#protein folding

[mindblowingscience]

While we often think of diseases as caused by foreign bodies—bacteria or viruses—there are hundreds of diseases affecting humans that result from errors in cellular production of proteins. A team of researchers led by the University of Massachusetts Amherst leveraged the power of cutting-edge technology, including an innovative technique called glycoproteomics, to unlock the carbohydrate-based code that governs how certain classes of proteins form themselves into the complex shapes necessary to keep us healthy. The research, published in the journal Molecular Cell, explores members of a family of proteins called serpins, which are implicated in a number of diseases. The research is the first to investigate how the location and composition of carbohydrates attached to the serpins ensure that they fold correctly. Serious diseases—ranging from emphysema and cystic fibrosis to Alzheimer's disease—can result when the cellular oversight of protein folding goes awry. Identifying the glyco-code responsible for high-fidelity folding and quality control could be a promising way for drug therapies to target many diseases.

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[cbirt]

Scientists from the University of Washington, USA, studied how deep learning boosts and improves de novo protein binder design and devised a protocol for deep learning-aided protein binder design. In recent times, it has been plausible to design novel high-affinity protein-binding proteins using the structural information of the target alone. However, given the low success rate of the overall design, the opportunities for improvement are manifold. The authors explore the deep learning-aided augmentation of energy-based protein binder design. The authors find that the design success rate increases nearly tenfold on using AlphaFold2 or RoseTTAFold for assessing the probability that the structure of the designed binder binds the target.

Protein binders with high affinity for their targets are of high significance in biomedicine. Methods developed for designing such protein binders are, therefore, highly significant for therapeutics as well as diagnostics. Most prevalent methodologies involve either the immunization of an animal with the target for antibody generation or the screening of random complex libraries of antibodies or other scaffolds. Apart from being highly labor-intensive, these experiments provide little scope for control over the properties of the binding molecules.

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[covenawhite66]

Updated research on small cellular machine called TRiC controls the folding of tubulin, a human protein that is the foundation of microtubules.

This challenges the previous understanding that TRiC and other machines like it, known as chaperonins, only passively create a favorable environment for folding but do not actively take part in it.

Many of the proteins that fold with the aid of TRiC are intimately linked to human diseases, including certain cancers and neurodegenerative disorders like Parkinson’s, Huntington’s, and Alzheimer’s diseases.

[whats-in-a-sentence]

There are several different classes of HSPs, including HSP70s that bind and release misfolded proteins, HSP60s that produce huge barrel-like complexes that are used as chambers for protein folding, HSP101s that mediate the disaggregation of protein aggregates, and sHSPs and other HSPs that bind and stabilize different complexes and membranes (Figure 24.21).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[ontonix]

Ontonix Publishes Article in Biomedical Journal of Science and Technology

Como, 5-th May, 2023. Ontonix Publishes Article in Biomedical Journal of Science and Technology on “Protein Folding – Quantification of Protein Complexity, Robustness and Amino Acid Participation”. The QCT (Quantitative Complexity Theory) algorithm has been applied to the analysis of the folding process of a protein composed of 435 atoms, monitoring its complexity at each step thereof. The…

[medicomunicare]

Anticancer weaponry upgraded: the more the knowledge below, the more specific the payload

Anticancer weaponry upgraded: the more the knowledge below, the more specific the payload

Although advances in chemotherapy over the past 20 years have led to better survival of patients with various forms of cancer, the continuing biological evolution of drug-driven tumors leads to the breakdown of resistant forms with the consequent possibility of therapeutic failures. This is why the continuous development of new categories of drugs is necessary to overcome the problem. A study in…

[megafunk]

The Prion Witch

A silly Mage-afunk as a birthday gift for myself :D

Based on Serbian folk costume if you couldn't tell haha Her staff is made out of glass beads and the top curvy part can separate like a beaded bracelet-> quick n easy whip weapon :)

Shame I couldn't show her doll body but it's a sacrifice I'm willing to take!

[macgirlism]

would be so funny if ryan reynolds really did play mac’s boyfriend and he did a bunch of elaborate, incredibly romantic gestures like just spent loads of time and money on mac only for dennis to pay mac one (1) singular compliment or do smth else weirdly homoerotic as he usually does and that’s what wins in the end. bc they’re codependent losers and they’re in love. sorry to ryan reynolds

[venturelovebot]

the venture brainrot grows strongly each day

It's a prion disease for sure

[existennialmemes]

I act like I'm fine, but I'm not

I am constantly afraid of Prion Diseases

You can't detect them

You can't kill them

They get inside your Brain and they REFOLD YOUR PROTEINS

Honestly they are way too overpowered, it's unfair to the others diseases

Nature needs to fix this in its next update

[dreamsicle262]

i need to know: does anyone who reads my fics get confused when i throw in medical terms

[megumi-fm]

every once in a while I remember that RT-QUIC is an actual diagnostic concept with good reproducibility that is somehow stuck in the same stage of research for years now and I go insane about it

[tanadrin]

Michael Hobbes fucking up the explanation of prion disease on Maintenance Phase is super annoying

[sleepymccoy]

Me, six months into a master's degree, writing an essay on the neuropathology of Alzheimer's disease: actually what the fuck is an amyloid anyway