#Aging Process

[soli-terri]

Untitled

By ungfio

Digital art

[emperornorton47]

[augustdoll]

It is said that every seven years

All of the cells in our body replace

Every seven years is our sun return

Every seven years is hard

Every seven days go by like water every seven years

The dam floods open

Sometimes I’m afraid it happens too young.

[authoring-myself]

Re-meeting her

Being here and hearing them

It makes me want to cry

Because suddenly I’m here again

Instead of 29

I’m 19 laughing with my friends

We’re reckless and we’re young

I’m mad my date won’t dance with me

While they’re all having fun

And then we’re all now 21

And now our life has just begun

My side parted hair

is dark and black

He breaks my heart

I break his back

The next thing I remember is

I’m suddenly 22

Our last day of life is coming up

And I’m just missing you

And then I’m turning 23

And I look at him

and he looks at me

We’re on the altar

And all I know

Is he’s my life

And he’s my home

But when I’m here

I’m here with them

And suddenly 19 again.

[rolypolyjolie]

Part of being an adult is learning that you don’t need a special occasion to make deviled eggs

[doccywhomst]

[familythings]

Discover Your Actual Biological Age with CheekAge Test

Imagine being able to find out how close you are to your “death date” with just a simple cheek swab. Scientists at Tally Health have created an innovative method called “CheekAge.” This groundbreaking test can determine the biological age of your cheek cells. It offers crucial insights into your health and longevity, making it easier to understand your body’s aging process. Understanding…

[diabetesreversalprograminindia]

How Does Aging Affect Your Health, and Can You Reverse It?

This article is originally published on Freedom from Diabetes website, available here. This is very common nowadays, many people seem to look older than their actual age? Diabetics often experience this accelerated aging, and there are clear reasons behind it.

To understand the aging, you should understand, Chronological Age, based on the number of years you’ve lived, And Biological Age, how well your organs and tissues are functioning right now.

For Diabetics, Aging Speeds Up For 5 Key Reasons

High BSL- High blood sugar speeds up aging by creating harmful compounds called AGEs. These cause skin wrinkling by damaging proteins and fats in the body.

High insulin levels- High insulin levels in type 2 diabetics can have devastating consequences, as they cause cells to absorb not only sugar but also excess water and fat, triggering oxidative stress and the formation of free radicals that can damage your heart and compromise brain function.

Oxidative stress- When high blood sugar and insulin flood your body with sugar and fat, it depletes antioxidants, leading to oxidative stress and inflammation. This speeds up aging and wears you down.

Metaflammation- The cumulative effect of the above changes over time leads to a state of chronic, low-grade inflammation known as metaflammation.

Cellular Senescence- All the previous factors lead to something called cellular senescence, where cells stop dividing and working as they should, speeding up aging. In type 2 diabetes, stress from high blood sugar causes early aging of cells, shown by higher levels of a marker called p16.

Now lets understand How to Reverse the Aging Process?

How to Reverse the Aging Process?

Go for Proper diet- Start a plant-based diet helps make the body more alkaline, reducing acidity and inflammation.

Practice Intermittent Fasting- You have to start intermittent fasting. Switching between eating and fasting triggers healing and repair processes in the body. These actions can help slow down or even reverse the aging process. Research shows that intermittent fasting can improve lifespan and health markers.

Chronic Stress- Various forms of stress, whether from relationships, work, or finances, can accelerate the aging process.

Mindset- As the body ages, the mind often begins to internalize the idea of getting older, which can further accelerate aging. This belief alone can be a significant factor in rapid aging. It’s important to think and feel young.

To know more about this, you can visit our Article. Also please connect with me on my website, Facebook page, and YouTube if you want to stay in touch or give me any feedback!

[bourbontrend]

Explore the world of limited edition bourbons worth $200 and discover what makes them so special! From unique oak finishes to high-age statements, these bourbons offer a symphony of flavors that's worth every penny. Check out our tasting notes and recommendations now. #BourbonLovers #WhiskeyTasting #LuxuriousSips

[abyssal-ilk]

i need everyone to consider vivienne and dorian bonding over taking care of the inquisitor after the end of dragon age inquisition as the mark progressively gets worse and worse. vivienne with her past of watching bastien get sicker and sicker and dorian doing the same with felix, and seeing it repeat with the inquisitor. take my hand 🖐,,

[xtruss]

Eating Fewer Calories Can Ward Off Ageing! And Various Existing Medicines May Offer Similar Benefits

— Published: September 25th 2023

Image: Anuj Shrestha

In 1991 eight volunteers sealed themselves into a huge greenhouse in the desert near Tucson, Arizona. They were part of an experiment seeking to discover whether a carefully curated selection of plants and animals could develop into a self-sustaining ecosystem: a “Biosphere 2” independent of “Biosphere 1”, aka the outside world.

