#Brain Stimulation

[wildcat2030]

. Aix-Marseille University researchers hypothesized that prepping the natural rhythm of a brain by finger-tapping could help you then better "tune in" to speech. Previous research into the "rhythmic priming effect" has looked into various modes of delivery and its impact on speech – such as music in language comprehension and therapy for children with developmental language disorder (DLD). But its application in broader contexts is largely unknown. "The motor system is known to process temporal information, and moving rhythmically while listening to a melody can improve auditory processing," the scientists wrote. "In three interrelated behavioral experiments, we demonstrate that this effect translates to speech processing. Motor priming improves the efficiency of subsequent naturalistic speech-in-noise processing under specific conditions."

[bpod-bpod]

Magnetic Head

Static magnetic stimulation changes the structural plasticity of neurons cultured in a dish – implications for its use in non-invasive brain stimulation

Read the published research article here

Image from work by J. L. Beros and E. S. King and colleagues

The Perron Institute for Neurological and Translational Science, Nedlands, Australia

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Scientific Reports, January 2024

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[theeccentricraven]

Brainstorming is not outlining. Brainstorming is full of random, scattered thoughts. It's just a bunch of bullet points of what-if questions as well as answers to questions. It's seeing an image and writing down thoughts on that image. It has no structure. Gail Carson Levine calls them junk ideas. It doesn't restrict your imagination, but does the opposite. Asking one question leads to asking more questions. It gets your brain brewing, igniting light bulb moments and stirring a storm of potential. Also, I encourage writers to consider that if you are not meeting your writing goals and get stuck without knowing how to get out, you might want to try a new method. I personally believe it's important to experiment rather than stick to one way. I hope that helps.

Had to make a meme to describe me currently

[barbietronix]

U wanna be on top?

U need a distraction, hun? From all the 'happy family fun day' hun? U wanna be an emotionally regulated Barbie Gorl Gang Gang, huh?

Time to play, Guess The Astrology! Either in the comments or create your own edit with labels. Y'know...if you feeel like it. Use your gifts to sus-out the sun signs/or rising signs according to visual clues, body language, framing, color story, accessories, vibes, etc.

One sign is left out on purpose.

They 👁️know 👁️why👀

[jcmarchi]

Tiny magnetic discs offer remote brain stimulation without transgenes

New Post has been published on https://thedigitalinsider.com/tiny-magnetic-discs-offer-remote-brain-stimulation-without-transgenes/

Tiny magnetic discs offer remote brain stimulation without transgenes

Novel magnetic nanodiscs could provide a much less invasive way of stimulating parts of the brain, paving the way for stimulation therapies without implants or genetic modification, MIT researchers report.

The scientists envision that the tiny discs, which are about 250 nanometers across (about 1/500 the width of a human hair), would be injected directly into the desired location in the brain. From there, they could be activated at any time simply by applying a magnetic field outside the body. The new particles could quickly find applications in biomedical research, and eventually, after sufficient testing, might be applied to clinical uses.

The development of these nanoparticles is described in the journal Nature Nanotechnology, in a paper by Polina Anikeeva, a professor in MIT’s departments of Materials Science and Engineering and Brain and Cognitive Sciences, graduate student Ye Ji Kim, and 17 others at MIT and in Germany.

Deep brain stimulation (DBS) is a common clinical procedure that uses electrodes implanted in the target brain regions to treat symptoms of neurological and psychiatric conditions such as Parkinson’s disease and obsessive-compulsive disorder. Despite its efficacy, the surgical difficulty and clinical complications associated with DBS limit the number of cases where such an invasive procedure is warranted. The new nanodiscs could provide a much more benign way of achieving the same results.

Over the past decade other implant-free methods of producing brain stimulation have been developed. However, these approaches were often limited by their spatial resolution or ability to target deep regions. For the past decade, Anikeeva’s Bioelectronics group as well as others in the field used magnetic nanomaterials to transduce remote magnetic signals into brain stimulation. However, these magnetic methods relied on genetic modifications and can’t be used in humans.

