#reduce aging effects

[diabetesreversalprograminindia]

How Does Aging Affect Your Health, and Can You Reverse It?

This article is originally published on Freedom from Diabetes website, available here. This is very common nowadays, many people seem to look older than their actual age? Diabetics often experience this accelerated aging, and there are clear reasons behind it.

To understand the aging, you should understand, Chronological Age, based on the number of years you’ve lived, And Biological Age, how well your organs and tissues are functioning right now.

For Diabetics, Aging Speeds Up For 5 Key Reasons

High BSL- High blood sugar speeds up aging by creating harmful compounds called AGEs. These cause skin wrinkling by damaging proteins and fats in the body.

High insulin levels- High insulin levels in type 2 diabetics can have devastating consequences, as they cause cells to absorb not only sugar but also excess water and fat, triggering oxidative stress and the formation of free radicals that can damage your heart and compromise brain function.

Oxidative stress- When high blood sugar and insulin flood your body with sugar and fat, it depletes antioxidants, leading to oxidative stress and inflammation. This speeds up aging and wears you down.

Metaflammation- The cumulative effect of the above changes over time leads to a state of chronic, low-grade inflammation known as metaflammation.

Cellular Senescence- All the previous factors lead to something called cellular senescence, where cells stop dividing and working as they should, speeding up aging. In type 2 diabetes, stress from high blood sugar causes early aging of cells, shown by higher levels of a marker called p16.

Now lets understand How to Reverse the Aging Process?

How to Reverse the Aging Process?

Go for Proper diet- Start a plant-based diet helps make the body more alkaline, reducing acidity and inflammation.

Practice Intermittent Fasting- You have to start intermittent fasting. Switching between eating and fasting triggers healing and repair processes in the body. These actions can help slow down or even reverse the aging process. Research shows that intermittent fasting can improve lifespan and health markers.

Chronic Stress- Various forms of stress, whether from relationships, work, or finances, can accelerate the aging process.

Mindset- As the body ages, the mind often begins to internalize the idea of getting older, which can further accelerate aging. This belief alone can be a significant factor in rapid aging. It’s important to think and feel young.

To know more about this, you can visit our Article. Also please connect with me on my website, Facebook page, and YouTube if you want to stay in touch or give me any feedback!

[chussy]

oh! one thing i want to say about skincare people™!

a lot of the "skincare community" is OBSESSED with sunscreen, like full "you should be applying SPF50 even if you're staying indoors on a dark winter day" type statements, and it's honestly crazy. SPF is constantly talked about in the context of anti-aging and wrinkle prevention when it's got a much more important use - preventing fucking SKIN CANCER!

now, as a man who's fighting with my mother and grandmother (gma especially because she's already had skin cancer) to wear sunscreen when out in direct sunlight, at least in the summer, it is true that as long as it gets someone to wear sunscreen it's a bit whatever what argument you use, however. I feel like pushing the "sunscreen = anti-aging product" thing turns a lot of people off of it, because even with beauty standards being the way they are, most people our age aren't obsessed with avoiding fine lines at all costs, and the constant anti age push can be fucking annoying to put it politely

so can we maybe talk about skin cancer prevention? I'd like to talk about skin cancer prevention!

[jenjensd]

There’s nothing wrong with adults reading books below their reading level. However, if that is all they have ever read, it is a detriment to them. They need to try reading more challenging books. They need to expand their horizons. Then, once they have some experience outside of YA, they can read all the twilight and hunger games they wish.

[littlebellesmama]

Raising Kids in a Screen-Filled World: How to Protect Their Joy, Growth, and Future

A whole generation of children is growing up surrounded by digital screens. Tablets, smartphones, smart TVs, and even interactive toys have become a regular part of many households. Technology has given us amazing tools, made learning more accessible, and connected us in ways we never imagined. But there’s also a shadow side to this constant digital stimulation—one we’re just beginning to…

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[obsessivevoidkitten]

Practical Demonstration

Kinktober Day 3: Exhibitionism Yandere Male Alpha Professor x Gender Neutral Omega Teacher Assistant CW: Noncon, public sex, exhibitionism, abuse of authority, knotting, musk, scent kink, biting, claiming bites, pheromones, overstimulation, a/b/o dynamics, slick, suppressants, manipulation, praise kink, general yandere behavior Word Count: 1.6k (Okay guys, hope you enjoy this given how long you have waited for it! PLEASE comment, comments feed me <3)

You were the teacher's assistant for the renowned and well-regarded Professor Reid Sullivan. He had degrees involving anatomy and physiology as well as the psychology of alphas and omegas, and the college he taught at was prestigious.

Professor Sullivan was a bit of a prodigy, already being a highly respected academic despite only being in his early-thirties. His unkempt shaggy hair, dark circles around his eyes, and slight stubble made him appear older. His classes were popular, though he refused to teach large crowds. They reduced his efficacy. At most, he would teach 24 students at a time. This class, though, was limited to 20.

This meant students were always clamoring to sign up before all the slots were filled. Not only were people eager to watch him teach because he was so accomplished and good at educating but also because he was considered rather attractive by many students.

It didn't help that he was also an alpha, and despite his tired nerdy demeanor, he was actually quite fit.

But the main reason his classes were so popular was that he often incorporated live demonstrations into his lessons. In the past, he had omegas demonstrate heat and alphas show off knots while he pointed to and described the anatomy and the purpose for it. He even had an alpha and omega pair demonstrate mating on more than one occasion.