In terms of proving grand ecological truths the Biosphere 2 experiments were something of a bust. As an illustration of what can happen when somewhat fringe-y science meets extreme wealth they were fascinating. There were fierce fallings-out on both sides of the glass. In 1994 Ed Bass, an oil dynast who had paid for the facility, threw out the management team and handed the reins to Steve Bannon, later a key adviser to Donald Trump. At the same time, though, there was what some took to be a breakthrough in the science of human ageing.

One of the eight biospherians was Roy Walford, a professor of pathology at the University of California, Los Angeles (ucla). Research by Walford and others had shown that restricting what animals ate could significantly lengthen their lives. The lifespans of nematode worms, fruit flies, rodents and dogs could be extended as much as 50% by laboratory protocols which gave them a diet with all the nutrients they needed in terms of minerals, vitamins and the like but fewer calories than were seen as normal.

Biosphere 2 allowed him to test the theory on humans in no position to sneak off for snacks. With a daily intake of 1,750-2,100 calories (7,320-8,790 kilojoules) the biospherians, trim to begin with, all slimmed down. But after eight months their weight stabilised. Gaunt as they were, their energy levels remained high. Blood tests showed physiological responses which matched those of calorie-restricted rodents with extended lifespans.

Some people have taken this as a reason to incorporate calorie restriction into their lives, as Walford did. But such diets, which go well beyond the sort of weight-restricting efforts to which any sensible person might aspire, are hard to maintain. That has provoked an interest in finding ways to get the benefits of calorie restriction without having to engage in it.

The Garden of Forking Paths

Calories are a measure of the amount of energy that cells can get from breaking food into its component chemical parts. The precise nature of that breaking down, and what happens with all the parts, is under the control of a range of signalling pathways which have the job of matching what the cell is doing with how much energy the organism needs and has available. Dysfunction in these nutrient-signalling pathways is one of the 12 hallmarks of ageing listed by Dr López-Otín and his colleagues.

If there is a general truth behind the success of calorie restriction, it is that when energy is on the scarce side, the nutrient signalling pathways in cells pay greater attention to what is going on and keep the cell in better shape. What is necessary if the same pathways are to be recruited without the calorie reduction is an understanding of what other cues can have the same effect.

The research would be both easier to do and easier to understand if these pathways all had distinct, clearly understood functions. Alas, this is not the case. Pathways frequently regulate more than one function, functions are frequently regulated by more than one pathway and the farthest-flung parts of pathways are often obscure. To make things yet less comprehensible, the proteins involved in the pathways have incredibly opaque names.

Take the mtorc1 pathway. The complex of proteins which gives it its name first came to attention because an immune suppressant called rapamycin has a strong effect on it: hence “mechanistic target of rapamycin complex 1”. That gives no real clue, however, to the fact that the signalling pathway in which mtorc1 sits is a complex set of controls and feedbacks designed to regulate metabolism in response both to the availability of nutrients (for example, glucose, which provides energy, and amino acids, from which proteins are made) and impediments to their use (for example, low oxygen levels).

The ambit of this regulatory power is broad; it influences the rate at which cells break down damaged internal structures (“autophagy”), the balance of their protein content (“proteostasis”) and the reproduction of their mitochondria, components responsible for turning the calories it receives into a form of energy its proteins can use. Autophagy, proteostasis and mitochondrial reproduction are three more of the 12 hallmarks of ageing.

Rap of Ages

What is more, rapamycin, the effects of which give mtorc1 its name, turns out to lengthen the lives of lab animals even though it curbs their immune responses. This has led some longevity enthusiasts to seek off-label prescriptions for it. But its side-effects, including anaemia and an insensitivity to insulin, make rapamycin ill-suited for widespread use. There is thus a search for “rapalogs” which provide the benefits of a tuned-up mtorc1 pathway without so many costs.

Another pathway which calorie-restriction studies have marked out as promising is named after a protein called ampk (don’t ask). This regulates the production of atp, a small energy-carrying molecule produced in mitochondria. When atp levels fall, the ampk pathway increases a cell’s sensitivity to insulin.

