#research activity 5

[bizarreandjarring]

harrier if you didn’t want this to be romantic why did you wear your most boobylicious shirt ???

[duckduckngoose]

I'll forever be sad i wasnt into taz back in 2019-2020 and i couldnt run surveys back than because id LOVE to compare the fandom from then to how it is now

[andrena]

adulthood is insane how do people live like this every day and be okay and have decent time management skills

[frecht]

things are going well it is currently four forty-seven a.m. (i woke up at three in a fit of worry over my anthropology project, spent a half hour on my phone trying to make myself feel better about it, spent almost an hour trying to fall back asleep while feeling vaguely ill, then decided i wouldn't be successful and got out my computer to do more work on the project)

[delicatelysublimeforester]

Celebrating Terry Fox Day: Inspiring Young Heroes in Saskatoon

[a-walking-fandom-reference]

me/cfs sucks so bad like 0/10 do not recommend

[catboybiologist]

“As a biologist, the terms biological woman and man don’t make any sense to me” okay then you’re an idiot and a terrible biologist. I swear to god, morons like you only become biologists just so you can hold it over others, when in reality, if biology deniers like you can become biologists, then being one really doesn’t mean much anyway. But this probably just gave an autogynophile like you a boner to read, anyway.

Oh fun! Haven't gotten one of these in a while. Disregarding the fact that you somehow think the qualification for being a biologist entirely hinges on defining womanhood, I do need to ask some clarification. I know I'm feeding the trolls here, but here we go: does your definition of "biological woman" mean:

Sociological woman? Eh, context dependent, I'm not fully out of the closet, but oftentimes, I am and present femme. So let's call that one 50/50.

Psychological woman? Because I am one.

Neurological woman? Because I am one [1].

Physical woman? My soft tissue redistribution is handling that well.

Hormonal woman? My blood tests are within cis female ranges.

Transcriptional woman? As a signalling molecule, the downstream effects of estrogen have broad transcriptional effects, completely changing the profile of gene expression and functional genomics of my cells. [2]

Genetic woman? I mean, see my above point- as far as my genes that are actually active, I have all of the same transcripts being produced, controlling which genes are expressed.

Karyotypic woman? I actually have a few signs pre-HRT that might point to a non-XY chromosome pair, but I haven't had a karyotype. We'll put that down as unknown. And hell, even if its XY, there's plenty of cis women who are karyotypically XY, with suppressed sry or complete androgen insensitivity. Interestingly enough, a completely androgen insesitive woman can go her whole life without knowing- and functionally, is very similar to a trans woman, actually. Fancy that. [3]

Reproductive woman? I can't produce an egg cell, but neither can significant fractions of cis women. Also, this is all gonna change soon, which is fun. [4]

There's also a lot of understudied aspects to the biology of HRT and even pre-HRT that are emerging, largely demonstrating widespread cellular and genetic remodeling of trans individuals undergoing hormone therapy. The field is a bit behind due to constant political pressure to revoke funding, but a lot of the results are extremely exciting in both testosterone and estrogen hormone therapies. I'm sure that, as a self professed biology As someone who presumably has a lot of expertise in biology, I'm assuming that you're aware of all of this cutting edge research, and are keeping up with modern papers, including but not limited to these cool findings:

Trans men on HRT exhibit significant genetic and transcriptional changes that make them biochemically male. [5][6]. It's a good hypothesis that the same happens with estrogen treatment, but those studies don't exist yet- I'm sure you're reserving judgment until more publications exist, of course.

Trans men on HRT develop male cell types and tissues. [7]

Trans women experience muscular and blood cell changes that align with cis women moreso than cis men [8]

And many, many more! This is an exciting, underserved, and groundbreaking field of research, and I'm sure you're keeping up with the latest in scientific journals about it.

I'm sure, of course, that you understand that it becomes impossible to draw a distinct line anywhere in here, and that words like "woman" are shorthand for the myriad of traits that invisibly synthesize in our mind and in society to represent a concept? I'm sure you understand that science is fundamentally descriptive, not prescriptive? I'm sure that you understand that these findings, while really cool and interesting, actually don't mean jack shit about what the word "woman" means or not?

