#Kinase

[whats-in-a-sentence]

One of these experiments, carried out by Emerson, measured the quantum yield of photosynthesis as a function of wavelength and revealed an effect known as the red drop (Figure 7.12). (...) The observation that the overall quantum yield of photosynthesis is nearly independent of wavelength (see Figure 7.12) strongly suggests that such a mechanism exists.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[deinheilpraktiker]

Das Coronavirus mit akutem Durchfallsyndrom bei Schweinen fördert die Replikation, indem es Autophagie auslöst

Ein kürzlich iScience Studie kommt zu dem Ergebnis, dass das Schweine-Akutes-Diarrhoe-Syndrom-Coronavirus (SADS-CoV) die Autophagie fördert, um seine Replikation in Wirtszellen aufrechtzuerhalten. Genauer gesagt reguliert das Virus den AKT/Säugerziel-Rapamycin-Signalweg (mTOR) herunter, um Autophagie auszulösen. Studie: Das Coronavirus mit akutem Schweinedurchfall-Syndrom induziert Autophagie, um…

[tenth-sentence]

The factors that determine these changes are not completely understood, but changes in the phosphorylation state of PINs mediated by the kinase PINOID and the phosphatase PP2 can have significant effects on PIN localization.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[nubs-mbee]

Medical oversharing on the internet! My new doctor said it could be limited scleroderma, or it could just be UCTD because it seemed like my symptoms weren’t getting worse but staying consistent. Either way I got meds to help with the fatigue and folic acid to help with the hair loss!

[humancelltournament]

Propaganda!

A spermatozoon (plural: spermatozoa) is a motile sperm cell, or moving form of the haploid cell that is the male gamete. A spermatozoon joins an ovum to form a zygote. (A zygote is a single cell, with a complete set of chromosomes, that normally develops into an embryo.) Sperm cells contribute approximately half of the nuclear genetic information to the diploid offspring.

A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes.

[alphaketoglutaricacid]

[exitwound]

WHY did you tag that dress CDK?!

it’s my tag for like. Forms when they give the vibe of being in some kind of active state after cyclin binding but still awaiting the spark of CAK phosphorylation and/or cell cycle regulation = determines the fate of what is being Given Form => cdk tag is for fabrics billowing in the wind or shapes full of air and also other forms that feel like they are “between” forms or trying to reach the most intense version of a form or split forms or merge forms or things going wrong with form like autoimmune or cancer

[emergencydrug]

Tofacitinib mechanism of action

Tofacitinib is a medication used to treat certain autoimmune diseases, primarily rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Its mechanism of action involves targeting specific molecules and pathways in the immune system to reduce inflammation and modulate the immune response. Here's an overview of how tofacitinib works:

Janus Kinase (JAK) Inhibition: Tofacitinib drug belongs to a class of known as Janus Kinase (JAK) inhibitors. JAKs are enzymes that play a crucial role in transmitting signals within immune cells. By inhibiting specific JAK enzymes, tofacitinib interferes with the signaling pathways that lead to inflammation and immune system activation.

Cytokine Inhibition: JAK enzymes are involved in the signaling of various cytokines, which are small proteins that regulate immune responses. Tofacitinib primarily inhibits JAK1 and JAK3, which are associated with signaling by cytokines like interleukin-6 (IL-6), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-7 (IL-7), interleukin-15 (IL-15), and interferon-gamma (IFN-gamma). By blocking these cytokine signals, tofacitinib helps reduce inflammation and control immune system activity.

Immune System Modulation: Tofacitinib helps modulate the immune response by reducing the activity of certain immune cells, particularly T cells and B cells, which are involved in autoimmune diseases. It can also affect other immune cells like natural killer (NK) cells and dendritic cells.

[sa-banana-ana]

I got bored, frankly, it's annoyance if anything, of going to my university library. To remedy that I've been going to a public library branch and today it really made my day!

They had a display about book recommendations based on zodiac signs. I always find zodiac themed items a little funny, and naturally, I wanted to see what would be deemed a good Sagittarius, my own zodiac sign, recommendation. I had actually been looking for my libraries collection of Neil Gaiman books the day before and was disappointed when GO wasn't there. Well, now I know why. 🥰

Anyways I spent the last 30 minutes before I had to leave reading and giggling to myself. 🤭

[wethecelestial]

huge gamer W

[bpod-bpod]

Big Hearted

When faced with challenges like exercise, the heart can grow a little larger to supply more blood to needy organs, a process known as hypertrophy. Yet long-term enlargement, linked to stress caused by genetic conditions or high blood pressure, is dangerous, raising the risk of heart failure. Within cells, processes regulating hypertrophy involve enzymes in the p38 family, themselves activated by the protein kinases MKK6 and MKK3. In mice, researchers investigating the specific roles of these proteins uncovered complicated interactions between them, making it difficult to control hypertrophy. Removing MKK6 dampened the activity of one p38 protein, p38α, but other p38s were boosted in response, ultimately activating another pathway promoting hypertrophy: mice lacking MKK6 thus had much larger hearts (pictured, right) than typical mice (left), leading to further cardiac problems and shorter lifespans. Within this complex regulatory web, targeting other p38 components could provide more promising solutions in the future.

Written by Emmanuelle Briolat

Image from work by Rafael Romero-Becerra and colleagues

Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, August 2022

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[whats-in-a-sentence]

In the dark, the N-terminal region, including the LOV domains, "cages" and inhibits the activity of the kinase domain (Figure 16.22). (...) A type 2A protein phosphatase mediates dephosphorylation and inactivation of phototropin in the dark (see Figure 16.22).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[deinheilpraktiker]

Neuropilin 2 wurde als neuartiger Regulator der Motilität der glatten Muskulatur des distalen Dickdarms identifiziert Störungen der Darmmotilität, insbesondere Probleme im Zusammenhang mit Verstopfung und Durchfall, kommen bei Erwachsenen und Kindern häufig vor und beeinträchtigen die Lebensqualität erheblich. Eine neue Studie im American Journal of Pathology, veröffentlicht von Elsevier, identifiziert Neuropilin 2 (NRP2) als neuartigen Regulator der distalen Motilität der glatten Muskulatur des Dickdarms. Seine Fähigkeit, den Tonus des Zytoskeletts zu regulieren und abnormale Kontrak... #Biomarker #Diabetes #Durchfall #Dysbiose #Entzündung #Forschung #Gefäß #Gen #Gesundheitspflege #Hirschsprung_Krankheit #in_vitro #Kinase #Kinder #Krankenhaus #Krebs #Krebs_Biomarker #Magen_Darmtrakt #Medizinschule #Molekül #Muskel #Nerv #Operation #Pathologie #Plättchen #Rezeptor #Tyrosin #Urologie #Verstopfung #Wachstumsfaktor

[tenth-sentence]

As with cryptochrome and phytochrome, the N-terminal photosensory region of the phototropins controls the activity of the C-terminal half of the protein, which contains a serine/threonine kinase domain (see Figure 16.21A).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[gnfkitten]

anybody know where the negative regulation is in this graph i fucking hate bio

[girl-kendallroy]

listening to shostakovichs 7th the way god intended (with noise cancelling airpods surrounded by people while i work on my biochem project)