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junejvoss · 2 months ago

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5205 BRIGHTON SHORE DRIVE Listing Site: https://ift.tt/o3P7BS9 Property Site:… https://ift.tt/DWGkT14 5205 BRIGHTON SHORE DRIVE Listing Site: https://ift.tt/o3P7BS9 Property Site: https://ift.tt/u9Qy2kh 5205 BRIGHTON SHORE DRIVE APOLLO BEACH, FL 33572 $949,000, 3 bed, 3.00 bath, 2,488 SF, MLS# TB8360624 Welcome to 5205 Brighton Shore Drive in Apollo Beach. This beautifully renovated 2,488 sq ft, 3-bedroom, 3-bathroom custom home, built by David Weekley, offers high-end finishes and an ideal open-concept floor plan for waterfront living. The inviting layout and abundant natural light draw your attention to breathtaking views of the Mirabay Lagoon. Situated on an oversized pie-shaped lot with over 156 feet of waterfront along a deep expanse of the lagoon, there’s ample room to create your dream backyard oasis. Your private boat dock, equipped with a 16,000 lb boat lift AND a jet ski lift, sits just steps from your back door, providing quick access to Tampa Bay’s world-class fishing and waterfront dining—reaching the bay in just 15 minutes. The main living areas feature a wall of water facing windows, durable tile flooring, open concept great room, high ceilings, updated interior paint and custom wall designs. A large flexible space at the front of the home can serve as a formal dining room, media room, or private office. The spacious primary suite offers a dedicated flex area that can be used as an office overlooking the lagoon, a workout space, or a morning reading nook. The suite also includes a large walk-in closet and an ensuite bath with dual sinks and a garden-style soaking tub. The two additional bedrooms are generously sized, each with their own private, professionally remodeled baths completed in 2024, offering privacy and comfort with a true split floor plan. The fully updated kitchen is the heart of the home, featuring leathered quartz countertops and backsplash, a newer stainless steel appliances including fridge, gas cooktop, double ovens, a custom vent hood, a new sink with a touchless faucet, and prewired under-cabinet lighting. Additional updates include a newer roof (2019) with a 25-year warranty, water heater (2022), a 5-ton HVAC system with a UV light filter (2022), a new water softener, and a new irrigation control station. For added peace of mind, the home also includes a 15,000-watt whole-home generator. This exceptional home is located in Mirabay, a highly sought-after waterfront community known for its resort-style amenities. Residents enjoy access to a 24-hour fitness center, heated pools, tennis and pickleball courts, and miles of scenic walking trails. The community offers a private boat launch, several parks, and a vibrant social calendar filled with activities for all ages. Mirabay’s waterfront lifestyle offers endless opportunities for kayaking, paddleboarding, and connecting with neighbors in this golf cart-friendly neighborhood. This home offers the ideal blend of comfort, functionality, and the sought-after Mirabay lifestyle. 3 full bath For more information, please contact: Shawna Calvert Align Right Realty [email protected] You can also text 172016 to 46835 Search All Listings: https://ift.tt/35imtnv AGENT SOCIAL ——————– Website: https://ift.tt/Ccr8LtX Showcase: https://ift.tt/w58AaMN Facebook: https://ift.tt/ldP50tx Instagram: https://ift.tt/mZW2ksv Twitter: https://twitter.com/ShawnaCalvert LinkedIn: https://ift.tt/tH5AqON Pinterest: https://ift.tt/OMSaNUu YouTube: https://www.youtube.com/@Shawnainparadise COMPANY SOCIAL ——————– Website: https://ift.tt/65GJMg1 Facebook: https://ift.tt/ZKA7d3Y Twitter: https://twitter.com/alignrightrealt?lang=en LinkedIn: https://ift.tt/l8VthJ0 YouTube: https://www.youtube.com/channel/UCJgtjS8PQiLXLMC3yIDqSnw via Shawna Calvert Realtor Align Right Realty https://www.youtube.com/channel/UCidsEJ85xGsZJnZiWvhpqXA April 09, 2025 at 11:52PM via Shawna Calvert Realtor Align Right Realty https://ift.tt/u4dOHbn April 10, 2025 at 01:41AM

#IFTTT #Shawna Calvert Realtor Align Right Realty

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silasmclark · 2 months ago

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5205 BRIGHTON SHORE DRIVE Listing Site: https://ift.tt/o3P7BS9 Property Site:… https://ift.tt/1a8tyBx 5205 BRIGHTON SHORE DRIVE Listing Site: https://ift.tt/o3P7BS9 Property Site: https://ift.tt/u9Qy2kh 5205 BRIGHTON SHORE DRIVE APOLLO BEACH, FL 33572 $949,000, 3 bed, 3.00 bath, 2,488 SF, MLS# TB8360624 Welcome to 5205 Brighton Shore Drive in Apollo Beach. This beautifully renovated 2,488 sq ft, 3-bedroom, 3-bathroom custom home, built by David Weekley, offers high-end finishes and an ideal open-concept floor plan for waterfront living. The inviting layout and abundant natural light draw your attention to breathtaking views of the Mirabay Lagoon. Situated on an oversized pie-shaped lot with over 156 feet of waterfront along a deep expanse of the lagoon, there’s ample room to create your dream backyard oasis. Your private boat dock, equipped with a 16,000 lb boat lift AND a jet ski lift, sits just steps from your back door, providing quick access to Tampa Bay’s world-class fishing and waterfront dining—reaching the bay in just 15 minutes. The main living areas feature a wall of water facing windows, durable tile flooring, open concept great room, high ceilings, updated interior paint and custom wall designs. A large flexible space at the front of the home can serve as a formal dining room, media room, or private office. The spacious primary suite offers a dedicated flex area that can be used as an office overlooking the lagoon, a workout space, or a morning reading nook. The suite also includes a large walk-in closet and an ensuite bath with dual sinks and a garden-style soaking tub. The two additional bedrooms are generously sized, each with their own private, professionally remodeled baths completed in 2024, offering privacy and comfort with a true split floor plan. The fully updated kitchen is the heart of the home, featuring leathered quartz countertops and backsplash, a newer stainless steel appliances including fridge, gas cooktop, double ovens, a custom vent hood, a new sink with a touchless faucet, and prewired under-cabinet lighting. Additional updates include a newer roof (2019) with a 25-year warranty, water heater (2022), a 5-ton HVAC system with a UV light filter (2022), a new water softener, and a new irrigation control station. For added peace of mind, the home also includes a 15,000-watt whole-home generator. This exceptional home is located in Mirabay, a highly sought-after waterfront community known for its resort-style amenities. Residents enjoy access to a 24-hour fitness center, heated pools, tennis and pickleball courts, and miles of scenic walking trails. The community offers a private boat launch, several parks, and a vibrant social calendar filled with activities for all ages. Mirabay’s waterfront lifestyle offers endless opportunities for kayaking, paddleboarding, and connecting with neighbors in this golf cart-friendly neighborhood. This home offers the ideal blend of comfort, functionality, and the sought-after Mirabay lifestyle. 3 full bath For more information, please contact: Shawna Calvert Align Right Realty [email protected] You can also text 172016 to 46835 Search All Listings: https://ift.tt/35imtnv AGENT SOCIAL ——————– Website: https://ift.tt/Ccr8LtX Showcase: https://ift.tt/w58AaMN Facebook: https://ift.tt/ldP50tx Instagram: https://ift.tt/mZW2ksv Twitter: https://twitter.com/ShawnaCalvert LinkedIn: https://ift.tt/tH5AqON Pinterest: https://ift.tt/OMSaNUu YouTube: https://www.youtube.com/@Shawnainparadise COMPANY SOCIAL ——————– Website: https://ift.tt/65GJMg1 Facebook: https://ift.tt/ZKA7d3Y Twitter: https://twitter.com/alignrightrealt?lang=en LinkedIn: https://ift.tt/l8VthJ0 YouTube: https://www.youtube.com/channel/UCJgtjS8PQiLXLMC3yIDqSnw via Shawna Calvert Realtor Align Right Realty https://www.youtube.com/channel/UCidsEJ85xGsZJnZiWvhpqXA April 09, 2025 at 11:52PM via Shawna Calvert Realtor Align Right Realty https://ift.tt/cRx0HlA April 10, 2025 at 01:41AM