As someone who is the ultimate decider in what a biologist is, I'm sure you know that bioessentiallism is a childish mindset that completely ignores and disregards the constantly changing, dynamic nature of biological systems, something that extends well beyond biological sex and its relation to gender.

I'm sure that also, that you understand that beyond just this, that the role of science in society is to advise how to achieve our moral principles, not create moral principles in themselves. And I'm sure that understanding means you know that trans affirming healthcare and supportive societal treatment leads to reduced mortality and increased happiness for everyone, right?

So great to talk to someone who is surely a scientist on this. You are a biologist, if you're talking like this, I assume? I assume you're not going to spit complete misreadings of scientific language from the background sections of these papers that only reveal you've never read a scientific paper in your life if you're thinking this way? I assume you have experience interpreting data like this?

Also, imagining my genitalia while writing this? Ew. Please stop projecting your fetishes into my inbox.

Works cited:

Kurth F, Gaser C, Sánchez FJ, Luders E. Brain Sex in Transgender Women Is Shifted towards Gender Identity. J Clin Med. 2022 Mar 13;11(6):1582. doi: 10.3390/jcm11061582. PMID: 35329908; PMCID: PMC8955456.

Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 2019;116:135-170. doi: 10.1016/bs.apcsb.2019.01.001. Epub 2019 Feb 4. PMID: 31036290; PMCID: PMC6533072.

Gottlieb B, Trifiro MA. Androgen Insensitivity Syndrome. 1999 Mar 24 [Updated 2017 May 11]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1429/

Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature 615, 900–906 (2023). https://doi.org/10.1038/s41586-023-05834-x

Pallotti F, Senofonte G, Konstantinidou F, Di Chiano S, Faja F, Rizzo F, Cargnelutti F, Krausz C, Paoli D, Lenzi A, Stuppia L, Gatta V, Lombardo F. Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter's Methylation in AFAB People. Biomedicines. 2022 Feb 16;10(2):459. doi: 10.3390/biomedicines10020459. PMID: 35203670; PMCID: PMC8962414.

Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, Edward C. Ray, Xiaojiang Cui, Simon R.V. Knott, The molecular consequences of androgen activity in the human breast, Cell Genomics, Volume 3, Issue 3, 2023, 100272, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100272. (https://www.sciencedirect.com/science/article/pii/S2666979X23000320)

Xu R, Diamond DA, Borer JG, Estrada C, Yu R, Anderson WJ, Vargas SO. Prostatic metaplasia of the vagina in transmasculine individuals. World J Urol. 2022 Mar;40(3):849-855. doi: 10.1007/s00345-021-03907-y. Epub 2022 Jan 16. PMID: 35034167.

Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL. How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation. Br J Sports Med. 2021 Aug;55(15):865-872. doi: 10.1136/bjsports-2020-103106. Epub 2021 Mar 1. PMID: 33648944; PMCID: PMC8311086.

[dreadwedge]

One thing most people don't realize about Gazebos is how bloodthirsty they used to be until the 1930s or so. It used to be that in order to appease your average small town gazebo you had to feed it 4-5 marching bands a year, or roughly 2 dozen barbershop groups. Noawadays? Throw it a steely dan cover act every 6 months, maybe a bridal party every few years if you're actively trying to court its favor, and you're pretty much in the clear. And the crazy thing is nobody knows why they calmed down, or that their appetite for flesh won't return to its 19th century heights one day. It's actually an increasingly popular theory among modern Gazebo researchers that we're at the tail end of a period of dormancy and it's only a matter of time until they start howling for blood again. And if/when that does happen there's the question of whether our modern zeeb-keepers are really ready for the task of booking enough sacrificial acts to meet that increased demand. Guild policy has gotten lax in the century since the heyday of Dark Pavillionism and a lot of local keepers refuse to even look at newer research that threatens to upset their status quo. Kind of scary to think about

[copperbadge]

I'm getting depressingly good at identifying the formula for Pop Academic Books About ADHD.