Working under him wasn't bad at all. You were an omega, so you were naturally pretty nervous at first. Working with an alpha superior could sometimes be rather hard. Even in this progressive age, there was still a degree of discrimination and power abuse.

Professor Sullivan was exceedingly kind to you. He even got you coffee and something to eat every morning, even though that would typically be a task more suited to you. He also let you sit in his large cushy chair and was quick to let you use his jacket as you rarely used one, and his classroom tended to be cold.

He was very patient and understanding, guiding you through lessons and helping you learn how to handle a class.

Then, on the day of the final lecture, his true colors were revealed.

He locked the door and then stood in front of it. He put on the display screen a presentation about seducing and breeding an omega.

"Omegas are instinctively attracted to mates that provide them with food. It doesn't have to be major, but a daily coffee and small bit of food will make them naturally more receptive to you..."

The lecture went into greater detail on the subject, also explaining how he microdosed the coffee to make suppressants less effective, but you weren't paying much attention. You were too busy staring at the screen that had pictures of you happily sipping coffee or nibbling on muffins or bagels. It was all so surreal.

"For a shy omega, you can't simply bombard them with your scent. It could scare them away or turn them off completely from your continued advances. Instead, get them acclimated to it..."

The screen now showed how he slightly scented his chair and jacket and gradually scented it more juxtaposed with images of you grading papers while wearing the jacket and sitting in his chair.

You were mortified. Professor Sullivan was a monster! You tried to push past him and get to the door. It almost worked as he was taken aback by your determination to escape, but the extra few seconds that you spent fiddling with the lock were all he needed to wrap his arms around you from behind.

"If your omega acts fearful before mating then the steps we took earlier will help us now."

“G-get off!”

You thrashed and squirmed, but he licked, sucked, and nibbled at your neck until the overstimulation clouded your mind and made your resistance much more feeble. After that, he turned you towards him and, after disrobing completely, pushed your head under his arm so that you got a full dose of his pheromones.

The students gave the professor their undivided attention. One or two omega students envied your place as they stared with wide-eyed fascination at Professor Sullivan's now throbbing cock. The rest were a bit uneasy because you clearly hadn't been willing. They weren't actually too shocked, though, this type of thing wasn't exactly uncommon.

"See how limp the omega is? That's because I canceled any bothersome suppressants, made them accepting of my scent, and subconsciously had them see me as a provider."

The professor had a student roll over his chair to the center of the class before locking the wheels in place. He sat you down tenderly after taking off all your clothing and setting it aside.

"Gather around class, feel free to masturbate as long as you pay attention. This is especially important for you alphas."

Some of the students rubbed their crotches. The alphas encouraged the omegas since it would be helpful later to get them all hot and bothered. After the class formed a circle around the two of you, he continued.

"Now, before an alpha inserts themself into their omega, they must make sure the omega is properly slicked up. Some was produced earlier, but we will want more."

He demonstrated the proper neck stimulation techniques as well as how to slowly stretch out and prepare an omega by inserting gradually more fingers. Then he showed them how to massage an omega’s entrance with their cocks before penetration.

Before he even slipped his cock into you, you were already drooling with a dazed expression.

"Okay class, I said today would be an interactive lesson. The 10 alpha students were each delegated an omega and as part of their final grade, they were tasked with doing everything to their omega classmate that I have done to the TA. Omega students will be granted a participation grade."

The alpha half of the class began pulling the omegas close, stuffing the omegas' faces into their musky crotches or underarms.

The omegas were all bewildered. One gladly accepted their fate, a few were shocked into inaction, and most struggled. Only one managed to escape and get out the door but was chased down and brought back.

These were all students with dreams and goals, most didn't want to be an alpha's property and cumdump. At least not before they did things with their lives.

"I made sure all of your desks were sturdy enough for this, you can prop your omegas up on them if you'd like, putting your clothes on the desk and laying your omega on that will make them more comfortable, like a miniature nest with your scent."

The alphas were all stoked and barely able to hold back.

"If you have your omega in a state like our wonderful TA here is demonstrating then you may slip your cock into them, go slowly though, at least at first."

Professor Sullivan was the first to sink in, causing you to moan softly, soon the entire room was filled with the gasps and moans of a room full of omegas mingling with the grunting and heavy breathing of their alpha lovers.

The air was heavy with pheromones, musk, and the scent of slick.

Your mind wasn't really able to process what was happening around you, though. Your nose was focused on the scent of the one mating you as you instinctively wrapped your arms and legs around him.

"Oh, don't forget to praise your omegas, they may not understand your words right now, but the tone will soothe them."

He kissed you possessively.

"You're such a good mate for me. A perfect partner. So good at helping me teach this lesson. Taking my cock so well~"

He cooed into your ear lovingly as the alpha students praised and complimented their mates. Occasionally, an omega shuddered and squealed in orgasm with their alphas not too far behind.

Sullivan sped the pace up for you, and you didn't last much longer after that. You spasmed wonderfully around his dick as you came hard. Not the only time, though, as he coaxed several more climaxes from your trembling body before he finally came himself and tied you with his big knot.

"Once you've knotted your lover you should bite their neck to mark them as yours. This is essential to making your omega feel safe and loved and will make you secure in the knowledge that everyone knows who they belong to."

The professor bit your neck hard, causing you to moan more even as you flinched in pain.

"You look so beautiful with my mark."