#IFTTT #Shawna Calvert Realtor Align Right Realty

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shawnacalvertrealtor · 2 months ago

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youtube

5205 BRIGHTON SHORE DRIVE Listing Site: https://ift.tt/o3P7BS9 Property Site: https://ift.tt/u9Qy2kh 5205 BRIGHTON SHORE DRIVE APOLLO BEACH, FL 33572 $949,000, 3 bed, 3.00 bath, 2,488 SF, MLS# TB8360624 Welcome to 5205 Brighton Shore Drive in Apollo Beach. This beautifully renovated 2,488 sq ft, 3-bedroom, 3-bathroom custom home, built by David Weekley, offers high-end finishes and an ideal open-concept floor plan for waterfront living. The inviting layout and abundant natural light draw your attention to breathtaking views of the Mirabay Lagoon. Situated on an oversized pie-shaped lot with over 156 feet of waterfront along a deep expanse of the lagoon, there’s ample room to create your dream backyard oasis. Your private boat dock, equipped with a 16,000 lb boat lift AND a jet ski lift, sits just steps from your back door, providing quick access to Tampa Bay’s world-class fishing and waterfront dining—reaching the bay in just 15 minutes. The main living areas feature a wall of water facing windows, durable tile flooring, open concept great room, high ceilings, updated interior paint and custom wall designs. A large flexible space at the front of the home can serve as a formal dining room, media room, or private office. The spacious primary suite offers a dedicated flex area that can be used as an office overlooking the lagoon, a workout space, or a morning reading nook. The suite also includes a large walk-in closet and an ensuite bath with dual sinks and a garden-style soaking tub. The two additional bedrooms are generously sized, each with their own private, professionally remodeled baths completed in 2024, offering privacy and comfort with a true split floor plan. The fully updated kitchen is the heart of the home, featuring leathered quartz countertops and backsplash, a newer stainless steel appliances including fridge, gas cooktop, double ovens, a custom vent hood, a new sink with a touchless faucet, and prewired under-cabinet lighting. Additional updates include a newer roof (2019) with a 25-year warranty, water heater (2022), a 5-ton HVAC system with a UV light filter (2022), a new water softener, and a new irrigation control station. For added peace of mind, the home also includes a 15,000-watt whole-home generator. This exceptional home is located in Mirabay, a highly sought-after waterfront community known for its resort-style amenities. Residents enjoy access to a 24-hour fitness center, heated pools, tennis and pickleball courts, and miles of scenic walking trails. The community offers a private boat launch, several parks, and a vibrant social calendar filled with activities for all ages. Mirabay’s waterfront lifestyle offers endless opportunities for kayaking, paddleboarding, and connecting with neighbors in this golf cart-friendly neighborhood. This home offers the ideal blend of comfort, functionality, and the sought-after Mirabay lifestyle. 3 full bath For more information, please contact: Shawna Calvert Align Right Realty [email protected] You can also text 172016 to 46835 Search All Listings: https://ift.tt/35imtnv AGENT SOCIAL -------------------- Website: https://ift.tt/Ccr8LtX Showcase: https://ift.tt/w58AaMN Facebook: https://ift.tt/ldP50tx Instagram: https://ift.tt/mZW2ksv Twitter: https://twitter.com/ShawnaCalvert LinkedIn: https://ift.tt/tH5AqON Pinterest: https://ift.tt/OMSaNUu YouTube: https://www.youtube.com/@Shawnainparadise COMPANY SOCIAL -------------------- Website: https://ift.tt/65GJMg1 Facebook: https://ift.tt/ZKA7d3Y Twitter: https://twitter.com/alignrightrealt?lang=en LinkedIn: https://ift.tt/l8VthJ0 YouTube: https://www.youtube.com/channel/UCJgtjS8PQiLXLMC3yIDqSnw via Shawna Calvert Realtor Align Right Realty https://www.youtube.com/channel/UCidsEJ85xGsZJnZiWvhpqXA April 09, 2025 at 11:52PM

#luxuryrealestate #luxurylifestyle #customhomes #dreamhomes #waterfrontproperty #realestateflorida #paradisehomes #apollobeach #renovatedhomes #Youtube

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cosmicgrapevine · 3 years ago

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A Brief Guide to Demonology

One of the stereotypes of amateur sf/f writers is that they can fill a whole encyclopedia’s worth of information about races, magic systems, political factions, and the like, but get stopped cold when it comes time to write the actual story. Ergo, in the interests of this not happening to me I am trying to focus on function over form, and only expand the lore as much as I need to. (Breaking out of the whole “I love writing except for the writing part” mindset is crucial in general, but that’s a different discussion.) That said, gone are the days when you could just make up this stuff as you went, so:

The term ‘Demon’ itself is a bit ambiguous, and I’m not sure at this point where its outer boundaries are. If American English had a term closer to youkai or sidhe, I would use that instead. Nor are they quite Abrahamic in origin; they’re corporeal, possession works more like parasite-induced metamorphosis, and it is usually permanent. I feel they are close enough for the term to make sense. They can take over people (but can also be exorcised) they’re mostly evil, but they’re diverse enough for a more broad term to make sense.

The weakest form of demon is the Imp. In their natural form, these guys are tiny, slimy, pathetic little things (think Envy’s caterpillar-like form from FMA) who are nonetheless basically living petroleum jelly and very hard to kill or exterminate for good. While they can technically force themselves to stay in a sapient host, it’s much easier for both if the host agrees to be possessed; that said, ‘agrees’ is interpreted very loosely among imp-kind.

They search for willing hosts by sensing negative emotions in a potential host that they can worm their way in by exploiting or manipulating. At this point, either the host recognizes what is happening and forces the imp out, or they sink further into whatever emotions or memories the imp is messing with, and the possession continues apace.

For any non-sapient host, the ceiling for the Imp is becoming a Half Demon. Basically, a non-sapient mind can only house an imp for so long, and as the clock ticks down, the host begins to mutate unpredictably. Eventually it will die, and if the imp hasn’t escaped, it will die as well. Something like a pig, ape, or bear might last a month; most invertebrates would die within 24 hours. When imps engage in organized warfare (not often, up until my plot starts) they use such beings as the equivalent of suicide bombers or kamikaze flyers.

In human territory Imps often try to make animal hosts ‘more humanlike’, both biologically and psychologically, but don’t understand humanity very well and more often create shambling half-sapient abominations. Half Demons also can occur when an imp is not compatible with a host, or the host tries to force it out but the imp tries to cling on inside, or any number of other complications.

If it goes well, you end up with what is called a Full, Pure, or True Demon; a demon that has fully synthesized with its sentient host and can only be expelled by an exorcist. With the intelligence and strength of a human and the resourcefulness and malice of an imp, these make for terrifying foes, especially the ones who have found juuust the right host to bond with (yes, there’s a bit of Venom going on here). They augment their host’s body, making them stronger, tougher, and faster than before. Furthermore, they can pass as human easily, only occasionally needing to cough up a little black ooze in private. True Demons will burn out eventually too, but it can take years.

True Demons who have ascended to great power, held the same host for 10+ years, and/or command other demons are known as Master-Demons, but this is a social distinction, not a scientific one.

Some other notes:

-Individual imps don’t really have a ‘self’, and basically take on the identity of their host.

-As you can surmise, the ‘magic’ here is very biological in origin and aesthetic; this is deliberate, and is meant to contrast sharply with the more mystical, fae-inspired paranormal characters that will show up later.

