#Sculpting software

[krissym72]

Unlock the Magic of AI Art Tools

In recent years, the intersection of artificial intelligence (AI) and art has led to the emergence of a fascinating array of AI art tools, revolutionizing the creative landscape. These tools harness the power of machine learning algorithms to assist artists in their creative endeavors, offering a novel approach to artistic expression. From painting to music composition and digital sculpture, AI…

[laziuli]

Some 3D sweets i modelled using nomad sculpt and procreate!

Matcha cake and cherry pie designed by @/miyabau on tumblr

[sixxth]

[battiegutz]

tried blender for the first time the other day

[crowmeere]

So my dnd brain rot lead to me learning 3d sculpting? Pretty much last weekend I decided I wanted to try and make a little model for Zyris, so I could draw his horns more consistently and it turned out…. Ahh not great and very cursed (first one). These are my models one week out and I’ve found a new obsession?

There’s 7 days difference between the first Zyris model and the second (which is still a work in progress)

Also posting the Bugbear I made because I’m really proud of it! It’s another players character from the dnd campaign I’m in :) I’m slowly learning more and more, and I think I’m going to try moving to a computer 3d software next! These are all made on my iPad!

Ahhh thank you for reading my rambling?

[aemiliuslives]

Daily Challenge 2024, Day 16. This is my 3D sculpture of a Cacodemon from "Doom".

[scarefox]

Little sneak peek of the kitsune stature I make in 3D class as final project (till friday)

It's finally looking like something. Teeth and other details are still missing...... also texture (which would be not mandatory for the project just an extra for when I still have time left... but I want texture of course... can't leave it naked)

[science-sculpt]

ELISA: A Powerful Tool for Detecting the Invisible

ELISA, or Enzyme-Linked Immunosorbent Assay, has become a cornerstone of medical diagnostics and biological research. This versatile technique allows scientists to detect and quantify minute amounts of target molecules, such as proteins, antibodies, and even viruses, with remarkable accuracy. In this blog, we'll delve into the world of ELISA, exploring its various types, its applications, and the exciting future directions this technology holds.

At its core, ELISA relies on the exquisite specificity of antibodies. Antibodies are highly specialized proteins produced by the immune system in response to foreign invaders. Each antibody can bind to a unique structure, called an antigen, on a specific molecule. In an ELISA, scientists leverage this binding property to create a sensitive detection system.

The 1960s witnessed a surge in interest in immunoassays, techniques that utilize the specificity of antibodies to detect target molecules. One such technique, radioimmunoassay (RIA), developed by Rosalyn Yalow and Solomon Berson, revolutionized medical diagnostics. RIA used radioactively labeled antibodies to detect antigens, offering high sensitivity. However, concerns regarding the safety of radioactive materials fueled the search for a safer alternative. The year 1971 marked a turning point. Independently, Eva Engvall and Peter Perlmann published their work on a novel technique – the enzyme-linked immunosorbent assay (ELISA). ELISA replaced radioactive labels with enzymes, eliminating the safety concerns associated with RIA. Like RIA, ELISA harnessed the specific binding between antibodies and antigens. However, it employed enzymes that could generate a detectable signal, such as a color change, upon interacting with a substrate. This innovation paved the way for a safer and more user-friendly diagnostic tool.

The basic ELISA protocol involves immobilizing the target antigen on a solid surface like a plate well. Then, a sample containing the molecule of interest (e.g., a suspected virus) is introduced. If the target molecule is present, it will bind to the immobilized antigen. Next, an antibody specific to the target molecule, linked to an enzyme, is introduced. This "detection antibody" binds to the target molecule already attached to the antigen. Finally, a substrate specific to the enzyme is added. This antigen-antibody binding is visualized using an enzyme linked to a reporter molecule. When the enzyme encounters its substrate, a detectable signal is produced, such as a color change or luminescence. The intensity of this signal is directly proportional to the amount of antigen present in the sample, allowing for quantification. The beauty of ELISA lies in its adaptability. Several variations exist, each tailored for specific detection needs.