After all the mating had finished and all the knots had deflated, the omegas were all still pretty out of it. Mating and being claimed took a lot out of them and it would probably be an hour or two before they recovered.

"Don't forget your homework! Aftercare is ESSENTIAL!!! Take your omegas to your dorms and make sure they are hydrated, well fed, and praised. If they get cranky at today's events, they probably just need another round or two of breeding."

Which, as it turns out, is exactly what he determined you needed when you wouldn't listen to reason at his home later. He tried to explain that it was all to enhance his teaching. He had been looking for the right omega to fall in love with and help with his lessons for YEARS!

And he finally found you. A TA aspiring to work in his field! You had always wanted a career in academics, and now you had one as his permanent assistant and live demonstration participant!

[alexanderwales]

Spells are a non-renewable resource. One a spell has been cast, it can never be cast again.

But thankfully, what counts as a unique spell is permissive, and very early on in the history of wizardry, wizards found many ways to use the arcane language to specify a similar effect even if the wording was different.

And still, spells were a non-renewable resource.

There are only so many ways to call forth a beam of lancing light, only a limited number of methods of purifying food to make it safe to eat. Soon it became necessary for the wizards to start casting spells that weren't quite what they wanted: a beam of light that arced to the left, a purifying spell that added a bitter taste, some changes cosmetic and others very functional.

And still, spells were a non-renewable resource.

Wizardry was divided into ages by the historiographers. The First Age was the age of plenty, when wizards could make minor tweaks to the spells and cast as much as they liked. The Second Age was the age of modification, when wizards were jumping through hoops and using methods with side effects. But the Third Age was the age of decay, when so many spells had been used that only the oddballs were left. It was impossible to cast anything even remotely resembling a fireball, not even one that hooked to the left and exploded with sharp green shards.