Since all nerve cells are sensitive to electrical signals, Kim, a graduate student in Anikeeva’s group, hypothesized that a magnetoelectric nanomaterial that can efficiently convert magnetization into electrical potential could offer a path toward remote magnetic brain stimulation. Creating a nanoscale magnetoelectric material was, however, a formidable challenge.

Kim synthesized novel magnetoelectric nanodiscs and collaborated with Noah Kent, a postdoc in Anikeeva’s lab with a background in physics who is a second author of the study, to understand the properties of these particles.

The structure of the new nanodiscs consists of a two-layer magnetic core and a piezoelectric shell. The magnetic core is magnetostrictive, which means it changes shape when magnetized. This deformation then induces strain in the piezoelectric shell which produces a varying electrical polarization. Through the combination of the two effects, these composite particles can deliver electrical pulses to neurons when exposed to magnetic fields.

One key to the discs’ effectiveness is their disc shape. Previous attempts to use magnetic nanoparticles had used spherical particles, but the magnetoelectric effect was very weak, says Kim. This anisotropy enhances magnetostriction by over a 1000-fold, adds Kent.

The team first added their nanodiscs to cultured neurons, which allowed then to activate these cells on demand with short pulses of magnetic field. This stimulation did not require any genetic modification.

They then injected small droplets of magnetoelectric nanodiscs solution into specific regions of the brains of mice. Then, simply turning on a relatively weak electromagnet nearby triggered the particles to release a tiny jolt of electricity in that brain region. The stimulation could be switched on and off remotely by the switching of the electromagnet. That electrical stimulation “had an impact on neuron activity and on behavior,” Kim says.

The team found that the magnetoelectric nanodiscs could stimulate a deep brain region, the ventral tegmental area, that is associated with feelings of reward.

The team also stimulated another brain area, the subthalamic nucleus, associated with motor control. “This is the region where electrodes typically get implanted to manage Parkinson’s disease,” Kim explains. The researchers were able to successfully demonstrate the modulation of motor control through the particles. Specifically, by injecting nanodiscs only in one hemisphere, the researchers could induce rotations in healthy mice by applying magnetic field.

The nanodiscs could trigger the neuronal activity comparable with conventional implanted electrodes delivering mild electrical stimulation. The authors achieved subsecond temporal precision for neural stimulation with their method yet observed significantly reduced foreign body responses as compared to the electrodes, potentially allowing for even safer deep brain stimulation.

The multilayered chemical composition and physical shape and size of the new multilayered nanodiscs is what made precise stimulation possible.

While the researchers successfully increased the magnetostrictive effect, the second part of the process, converting the magnetic effect into an electrical output, still needs more work, Anikeeva says. While the magnetic response was a thousand times greater, the conversion to an electric impulse was only four times greater than with conventional spherical particles.

“This massive enhancement of a thousand times didn’t completely translate into the magnetoelectric enhancement,” says Kim. “That’s where a lot of the future work will be focused, on making sure that the thousand times amplification in magnetostriction can be converted into a thousand times amplification in the magnetoelectric coupling.”

What the team found, in terms of the way the particles’ shapes affects their magnetostriction, was quite unexpected. “It’s kind of a new thing that just appeared when we tried to figure out why these particles worked so well,” says Kent.

Anikeeva adds: “Yes, it’s a record-breaking particle, but it’s not as record-breaking as it could be.” That remains a topic for further work, but the team has ideas about how to make further progress.

While these nanodiscs could in principle already be applied to basic research using animal models, to translate them to clinical use in humans would require several more steps, including large-scale safety studies, “which is something academic researchers are not necessarily most well-positioned to do,” Anikeeva says. “When we find that these particles are really useful in a particular clinical context, then we imagine that there will be a pathway for them to undergo more rigorous large animal safety studies.”