-The King of Demons, insomuch as there is one, is a Master-Demon named George E. Scutari, who has formed an allegiance with the aforementioned fae, and is combining fae and demon magic, at scale, to terrifying effect. He is the ultimate pursuer of Lind in the early chapters, for a magical artifact he thinks Lind holds. I may soon do a Major Antagonists page in which he will be described in more detail.

#writing #lore #worldbuilding #demons #demonology

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summerrplays · 6 years ago

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RVSN x SP Living Room Set

I recently had the opportunity to design a living room set with a very talented and wonderful custom content creator @ravasheencc.

Since her Couldn’t Chair Less Sectional Set was the reason we started talking, it was only natural we build the new set around those amazing couches.

We came up with a beautiful, modern and clean living room that any Sim would enjoy. I was responsible for the design elements of the set, while my dear friend Ravasheen did all the hard work by creating all these wonderful meshes. The set follows her chic maxis match plus style and looks beautiful ingame. We covered floors to ceiling and everything in between!

The main focus of the set is the amazing modular couch that snaps together seamlessly in many combinations. It can be a sectional, a sofa, a loveseat or a chaise sofa. It is fully functional and your Sims can lay down and sit on it. There are 6 swatches with matching decor pillows, a chaise, and an armchair.

Completing the set are two sets of built-in shelves, one with drawers and one without. A chevron top coffee table and a fireplace that connects seamlessly with the shelves for a variety of combinations, complete the set. And since I LOVE clutter we added some essential clutter as well.

Make sure to watch the reveal video below, every item and every swatch is shown, as well as some finished living rooms to serve as an inspiration what you could do with the set.

Set includes (24 items in 6 swatches):

Modular couch

Chaise

Armchair

Built-in Shelves

Built-in shelves with drawers

Built-in Fireplace

Coffee Table

Large area rug

Medium area rug

Pillows

Picture Frame

Decor Tray

Decor Vase

Flower Bouquet

Candle

Standing Books

Stacked Books

Decor Basket

Wallpaper

DOWNLOAD HERE (SFS)

Please tag @summerrplays and @ravasheencc if you use it! We would LOVE to see what you come up with.

Watch the full reveal video ❤

youtube

#sims #thesims #sims4 #thesims 4 #sims 4 custom content #ts4 #ts4 maxis cc #maxis match #ravasheencc #summerrplays #ts4 maxis match

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writingcuredmyfrown · 5 years ago

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U-topia

The year is 3201, the world has gone through an array of changes - many old things are now long forgotten, branded useless and unnecessary in this new world. The new things that have emerged are countless: people no longer need to go school, it goes to them through the world wide web, to which everyone is connected. Vehicles are no longer needed, transportation happens through limbic teleportation, which is possible because there is a genetic copy of each and every person, stored in a cryo tank, ready for the process of teleportation. The only vehicles that operate are those for transporting goods, but even they are rarely seen as they function primarily underground. There are no diseases, no major illnesses, little to no health complications when one reaches old age. It’s impossible to be unemployed, you can live anywhere in the world, social and racial injustice is gone forever. The world has become a giant megalopolis, governed by the flawless mathematics of technology, in a way that makes its citizens as happy as they could be. We call this world Utopia One. More planets are yet to be colonized.

Almost every living human right now is happy with the way things are. They nod in agreement with everything we ask them, they don’t ask questions, they don’t give long answers, they just nod and agree. And then they go off to work, knowing that there’s no better place to be alive, and there probably will never be. Not even on Earth, but possibly in the entire Universe, which is now fully explored and mapped out. Life, however, was not found.

For me, SC-SF-01899, an ordinary surveillance camera in the city’s subway network, life is more than perfect. My creators have given me the ability to behave and think just like them, the only downside being that I’m trapped inside a microchip. Doesn’t that sound interesting? A human inside a microchip? I’ve philoosophised over this multiple times, and found that there’s no use. I’m here to do the job, just like every other machine around me.

A few days ago something bizarre happened to me, something which I couldn’t really explain. It felt like something I wasn’t in control of, which shouldn’t really happen, because I’m a flawless machine with no errors ever recorded. And yes, I do have a digital diary, I write down things, I wander around the world through the web, I think about things, all while working 24/7 to ensure the safety of all.

I will share with you my log for that day. I’m still a bit shaken, because I feel something deep inside me that isn’t really a part of me. I could never...I could...why? Why did I do it?

Date: 24.04.3201. Time: 14:56. Man enters tunnel fourteen. All signs visible. Male, 32, works as a programmer for June Digital & Co. No anomalies. Clear.

Date: 24.04.3201. Time: 14:57. Man enters tunnel fourteen. All signs visible. Male, 18, studies engineering at Maplewood University. No anomalies. Clear.

Date: 24.04.3201. Time: 14:58. Woman enters tunnel fourteen. All signs visible. Female, 45, works as a sex worker. No anomalies. Clear.

Date: 24.04.3201. Time: 15:00. Two men enter tunnel fourteen. All signs visible. Males, 33 and 31, chefs at the La’Noe restaurant. No anomalies. Peculiar symbols: holding hands. Checking laws...requesting access to government files...Clear.

Date: 24.04.3201. Time: 15:03. Woman enters tunnel fourteen. All signs visible. Female, 23, works as a gardener at Larry’s. Anomaly detected: Facial feature - smile. Checking laws...requesting access to government files...processing judicial trial...preparing to administer punishment...sentencing subject to death...activating emergency photon cannon...firing. Subject neutralized. Calling an ambulance...calling a mortician...suspending the entrance to tunnel fourteen...Clear.

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thejakeformerlyknownasprince · 6 years ago

Note

For each of the Animoprhs, which book would you consider the best for showing their characterization? Best book for understanding Jake's character, best for Rachel, etc.

If I can give a very me answer (i.e. verbose and bad at choosing things), I’m not sure there are any books that don’t advance the character arc of the narrator in a meaningful way. Going down the list:

Jake: Starts the series as a somewhat naïve, privileged kid who wants to save his big brother but isn’t sure why he’s in charge. Ends the series as a highly competent but also ruthless general who defeats the Yeerk Empire at the expense of his big brother.

#1: Establishes his antebellum family life, and his casual certainty that everything’s going to work out once the andalites come to help.

#6: Forces Jake to confront the simultaneous realities of the controllers’ helplessness in the face of trauma and the dangerous realities of their bodies becoming weapons, cementing his convictions about the war.

#11: Features Jake’s first real crisis as a leader and forms much of the basis for his incessant rumination on alternative outcomes.

#16: Establishes Jake’s biggest Achilles heel as a leader: that he consistently fails to secure his own oxygen mask before helping others. The plot also punishes indecisiveness and rewards recklessness.

#21: Causes Jake to have to define his role as a leader in response to David presenting the first real challenge to Jake’s authority.

#26: Gives Jake the chance to be his most awesome and competent as a leader, from managing Ax’s emotions and skillfully deploying Rachel and Erek to the Gordian-knot-cutting gambit that makes Crayak himself sit up and take notice.

#31: Confronts Jake with the slow-burning crisis he’s been struggling to ignore within his own family, causing him to (largely unsuccessfully) deal with the threat presented by Tom’s continued existence.

#36: Gives us some heartwarming moments of Jake expressing his love for his team while throwing himself between them and danger.

#41: Features Jake grappling with the realization that he can’t — and shouldn’t — save his own loved ones at the expense of someone else’s.

#47: Largely inconsequential, but does involve the only instance of Jake leading an army against invading forces in a “traditional” battle.

#53: In which Jake applies everything he’s learned to take over the U.S. Air Force, recruit the taxxons, manipulate multiple yeerk vissers, and strategically use all his allies in ways that are effective but brutal. Also, he FINALLY does something about Tom — and it comes at the expense of Rachel’s life.

Tobias: Starts the series as a dreamy-eyed idealist with no clear-cut identity who eagerly commits himself to the first cause that comes along. Ends the series as a pragmatic survivalist who values self-sufficiency but also his connections to his hawk and human and andalite and hork-bajir sides.