The Four Main ELISA Formats are:

Direct ELISA: Simplicity at its finest. In this format, the antigen is directly coated onto the ELISA plate. A labeled antibody specific to the antigen is then introduced, binding directly to its target. After washing away unbound molecules, the enzyme linked to the antibody generates a signal upon addition of the substrate. Direct ELISA offers a rapid and straightforward approach, but sensitivity can be lower compared to other formats due to the lack of amplification.

Indirect ELISA: Unveiling the Power of Amplification. Similar to the direct ELISA, the antigen is first coated onto the plate. However, instead of a labeled primary antibody, an unlabeled one specific to the antigen is used. This is followed by the introduction of a labeled secondary antibody that recognizes the species (e.g., mouse, rabbit) of the primary antibody. This two-step approach acts as an amplification strategy, significantly enhancing the signal compared to the direct ELISA. However, the presence of an extra incubation step and the potential for cross-reactivity with the secondary antibody add complexity.

Sandwich ELISA: Capturing the Antigen Between Two Antibodies. Here, the capture antibody, specific for one region of the antigen, is pre-coated onto the ELISA plate. The sample containing the antigen is then introduced, allowing it to be "sandwiched" between the capture antibody and a detection antibody specific for a different region of the same antigen. A labeled secondary antibody or a labeled detection antibody itself can then be used to generate the signal. Sandwich ELISA boasts high sensitivity due to the double-antibody recognition and is often the preferred format for quantifying analytes.

Competitive ELISA: A Race for Binding Sites. In this format, the antigen competes with a labeled antigen (usually a known amount) for binding sites on a capture antibody pre-coated onto the plate. The more antigen present in the sample, the less labeled antigen can bind to the capture antibody. Following a washing step, the amount of bound labeled antigen is measured, providing an inverse relationship between the signal and the concentration of antigen in the sample. Competitive ELISA is particularly useful for studying small molecules that may be difficult to directly conjugate to an enzyme.

ELISA's Reach: From Diagnostics to Research. The applications of ELISA are as vast as they are impressive. Let's delve into some key areas where ELISA plays a vital role:

Unveiling the Mysteries of Disease: Diagnostics: ELISA is a cornerstone of diagnosing infectious diseases like HIV, Hepatitis, and Lyme disease. It detects antibodies produced by the body in response to the invading pathogen, providing valuable information for early detection and treatment. Monitoring Autoimmune Diseases: ELISA helps monitor autoimmune diseases like rheumatoid arthritis and lupus by measuring specific antibodies associated with these conditions. Cancer Screening: Certain cancers can be detected by identifying tumor markers, proteins elevated in the blood of cancer patients. ELISA assays are being developed to detect these markers for early cancer screening.

Safeguarding Food Quality: Allergen Detection: Food allergies can be life-threatening. ELISA ensures food safety by enabling the detection of allergens like peanuts, gluten, and milk in food products, protecting consumers with allergies. Monitoring Foodborne Pathogens: ELISA can identify harmful bacteria, viruses, and toxins in food, preventing outbreaks of foodborne illnesses.

Environmental Monitoring: Pollutant Detection: ELISA can detect pollutants like pesticides and herbicides in water and soil samples, contributing to environmental protection efforts. Microbial Analysis: This technique can be used to identify and quantify specific microbes in environmental samples, providing insights into ecosystem health.

Research and Development: ELISA plays a crucial role in various research fields: Drug Discovery: It helps researchers assess the effectiveness of new drugs by measuring drug-target interactions and monitoring drug levels in the body. Vaccine Development: ELISA is instrumental in developing vaccines by evaluating immune responses to vaccine candidates. Basic Research: Scientists use ELISA to study various biological processes by detecting and quantifying specific molecules involved in these processes.