The team included researchers affiliated with MIT’s departments of Materials Science and Engineering, Electrical Engineering and Computer Science, Chemistry, and Brain and Cognitive Sciences; the Research Laboratory of Electronics; the McGovern Institute for Brain Research; and the Koch Institute for Integrative Cancer Research; and from the Friedrich-Alexander University of Erlangen, Germany. The work was supported, in part, by the National Institutes of Health, the National Center for Complementary and Integrative Health, the National Institute for Neurological Disorders and Stroke, the McGovern Institute for Brain Research, and the K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience.

[creativeera]

The Brain Health Devices Market is Rising due to Increasing Incidences of Target Disorders

Global brain health devices market is estimated to be valued at USD 15.10 Bn in 2024 and is expected to reach USD 26.50 Bn by 2031, exhibiting a compound annual growth rate (CAGR) of 8.4% from 2024 to 2031.

Brain health devices include wearable devices and handheld devices for monitoring brain activity and diagnosing target disorders. These devices help diagnose neurological conditions like sleep disorders, epilepsy, migraines, Alzheimer’s, Parkinson’s and other dementias early and non-invasively through continuous monitoring of brain signals. The growing prevalence of neurological & sleep disorders and the subsequent increase in demand for effective diagnostic and monitoring devices are propelling the brain health devices market. Key players operating in the brain health devices market are Medtronic plc, Natus Medical Incorporated, Advanced Brain Monitoring, Inc., ElectroCore LLC, Neuropace, Inc., Integra LifeSciences Corporation, Boston Scientific Corporation, LivaNova PLC, Masimo Corporation, Magstim, Soterix Medical Inc., Cadwell Industries, Inc., Cogmedix, Inc., Emotiv, Compumedics Limited, NeuroSky, Mindmaze, Philips Healthcare. Key players are focused on developing innovative devices with advanced features and expanded indications to gain a competitive edge in the market. Key Takeaways Key players: Key players operating in the brain health devices are Medtronic plc, Natus Medical Incorporated, Advanced Brain Monitoring, Inc., ElectroCore LLC, Neuropace, Inc., Integra LifeSciences Corporation, Boston Scientific Corporation, LivaNova PLC, Masimo Corporation, Magstim, Soterix Medical Inc., Cadwell Industries, Inc., Cogmedix, Inc., Emotiv, Compumedics Limited, NeuroSky, Mindmaze, Philips Healthcare. Growing demand: The increasing prevalence of neurological disorders like Alzheimer's disease, Parkinson's disease, epilepsy and sleep disorders is driving the Brain Health Devices Market Demand globally. Continuous monitoring solutions can help in early detection and timely intervention. Global expansion: Major players are focusing on expanding their global footprint through partnerships and distribution agreements to tap new growth opportunities. Regions like Asia Pacific and Latin America with a large patient pool and growing medical infrastructure present lucrative business opportunities. Market Key Trends Wearables for neurological monitoring is a key Brain Health Devices Market Size and Trends in the brain health devices market. Wearable brain monitoring devices are portable, comfortable to wear for long duration and enable continuous, real-time and ambulatory monitoring of brain activity and various vital signs. This provides valuable insights into disease progression and therapeutic response over extended periods compared to devices requiring hospital visits.Devices are being integrated with artificial intelligence capabilities for automated interpretation of brain signals and early detection of anomalies indicative of diseases.

Porter’s Analysis Threat of new entrants: Low cost of production and lack of intellectual property rights barriers will enable new players to enter the market. However, the presence of major players with strong brand recognition and distribution networks pose a challenge for new entrants. Bargaining power of buyers: Buyers have moderate bargaining power in the fragmented brain health devices market due to the availability of various product options from different brands. However, switching costs are relatively low. Bargaining power of suppliers: The bargaining power of suppliers is moderate as the raw materials used in brain health devices production such as silicon, semiconductors, and metals are commoditized. Threat of new substitutes: Substitutes like CT scans and MRIs pose a limited threat currently due to their higher costs, inconvenience, and invasiveness compared to brain health devices. However, technological advancements may increase substitute threats in the future. Competitive rivalry: The global brain health devices market is highly competitive due to the presence of major multinational players. Players compete based on technological innovations, device efficacies, and strategic collaborations. Geographical Regions North America holds the major share of the global brain health devices market and is expected to continue its dominance during the forecast period. Rising incidence of neurological disorders, supportive reimbursement policies, technologically advanced healthcare infrastructure, and increasing R&D investments by key players drive the North American market. Asia Pacific is poised to be the fastest-growing market for brain health devices from 2024 to 2031 fueled by growing healthcare expenditures, expanding medical tourism industries, and increasing awareness about neurological conditions in developing countries. China and India are projected to emerge as major markets in Asia Pacific during the forecast timeline. Europe holds the second-largest share globally led by advanced economies like Germany, UK, and France that are hubs for neurology research and development.