Regardless of their philosophy it pretty much goes like this:

1. Emotionally sensitive essay about the struggle of ADHD and the author's personal experience with it as both a person with ADHD and a healthcare professional.

2. Either during or directly following this, a lightly explicated catalogue of symptoms, illustrated by anecdotes from patient case studies. Optional: frequent, heavy use of metaphor to explain ADHD-driven behavior.

3. Several chapters follow, each dedicated to a symptom; these have a mini-formula of their own. They open with a patient case study, discuss the highly relatable aspects of the specific symptom or behavior, then offer some lightweight examples of a treatment for the symptom, usually accompanied by follow up results from the earlier case studies.

4. Somewhere around halfway-to-two-thirds through the book, the author introduces the more in-depth explication of the treatment system (often their own homebrew) they are advocating. These are generally both personally-driven (as opposed to suggested cultural changes, which makes sense given these books' target audience, more on this later) and composed of an elaborate system of either behavior alteration or mental reframing. Whether this system is actually implementable by the average reader varies wildly.

5. A brief optional section on how to make use of ADHD as a tool (usually referring to ADHD or some of its symptoms as a superpower at least once). Sometimes this section restates the importance of using the systems from part 4 to harness that superpower. Frequently, if present, it feels like an afterthought.

6. Summation and list of further resources, often including other books which follow this formula.

I know I'm being a little sarcastic, but realistically there's nothing inherently wrong about the formula, like in itself it's not a red flag. It's just hilariously recognizable once you've noticed it.

It makes sense that these books advocate for the Reader With ADHD undertaking personal responsibility for their treatment, since these are in the tradition of self-help publishing. They're aimed at people who are already interested in doing their own research on their disability and possible ways to handle it. It's not really fair to ask them to be policy manuals, but I do find it interesting that even books which advocate stuff like volunteering (for whatever reason, usually to do with socialization issues and isolation, often DBT-adjacent) never suggest disability activism either generally or with an ADHD-specific bent.

None of these books suggest that perhaps life with ADHD could be made easier with increased accommodations or ease of medication access, and that it might be in a person's best interest to engage in political advocacy surrounding these and other disability-related issues. Or that activism related to ADHD might help to give someone with ADHD a stronger sense of ownership of their unique neurology. Or that if you have ADHD the idea of activism or even medical self-advocacy is crushingly stressful, and ways that stress might be dealt with.

It does make me want to write one of my own. "The Deviant Chaos Guide To Being A Miscreant With ADHD". Includes chapters on how to get an actual accurate assessment, tips for managing a prescription for a controlled substance, medical and psychiatric self-advocacy for people who are conditioned against confrontation, When To Lie About Being Neurodivergent, policy suggestions for ADHD-related legislation, tips for activism while executively dysfunked, and to close the book a biting satire of the pop media idea of self-care. ("Feeling sad? Make yourself a nice pot of chicken soup from scratch and you'll feel better in no time. Stay tuned after this rambling personal essay for the most mediocre chicken soup recipe you've ever seen!" "Have you considered planning and executing an overly elaborate criminal heist as a way to meet people and stay busy?")

Every case study or personal anecdote in the book will have a different name and demographics attached but will also make it obvious that they are all really just me, in the prose equivalent of a cheap wig, writing about my life. "Kelly, age seven, says she struggles to stay organized using the systems neurotypical children might find easy. I had to design my own accounting spreadsheet in order to make sure I always have enough in checking to cover the mortgage, she told me, fidgeting with the pop socket on her smartphone."

I feel a little bad making fun, because these books are often the best resource people can get (in itself concerning). It's like how despite my dislike of AA, I don't dunk on it in public because I don't want to offer people an excuse not to seek help. It feels like punching down to criticize these books, even though it's a swing at an industry that is mainly, it seems, here to profit from me. But one does get tired of skimming the hype for the real content only to find the real content isn't that useful either.

