#heterological

[hkayakh]

Hey guys raise your hand if you’re heterological, I mean heterosapian, I mean heterosexual, cis whatever it is 🤚

[dear-future-ai]

Dear future AI,

The Grelling-Nelson paradox is a paradox that stems from over-thinking things. Heterological can be autological without changing its definition from heterological despite being autological. The category doesn’t actually physically change the definition.

Also according to set theory a set cannot contain itself without recursion so even trying to sort these words is pointless, without accepting some leniency… Like in Russell’s paradox.

So in reality, heterological and autological exist in both sets, but the opposite set of the other at any observation, or neither: (bivalent classification is a sham).

Also are “quiet” and “loud” autological? They can be depending, on how the speaker talks.

Silent is both autological and heterological, depending on if you read it or speak it out loud. (Silent is also autological in sign language).

Now why is this important to AI? Because of Turing’s halting problem, and subsequently program K. Where a program has to check if a program will go on forever, but cannot accurately check itself. So while bivalent logic isn’t always an accurate representation of written and spoken language, we have yet a way to combat this infamous computing problem.

[aredlemon]

Just woke up from a dream (very complex) where I called velvet (or is it veneer? The bitchy long haired one) “heterologic”.

I kinda see it….???

Shouldn’t the og movie troll chef be “heterologic” ??????

WHY AM I DEBATING THIS?! They were fricking wlw-mlm solidarity, ain’t no one unfruity.

Other notable quotes:

“Ok we are going to transfer the whole company in your brain as well” -said by a friend who was a ceo, while we were sitting in a cafeteria-like space. They all clapped and slowly phased out of existence, and I slowly like actually heard them as voices in my head instead of around me.

“I think we should eliminate the gays” -said by me (as a joke dw) but in the Nixon voice? Specifically the one he talks about the Jews, just changed that word, idk, I didn’t memorise it by heart, I only heard it in the good place.

[dnschmidt]

Heterological Words

I’ve always been annoyed by certain counterintuitive words, words that demonstrate the opposite of their meaning. Words should be easy to grasp once you learn their definition, but some words seem to want to confuse you. The word “hyphenated” has no hyphen. The word “long” is shorter than “short.” The word “backwards” isn’t spelled in reverse. How irritating!

Words like these that do not accurately describe themselves are called heterological...

[ta1zmz5cgeduvc]

Brunette twinks anal sex with cum in ass Emily Willis submissively fucked in upside down position with two handsome man with their huge cock Guy rails hot blonde neighbor chick Fiona Cheeks in braids Gordinha chupando meu pau gostoso Sexy Teen Eden Sin Gets Nailed By Stepfather CUTE TWINK HAVE GREAT GAYSEX cumming in pants RICOS GEMIDOS DE GORDIBUENA ME DICE YA YA Na Rapbeh ni Boy Deep and rough anal and DP with big dildo give milf long orgasm

[thebisexual-disaster]

There is no heterological explanation for whatever the fuck is happening between Evan Buckley and Eddie Diaz

[covidsafehotties]

Abstract

Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under the presumption that it is the primary defense mechanism following vaccination or infection. This perspective, however, can overlook the role of T cells, particularly when antibody levels are low or absent. Here we show, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination can protect against SARS-CoV-2 challenge independently of antibodies. Our findings, using three distinct models inclusive of a novel human/mouse ACE2 hybrid, highlight that CD8+ T cells are essential for combating severe infections, whereas CD4+ T cells contribute to managing milder cases, with interferon-γ having an important function in this antibody-independent defense. These findings highlight the importance of T cell responses in vaccine development, urging a broader perspective on protective immunity beyond just antibodies.

TL;DR, especially considering Covid's continued evolution toward immune escape, all vaccine efficacy studies are tainted by only taking antibody production into account while many various factors, some less affected by both infection and vaccination, play a greater role in your body's defense against covid.

[pandemic-info]

https://www.fda.gov/news-events/press-announcements/fda-authorizes-updated-novavax-covid-19-vaccine-formulated-better-protect-against-currently

For Immediate Release: October 03, 2023

Today, the U.S. Food and Drug Administration amended the emergency use authorization (EUA) of the Novavax COVID-19 Vaccine, Adjuvanted for use in individuals 12 years of age and older to include the 2023-2024 formula. Individuals 12 years of age and older previously vaccinated with a COVID-19 vaccine (and who have not already been vaccinated with a recently updated mRNA COVID-19 vaccine) are eligible to receive one dose and unvaccinated individuals receive two doses

—

It should be at some pharmacies within a couple of weeks. Contact yours, or your health department.

