#sequelae

[pandemic-info]

Long-Term Long Covid - by Eric Topol

Unfortunately, what was seen at 6 months largely continues out to 2 years. 

... [New paper at] Nature Medicine addresses what happened 2 years later to nearly 140,000 people who had Covid, compared with almost 6 million people non-infected controls.

... in the non-hospitalized group a substantial proportion— about 30%— of the 80 sequelae, including GI and neurologic, remained significantly elevated. 

... I’d like to point out the data analyzed in this study was enormous, as I tried to capture with one of the supplemental tables below, representative of many others. The authors took on many advanced analytic approaches with weighting, conditional modeling, and sensitivity analyses that I’m not going to review here.

... While this is the first comprehensive and systematic study of Covid at 2 years, it unfortunately is within a highly skewed population. The demographics of nearly 90% men, with a mean age 61 years, is far different than the prototypic person with Long Covid who is more apt to be female and age 30-39 years. Furthermore, to get 2 year follow-up it meant studying a population who had Covid early in the pandemic, before vaccines or the marked evolution of the virus with new variants, including Delta, which was more virulent that the ancestral or Alpha strains that preceded it. So please keep this in mind—the results are important but they may well not be representative of the real world, broader population, of Covid and Long Covid. That’s already a major hole in our knowledge base since there is no other report yet to systematically address a more representative population.

...

Summary

At two years after Covid, there’s a persistent and considerable burden of symptoms and multi-system organ involvement in an important subgroup of people. It’s also unpredictable who will be afflicted with protracted symptoms and new medical diagnoses. While there still is no validated treatment (the Big Miss, as recently reviewed), Long Covid marches on, not just over time for most of those already suffering, but also among newly infected or re-infected individuals — like we are seeing now with increase in cases in the United States and many other countries. The main emphasis here, beyond the enduring and very concerning symptoms and organ dysfunction, is that we are still in the dark. It will take many years to fully know the sequelae of Covid, be it from unforeseen, delayed adverse outcomes like what occurred many years after influenza or polio, or the secondary outcomes of organ systems that are clearly affected, or via promotion of autoimmune conditions or pro-inflammatory pathways, potentially exacerbating risk of atherosclerosis. We’re going to need many more years of careful follow-up to fully understand the ways and extent Covid has hurt us. Meanwhile, beyond the known strategies for prevention of infection, we must consider finding effective ways to treat people who suffer from Long Covid as an urgent and foremost priority.

[gennsoup]

I figure in the dreams of people who do not even know me

Audre Lorde, Sequelae

[saveyoursunshine]

i love when artists explicitly write/draw eddie and steve with very noticeable, maybe even deforming scars. i love when they dont fail to mention the repercussions the things they've been through have left on their bodies. because yes, we talk a lot about ptsd and horrible nightmares and all the psychoemotional issues, but we should totally talk more about the physical side of it.

eddie with a scar on his jaw that tugs when he smiles and aches after a long effusive rant. having to use mobility aides like a crutch or a walking stick because the muscles on his leg never fully recovered and the scars on his abdomen hurt if he tries to tighten his core too hard.

steve with awful migranes and early onset hearing loss and complex vision problems and slight trouble breathing because his head/face got fucked up one too many times. the scars on his back that got infected because no one gave them notice, that are now scars that twinge when he moves his arms and hurt after a day of running around with the kids. the scars on his abdomen that restrict his range of motion. that raspiness in his voice that never went away after a bat tried to crush his windpipe.

i don't know where i'm going with this i just... we constantly recognize their heroic deeds, but i think it's also important to remember that they are not heroes. they are just teenagers who were in the wrong place at the wrong time. they were doomed by the narrative, literally cannon fodder, and their bodies tell the history of that, and of how they're still here despite it all.

[vergess]

GOOD EVENING EVERYPONY LONG COVID FINALLY HAS AN OFFICIAL MEDICAL DEFINITION WOOOOO

Not sure why this matters?

It's the first step in creating accurate diagnosis which is critical on researching how to improve recovery outcomes.

You can read more here:

As always, remember to mask up and stay vaccinated.

[disasterhimbo]

Everyone should watch Unrest (2017). It has captions and subtitles in many languages, so you can probably watch it even if English isn’t your first language. Please, if you ever have an hour and a half of spare time, please watch this movie:

It’s all about ME/CFS, an often-debilitating chronic illness that’s one of the most frequent conditions people develop after acute covid infections. The filmmaker, Jennifer Brea, has it, and she interviews many other people who have it, their families, and doctors, as well as going into the history of the illness. It’s important to watch this to support your friends who have it, and at this point, some of your friends probably do have it.

Edit: content warnings for discussion of suicide and suicidal ideation in the movie (but it ends on a hopeful note).