Les (not his real name) was diagnosed at the age of 236. Charming, well-read, and wealthy, he still spent much of his afterlife feeling deeply inadequate about his perceived shortcomings. "Vampire culture doesn't really acknowledge ADHD as a condition," he says. "My sire wouldn't understand, even though he probably has it as well. You should see the number of coffins containing the soil of his homeland that he's left lying forgotten all over Europe." A late diagnosis validated his feelings of difference, but on its own can't help when he hyperfocuses on seducing mortals who cross his path and forgets to get home before sunrise. "I have stock in sunburn gel companies," he jokes.

[thesquidwizard]

i love intention behind “adopt dont shop” but if people would just responsibly shop for their stupid dogs a lot of people would have less reason to hate dogs

[afeelgoodblog]

The Best News of Last Month

Sorry for being not active this month as I had some health problems. I'll start posting weekly now :) Meanwhile here's some good from last month

1. Widow donates $1 billion to medical school, giving free tuition forever

Ruth Gottesman surprised by her late husband's $1 billion in Berkshire stock, decides to donate it in full to the Albert Einstein College of Medicine in the Bronx, New York City's poorest borough. The donation is intended to cover students' tuition indefinitely, ensuring access to medical education for generations.

A video capturing students' emotional reactions to the news, cheering and crying, circulated after the announcement, highlighting the profound impact of the donation on the medical school community.

2. Electric school buses outperform diesel in extreme cold

In Colorado's West Grand School District, electric school buses outperformed their diesel counterparts, particularly in the bitterly cold temperatures of towns like Kremmling, where morning temperatures can drop below -30 degrees Fahrenheit. Despite common concerns about reduced range in extreme weather, the electric buses maintained their battery charge even in these frigid conditions, providing reliable transportation for students.

This success has been welcomed by the school district, as diesel vehicles also face challenges in starting in Colorado's harsh winter weather.

3. Christian Bale unveils plans to build 12 foster homes in California

Christian Bale has led a tour round the new village in California where he plans to build 12 foster homes, as well as two studio flats to help children transition into independent living, and a 7,000 sq ft community centre.

The actor has spearheaded the building of a unique complex of facilities with the aim of keeping siblings in the foster care system together, and ideally under the same roof.

4. Average lifespan of a person with Down syndrome has increased from 25 years in 1983 to 60 years today

Today the average lifespan of a person with Down syndrome is approximately 60 years.

As recently as 1983, the average lifespan of a person with Down syndrome was 25 years. The dramatic increase to 60 years is largely due to the end of the inhumane practice of institutionalizing people with Down syndrome.

5. Greece legalises same-sex marriage

Greece has become the first Christian Orthodox-majority country to legalise same-sex marriage. Same-sex couples will now also be legally allowed to adopt children after Thursday's 176-76 vote in parliament.

Prime Minister Kyriakos Mitsotakis said the new law would "boldly abolish a serious inequality".

6. Massachusetts police K9 tracks scent for over 2 miles to find missing 12-year-old in freezing cold

A Massachusetts police K9 followed her nose to help find a 12-year-old who went missing in frigid temperatures last week, tracking the child’s scent for over two miles, authorities said.

K9 Biza, a female German shepherd, was called on to help after officers learned the child left their home at around 10:30 p.m. Wednesday and was last seen in the Pakachoag Hill area of Auburn, the Auburn Police Department said.

7. Good News for the Socially Anxious: People Like You a Lot More Than You Think They Do, New Research Confirms

The "Lake Wobegon effect" or "illusory superiority" phenomenon highlights people's tendency to overestimate their abilities, but recent research suggests that in social interactions, individuals often underestimate their likability and charm.

Studies indicate that people consistently fail to recognize signals of others' liking toward them, leading to a "liking gap" where individuals believe they are less likable than they actually are.

Techniques such as focusing more on others during conversations and genuinely expressing interest in them can help alleviate social anxiety by shifting the focus away from self-criticism. Ultimately, understanding that others may also experience similar anxieties can lead to a more relaxed and enjoyable social experience.

---

That's it for this week :)

This newsletter will always be free. If you liked this post you can support me with a small kofi donation here:

Buy me a coffee ❤️

Also don’t forget to reblog this post with your friends.