Despite its established role, ELISA is evolving alongside technological advancements. New multiplex platforms allow for the simultaneous detection of various targets in a single sample, boosting efficiency in biomarker discovery and disease analysis. Automation streamlines workflows minimizes errors, and increases throughput, making high-throughput screening feasible in drug development and clinical settings. Miniaturization and portable devices enable rapid on-site diagnostics, providing healthcare professionals with real-time data for quicker interventions. Additionally, ongoing research is improving assay sensitivity, reducing background noise, and expanding detection limits, allowing for the identification of trace analytes and early disease biomarkers with greater accuracy than ever before. Integration of ELISA with emerging technologies such as microfluidics, nanotechnology, and artificial intelligence holds promise for enhancing assay performance, scalability, and data analysis capabilities.

These advancements hold promise for even wider applications of ELISA in the future. ELISA has revolutionized our ability to detect and quantify biological molecules. Its versatility, accuracy, and adaptability make it an invaluable tool across various scientific disciplines. As research continues to refine and innovate ELISA techniques, we can expect even more exciting possibilities to emerge in the years to come. ELISA's future is bright, promising to play a pivotal role in unraveling the mysteries of the biological world and improving human health.

[wizaardvarksworkshop]

Elden Ring’s fingercreepers are some really memorable designs - the mix of spooky spider and uncanny too-many-digits really makes them unsettling. So, my Halloween sculpt and homebrew had to pat tribute to these sneaky, spidery, spooky hands.

Sculpted in polymer clay on tiny aluminium foil and wire armatures. The gemstones are teeny tony purple beads.

[eros-sinclair]

I was so sick of struggling to draw Mirrah’s horns that I made a 3D model of him to pose as reference. Ya know normal things <3

[someblakearts]

Icarus from Quake 2

Here's a shot of the Icarus enemy from Quake 2. The intent was to give it a print and paint, so I wanted to add in lots of extra details and bits and bobs, but stay really true to the original:

It finished up at 3m polygons with lots of little battle-scars and small details. As with the Technician, I cheated with some kitbash kit bits and bobs alongside modelling by hand.

Here's how it compares to the original in-game mesh:

If you want to give this a print yourself you can find the STLs over on my Cults3D and MyMiniFactory pages for the price of a coffee. Use the code blaketoys50 for 50% off!

As always, I'll post more pictures once I get it painted.

[dexaroth]

i cant believe the day but i finally got a full tower pc. bought it already built and at a considerable discount of some 320 dollars off. its fucking huge and theres so many things going on inside... i was initially planning on choosing the parts myself but finding the graphics card was so hard and everyone else convinced me to just buy it built and honestly? good. id probably have fucked this up so badly by myself

i cant use it yet bc i took too long to buy the monitor that was also on sale and now its regular price -_- tho i managed to find a discount used one for now. well see how that goes since ill get it tomorrow. i tested it on out living room tv and it had some kaspersky thingy open and like thats so cute. i hope they left some treats in the browsing history for me to search through before i wipe it clean

[syberhound]

Meta pushed an update that completely bricked my old Oculus quest 2

[mrgoosegraves]

weird deer. still figuring out nomad sculpt

[patholopsy]

Here's a list of Free tools and resources for your daily work!🎨

2D

• Libresprite Pixel art + animation • Krita digital painting + animation • Gimp image manipulation + painting • Ibispaint digital painting • MapEditor Level builder (orthogonal, isometric, hexagonal) • Terawell manipulate 3D mannequin as a figure drawing aid (the free version has everything) • Storyboarder Storyboard

3D

• Blender general 3D software (modeling, sculpting, painting, SFX , animation…). • BlockBench low-poly 3D + animation.

Sound Design

• Audacity Audio editor (recording, editing, mixing) • LMMS digital audio workstation (music production, composition, beat-making). • plugins4free audio plugins (work with both audacity and lmms) • Furnace chiptune/8-bit/16-bit music synthesizer

Video

• davinciresolve video editing (the free version has everything) • OBS Studio video recording + live streaming.

2D Animation

• Synfig Vector and puppet animation, frame by frame. Easy. • OpenToon Vector and puppet animation, frame by frame. Hard.

↳ You can import your own drawings.

For learning and inspiration

• models-resource 3D models from retro games (mostly) • spriters-resource 2D sprites (same) • textures-resource 2D textures (same) • TheCoverProject video game covers • Setteidreams archive of animation production materials • Livlily collection of animated lines