Get more insights on Brain Health Devices Market

About Author:

Money Singh is a seasoned content writer with over four years of experience in the market research sector. Her expertise spans various industries, including food and beverages, biotechnology, chemical and materials, defense and aerospace, consumer goods, etc. (https://www.linkedin.com/in/money-singh-590844163)

[raw1111official]

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[scientificinquirer-blog]

DAILY DOSE: Novo Nordisk CEO to Testify on Drug Prices; tDCS Headsets Show Promise in Treating Love Trauma From Breaking Up.

SANDERS FORCES NOVO NORDISK CEO TO TESTIFY Sen. Bernie Sanders has successfully persuaded Novo Nordisk CEO Lars Jørgensen to testify before the Senate HELP Committee regarding the high prices of Ozempic and Wegovy in the US. Scheduled for early September, this testimony comes after Sanders’s persistent efforts, including a threat to subpoena the company, to address the significant price…

[webtalkradio]

Transition Awareness Breathing podcast 194: Taking a walk off the path

Welcome to the world of Transition Awareness Breathing, where we embark on a profound journey into neuroplasticity. Here, we explore the transformative power of the mind and uncover strategies tailored to stimulate brain growth. Embracing the challenge of stepping beyond the confines of familiarity is essential, for it is within the discomfort of the unknown that our true potential lies dormant, waiting to be unleashed.

Transition Awareness Breathing podcast invites you to embrace this challenge wholeheartedly, recognizing it as the key to unlocking the boundless capabilities of your brain. By venturing beyond your comfort zone, you open doors to new experiences, insights, and capabilities that can enrich every aspect of your life. Join us as we dive deep into the wonders of neuroplasticity, empowering you to embrace change, adapt, and thrive in an ever-evolving world.

[adhdandcomics]

"adhd is the easiest disability to have" “sure plenty of people have adhd but most people are faking” “people are abusing the resources that WE need so that’s why i can’t get my adderall!”

there has been an artificial shortage of all adhd medication for the past 4 years in the US. every investigation into this shortage has returned with the unequivocal result that simply nobody thinks we need it enough to solve the problem.

so they point fingers at the “faker” gaming the system to get adderall who “thinks” they have adhd or is “abusing stimulants to get ahead” for a problem that Our system MANUFACTURED.

so we would be at each others throats instead of realizing that our government and big pharma is to blame for all of this. because their First priority is to punish addicts and to punish folks with adhd and to punish anyone who relies on medication. over everything else. even over profit.

[idontmindifuforgetme]

Once I was listening to a podcast and one of the hosts was like “the key to confidence isn’t never making mistakes and knowing everything, but making mistakes and being totally okay w the fact because everyone makes mistakes and it’s not a statement about your worth” and oh my god okay. My trauma bond w shame is dying a slow death.

[ancientroyalblood]

Conquering Writer's Block: Techniques to Regain Your Creative Flow

Writer’s block, that dreaded barrier that stalls creativity, is a challenge every writer faces at some point. It’s that moment when ideas seem to evaporate, and the blank page becomes an insurmountable obstacle. But fear not, for within the realm of writing, there exist techniques to overcome this creative standstill. In this blog post, we’ll delve into the realm of writer’s block and explore…

[biology-geology-beaches-india]

The Science Research Folios. Page 323.

[tumbler-polls]

Give this brain rot game a try 🧠🔫