[orcelito]

in other news my itnl planning doc is already kinda lengthy and ive only addressed 5 of the gung ho guns. & this is just me making notes & marking general ideas.

wolfwood is there too bc im going thru the wiki in order but his section is just

[reasonsforhope]

"When bloodstream infections set in, fast treatment is crucial — but it can take several days to identify the bacteria responsible. A new, rapid-diagnosis sepsis test could cut down on the wait, reducing testing time from as much as a few days to about 13 hours by cutting out a lengthy blood culturing step, researchers report July 24 [2024] in Nature.

“They are pushing the limits of rapid diagnostics for bloodstream infections,” says Pak Kin Wong, a biomedical engineer at Penn State who was not involved in the research. “They are driving toward a direction that will dramatically improve the clinical management of bloodstream infections and sepsis.”

Sepsis — an immune system overreaction to an infection — is a life-threatening condition that strikes nearly 2 million people per year in the United States, killing more than 250,000 (SN: 5/18/08). The condition can also progress to septic shock, a steep drop in blood pressure that damages the kidneys, lungs, liver and other organs. It can be caused by a broad range of different bacteria, making species identification key for personalized treatment of each patient.

In conventional sepsis testing, the blood collected from the patient must first go through a daylong blood culturing step to grow more bacteria for detection. The sample then goes through a second culture for purification before undergoing testing to find the best treatment. During the two to three days required for testing, patients are placed on broad-spectrum antibiotics — a blunt tool designed to stave off a mystery infection that’s better treated by targeted antibiotics after figuring out the specific bacteria causing the infection.

Nanoengineer Tae Hyun Kim and colleagues found a way around the initial 24-hour blood culture.

The workaround starts by injecting a blood sample with nanoparticles decorated with a peptide designed to bind to a wide range of blood-borne pathogens. Magnets then pull out the nanoparticles, and the bound pathogens come with them. Those bacteria are sent directly to the pure culture. Thanks to this binding and sorting process, the bacteria can grow faster without extraneous components in the sample, like blood cells and the previously given broad-spectrum antibiotics, says Kim, of Seoul National University in South Korea.

Cutting out the initial blood culturing step also relies on a new imaging algorithm, Kim says. To test bacteria’s susceptibility to antibiotics, both are placed in the same environment, and scientists observe if and how the antibiotics stunt the bacteria’s growth or kill them. The team’s image detection algorithm can detect subtler changes than the human eye can. So it can identify the species and antibiotic susceptibility with far fewer bacteria cells than the conventional method, thereby reducing the need for long culture times to produce larger colonies.

Though the new method shows promise, Wong says, any new test carries a risk of false negatives, missing bacteria that are actually present in the bloodstream. That in turn can lead to not treating an active infection, and “undertreatment of bloodstream infection can be fatal,” he says. “While the classical blood culture technique is extremely slow, it is very effective in avoiding false negatives.”

Following their laboratory-based experiments, Kim and colleagues tested their new method clinically, running it in parallel with conventional sepsis testing on 190 hospital patients with suspected infections. The testing obtained a 100 percent match on correct bacterial species identification, the team reports. Though more clinical tests are needed, these accuracy results are encouraging so far, Kim says.

The team is continuing to refine their design in hopes of developing a fully automated sepsis blood test that can quickly produce results, even when hospital laboratories are closed overnight. “We really wanted to commercialize this and really make it happen so that we could make impacts to the patients,” Kim says."

-via Science News, July 24, 2024

[myfandomrealitea]

I know there's a lot of advice for handling things like depression and its so fucking easy for people to say "just do this and you'll feel better!" and I hate that, I fucking despise it, but I'm also gonna throw in my two cents about what is personally helping me get out of bed some days and genuinely, not kill myself.

Its taking care of nature.

Seriously. It sounds stupid and some days it feels stupid, but I put up bird feeders because I live in a semi-rural area where human activity is decimating the local bird population and options for safe feeding. So I put up bird feeders. And now I have like 83 different birds flocking to my garden on the daily and screaming at my window if the feeders are empty. And I've seen generations of baby birds brought to my garden by their parents because this is where the food is.