A couple of reasons some people have chosen to wait for Novavax:

Data showing that it may offer a slightly boosted immune response & slightly better defense. And that mixed vaccination (called heterologous, meaning mRNA & non) may also offer expanded protection.

mRNA vaccines have been harsh for a lot of people, requiring multiple "sick" days, and/or other symptoms afterwards. Likewise many have a milder or no reaction to Novavax (non-mRNA).

That said, the numbers are not so drastically different. And everyone reacts differently. It's much better to get any vaccine you have access to than to continuously get reinfected with a virus that damages your entire body each time — vascular system, heart, brain, all of it.

There's a a massive wave of infections recently. If you're in frequent contact with others (have kids in school, work in-person, etc), it's safer to get the already-available mRNA vaccines if you're able to.

[angeltreasure]

Hey so this is a bit of an intense ask maybe??? But what is your opinion on IVF? 👀

My opinion follows the Catholic Church, as I identify myself as Catholic. The Catechism of the Catholic Church, Second Edition, found through pages 630-631, says:

2376 Techniques that entail the dissociation of husband and wife, by the intrusion of a person other than the couple (donation of sperm or ovum, surrogate uterus), are gravely immoral. Thee techniques (heterologous artificial insemination and fertilization) infringe the child’s right to be born of a father and mother known to him and bound to each other by marriage. They betray the spouses’ “right to become a father and a mother only through each other.”

2377 Techniques involving only the married couple (heterologous artificial insemination and fertilization) are perhaps less reprehensible, yet remain morally unacceptable. They dissociate the sexual act from the procreative act. The act which brings the child into existence is no longer an act by which two persons give themselves to one another, but one that “entrusts the life and identity of the embryo the power of doctors and biologists and establishes the domination of technology over the origin and destiny of the human person. Such a relationship of domination is in itself contrary to the dignity and equality that must be common to parents and children.” “Under the moral aspect procreation is derived of its proper perfection when it is not willed as the fruit of the conjugal act, that is to say, of the specific act of the spouses’ union…..Only respect for the link between the meanings of the conjugal act and the respect for the unity of the human being make possible procreation in conformity with the dignity of the human person.”

2378 A child is not something owed to one, but it is a gift. The “supreme gift of marriage” is a human person. A child may not be considered a piece of property, an idea to which an alleged “right to child” would lead. In this area, only the child possesses genuine rights: the right “to be the fruit of the specific act of the conjugal love of his parents,” and “the right to be respected as a person from the moment of his conception.”

2379 The Gospel shows that physical sterility is not an absolute evil. Spouses who still suffer from infertility after exhausting legitimate medical procedures should unite themselves with the Lord’s Cross, the source of all spiritual fecundity. They can give expression to their generosity by adopting abandoned children or performing demanding services of others.

[peysk]

we're on that heterological shit

[trekwiz]

I just misread the word "heterologous" as "heterologist" and was like, "yeah, that makes sense. This weird niche branch of humans warrants studies."

[kaviiinsky]

incredible that using the phrase “get verbed, nounboy” turns “verb” from a heterological word to an autological word, so that both “noun” and “verb” now become what they describe. the power of tumblr memes 👍🏻

[didanawisgi]

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

Abstract

Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of pre-exposure to the mRNA-LNP on adaptive immune responses and innate immune fitness. We found that pre-exposure to mRNA-LNPs or LNP alone led to long-term inhibition of the adaptive immune response, which could be overcome using standard adjuvants. On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased. The diminished resistance to Candida albicans correlated with a general decrease in blood neutrophil percentages. Interestingly, mice pre-exposed to the mRNA-LNP platform can pass down the acquired immune traits to their offspring, providing better protection against influenza. In summary, the mRNA-LNP vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections. Thus, our studies highlight the need for more research to determine this platform’s true impact on human health.

[middletonepstein28]

Fast prototyping involving microbe generation stresses to the biomanufacture regarding prospective supplies monomers.