#3: Acts as the comedown of Tobias’s idealism following his somewhat-impulsive, somewhat-forced decision, as the reality of predation and nothlitization sinks in.

#13: Establishes Tobias as the kind of guy who (literally) looks higher powers in the eye and calls “bull,” but also the eyes in the sky for the team.

#23: Further complexifies Tobias’s already-complex species identity, but also gives him the chacne to be badass and self-reliant in a world that used to stuff his head in toilet bowls.

#33: Puts Tobias through the kind of pressure test that allows him to realize what’s really important to him, from his andalite family to his love for Rachel.

#43: Gives power back to Tobias through showing him — both in flashbacks and in the present conflict with Taylor — embracing the power not to decide (X).

#49: Leads Tobias to the realization that he may never have a nuclear family like Jake’s or Cassie’s, but that his crappy upbringing imbued him with a level of resiliency that Jake frankly lacks.

Ax: Starts the series as a kid who knows exactly who he is (a proud aristh in The Greatest Military in the galaxy) and where he’s from (andalite culture) and just wants to get home. Ends the series identified as “Aximili of Earth,” with a relentless wanderlust and a reputation for undercutting traditional andalite power structures.

#8: Establishes Ax as a lonely kid under enormous pressure to conform to two different cultures in two different ways, and sets him on the path to balancing those conflicting demands.

#18: Probably the apex of Ax’s embracing andaliteness at the expense of humanity, forcing him to realize that people are people and there’s no rank-ordering entire groups.

#28: Confronts Ax with the nastiest sides of humanity — animal testing and factory farming — to cast him as a witness to whom his human friends must justify themselves.

#38: Allows Ax to measure himself and his team against the andalites’ standards for competency and morality alike, and to find it is the andalites who are wanting.

#46: Probably the nadir of Ax’s embracing andaliteness, with all his prior experience culminating in deep longing to be human in light of the Air Force’s unflinching nobility and the craven imperialism of the Andalite Electorate.

#52: Culminates the conflict between Ax’s cultures through leading him to conclude that his friends specifically and humans as a whole don’t have to be perfect to have fundamental rights and dignity.

Cassie: Starts the war deeply uncomfortable with major decisions but nevertheless convinced that there’s a single “right” answer to every situation, largely only involved at all for love of her friends. Ends the war as a “one woman army” (emphasis on one) with a nuanced morality system and a willingness to go her own way rather than setting herself on fire to keep others warm.

#4: Forces her out of her comfort zone and into making decisions for the entire team, causing her to discover that she’s braver and stronger than she ever realized.

#9: Crystalizes Cassie’s willingness to embrace and protect the Earth in spite of fully recognizing its inherent brutality.

#14: Undeniably inane, but gets some great humor out of Cassie being a sweet straightforward kid and a terrible liar.

#19: Establishes Cassie’s Achilles heel: that she functions brilliantly with no one to watch out for but herself, but doesn’t play well with others. Also knocks her off her high horse through forcing her to realize that many enemy soldiers are just as clueless as she is.

#24: Acts as a check-in after the events of the David trilogy, showing just how jaded the kids have become that Cassie and Marco find violent alien abduction to be little more than a minor annoyance.

#29: Plays to Cassie’s strengths — working alone, developing her unusual allies, taking care of her friends, remaining focused under fire — to show her at her most awesome and draw out her competencies.

#34: Gives Cassie a glimpse of what it means to be a compassionate but still powerful leader.

#39: Sets up the end of the series through using the wolf morph to show Cassie’s ability to keep running and changing and being many things at once (both figuratively and literally) after all her friends have fallen behind.

#44: Foreshadows Cassie’s breakup with Jake through contrasting her ability to get by alone in Australia with his “zombielike” state of lost dependence while she’s gone.

#50: Drives a wedge between Cassie and her team, with the consolation prize that she makes a compassionate and discerning move which ultimately sets the Animorphs up to win the war.

Rachel: Starts the series as a restless “mall rat” who enjoys risk and challenge for their own sake, and has casually absolute faith in her own abilities. Ends the series by telling the reader outright that she’s scared, but that she must do what’s right for her team; uses her last minutes to apologize to Tom for killing him and to seek reassurance from the Ellimist that she made a difference.

#2: Establishes that she’s cocky and fun-loving even after being confronted with the realities of war, but also that she’ll gladly die for love of her friends, from Tobias to Melissa.

#7: Brings out Rachel’s truly reckless side through backing her into a corner — which is when she’s most dangerous. Also serves as maybe the biggest blow the Animorphs ever inflict on the yeerks with minimal loss of life, crystalizing Rachel’s sense of self-righteousness.

#12: Shows the struggle hidden under her role as “the strong one,” both for her team and for her sisters.

#17: Involves Rachel interrogating how her friends see her, including her awareness that this team would never be able to talk itself into continuously reentering the hell of war without her.

#22: Confronts Rachel with the darkest depths of her own brutality, but also establishes that she’s willing to be the one to do the hard jobs of the war if it keeps the others from having to listen to David’s pleas for help.

#27: Fully cements Rachel’s relationship with Tobias through allowing her to realize what’s really important to her.

#32: Uses one of those awesome SF identity premises to give Rachel the chance to literally argue with herself, and — by showing how much each of her halves relies on the other — shows how all the facets of her identity, ugly and pretty alike, make her who she is.

#37: Contains a couple different truly awesome moments with Rachel realizing that her strengths are not Jake’s, nor are they Marco’s, but that the team will carry her through at the end of the day.

#42: A little silly, but gives Rachel the chance to out-bluster even helmacrons and to force the hard decision that Jake hesitates to make — that they need to sacrifice Marco to save their own lives.

#48: Frustratingly inconsequential, but brings together the disparate threads of her conflict with Crayak, her conflict with David, and her conflict with Jake, and culminates with Rachel confronting Cassie with the reality that if Rachel herself doesn’t do the awful things (kill David, kill Tom) then no one else will.

Marco: Starts the war as a never-serious kid who is nevertheless familiar enough with the reality of death to try and hit the brakes before inevitable tragedy gets too close to his loved ones. Ends the war as a ruthlessly machiavellian strategist who believes in the necessity of matricide and even war crimes to keep the planet spinning on its axis.

#5: Contains the hilarity of Ax-wrangling and the utter horror of Marco realizing that Visser One thoughtlessly destroyed the lives of his entire family as an incidental aside on her rise to power, establishing early that he’s willing to burn down the world to protect his family.

#10: Gives Marco the chance to call bullshit on the chee’s moralizing about their own nonintervention in the face of massive injustice, delineating his own code of ethics.

#15: Forces Marco to confront his own trauma and becomes the first time that he must make a major ethical choice with no good solutions — and, by no coincidence, is all about him turning into a shark.

#20: Brings out the worst in Marco through emphasizing his mistrust (and lack of compassion) for strangers, his possessiveness of his friends, and his willingness to be a bully when David fails to see the big picture.

#25: Becomes the book where Marco calls himself “Mr. Ruthless” and also sees himself in a motherless pair of baby seals, where he expresses admiration for Jake’s growing manipulativeness and successfully distracts everyone from waiting around for their own deaths with really bad “dumb blond” jokes.

#30: Involves Marco giving an account of himself (as Cates would say) through justifying his decision to the reader as he plans his mom’s execution.

#35: Acts as some much-needed comic relief because of Marco’s refusal to take himself seriously, while continuing arc of his coming apart at the seams when he can’t define himself by his family.

#40: Has a deeply troubling after-school special vibe that culminates in Marco discovering that *gasp* disabled people are people too, and... Sorry, I can’t come up with anything nice to say about this book.

#45: Shows that (unlike Jake) Marco can find the balance between protecting his family and protecting the planet, and also that Marco’s brilliance has a very very dark side when it comes to manipulating Peter.

#51: Again acts as much-needed comic relief during one of the bleakest points in the war, while also showing that Marco may have overcome his intial mutual hostility with Tobias but that he’s also whistling as the world burns at a time when Jake and Rachel could both really use fewer jokes and more emotional support.

