitimately pushed the envelope in terms of what it was possible for a first-person shooter to be – in many ways it's just as foundational to the genre in its modern form as Wolfenstein 3D or Doom. You can't recapture that with dick jokes, and if you're not willing to take risks in terms of basic game design, dick jokes are all you have.
Ultimately, what the franchise really needs to shake off its creative rust is to stop trying to iterate on its established formula and shift genres entirely. To this end, I have a proposal: make the next Duke Nukem game a side-scrolling metroidvania. In this essay
I think modern day Duke Nukem would be a total chaser because he’d come out of whatever coma Randy ‘Greaseball’ Pitchford has him in and he’d hear about trans women and be like “Damn… they’re making new chicks… I gotta get a piece of that action.” And he’d pull his notepad (labeled ‘SHIT I GOTTA TRY’) and crayon out and write ‘TGIRL PUSSY’ directly under ‘NEW MCRIB’ and ‘CONCUSSION’
It's a scientific fact that Doom would be cooler if Doomguy was a woman. You wouldn't have to change anything else. Just make it about a lady shooting demons. You could even still call her Doomguy.
Every 90s FPS game put you in the shoes of an unstoppable badass with a fully loaded arsenal and a incomplete understanding of how to climb ladders, living in a world where opening a door the wrong way can cause you to spontaneously explode