It came to be that few wizards could produce a spell on their first attempt. They would try, only to discover that someone else had already taken their idea and the spell does not work. They would try again, only to discover that their second idea had also been taken. Wizard battles, which had once been glorious light shows, were reduced to two wizards standing in a field trying to be the first one to stumble upon a spell that had never been cast before.

~~~~

Here are some plot hooks:

Wizards jealously guard their knowledge, fearful that someone will learn of a "seam" of untapped spells, but they also write down every spell they know to have been cast, to reduce their search space. Obviously this trove of knowledge is highly valuable.

The existence of spell "seams", which are really just collections of spells that work off the same cluster of discrete variations, mean that wizards tend to be very specialized. The Sheep Wizard knows eight hundred ways of turning someone into a sheep, because he's studied that area of the arcane language extensively, as well as historical precedents that have been ruled out. The natural enemy of a Sheep Wizard is, of course, another Sheep Wizard.

During the Second Age, a group of wizards get together to deliberately reduce the spell-space, largely in the hopes of reducing the capacity of wizard-kind for making war. Their work largely consists of sitting around casting as many fireballs as they can, depleting all options for everyone else.

During the Third Age, a group of wizards gets together and in the spirit of mutual cooperation begins to define "spell blocks", a collection of spells that a single wizard is entitled to and all other wizards agree not to use. When you become a wizard, you're given a thousand spells which are thought to still be valid, and will lose your license to practice wizardry if you cast any spells that are outside your block. This is difficult to enforce, rife with accusations and suspicion, but is thought to be better than nothing.

During the Fourth Age, a group of "wizards" (none of whom have ever actually cast a spell) are working on the arcane language in the hopes of a revival. As the age of hoarded knowledge has mostly passed, they're able to get their hands on many books that weren't previously available. One day, they invent a new form of specification that allows hundreds of thousands of new spells, re-igniting wizardry.

[sightoru]

Here is the child free friendly doctors list. the people on this list are compiled by other childfree people who do not want children. people submit doctors who did their sterilization regardless of age, children, or marital status.

here is a breakdown of how the ACA (affordable care act) works, and how it applies to sterilization. this is only for AFAB people however. vasectomies do not count. You cannot be charged for this surgery. No coinsurance, no deductible, nothing. my hospital originally wanted $4k from me. I told them to bill me and I'll discuss with my insurance. they might be pushy, and try to get you to pay for it ahead of time, but refuse and have them bill it.

If you are getting a bilateral salpingectomy (shortened: bisalp) (COMPLETE TUBAL REMOVAL not 'tubes tied', which is where they snip the tubes and tie them with clips [called a 'tubal ligation']) there is no possible way you can become pregnant. and it does not effect your hormones at all. im being so fr, do not let people say it effects your hormones, because theres no hormones in your tubes. those are carried in ur ovaries.

If you have a family history of reproductive cancer, a bisalp greatly reduces your risks of getting those cancers. insurance codes are CPT codes of either 58661 or 58670 and the ICD-10 code of Z30.2 you might have to plug both in and talk to insurance. if someone on the phone is an asshole to you, just hang up and try again with someone else. On the other side, I've been on plenty of birth control options. for 6 years I had a copper IUD. it does make your periods heavier, and crampier if you can stand that, but it has no hormones in it and it lasts 12 years.

[mortalislabs]

Trigonelline is a methylated form of niacin and is a recently isolated molecule that could be the secret ingredient in your stack. This form of the B vitamin is involved in the generation of NAD+, a cofactor for over 500 metabolic processes in cells. Trigonelline promotes cellular repair and energy, and as we’ll see, exerts quite a few benefits that are specifically useful for anyone training seriously.

Trigonelline is found in several plant-based foods, notably coffee beans and fenugreek seeds. Green coffee beans contain trigonelline concentrations ranging from 0.6% to 1.0% by weight. However, traditional dietary sources don’t provide sufficient amounts to elicit significant physiological effects. For instance, the average trigonelline content in a cup of coffee is approximately 53 mg, and about 50-80% of trigonelline decomposes during the roasting process, leaving virtually nothing for your body to make use of.

Recent research published on this naturally occurring alkaloid highlights its potential in enhancing muscle function and combating age-related decline. A 2024 study published in Nature Metabolism identified trigonelline as a novel precursor to nicotinamide adenine dinucleotide (NAD+), a molecule essential for energy metabolism and mitochondrial function. The study demonstrated that trigonelline supplementation improved muscle strength and reduced fatigue in aged mice, suggesting that it can head off the natural muscle decline seen in aging, even in those who are already training at capacity.

NAD+ gets discussed a lot in the longevity space because of its natural and steep decline over the years, tied to all the diseases of aging. It's a metabolic linchpin that determines how efficiently your cells convert fuel into usable energy. For athletes, that efficiency translates into faster recovery, better performance under load, and greater resilience under metabolic stress. Or, you know, complete lack of those things if you don’t have enough of it.

NAD+ is required for redox (oxidation–reduction) reactions in mitochondrial energy production and is a cofactor and substrate for longevity-promoting sirtuins and other enzymes involved in muscle repair and adaptation. During intense physical activity, NAD+ levels drop as demand for ATP surges. Replenishing intracellular NAD+ is critical not only for restoring mitochondrial output but also for initiating the cellular programs that rebuild and reinforce muscle tissue [1].

Trigonelline offers a direct path to NAD+—one that bypasses the liver and supports muscle tissue specifically. In a landmark 2024 study, researchers at EPFL and Nestlé Health Sciences (yes, that Nestlé, but there aren’t any conflicts of interest, we checked) demonstrated that trigonelline functions as a previously unidentified NAD+ precursor, rapidly taken up by skeletal muscle cells and converted into NAD+ via a salvage pathway independent of the traditional NR or NMN routes [2]. This muscle-specific uptake is particularly important for athletes, who require localized replenishment in the very tissues under stress.