Anon, I promise I will do my best to narrow this list down, but your ask sent me off into rapturous enumerations about the tightly-woven character arcs in this series and the fact that even the ghostwritten books are remarkably consistent in light of the big picture for each of the six kids.

#animorphs #animorphs meta #animorphs spoilers #long post #asks #jake berenson #tobias fangor #rachel berenson #aximili esgarrouth isthill #i am bad at choosing things #Anonymous

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madamlaydebug · 6 years ago

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PAY ATTENTION 👑

TREE OF LIFE: Kemet Vs. Kabbalah

"Rooted in the ancient Egyptian Mysteries, three different versions of essentially the same teachings of KMT can be identified by three different spellings: Kabbalah, Cabala and Qabalah. ...their origins? Africa.

The Tree of Life is a Cosmo gram which graphically depicts the order of the universe. It is a graphic compliment of the cosmology of the universe. The Tree is also a guide for creating any event and a guide for thinking and understanding the myriad things in the universe which illustrates the manner in which they all interrelate. The Tree highlights the steps a prospective initiate must take and the experiences she must undergo in order to achieve the apex of enlightenment.

African Cosmology

theafrican.com/Magazine/Cosmo.htm

tree of life pics

www.tehutionline.com/newpage28.htm

click on tree pics

aasorlando.org/

TREE OF LIFE

The greatest error that can be made at this point is to interpret this diagram as an arbitrarily created conceptual or theoretical explanation of the ordering system underlying physical reality. It represents the nine emanations [note: spheres 0 and 10 represent different realities outside of the nine emanations discussed here --editor] that are the shaping factors of all physical structures and events. They underlie, direct, and integrate all physical realities, from the subtlest sub-electronic forces, to the complex galaxies, to the organ systems making up the physical body of Man.... from the most primitive instinct of a slime mold to the most divine manifestation of the spirit of Man. They are what the Kamitians call the Neteru; Yorubas call the Orishas, and Westerners have translated as dieties, Archangels, angels, etc.

It is very important to understand, that contrary to popular opinion, cosmology does not attempt to explain how physical things, on the atomic and molecular levels, come into being. It concentrates on the coming into being of the metaphysical factors that will function as the vehicles through which the physical things will come into existence, as well as the means of regulating their structural and functional components, hence external behavior. In other words, a cosmogony deals with the "generation" (from "gonus") of a “system”. Properly understood, the terms "System" and "Cosmos" are synonymous; an assemblage, or combination of things or parts, working in unity, as a whole, cooperating to carry out the same function, to achieve the same goal, etc.

It was said that the emanations, one to nine, are parts of a “system” through which Subjective Being, represented by zero (the absence of things, but not of Being) creates and administrates physical reality; “10”. These nine “DEITIES” – the PAUT NETERU – compose the “organs systems” making up the spiritual bodies of all physical things. They link them with their source of being and subsistence, and direct their functions. African religion, better comprehended as a Way of Life, is based on the understanding of the functioning of these nine metaphysical vessels of creation and administration. As they are shaping and governing functions, their activities carry the force of law.

For example, you wouldn’t attempt to feed on hay because the functions that govern your digestive mechanism can't digest it. It is in this manner that the attributes of the Deities (Neteru, Orishas, etc.) represent the laws governing our lives on Earth. Observance of these laws allows them to fully bring forth their powers through our being. According to our chronological age, state of health, and level of spiritual development, the manifestation of these “powers” will range from our basest urges, to the commonly evolved “mental abilities”, to the psychical abilities held by a few, to the attainment of divine perfection, i.e., Man-Godhood on Earth.

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Re: TREE OF LIFE: Kemet Vs. Kabbalah Fri, February 23, 2007 - 8:23 AM

AMEN

Amen means “concealed”. It is the Kamitic counterpart of the term “Subjective” as we have used it in this book. It corresponds to the essential nature of the Supreme Being, which is the same as the essence of Man’s being. It is our unmanifested, unmanifestable, unconditioned Self – That which is the ultimate source of life and consciousness. It is the unseen and unseeable that looks out into the Objective Realm of spirits, thoughts, feelings, and physical phenomena. We must return our focus of consciousness back to it by the cessation of all thought activity. Once we have established this innermost point as our place of being – i.e., living beyond emotional influences – we will attain to the state of Hetep. This is a state in which we are able to fully ignore all emotions that may rise into our awareness, and thus attain to a peace that cannot be disturbed by any challenge in life. In the Hindu tradition it is called Parabrahm Sarvikalpa Nirvana. This state of inner peace is the prime foundation for the functioning of the healing functions of the life-force (Ra), and is the source of all spiritual power.

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Re: TREE OF LIFE: Kemet Vs. Kabbalah Fri, February 23, 2007 - 8:24 AM

AUSAR

The most important accomplishment in your life, which you must pursue with the utmost urgency, is the experiencing of that part of your being that directs and coordinates the activities of the billions of cells that make up your physical body, and directs the activities of your spirit and subconscious. This indwelling intelligence that is obviously in possession of the knowledge of the workings of the universe, is God's consciousness itself. This is Ausar, your true Self. Your true, entire, only, and ultimate purpose for being on earth is the resurrection of this indwelling intelligence, that it may guide your endeavors in life with the same omniscience that it uses to guide your physiological and subconscious mental activities. Identification with, and living by the guidance of this indwelling intelligence is the true worship of God. It is the true process of religion.

As omnipresence is an attribute of this indwelling intelligence, its resurrection, i.e., the extension of its function from the subconscious to the conscious sphere of Man's life, or the doing of that Glory on earth that is done in heaven, if you prefer, is the only way to bring about the unity that is the prerequisite for peace on earth and prosperity for all. Viewed from another perspective, omnipresence means that there can only be one Being dwelling in and as all creatures. This is the basis of unity in the world. Most important, we must understand that this is the real meaning of monotheism, which does not denote a one God, but the Unitarian reality that is the life of all creatures, and the source of all the metaphysical intelligences through which the activities of the world are administered. Understand this and you will know that in killing others, you are destroying a vessel through which God expresses Itself.

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Re: TREE OF LIFE: Kemet Vs. Kabbalah Fri, February 23, 2007 - 8:25 AM

TEHUTI

TREE OF LIFE MEDITATION SYSTEM (TOLM),

Avoiding and resolving conflicts is one of the chief functions of Tehuti, the faculty of wisdom. It is the total antithesis of the intellect. While the latter derives its information from Man's worldly experiences, the wisdom faculty gets its knowledge from God dwelling in Man's spirit. In other words, for wisdom to manifest itself, we must shut down our intellectual and imaginative thought processes, in order to receive the intuition from God, dwelling within. In this state where there are no thoughts, consciousness enters into the same state of Hetep (Nirvana) as described by the ogdoad. There are, therefore, no thoughts as in the syllogistic logical process that we can follow. All that can be given are instructions leading to the shutting down of the thought processes making the mind blank, Satori which is the requirement for the functioning of the wisdom faculty.

Since this faculty is not really of Man, but belongs to God dwelling in one's spirit, the procedure can be explained as the stilling of the thought processes of the intellect and the imagination, in order to receive instructions from God. It is of interest to note that the 'Hu' in Tehuti is the mantra (word of power) of the wisdom goddess Chinnamasta of Black India (Indus Kush), and of the Guru (wisdom) chakra. It operates by suppressing the formation of thought processes by cutting the mind off from the senses.

This ties in with Kamitic spiritual science. 'Hu' is metaphorized as Ptah's tongue which utters the word of power that initiates the process of creation. It is also the 'deity' of the senses, in which capacity it plays the same role as the mantra Hu(ng) of the Guru chakra. In other words, to shut the mind down, it must be cut off from its ports (the senses) to the outside world. This is of course, a brief account of the process. The most important point to understand is that ultimately, the most important part of the deity's name is 'Hu,' understood not as a word with meaning, but as the word of power which leads to the manifestation of wisdom in the initiate.