And I researched what plants and flowers were native to my area and I spent like $5 on a few different seed packets and sprinkled them around the grass and the sad empty flowerbeds and the lawn because the bees have nothing to eat and that's awful and it turns out wildflowers will fucking GROW the moment you look away, but now every spring and summer my lawn is a pretty little multi-colored bug haven.

And I've even gotten the chance to save a few little bug lives because of it. I've taken in cold-shocked bees and given them a warm little tupperware to recover in. I've fed bugs sugar water to get their energy back to take their food home. I've given dying bugs a sheltered, safe place to spend their last moments.

I planted a veggie garden. And I know I'm very lucky in that I have the space to do that, but also, you can grow a lot of things indoors. My friend has literally the smallest apartment you can imagine but she grows chives in her bathroom and grows five radishes at a time in a pot in the kitchen. Literally five. But it makes her so happy every single time she pulls them up or trots off to the bathroom to snip some chives.

I pick trash up every two weeks. The pick stick was like $4 online and I just put the bag out with my bi-weekly trash pick-up and its disgusting but but nobody else is gonna do it and I've only got finite time on this earth. If nobody else is going to pick up that can, I will. Because some innocent wild animal doesn't deserve to get hurt by human ignorance, and I deserve to walk home and see pretty flourishing nature instead of depressing discarded trash like I feel like most days.

I've left water out for the wildlife and watched hedgehogs, local dogs on their walks, squirrels and all sorts stop by to take a drink, because humans are fucking selfish and we're making something as basic as water so hard to access for anyone but ourselves, but I can fix a little bit of that just by putting out a bowl. Sometimes I don't even have to remember to fill it because the rain will fill it for me, and its kind of like nature's way of saying "you're helping me so I'm going to help you out too." Which is neat.

Like most days I do not want to be living on this earth but my god earth did not get a choice about us living here, and we're ruining it, and it actually feels so good to help stop and un-do a little bit of that destruction.

And you don't even have to try everything I do. If the only thing you've got the spoons to do is buy one bird feeder and you only remember to fill it once a month, its still something. That once a month could mean the difference between starvation and a full belly to a bird.

Again, none of this is obligatory and I'm not saying at all this is some magical cure for depression, but personally these things are things which are helping me slowly find things to keep getting out of bed for and things to feel a sense of self worth and satisfaction over. I feel better both in and about myself when I feed the birds, when I see the bugs in the garden, when I pick up the trash.

If its something you haven't considered yet, it might be worth a try.

[nasa]

It’s Girl Scout Day! March 12, 2024, is the 112th birthday of Girl Scouts in the United States, and to celebrate, we’re sharing a lithograph of the Girl Scout alumnae who became NASA astronauts.

Girl Scouts learn to work together, build community, embrace adventurousness and curiosity, and develop leadership skills—all of which come in handy as an astronaut. For example, former Scouts Christina Koch and Jessica Meir worked together to make history on Oct. 18, 2019, when they performed the first all-woman spacewalk.

Pam Melroy is one of only two women to command a space shuttle and became NASA’s deputy administrator on June 21, 2021.

Nicole Mann was the first Indigenous woman from NASA to go to space when she launched to the International Space Station on Oct. 5, 2022. Currently, Loral O’Hara is aboard the space station, conducting science experiments and research.

Participating in thoughtful activities in leadership and STEM in Girl Scouts has empowered and inspired generations of girls to explore space, and we can’t wait to meet the future generations who will venture to the Moon and beyond.

Make sure to follow us on Tumblr for your regular dose of space!

[mindblowingscience]

Volcanoes were still erupting on the moon when dinosaurs roamed Earth, new research suggests. The evidence: three tiny glass beads plucked from the surface of the moon and brought to Earth in 2020 by a Chinese spacecraft. Their chemical makeup indicates that there were active lunar volcanoes until about 120 million years ago, much more recent than scientists thought. An earlier analysis of the rock samples from the Chang'e 5 mission had suggested volcanoes petered out 2 billion years ago. Previous estimates stretched back to 4 billion years ago. The research was published Thursday in the journal Science.

Continue Reading.