[willowreader]

This is good news for those who have lung issues due to Covid. I looked up what pulmonary sequelae refers to. Here is what I found. "The pulmonary sequelae of COVID-19 include thromboembolic disease, with thrombi and microvascular thrombi identified in the pulmonary vasculature; further work is needed to define the underlying mechanisms of chronic vascular disease after COVID-19 to inform diagnostic and therapeutic approaches."

I know someone with Interstitial lung disease acquired after a Covid infection and so this is great news. Here is a link to this disease.

This study is very technical. The image below is from The Lancet, not from the study shown above.

[serotinesart]

lil extra animaton for pooka!

[thehollowwriter]

Now that I'm thinking about her, Zira was... certainly a character.

Yeah, she's fully willing to kill a cub, yes I know Scar sent the Hyenas to kill Simba as a cub but she wanted to do it herself.. Yeah, she wants Simba to suffer, and she wants to hear the mournful cry of his pride after his death. She manipulated and brainwashed all of her children.

She's vicious af and extremely devoted to Scar. She's sadistic and ruthless. One of her lines is literally "break his jaw!" She willingly let herself fall into a ravine after she lost. She plotted Simba's death for years on end.

Her villain song includes lyrics like "the sound of Simba's of dying gasp, his daughter squealing in my grasp" "though the battle may be bloody, that kinda works for me" "a symphony of death, oh my, now that's my lullaby"

Wowee

I wanna make an oc off her now

[sedlex]

Alright I lowered a bit the quality to be able to fit the NINE MINUTES it took to do 55 SECONDS of "fencing", so if anybody else wants to be annoyed, they could "enjoy" this.

And I know, I know, it is well within the rules,

and a quite effective way to make the time pass,

and a pretty decent way to grate on the opponent's nerves and cause mistakes,

and it is my country's team so I should be mildly laughing too at the strategic brilliance of a continuous "lean back and cover any part of the valid target area and nothing else", but

I for one wouldn't have done this, medal be damned and team strategy be extra damned.

[ilfalcoperegrinus]

SATANA SVIA, un commento al vangelo della 1a domenica di Quaresima, disponibile anche come audio-commento e con testo tradotto in lingua spagnola, entrando nella sezione "Commenti al vangelo" del menu principale di www.predicatelosuitetti.com

[ultimate-word-tournament]

Ultimate Word Tournament!

Season 2

sequela (English) /sɪˈkwɛlə/ a disease or condition which follows chronologically after an earlier disease or problem, being either wholly or partly caused by it, or made possible by it.

knuffel (Dutch) /ˈknʏ.fəl/ 1. A hug, cuddle. 2. A cuddly animal or other stuffed toy, plushie, soft toy.

Knuffel Propaganda

[pandemic-info]

(via If we don't develop a treatment we're f*cked)

“Not to be a downer, but this is the result of a study researches led at the University of Toronto following SARS1 patients who were disabled by the virus initially and how they were doing 20 years later.“

Screenshot “from the presentation by; Prof. Daniel M. Altmann, Department of Immunology and Inflammation, Imperial College, Faculty of Medicine, London, UK at #UniteToFight2024 https://unitetofight2024.world/program/”

+ important comment:

“A study on SARS 1 survivors, if you're curious:

2023 study in The Lancet on SARS 1 survivors

Lots had femoral necrosis (bone death), osteoporosis, and long-lasting, possibly immunologically-based fatigue.

Just a reminder that while there are similarities, these are two different diseases. SARS CoV 1 hospitalized 70% of infected and killed 10% at the time of containment. They're similar in disease profile and in genetics, but they are NOT the same.

COVID-19 is much more infectious and less lethal, and the range of post-viral complications is different. Plus, we don't know what treatments will come out for Long COVID patients, but medicine is much more advanced and there is much more funding for Long COVID than there was for SARS CoV 1 survivors, who were infected in 2003, and never had access to a vaccine.”

[wetslug]

ive been so subtly off this week just so exhausted and not in a mood to talk or socialize or do anything fun and then i remembered ohhhh im on my period + my dog just died . no fucking wonder

[pandemichub]

[disasterhimbo]

This is super specific but ever since I had covid, I misspell homophones (like two/to/too and there/their/they’re) and this NEVER used to happen to me before, spelling has always come naturally to me, and basically I was just wondering if anyone else has had a similar experience?

Edit: I said two/to/two instead of two/to/too. I made the mistake in the fucking post.

[ramblingandpie]

Uiuuuuugh my hand was having pain issues before the bar exam and I chalked it up to exam prep and figured it would subside after the test BUT NO it's gotten worse? And it feels like it's the osteoarthritis in... all my fingers/knuckles except my index finger somehow? Worst in my thumb and middle finger to the point that today I couldn't hold a pen. Also my right elbow and shoulder hurt. So. Uh.

Whyyyyy???