Most NAD+ precursors—including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—undergo hepatic metabolism before entering systemic circulation. This creates a bottleneck at your liver for targeted muscle repair. Trigonelline appears to bypass that constraint by delivering precursors directly where they're needed most: the muscle fibers responsible for performance and endurance.

This shift in delivery has implications beyond simple NAD+ restoration. In the same Nature Metabolism study, aged mice supplemented with trigonelline showed significant improvements in grip strength and fatigue resistance—outcomes tightly linked to muscle NAD+ availability. Unlike systemic precursors that may elevate circulating NAD+ levels without improving localized bioenergetics, trigonelline drives changes in muscle mitochondrial density and function.

For athletes, this is the difference between feeling recovered and actually being rebuilt.

Mitochondria Make Muscles Move

Endurance Starts in the Electron Transport Chain

Every sprint, every lift, every set depends on one thing: mitochondrial output. The ability to generate ATP on demand—efficiently and cleanly—is the defining line between sustained power and early fatigue. Trigonelline’s value lies not just in elevating NAD+ levels, but in what that elevation enables at the level of mitochondrial performance.

NAD+ drives oxidative phosphorylation, the mitochondrial pathway responsible for converting nutrients into ATP. When NAD+ is depleted, electron transport slows, reactive oxygen species accumulate, and mitochondrial output tanks—resulting in performance collapse and prolonged recovery. Replenishing NAD+ restores mitochondrial throughput, enhances metabolic flexibility, and allows cells to switch between carbohydrate and fat oxidation with minimal friction [3].

Trigonelline’s role as a direct NAD+ precursor in muscle tissue makes it especially powerful in this context. By bypassing hepatic metabolism and restoring NAD+ where it's most needed, it kickstarts mitochondrial biogenesis—activating pathways like PGC-1α that drive the formation of new mitochondria and increase the efficiency of existing ones [4]. This isn’t theoretical: in the 2024 Nature Metabolism study, trigonelline supplementation significantly boosted mitochondrial content and activity in aged mice, restoring performance metrics typically lost with age and overtraining [2].

This cellular shift translates directly to the field, the track, and the gym. More mitochondria means more ATP per unit of oxygen consumed. This is the underpinning of higher VO₂ max, improved lactate clearance, and extended time-to-exhaustion. Trigonelline supports this adaptation at the source, which means athletes can train harder, go longer, and bounce back faster—without relying on stimulants or sketchy ergogenics.

More NAD+ in muscle equals better mitochondrial kinetics, which equals better athletic output. Period.

Strength and Muscle Health

Preserving Power, Not Just Mass

Strength isn’t only about size—it’s about contractile quality, neuromuscular precision, and the cellular capacity to resist breakdown under stress. Trigonelline’s impact on muscle tissue reaches beyond endurance. It supports structural integrity, performance output, and resilience across multiple pathways—especially in the context of aging or chronic training demand.

In the 2024 Nature Metabolism study, trigonelline supplementation restored muscle grip strength and improved fatigue resistance in aged mice, with outcomes exceeding those observed in control groups receiving traditional NAD+ precursors [2]. This effect was tied to increased NAD+ availability in skeletal muscle, which reactivated SIRT1- and PGC-1α-dependent pathways responsible for mitochondrial biogenesis, inflammation control, and protein maintenance—all critical for contractile performance and mass preservation [5].

NAD+ also plays a protective role against muscle wasting. It regulates the balance between anabolic and catabolic signaling, modulating FoxO transcription factors and suppressing atrophy-related genes like MuRF1 and atrogin-1 [6]. This anti-catabolic signaling becomes especially important during periods of calorie deficit, illness, or overreaching, when muscle degradation accelerates. Trigonelline, by supplying NAD+ directly to muscle cells, may help maintain lean mass even under systemic stress.

One overlooked aspect of muscle performance is neuromuscular junction (NMJ) stability, or, the connections between nerves and muscle fibers. These connections go both ways, with afferent signals carrying sensory feedback from muscle to brain, and efferent signals delivering motor commands from brain to muscle. Maintaining the integrity of this bidirectional communication is essential for coordination, strength, and rapid recovery from fatigue. NAD+ is required for the function of enzymes that protect NMJ architecture—particularly in aging or disease models where synaptic decline contributes to strength loss [7]. Trigonelline’s direct muscle delivery may therefore preserve the electrical signaling fidelity needed for explosive power and motor unit recruitment.

Muscle Fiber Type Preservation

Emerging evidence suggests that NAD+ availability influences muscle fiber type composition. High NAD+ levels favor the maintenance of fast-twitch (Type II) fibers—those responsible for strength, speed, and power—by enhancing mitochondrial support without triggering full transition to slow-twitch oxidative profiles [8]. This has implications for athletes seeking to maintain peak force output without compromising endurance. By elevating muscle NAD+ directly, trigonelline may help preserve this delicate fiber balance.

Trigonelline is formulated not to just support general energy—but to protect the architecture of athleticism at the cellular level.

For a reliable, pure form of trigonelline with zero additives, you can trust Mortalis Labs.

[bloomzone]

The essential skincare acids guide

type of acids sheet

Salicylic Acid – Best for oily and acne-prone skin. It penetrates deep into the pores, unclogs blackheads and whiteheads, controls excess oil, and prevents breakouts.

Glycolic Acid – Ideal for normal to oily skin. It exfoliates the top layer, brightens the skin, improves texture, and reduces fine lines and hyperpigmentation.

Lactic Acid – Suitable for dry and sensitive skin. It gently exfoliates while providing hydration, making it great for dullness and rough texture without irritation.

Mandelic Acid – Best for sensitive and acne-prone skin. It helps with uneven skin tone, reduces breakouts, and provides mild exfoliation without irritation.

Azelaic Acid – Works for all skin types, including sensitive skin. It reduces redness, fades hyperpigmentation, treats acne, and calms rosacea.

Kojic Acid – Best for hyperpigmented and sun-damaged skin. It helps lighten dark spots, melasma, and discoloration caused by acne scars or sun exposure.

Tranexamic Acid – Ideal for all skin types struggling with stubborn pigmentation. It effectively reduces melasma, post-inflammatory hyperpigmentation (PIH), and sunspots.

Hyaluronic Acid – Suitable for all skin types, especially dry and dehydrated skin. It deeply hydrates, plumps fine lines, and retains moisture for a youthful look.