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Re: TREE OF LIFE: Kemet Vs. Kabbalah Fri, February 23, 2007 - 8:27 AM

SEKER

Seker (the 3rd sphere of the Tree of Life) is the divine faculty that is in charge of the life-force (Ra), which is the formative base of all things in the world. Although the source of life is infinite, each entity is allowed to share in its infinity through a series of cycles of births. Each entity is thus allotted a finite portion of this life-force at a time, for its adventure in the world. This recycling principle governs the cycles of birth, growth, decay, death, rebirth and so on. The life-force behaves in this manner in conformity with the divine intention of guiding man to the realization of his divinity. Would most people bother to develop themselves, and exert themselves if they were to be born with full functionality (as many reptiles and lower creatures are), external youth and indestructibility? We are thus spurred on to exert ourselves in our youth to provide for the days that will surely come when we will be incapable of doing so, and of course by the ultimate, which is death.

The subjection of the existence of all things to cyclical revolutions, which is governed by the “deity” (divine faculty) Khepere, divides their life term into two fundamental phases. Birth (rebirth)/growth, and decay/death (rebirth into the plane of origin!). Thus we achieve an infinitude of experiences through an infinite chain of finite existences.

The phase of birth (rebirth) is under the dominion of Khepere (Aima, the fertile mother in the Canaanite tradition), while the phase of decay and death is symbolized by the Hennu or Af (dead flesh) boat in which travels the “aged Ra” (Ama, the dreaded sterile mother, and Kali).

Khepere or Aima brings all things into manifestation through the 50 sound units of power residing in the 3rd sphere. These sound units, which are the basis of all hekau, are metaphorized as the eggs of the beetle symbolizing Khepere, the 50 gates of Binah, the 50 skulls strung as the necklace of Kali (the Indus Kush Seker), the 50 oarsmen propelling the boat of Ausar, and they are analogous to the 500,000 or so eggs that every woman is born with. At this level, these spiritual powers do not manifest the things of which they are the germs, but the underlying structure (divine plan) that provides the order governing the harmonious interaction of the forces shaping the formation of things, and their interaction. These structures appoint the places in space and time ordering all manifestations. Incidentally, because it’s creative function corresponds to the female gender, which the Canaanite tradition supports (the Goddess Aima), this deity often appears (possesses) in its female form when invoked. As such, her name is Sekert.

The male side of the Deity rules over the death process. Seker was the Deity of the necropolis at Sakkara. Allied to it in this function was the “monster” Aum-mit or Aummaum, whose functions was to destroy the Ab (part of the spirit housing the conscience and will) of the deceased who failed to live in harmony with the laws of Maat (divine laws). During life, its activities are felt as the pangs of conscience, guilt, self recriminations, etc. These are warnings that we are on the path to a failed destiny.

This is to be expected as Seker governs our destiny. The Kamitic term for “destiny” is Skher”, and for “plan” is Sekher”, which are clearly etymologically related to “Seker”. No two things can occupy the same place at the same time. Divine law, therefore, guarantees all things their day in the sun. Our coming into being, and the unfolding of all events in our life are controlled by the spiritual forces (Ptah) at the Seker level for the sake of maintaining order in the world. Destiny, therefore, is nothing more nor less than the expression of the structure, the plan that governs the unfolding of people’s lives in order to guarantee them success. It is amazing to see how people are aware of the confusion and disorder that follow from the lack of planning and structure yet fail to realize that the same would happen in nature and in the world, if the Supreme Being had not laid a plan to guide the lives of men and nations. As above, So below!

When we die or transcend the way of life in which earthly pleasure and personal interests are the motivating factors of our actions and undertakings, we come under the governorship of the Deity Seker. In either case, we have died to the earth-physically or spiritually. The doctrines of Seker, represent then, the teachings that kill. We must remember that this does not mean a joyless life. Quite the contrary, it is one, as we will later see, that leads to greater ecstasy. When we keep in mind that the spirit is essentially unconditioned, it will be realized that our spirit is ever receptive to be reprogrammed to express joy and pleasure in response to any situation or stimulus. We can therefore transcend a way of life in which our will is lead by what gives us pleasure, and change over to a way in which pleasure follows our will to live new truths.

Allied with the idea of dying to the things of the world is the host of symbols used to explain the domain of the Deity. In the “Book of that Which is in the Underworld”, the Fourth Hour which represents the domain of Seker is described as a region in which there are no cultivation fields to be distributed to the faithful followers of Ra. It is full of thick darkness, its floor is covered with sand, and it is lacking in water (hence, barren). This region is called Ta (land ‘of’) Sekri. Note that “kri” in the name conceals the heka—Kring—of the Deity.

The truths that we must live at this sphere of the Tree of Life corresponds to the cycles governing natural phenomena. These were discussed in previous chapters. The point to note here is that the times for eating, exercising, having sex, performing certain types of work, meditating must not be dictated by our feelings, cravings, social or economic factors, but by the cyclical mechanisms governing nature.

The discipline of adhering to the cycles governing life that this sphere imposes upon us is for the sake of enabling us to succeed in the use of words of power, as their manifestations are ordered by the law of cycles in order to keep them from conflicting with each other. All hekau (plural of heka) are based on 50 single sounds units which are symbolized in the Phoenicial Kabalistical system as the 50 gates of Binah, or the Goddess Ama through which all things in the world come into being, and are recycled. In India she appears a Kundala or Kali, the Great Mother who wears the necklace of 50 skulls. As mistress of the words of power, and mother of all living things, she is depicted traveling in the boat of the star Sepdt (Sirius), which is propelled by 50 oarsmen. These sound units are distributed throughout the 14 chakras making up man’s subtle body. As this sphere corresponds to the highest manifestation of man’s spiritual power, it is the dwelling place of the power aspect of his spirit. In the Kamitic tradition it is the Shekem (Sahidic Coptic “Shkum”); in the Kabalistical, the Shekinah; in the Indus tradition, the Shakti.

Men who wielded this power were given the title of “Shekem”. In fact, this is the true title for the Kamitic king of kings. The term found its way into the Arabic where we find that the great royal leaders are called Sheik. In India the kundalini yogis are called shakta, and their counterpart further up north are called shamans. It is important to note that all of these cognate terms all begin with the letter “Sh”. Egyptologists commonly render the term as “Sekem”, even though many words written with the hieroglyph for “S” appear as “Sh” in the Coptic, Hebraic, and Phoenician. We see the same in the Hindu rendition of many Dravidian words. For example, Shakti and shakta are also rendered sakti and sakta.

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exhausthoodcleaning · 6 years ago

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MFS Exhaust Hood cleaning School

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childishzombiejellyfish · 7 years ago

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gays of bletchley circle: san francisco (some original bc references and I havent finished sf yet)

@sententiousandbellicose

Millie: functional lesbian. picks verbal fights at the drop of a hat and brings guns to fights. "I'm chill" - is literally never chill. falls in love with every woman she meets. morals consist of protecting women and having good lipstick/hair/outfits. Cares. Very. Loudly.

Iris: distinguished bi. “men are unfortunate” “maybe you’re a lesbian” “no I’m bi, I just think men are unfortunate”. anxious but Does It Anyway. would kill for her fam. polite until you fuck with them then acid-tongued and ready to go to the ends of the earth. thinks she wants a quiet life. craves that adventure. -see Olivia below-

Jean: distinguished gay. The Mum Friend. has a secret wicked sense of humour and subterfuge skills. for some reason isnt the person they send to the police to be level-headed even tho she’s clearly the best at pretending she’s not a threat. is definitely a threat. doesnt realise shes married to millie (yet).

Hailey: disaster gay. the baby gay. Fite Me1!!!!!!!!!!!!! mechanic and plumber and brainiac and hillbilly. is not subtle ever!!! openly lusting after older gay women 24/7. “doing it for the vine” doesn’t swear on the show and I believe she’d use “holy doodle” even if this was r-rated. “... oh yes. the men. husbands...”