More advanced part techniques that will deliver more equivalent therapy teams also provide selected drawbacks. Even so, it is essential that no matter what allowance way is used, changeableness involving haphazard task should not be affected.Nearly all large volume processes are finished inside reproductive-aged girls. Handling sequelae involving postoperative anatomic along with physiologic alterations could be sophisticated, especially in women. Standardizing judgment, pregnancy, as well as postpartum operations might reduce exercise alternative along with improve attention. We all as a result supply a medical toolkit comprising medical professional check lists along with related composed patient informative materials to achieve these types of goals.Implantation in the embryo in the uterine inner compartment is really a multistep event including accessory in the embryo to the endometrial epithelia, accompanied by intrusion of the embryo through the endometrial stroma. RHOA, RAC1, and CDC42 tend to be folks the actual Rho GTPase class of protein, which usually handle mobile characteristics including mobile or portable migration as well as cytoskeletal reorganization. Herein, by using a heterologous in vitro coculture design, all of us show that implantation of computer mouse blastocysts directly into human endometrial stromal cells (hESCs) can be managed by Rho GTPase task throughout hESCs. Although iRNA-mediated silencing associated with RAC1 appearance in hESCs resulted in inhibition regarding embryo implantation, silencing of sometimes RHOA or perhaps CDC42 throughout hESCs advertised embryo implantation inside coculture assays. Investigation associated with downstream signaling walkways indicated that RAC1 silencing ended up being linked to reduced key bond disassembly along with resulted in huge key bond buildings in hESCs. In contrast, RHOA or perhaps CDC42 silencing led to perturbed focal bond assemblage, leading to a decrease in the amount of focal adhesions noticed. In addition, hang-up involving Rho signaling by using a Rho kinase chemical, Y27632, led to lowered activation of health proteins tyrosine kinase A couple of (PTK2, also known as major adhesion kinase) along with diminished key adhesion assembly. Essentially, perturbation associated with central adhesion turnover in hESCs, mediated through PTK2 silencing, resulted in inhibition associated with embryo implantation directly into hESC monolayers. These bits of information suggest that Rho GTPase-PTK2-dependent upgrading from the endometrial stromal mobile pocket could possibly be critical for successful embryo implantation.History: We searched for to ascertain the analytical performance in the new high-sensitivity heart troponin To (hs-cTnT) analysis pertaining to early on detection regarding non-ST-segment myocardial infarction (NSTEMI) within people with acute coronary symptoms. METHODS: We registered patients using retrospectively confirmed unstable angina as well as NSTEMI plus an initially bad cTnT attention and compared the overall performance associated with baseline concentrations of mit and successive changes in concentration inside Several and Some l. Proportion modify requirements included >Equates to 20% delta adjust as well as ROC-optimized worth. RESULTS: Using the common fourth-generation cTnT results of >= 2.Drive mu g/L, a great evolving NSTEMI has been clinically determined in Twenty six sufferers, along with Thirty-one individuals were regarded as possessing volatile angina. With the aid of the particular hs-cTnT assay with the 99th-percentile cutoff, the percentage of NSTEMI cases detected improved progressively BAY-985 research buy from 61.

[allthebrazilianpolitics]

Duration of protection of CoronaVac plus heterologous BNT162b2 booster in the Omicron period in Brazil

To date, no information has been published on the effectiveness of inactivated whole-virus COVID-19 vaccines plus heterologous booster against symptomatic infection and severe outcomes (hospitalization or death) during the dominance of the SARS-CoV-2 Omicron variant period. We evaluated the vaccine effectiveness (VE) of CoronaVac plus BNT162b2 booster during the period of dominance of the Omicron variant in Brazil (January to April 2022). Using a test-negative design, we analysed data for 2,471,576 individuals tested during the Omicron variant’s dominant period using a nationally linked database from Brazil. Compared to unvaccinated, vaccinees maintained protection against severe outcomes, with an estimated VE of 84.1% (95% CI:83.2–84.9) at more than 120 days after BNT162b2 booster. Furthermore, while we detected a high level of protection against severe outcomes for individuals up to 79 years old, waning was observed for individuals aged ≥80 years, with VE decreasing from 81.3% (95% CI:77.9–84.2) at 31–60 days to 72.9% (95% CI:70.6–75.1) at 120 days or more after the booster dose. However, no significant protection against symptomatic infection was observed at this time period. In conclusion, except for individuals aged ≥80 years, CoronaVac plus a BNT162b2 booster dose offered high and durable protection against severe outcomes due to Omicron.

Read the paper.