Polyglutamic Acid – Great for dry and dehydrated skin. It locks in moisture, provides long-lasting hydration, and enhances the skin’s elasticity.

Ascorbic Acid (Vitamin C) – Best for dull, uneven, and aging skin. It brightens, reduces pigmentation, fights free radicals, and boosts collagen production.

Ferulic Acid – Works for all skin types, particularly those using Vitamin C. It enhances the antioxidant power of Vitamin C and E, preventing premature aging.

Ceramides (Fatty Acids) – Essential for dry and sensitive skin. They repair and strengthen the skin barrier, preventing water loss and irritation.

Linoleic Acid (Omega-6 Fatty Acid) – Ideal for acne-prone and oily skin. It reduces clogged pores, balances oil production, and supports a healthy skin barrier.

Ellagic Acid – Good for sun-damaged and aging skin. It protects against UV damage, brightens skin, and provides antioxidant benefits.

Cinnamic Acid – Suitable for all skin types. It has anti-inflammatory properties and helps protect against environmental damage.

Succinic Acid – Best for oily and acne-prone skin. It controls sebum production, fights acne-causing bacteria, and soothes inflammation.

How to choose the right skincare acid for ur skin type

Oily & Acne-Prone Skin

Salicylic Acid (BHA): Penetrates deep into pores to remove excess oil and prevent breakouts.

Azelaic Acid: Reduces acne, fades dark spots, and calms redness.

Succinic Acid: A gentle anti-inflammatory that helps control breakouts.

Dry & Dehydrated Skin

Lactic Acid (AHA): Exfoliates while hydrating the skin.

Hyaluronic Acid: Retains moisture and plumps the skin.

Mandelic Acid: A mild exfoliant that improves texture without drying.

Combination Skin

Glycolic Acid (AHA): Brightens skin and smooths texture.

Salicylic Acid (BHA) (my bff🦅) : Controls oil production in the T-zone.

Hyaluronic Acid: Hydrates dry areas while balancing oil.

Sensitive Skin

Mandelic Acid: A gentle AHA that exfoliates with minimal irritation.

Azelaic Acid: Soothes inflammation and reduces redness.

PHA (Polyhydroxy Acids): Provides mild exfoliation while boosting hydration.

Hyperpigmentation & Dark Spots

Kojic Acid: Brightens skin and reduces discoloration.

Tranexamic Acid: Fades stubborn dark spots and melasma.

Glycolic Acid (AHA): Speeds up cell turnover for an even skin tone.

Aging & Wrinkles

Glycolic Acid (AHA): Stimulates collagen production and smooths fine lines.

Ferulic Acid: Enhances antioxidant protection and stabilizes vitamin C.

Ascorbic Acid (Vitamin C): Brightens skin and fights free radical damage.

Common Mistakes When Using Skincare Acids

Using skincare acids can transform your skin, but when used incorrectly, they can cause irritation, sensitivity, or even worsen skin concerns. Here are some common mistakes to avoid:

1. Over-Exfoliating

Many people think using glycolic or salicylic acid daily will give them faster results, but excessive exfoliation weakens the skin barrier. This can lead to redness, peeling, breakouts, and sensitivity. (especially for oily skin)

Solution: Use exfoliating acids (AHAs/BHAs) 2-3 times per week and always listen to your skin. If it feels irritated, take a break pleaaase

2. Skipping Sunscreen

Acids like glycolic, lactic, and salicylic acid increase your skin’s sensitivity to the sun. Without SPF, you risk sunburn, premature aging, and even worsening of dark spots.

Solution: Always use a broad-spectrum SPF 30+ sunscreen daily when using serums with those acids.

3. Mixing the Wrong Acids

Not all acids work well together. Using too many active ingredients in one routine can cause irritation.

🔴 Examples of bad combinations:

Vitamin C + AHAs/BHAs → Can cause irritation and weaken Vitamin C’s effectiveness.

Retinol + AHAs/BHAs → Too harsh on the skin, leading to peeling and sensitivity. (by experience 💁🏻‍♀️)

Niacinamide + Vitamin C (unless properly formulated) → Can cause flushing or reduce effectiveness.

Solution: Use exfoliating acids on alternate days and simplify your routine to avoid irritation.

4. Not Hydrating Properly

Exfoliating acids remove dead skin cells but can also strip away moisture. Without proper hydration, the skin can feel tight, dry, or irritated.

Solution: After using acids, apply thick a moisturizer to maintain balance especially if the acids dry ur skin so fast

@bloomzone

[batboyblog]

Things the Biden-Harris Administration Did This Week #32

August 30-September 6 2024.

President Biden announced $7.3 billion in clean energy investment for rural communities. This marks the largest investment in rural electrification since the New Deal. The money will go to 16 rural electric cooperatives across 23 states Alaska, Arizona, California, Colorado, Florida, Illinois, Indiana, Iowa, Kentucky, Michigan, Minnesota, Montana, Nebraska, New Jersey, New Mexico, Nevada, North Dakota, Ohio, Pennsylvania, South Dakota, Texas, Wisconsin, and Wyoming. Together they will be able to generate 10 gigawatts of clean energy, enough to power 5 million households about 20% of America's rural population. This clean energy will reduce greenhouse emissions by 43.7 million tons a year, equivalent to removing more than 10 million cars off the road every year.

The Biden-Harris Administration announced a historic 10th offshore wind project. The latest project approved for the Atlantic coast of Maryland will generate 2,200 megawatts of clean, reliable renewable energy to power 770,000 homes. All together the 10 offshore wind projects approved by the Biden-Harris Administration will generation 15 gigawatts, enough to power 5.25 million homes. This is half way to the Administration's goal of 30 gigawatts of clean offshore wind power by 2030.

President Biden signed an Executive Order aimed at supporting and expanding unions. Called the "Good Jobs EO" the order will direct all federal agencies to take steps to recognize unions, to not interfere with the formation of unions and reach labor agreements on federally supported projects. It also directs agencies to prioritize equal pay and pay transparency, support projects that offer workers benefits like child care, health insurance, paid leave, and retirement benefits. It will also push workforce development and workplace safety.

The Department of Transportation announced $1 billion to make local roads safer. The money will go to 354 local communities across America to improve roadway safety and prevent deaths and serious injuries. This is part of the National Roadway Safety Strategy launched in 2022, since then traffic fatalities have decreased for 9 straight quarters. Since 2022 the program has supported projects in 1,400 communities effecting 75% of all Americans.

The Department of Energy announced $430 million to support America's aging hydropower. Hydropower currently accounts for nearly 27% of renewable electricity generation in the United States. However many of our dams were built during the New Deal for a national average of 79 years old. The money will go to 293 projects across 33 states. These updates will improve energy generation, workplace safety, and have a positive environmental impact on local fish and wildlife.