Olivia: closeted. quietly brilliant but doesnt fully believe in herself yet! feels torn between a normal life and being considered an equal. is quietly in solidarity with ladies but is afraid of breaking out of her own status quo. needs to punch a guy. itd do her good. definitely swears under her breath. she and Iris dated during the war and they never quite got over it.

#the bletchley circle #the bletchley circle: san francisco #reg this is for u #I'd do one for unforgotten but it's literally only Cass and Sunil none of the other characters have enough depth for this #unless I did a season-by-season mains but man. idek know what to say about lots of the characters other than *traumatised. needs hugs*

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weekinethereum · 7 years ago

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September 21, 2018

News and Links

Protocol

[SNARKs] Toward ~500 tx/sec through mass tx validation

[ewasm] Latest Ewasm call

[Eth 2.0] Prysmatic’s latest implementation update: proposer & attester responsibilities, RPC validator interactions and minimal beacon chain processing & fork choice. Chose Bolt for database.

[Eth 2.0] Notes from last Eth 2.0 implementers call.

[Eth 2.0] Sigma Prime introduces its Lighthouse Eth 2.0 client

[State channels] Latest state channels call

[State channels] Learn State Channels, similiar to Learn Plasma

[Plasma] snapp - fully verified plasma chain using SNARKs and BarryWhiteHat’s roll_up

[Plasma] Enabling Faster Plasma Exits - NFT collateralization

[Plasma] Data Availability Solution for Plasma EVM without Confirmation

[Plasma] Quark–gluon Plasma - verified Plasma chain without confirmation signatures

[Plasma] Plasma Cash Defragmentation

[Plasma] Plasma Cash Minimal Atomic Swap

[Plasma] The current state of Plasma (before this week anyway!) by Kevin Zhang

[Plasma] Latest Plasma implementers call

A suggestion: if you want to work in this industry, publishing notes on any of these calls (Plasma, Ewasm, Eth 2.0, state channels, etc) is a great way to build knowledge and reputation.

Stuff for developers

Parameterized transaction reviews for when you want to decide which signers you want to approve different types of transactions

hosted Eth nodes and load balancing

Deconstructing Solidity, pt 5: function bodies

Solidity capture the flag pt 4 challenge, with pt 3 writeup

Sigma Prime’s Mehdi Zerouali: ‘breaking smart contracts for fun and profit’ slides

event logs parser

ethjs-abi for use in BigQuery, to decode Ethereum event logs

Ethereum in Google’s BigQuery: how we built this dataset

Ameen Solemaini video code walk through of Moloch DAO

Using APM to replace centralized package managers

Implementing Harberger tax deeds

Zymbit and Oaken blockchain security module available for pre-order for $47. i2c, Raspberry Pi ready. Ships mid-October

Registration open for next ConsenSys Academy cohort. Zastrin also just released an NFT/ERC721 course

RuntimeVerification’s formal verification spec in K of ERC777

Releases

Parity v2.1.1 beta and v.2.0.6 stable. Parity 1.x end of life.

Ecosystem

Multi-Collateral Dai: the code is formally verified and ready. Check it out on Kovan.

Avsa’s Universal logins working demo: first code release

Beltran on UX for mass adoption

Wyohackathon submissions and winners. EthBerlin winners. Also Hack the North Ethereum submissions

What Eth 2.0 layer 1 scalability will look like, by the numbers

TurboGeth is in private beta, per Rachel O’Leary’s interview with Alexey Akhunov

MEWConnect iOS app is out from My Ether Wallet

Ethfinex Trustless - non-custodial trading using Bitfinex order book, settlement on-chain

Governance and Standards

EIP1418: blockchain rent proposal

ERC820 pseudo-introspection registry is in last call

ERC1412: Batch Transfers For Non-Fungible Tokens

ERC1410: partially fungle token

ERC1417: poll standard

Nick Johnson had a chat with Kristy-Leigh Minehan and switched to supporting ProgPOW. Currently, there’s a 20x increase in processing over ethash in benchmarking, though Minehan says that’s because the CPU code is currently just a copy of the GPU code

Tokensoft on its ERC1404: simple restricted token standard

Project Updates

CasinoFair will be the first live FunFair casino later this month. Available in Canada, Switzerland, Finland, Norway and Thailand. Signup for free FUN

Raiden update on mainnet launch. Testnet release: v0.10.0

Augur app v1.5

Streamr helping build a nationwide traffic map in Georgia

WindingTree’s summer demo release

Santiment’s daily active addresses and Github commit data is free.

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Two great Blockcrunch podcasts on state channels: Connext’s Arjun Bhuptani and Celer Network’s Mo Dong

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GRANDPA block finality in Polkadot

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Cloudflare now runs an IPFS gateway. How they built it e2e

General

15 of the world’s largest banks and trading firms start Komgo to build a commodity trading platform on Ethereum.

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Rep Emmer (R-MN) unveils blockchain-friendly bills to clarify tax with regard to forks and not require miners to register as MSBs (which would be a truly asinine requirement)

NY AG claimed that Coinbase was doing its own trading. Actually, 20% of Coinbase exchange volume comes from Coinbase’s retail. It doesn’t even have an OTC desk.

Putting a Syrian airstrike early warning system on Ethereum for data transparency

SEC Commissioner Peirce speech on being CryptoMom

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your-dietician · 4 years ago

Text

Long-Term CRYSVITA® ▼ (burosumab) Treatment Reduces the Burden of Disease in Adults With X-Linked Hypophosphataemia (XLH), a Rare Genetic Metabolic Bone Disease

New Post has been published on https://depression-md.com/long-term-crysvita-%e2%96%bc-burosumab-treatment-reduces-the-burden-of-disease-in-adults-with-x-linked-hypophosphataemia-xlh-a-rare-genetic-metabolic-bone-disease/

Long-Term CRYSVITA® ▼ (burosumab) Treatment Reduces the Burden of Disease in Adults With X-Linked Hypophosphataemia (XLH), a Rare Genetic Metabolic Bone Disease

TOKYO–(BUSINESS WIRE)–Kyowa Kirin Co., Ltd. (TSE:4151, Kyowa Kirin) today announced the publication of new data highlighting the sustained benefits of treatment with CRYSVITA® (burosumab) in adults with X-linked hypophosphataemia (XLH), a rare genetic metabolic bone disease. The data show that adults with XLH experience substantial pain, stiffness, fatigue and impairment in physical and ambulatory function. Treatment with CRYSVITA was associated with a significant improvement from baseline after 96 weeks.1

The data are from a randomised, double-blind, placebo-controlled, phase 3 study with an open-label extension to assess the efficacy and safety of CRYSVITA in adults with XLH.2 The study met its primary endpoint, showing a statistically significant effect in increasing serum phosphorus concentrations at 24 weeks, compared to placebo.3 After 24 weeks, all patients were switched to CRYSVITA treatment and data was collected on metabolic and biochemical markers, patient reported outcomes (PROs) and measures of mobility up to 96 weeks. This new publication focuses on the results from the PRO analysis and mobility scores.1

At week 96, the study showed statistically significant improvements in PROs, including the Western Ontario and the McMaster Universities Osteoarthritis Index (WOMAC), Brief Pain Inventory–Short Form (BPI-SF) and Brief Fatigue Inventory (BFI), compared to baseline.1 Statistically significant improvements in ambulatory function, measured by the 6-minute walk test (6MWT), were also seen at 96 weeks compared to baseline.1 Data previously published at 48 weeks also showed improvements in some PROs, including stiffness and pain, as well as fracture healing.3

Lead author Pr Karine Briot, Hôpital Cochin, Paris, France said: “The study highlights the many physical challenges faced by adult patients with XLH, including pain, stiffness, fatigue and difficulty walking or physical function. Burosumab treatment has previously been shown to improve phosphate homeostasis in adult XLH patients, compared to placebo. This new analysis suggests that, despite the long-term complications and physical impairment associated with XLH in adults, treatment with burosumab can also improve the physical function and quality of life of adults with XLH over the longer term.”