Metformin, a drug used to treat type-2 diabetes, does so by activating the ampk pathway. Like rapamycin, it extends the lifespans of healthy mice. It does the same for diabetic humans. A study published in 2014 showed that diabetes patients treated with metformin enjoyed a decreased mortality rate, not just compared with patients who were not treated with it, but also with healthy controls who were not given the drug.

Not surprisingly, metformin is also used off-label, probably more widely than rapamycin. The American Federation for Ageing Research, a not-for-profit organisation, hopes soon to start a six-year, 3,000-person clinical trial to measure its effects in people from 65- to 79-years-old. The Targeting Ageing with Metformin (tame) trial will see if metformin helps prevent cardiovascular disease, cancer and cognitive decline; it will also test the hypothesis that it reduces all-cause mortality.

A further set of medicines developed to treat diabetes but now used more widely are the glp-1 receptor agonists. The best known, semaglutide (sold as Wegovy), has been specifically licensed in various places for use in people without diabetes who nevertheless need to lose weight. Whether they might live longer than someone of the same final weight who does not take one of the drugs is an open question. There are no published studies that show the drugs to have an effect on the lifespans of laboratory animals.

One thing that does do the job for lab animals is taurine, an amino acid widely used as a dietary supplement. According to a recent paper by Parminder Singh of the Buck Institute for Research on Ageing in Novato, California, and colleagues, in mice taurine increases lifespan by 10%; some of this seems to be due to nutrient signalling. But there are effects on four or five other hallmarks of ageing, too. Taurine levels drop with age in humans but, in those who live to be over 100, levels stay significantly higher.

Nutrient sensitivity may also be enhanced by a molecule called nad+. Some enzymes—proteins which catalyse chemical reactions—require the presence of a small extra molecule to do their thing. nad+ is such a “co-enzyme”. More than 300 enzymes need it to be present if they are to do their bit for the cell. And if you give mice more of it, they live longer.

Considering that nad+ is so generous with its favours it is difficult to know exactly which of the enzymes it helps are responsible for delivering this effect. But one connection which looks particularly interesting is that with a set of proteins called sirtuins.

La Vie En Vin Rouge

Sirtuins came to prominence two decades ago when David Sinclair, who is now co-director of the Centre for Biology of Ageing Research at Harvard University, showed that stimulating their production prolongs life in a variety of laboratory animals. One form of stimulation is calorie restriction. But Dr Sinclair discovered a chemical alternative: resveratrol, a molecule found, among other places, in the skins of red grapes.

Dr Sinclair is by no means publicity-shy; his discovery saw a great deal of brouhaha. He founded a company, Sirtris, to produce resveratrol derivatives suited to the human body. The work did not amount to much. Sirtris, having been bought by GlaxoSmithKline, ceased to exist as a separate entity in 2013.

That might seem a cautionary tale. But it can also be seen as grounds for hope. Sirtuins got a lot of attention because there had been no similarly credible claims about longevity for some time. Their story set out a blueprint for looking into such things: a mechanism looked interesting, a molecule seemed promising, investigations were carried out, conclusions were drawn. Many more mechanisms and drugs are now being scrutinised in the same way. Some scepticism is warranted. But there is no reason to believe that none of them will get results just because the few looked at so far have not. ■

— This article appeared in the Technology Quarterly section of the print edition under the headline "Don’t Be Greedy"

[vodid]

dysphoria

[lokorum]

watching tlou reminded me of another revenge story that ended totally well and nothing bad happened to anyone :)))) 

boosty | patreon

[dstprl]

The Guide to Defying Aging and Staying Fit

Embrace the power of fitness as you age to experience increased muscle strength, better heart health, improved mood regulation, and boosted energy levels. #seniorfit #seniorfitness #agingprocess #aging

Get ready to defy the aging process and embark on a fitness journey like no other. In this entertaining guide, we will unveil the secrets to staying fit, healthy, and vibrant as the years unfold. So, buckle up and prepare to be captivated as we navigate the ever-elusive quest to defy aging and maintain optimum fitness levels. Aging is an inevitable part of life, but that doesn’t mean we have to…

[nativeyoga]

Pranidhi Varshney - Cultivating Community and Challenging Hierarchies in Yoga Practice

Listen to podcast episode 142 here for free Pranidhi Varshney, owner of Yoga Shala West, discusses her journey in the world of yoga and the importance of cultivating community. She shares her experience of running a yoga studio during the pandemic and the challenges she faced. Pranidhi also emphasizes the need for inclusivity in the Ashtanga yoga community and the importance of leading with love…

[storytellering]

That's the way it is.