The EPA announced $300 million to help support tribal nations, and US territories cut climate pollution and boost green energy. The money will support projects by 33 tribes, and the Island of Saipan in the Northern Mariana Islands. EPA Administer Michael S. Regan announced the funds along side Secretary of the Interior Deb Haaland in Arizona to highlight one of the projects. A project that will bring electricity for the first time to 900 homes on the Hopi Reservation.

The Biden-Harris Administration is investing $179 million in literacy. This investment in the Comprehensive Literacy State Development Grant is the largest in history. Studies have shown that the 3rd grade is a key moment in a students literacy development, the CLSD is designed to help support states research, develop, and implement evidence-based literacy interventions to help students achieve key literacy milestones.

The US government secured the release of 135 political prisoners from Nicaragua. Nicaragua's dictator President Daniel Ortega has jailed large numbers of citizens since protests against his rule broke out in 2018. In February 2023 the US secured the release of over 200 political prisoners. Human rights orgs have documented torture and sexual abuse in Ortega's prisons.

The Justice Department announced the disruption of a major effort by Russia to interfere with the 2024 US Elections. Russian propaganda network, RT, deployed $10 million to Tenet Media to help spread Russian propaganda and help sway the election in favor of Trump and the Republicans as well as disrupting American society. Tenet Media employs many well known conservative on-line personalities such as Benny Johnson, Tim Pool, Lauren Southern, Dave Rubin, Tayler Hansen and Matt Christiansen.

Vice-President Harris outlined her plan for Small Businesses at a campaign stop in New Hampshire. Harris wants to expand from $5,000 to $50,000 tax incentives for startup expenses. This would help start 25 million new small business over four years.

[reasonsforhope]

"Vice President Kamala Harris is proposing to provide federal funding to cover home care costs for older Americans, aiming to help the “ sandwich generation " of adults caring for aging parents while raising their children at the same time.

Appearing Tuesday on ABC’s “The View,” Harris talked about taking care of her mother when she was dying and personally experiencing the challenges many families face when seeking affordable in-home care for their aging loved ones.

She promised that if, elected in November, she will seek to expand Medicare, the federal health insurance program for older Americans, so that it covers long-term care and includes services like in-home aides. Harris said aides could help seniors do things as simple as preparing meals or putting on sweaters because it is “about dignity for that individual. It’s about independence for that individual.”

Her proposal is a new one just a month out from Election Day but the issue is one that President Joe Biden's administration has been working on for years.

In an effort to soften the effects of inflation, the White House promoted as part of Build Back Better, its legislative agenda that stalled on Capitol Hill years ago, steeply increased federal spending for child care as well as for seniors. After Build Back Better collapsed, the Biden administration continued to promote increasing spending for what it calls “the care economy,” a cause Harris has continued to mention after replacing Biden at the top of the Democratic ticket.

“These plans are common sense. They can help family caregivers work and save both families and the federal government money by allowing seniors to stay in their homes instead of being sent to nursing homes,” the Harris campaign said in a fact sheet detailing her proposal. “Medicare at Home will also reduce hospitalizations.”

As part of a blitz of media interviews she’s been doing in recent days, Harris sat down after her appearance on “The View” with radio personality Howard Stern, who said that his mother is 97. Taking care of an elderly parent, he said, “will bankrupt you.”

Such costs have increased pressure on adults caring for their parents and kids simultaneously. In 2019, roughly 30% of family caregivers of older Americans lived in households that included children or grandchildren, according to AARP.

Harris would likely have to work with Congress to achieve key parts of her proposal. Harris’ campaign points to past, similar proposals projected to cost $40 billion annually, but says much of that can be offset by savings achieved through efforts begun by the Biden administration to expand Medicare’s ability to negotiation prices with major drug manufacturers.

Harris is also promising to further expand Medicare to include hearing and vision coverage, while changing existing rules that can allow federal authorities to seize a deceased beneficiary’s home to recuperate costs. [Note: I'm sorry the current rules fucking what] The campaign fact sheet says that practice “means that those homes are not passed on to the seniors’ children, which particularly harms rural and minority families.”"

-via AP News, October 8, 2024

[realcube]

dilf december

day twelve ⭑ suna rintaro ⭑ filming!

tw: nsfw minors dni, age gap, filming, vaginal, slight analplay & slight degradation

sometimes suna doubts if he chose the right career.

working as a pro-volleyball player was tireless work and massively strained his body. hard-work and practise didn't nessecarily parallel success and fame so he often felt his efforts went without reward. win or loss; he sometimes pondered whether his enjoyment of the sport was even worth all the stress and pressure.

however, now that he's retired, he's almost certain he made the right decision.

he may not be the most well-known or affluent athlete in the entire world, but he made enough money that he was able to retire comfortly at 37. and he was famous enough that he was able to land himself a hot, younger girlfriend.

so pretty, is all he can think to himself when he looks at you. he must've done something right in his life if he was able to earn the affection of an absolute goddess. anyone other guy would obsess over you like he does, which is why he was so tempted to keep you inside and away from the limelight at all times; safe and sound, for his eyes only.

but at the same time, you were like his most prized possession — a trophy for his hard-work — so naturally he wanted to show you off, let everyone know how lucky he was and let them yearn for what they can never have.

so, he thought of a way to achieve both simultaneously.

you're laying on the bed with your tits pushed against the mattress, and your head buried between pillows, allowing them to muffle your scream so the neighbours don't file a noise complaint. suna rams his thick cock into your pussy repeatedly; the lewd squealching noises echoing through the room.

it was always this loud when you fucked. his length could only penetrate your tight cunt if you were soaked, so of course there was a lot of fingering and licking in preparation.

his narrow eyes watched in concentration as your gracious hole sucked him all up, your walls hugging him so tightly and leaving a cloudly ring of fluids at the base of his cock, which only thickened with every powerful thrust into you.