Tomohiro Sudo, Executive Officer, Head of Global Product Strategy Department of Kyowa Kirin, said: “Kyowa Kirin is committed to improving the lives of people with XLH and their families. One of our areas of focus is to generate new data that improve our understanding of how best to manage and treat XLH. These important new data highlight the many physical challenges that people living with XLH face every day, how their needs could be better met and how Kyowa Kirin is delivering on its purpose, to make people smile.”

The data were published today in the BMJ journal RMD Open, Rheumatic and Musculoskeletal Diseases.1 CRYSVITA is licensed in Europe for the treatment of XLH in children and adolescents aged 1 to 17 years with radiographic evidence of bone disease, and in adults.4

▼This medicinal product is subject to additional monitoring.

About X-linked hypophosphataemia

X-linked hypophosphataemia (XLH) is a rare, genetic disease that causes abnormalities in the bones, muscles, and joints.5,6 XLH is not life-threatening, but its burden is life-long and progressive, and it may reduce a person’s quality of life.7

People with XLH have a genetic defect on the X-chromosome, which causes an excessive loss of phosphate through the urine and poor absorption from the gut due to excess of a hormone known as fibroblast growth factor-23 (FGF23), resulting in chronically low levels of phosphate in the blood.4,8 Phosphate is a key mineral needed for maintaining the body’s energy levels, muscle function, and the formation of healthy bones and teeth.9,10 While there is no cure for XLH, therapies aimed at helping to restore and maintain phosphate to normal levels within the body may help to improve the progression of disease symptoms.2

XLH is the most common form of hereditary rickets.11 It can sometimes appear in individuals with no family history of the disease but is usually passed down from a parent who carries the defective gene.12

About CRYSVITA® (burosumab)

CRYSVITA (burosumab) was created and developed by Kyowa Kirin and is a recombinant fully human monoclonal IgG1 antibody against the phosphaturic hormone fibroblast growth factor 23 (FGF23). FGF23 is a hormone that reduces serum levels of phosphate by regulating phosphate excretion and active vitamin D production by the kidney. Phosphate wasting and resulting hypophosphataemia in X-linked hypophosphataemia (XLH) is caused by excess FGF23. CRYSVITA is designed to bind to, and thereby inhibit, the biological activity of FGF23. By blocking excess FGF23 in patients, CRYSVITA is intended to increase phosphate reabsorption from the kidney and increase the production of active vitamin D, which enhances intestinal absorption of phosphate and calcium.

CRYSVITA has been available for clinical use since 2018. The first approval came from the European Commission, that granted a conditional marketing authorisation for CRYSVITA for the treatment of XLH with radiographic evidence of bone disease in children one year of age and older and adolescents with growing skeletons. In 2020, this authorisation was subsequently expanded to include older adolescents and adults.2

CRYSVITA is approved by the US Food and Drug Administration (FDA) for patients with XLH aged 6 months and older and by Health Canada for patients with XLH aged one year and older.13,14

In 2019, CRYSVITA received approval from Japan’s Ministry of Health, Labour and Welfare for the treatment of FGF23-related hypophosphataemic rickets and osteomalacia. In 2020, CRYSVITA was reimbursed by National Health Insurance (NHI) in Japan as a self-injection presentation for the treatment of FGF23-related hypophosphataemic rickets and osteomalacia.

In January 2020, Swissmedic approved CRYSVITA for the treatment of adults, adolescents and children (one year of age and older) with XLH.15

In June 2020, the U.S. Food and Drug Administration (FDA) approved CRYSVITA for patients aged two and older with tumour-induced osteomalacia (TIO), a rare disease that is characterised by the development of tumours that cause weakened and softened bones.16

Kyowa Kirin and Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE: Ultragenyx) have been collaborating in the development and commercialisation of CRYSVITA globally, based on the collaboration and licence agreement between Kyowa Kirin and Ultragenyx.

About Kyowa Kirin

Kyowa Kirin strives to create and deliver novel medicines with life-changing value. As a Japan-based Global Specialty Pharmaceutical Company with a more than 70-year heritage, the company applies cutting-edge science including an expertise in antibody research and engineering, to address the needs of patients and society across multiple therapeutic areas including Nephrology, Oncology, Immunology/Allergy and Neurology. Across our four regions – Japan, Asia Pacific, North America and EMEA/International – we focus on our purpose, to make people smile, and are united by our shared values of commitment to life, teamwork/Wa, innovation, and integrity. You can learn more about the business of Kyowa Kirin at: https://www.kyowakirin.com/

Kyowa Kirin International

http://www.international.kyowa-kirin.com / www.kyowakirin.com

Galabank Business Park

Galashiels, TD1 1QH

United Kingdom

References

1 Briot K, Portale AA, Brandi ML, et al. RMD Open 2021;7:e001714. doi: 10.1136/rmdopen-2021-001714.

2 Insogna KL, Rauch F, Kamenický P, et al. Burosumab improved histomorphometric measures of osteomalacia in adults with X-linked hypophosphatemia: a Phase 3, single-arm, international trial. J Bone Miner Res. 2019;34:2183-2191.

3 Portale AA, Carpenter TO, Brandi ML, et al. Calcif Tissue Int 2019;105:271–84.

4 European Medicines Agency. CRYSVITA EPAR product information. Summary of Product Characteristics. Available at: Crysvita, INN-burosumab; (europa.eu). Last updated: June 2021. Last accessed: July 2021.

5 Linglart A, Biosse-Duplan M, Briot K, et al. Therapeutic management of hypophosphatemic rickets from infancy to adulthood. Endocr Connect. 2014;3:R13-30.

6 Haffner D, Emma F, Eastwood DM, et al. Consensus Statement. Evidence-based guideline. Clinical practice recommendations for the diagnosis and management of X-linked hypophosphatemia. Nat Rev Nephrol. 2019;15;435-455.

7 Skrinar A, Dvorak-Ewell M, Evins A, et al. The lifelong impact of X-linked hypophosphatemia: Results from a burden of disease survey. J Endocr Soc. 2019;3:1321-1334.

8 Beck-Nielsen SS, Mughal Z, Haffner D, et al. FGF23 and its role in X-linked hypophosphatemia-related morbidity. Orphanet J Rare Dis. 2019;14:58.

9 Pesta D, Tsirigotis DN, Befroy DE, et al. Hypophosphatemia promotes lower rates of muscle ATP synthesis. The FAESB Journal. 2016;39:3378-3387.

10 Unnanuntana A, Rebolledo BJ, Khair MM, et al. Diseases affecting bone quality: beyond osteoporosis. Clin Orthop Relat Res. 2011;469:2194-2206.

11 Carpenter TO, Imel EA, Holm IA, et al. A clinician’s guide to X-linked hypophosphatemia. J Bone Miner Res. 2011;26:1381-8.

12 National Center for Advancing Translational Sciences. X-linked hypophosphatemia. Available at: https://rarediseases.info.nih.gov/diseases/12943/x-linked-hypophosphatemia. Last updated: February 2018. Last accessed: July 2021.

13 Health Canada. Regulatory Decision Summary – CRYSVITA. Available at: https://hpr-rps.hres.ca/reg-content/regulatory-decision-summary-detail.php?linkID=RDS00463. Last updated: April 2020. Last accessed: April 2021.

14 Available at : https://www.kyowakirin.com/media_center/news_releases/2019/e20190930_01.html. Last accessed: July 2021

15 Swissmedic. Crysvita, injektionslösung (burosumabum). Available at: https://www.swissmedic.ch/swissmedic/en/home/humanarzneimittel/authorisations/new-medicines/vrysvita-injektionsloesung_burosumabum.html. Last updated: January 2020. Last accessed: July 2021.

16 FDA. Available at: FDA Approves First Therapy for Rare Disease that Causes Low Phosphate Blood Levels, Bone Softening | FDA. Last accessed: July 2021

KKI/INT/BUR/1174

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