#Small in Size

[heyhanibee]

cliffhanger so disrespectful i had to draw it sorry🐸🐸🐸

[tyrannosaurus-trainwreck]

Actually, I know damn well Darcy never sat down and thought about marrying Lizzie. If he had, it would have been a week before he was rounding up Bingley, sitting him down, and looking him in the eye like he was about to propose high treason and going, "Jane. You still down bad for her?"

Coin toss whether Bingley would actually get to answer before Darcy turned around and flipped over a whiteboard like

and launched right into the most detailed migration pattern known to Regency England to keep the extraneous Bennets as contained as humanly possible by rotating them between various Bingley/Darcy estates. Like, we're talking about trading them off for minor holidays a decade out kind of detailed.

"If you and Jane take them for Lady Day ten years hence, Elizabeth and I will take them for Michaelmas. We'll all be together for Christmas and Midsummer, so we'll divide the responsibility individually on those days."

This would be followed by thirteen different spreadsheets projecting joint expenditures so Bingley knows what sort of financial commitment he'll be shouldering and how to minimize it, what proportion Darcy will take care of, what the estate plans are in case Darcy predeceases anybody, when they should probably roll out various stages to keep it from affecting their respective sisters' ability to maximize their own husband-hunting--whole nine yards.

Darcy does not know that he'll probably be murdered when the Bingley sisters find out why he asked for their social calendars. He'd be marginally fine with that at this point, because the fucking Napoleonic War campaigns were not as meticulously planned as his roadmap to getting the other three Bennets satisfactorily married, and Darcy feels about as able as if he'd spent the last year on Elba.

It takes Bingley a few minutes to realize why this is happening, then he's like

"You proposed to Elizabeth?! Congratulations!"

Darcy... knew there was something he was forgetting.

That man would have kicked the Collins's door open with four binders tucked under each arm, dumped them in a pile in front of Elizabeth, and loudly announced that if they get married tomorrow he can have her entire family except for Jane extraordinary renditioned to the Scottish moors by Sunday and then been like

"Why are you yelling at me?! I promise you, it will work! You'll never see anyone in your family except for Jane again, I swear it!" when she starts yelling at him.

[soapbbox]

In my heart I think tfp would fold under a single genuine compliment, and I feel like D-16 was always liberal with complements sooo

[mayakern]

as a fat person it's SO hard to find a good pair of shorts that fit w/o being cling wrapped to my apron belly bc most brands' plus size sizing data is either out of date or nonexistent.

we used measurements from our customers to create our own unique grading to fit REAL bodies sizes S-6X.

preorders for this super cute and comfy summer loungewear set will be open from march 20th thru april 6th at store.mayakern.com

you can read more about how this set was created here:

[foolsocracy]

they barge into justice league meetings saying they have something very important to show them. and do stuff like this

[pangur-and-grim]

me and my son

[inoirettes]

sorry for being unactive daddy :(((

[deunmiu-dessie]

older boyfriend!simon who's been pulling out to finish on your thighs since you've started dating. older boyfriend!simon who can't help but want to cum inside of you, especially when your cute little pussy clenches around his cock so greedily. older boyfriend!simon who moans when you cream around the base of him, whining and shaking. older boyfriend!simon who presses a sloppy kiss to your puffy lips when you beg for him to fill you up dazedly, with tear-stained cheeks. older boyfriend!simon who finally gives in. "wan' me t'a stuff y'r pretty pussy with my cum, hm?" ˙ᵕ˙

˖⁺‧₊˚♡˚₊‧⁺˖ - 𝒸𝓁𝒾𝒸𝓀 𝓂𝑒! ⁽ nsfw ⁾

[mushroom-punk]

playing his dress up games

[astyrra]

joker's 6th part-time job is cat videos

[hilacopter]

tbh ryoko kui cooked with this one why is this the funniest image I have ever seen

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[teaboot]

*deposits a creature into your hands*

What does it look like? What will you all do together?

OH IM SO GLAD U ASKED

I have this lil baby in the barrel just in case God wants to give me a freebie

It’s called a Plom and you can pet it in any direction

[tokkimins]

my little lord

[dailyhogz]

Lancelot (Shadow) riding a horse with armor resembling the dark rider

180. horsin around