your body was mesmerising too; your perfect curves and deep arch. the way it responded to him was so intoxicating. your perky ass would bounce every time his hips slammed into it and your waist would shake and wiggle whenever he would hit it from a different angle.

it was all such a delicious sight. if only he could sear the memory into his mind for eternity. alas, he'd have to try the next best thing.

he reached his hand forward to grab his phone, which he had placed face-down on the small of your back. he braces you with one hand gripping your waist, and he continues to plough into your dripping hole, while the other lazily opens up the camera app and begins recording with the flash on.

the bright light accenuates your glistening hole and the arsousal staining your thighs, as well as dripping off your sticky folds and onto the bedsheets. with your face pressed into the pillow, you can only somewhat see the flash out of the corner of your eye, but you can definitively hear the sound-effect of the video starting.

hence, you stagger quietly through moans, while still grinding against his fat cock, "w — what're you doing?"

"appreciating what's mine." suna comment, thrusts faltering as he spreads your asscheeks so the camera can get a good look at both of your holes.

his reduced pace allows you reply somewhat coherently, "where're you gonna post that?"

he grazes his your hole with his thumb in admiration, still filming, and muses, "no where." he pauses for a moment, gripping at the flesh of your ass, "unless you want me to?"

he smirks at the thought, leaning forward so his hips are flush against yours — therefore forcing your dick the furtherest inside you — and his chest is pressed against your back, so he can whisper in your ear, "you'd like that?"

you simply whimper quietly in response. not real answer, mostly because you are undecided. you're kinda opposed to random strangers on the internet seeing your hole, but considering your position, it's unlikely they'd know it's you. plus, the idea of suna wanting to show you off is just so hot.

he takes that as a sufficient response and stands up straight again. "how about this: if you can make me cum in the next four minutes, i'll keep the video to myself." he explain, gradually reestablishing a rhythm. "any longer than that, and i'll post your slutty fuckin' hole on every platform i got. so everyone can see you cum on me, hm?"

[literaryvein-reblogs]

Writing a "Curious" Character

Curiosity - the impulse or desire to investigate, observe, or gather information, particularly when the material is novel or interesting.

This drive appears spontaneously in nonhuman animals and in young children, who use sensory exploration and motor manipulation to inspect, bite, handle, taste, or smell practically everything in the immediate environment.

The Five-Dimensional Model of Curiosity

Deprivation sensitivity—recognizing a gap in knowledge the filling of which offers relief. This type of curiosity doesn’t necessarily feel good, but people who experience it work relentlessly to solve problems. This dimension was derived from Berlyne and Loewenstein’s work.

Joyous exploration—being consumed with wonder about the fascinating features of the world. This is a pleasurable state; people in it seem to possess a joie de vivre. This dimension was influenced by Deci’s research.

Social curiosity—talking, listening, and observing others to learn what they are thinking and doing. Human beings are inherently social animals, and the most effective and efficient way to determine whether someone is friend or foe is to gain information. Some may even snoop, eavesdrop, or gossip to do so. This dimension stems from Renner’s research.

Stress tolerance—a willingness to accept and even harness the anxiety associated with novelty. People lacking this ability see information gaps, experience wonder, and are interested in others but are unlikely to step forward and explore. This dimension builds on recent work by Paul Silvia, a psychologist at the University of North Carolina at Greensboro.

Thrill seeking—being willing to take physical, social, and financial risks to acquire varied, complex, and intense experiences. For people with this capacity, the anxiety of confronting novelty is something to be amplified, not reduced. This dimension was inspired by Zuckerman's work.

The researchers conducted surveys across the United States to discover which of the dimensions lead to the best outcomes and generate particular benefits.

For instance, joyous exploration has the strongest link with the experience of intense positive emotions.

Stress tolerance has the strongest link with satisfying the need to feel competent, autonomous, and that one belongs.

Social curiosity has the strongest link with being a kind, generous, modest person.

They also explored attitudes toward and expressions of work-related curiosity.

In a survey of 3,000 workers in China, Germany, and the United States, they found that 84% believe that curiosity catalyzes new ideas, 74% think it inspires unique, valuable talents, and 63% think it helps one get promoted.

In other studies across diverse units and geographies, they have found evidence that 4 of the dimensions—joyous exploration, deprivation sensitivity, stress tolerance, and social curiosity—improve work outcomes.

The latter two seem to be particularly important: Without the ability to tolerate stress, employees are less likely to seek challenges and resources and to voice dissent and are more likely to feel enervated and to disengage.

And socially curious employees are better than others at resolving conflicts with colleagues, more likely to receive social support, and more effective at building connections, trust, and commitment on their teams.

People or groups high in both dimensions are more innovative and creative.

A monolithic view of curiosity is insufficient to understand how that quality drives success and fulfillment in work and life. To discover and leverage talent and to form groups that are greater than the sum of their parts, a more nuanced approach is needed.

Psychologists have compiled a large body of research on the many benefits of curiosity:

It enhances intelligence: In one study, highly curious children aged three to 11 improved their intelligence test scores by 12 points more than their least-curious counterparts did.

It increases perseverance, or grit: Merely describing a day when you felt curious has been shown to boost mental and physical energy by 20% more than recounting a time of profound happiness.

And curiosity propels us toward deeper engagement, superior performance, and more-meaningful goals: Psychology students who felt more curious than others during their first class enjoyed lectures more, got higher final grades, and subsequently enrolled in more courses in the discipline.

Since the 1950s psychologists have offered competing theories about what makes one person more curious than another. Rather than regard curiosity as a single trait, we can now break it down into five distinct dimensions. Instead of asking, “How curious are you?” we can ask, “How are you curious?”

Sources: 1 2 ⚜ More: Writing Notes & References ⚜ Writing Resources PDFs