#multiplesclerosis

[chronicillnesshumor]

[mymanysituations]

[aaliyahunleashed]

#OnThisDay Friday, November 14th, 1997

(From left to right) China Chow, Gwen Stefani, Kidada Jones, Aaliyah, and Rashida Jones attending the 5th Annual Race to Erase MS Gala & Fashion Show at the Century Plaza Hotel, Los Angeles, CA.

Race to Erase MS ( @racetoerasems ) is a non-profit organization dedicated to the treatment and ultimate cure of Multiple Sclerosis.

The foundation has gained the support of many key individuals in the fashion and entertainment worlds, including Tommy Hilfiger who supported and sponsored the organization since its inception. In April 2015, Tommy Hilfiger was honored with the Medal of Hope from the organization.

[wipeoutms]

This is a good article about some of invisible issues with MS. It also answers some questions that people have about MS. Like I've been asked a number of times, can you catch Multiple Sclerosis.

Another topic that is covered is MS support groups. They recommend that everyone with MS should join a support I agree with too.

[scienceblogs]

Our Frontiers in Molecular Neuroscience review explores how microRNAs (miRNAs) could transform early diagnosis of neurodegenerative diseases 🧠

🧬 Also covers aging & protein PTMs!

📖 https://doi.org/10.3389/fnmol.2024.1386735

#Neuroscience #microRNA #Neurodegeneration #Biomarkers #Alzheimers #OpenScience

[disabled-not-dead]

I Don't Jump to Conclusions

https://bit.ly/4cdCJ7z

[ericblancony]

The more you know.

[djshanichi]

For the second year in a row, I'm participating in Walk MS.

Donate what you can!

[nonpracticingbitch]

Multiple sclerosis implies that there can be singular sclerosis.

A few sclerosis

Too many sclerosis

Just a couple sclerosis

Oops! All sclerosis

An ass load of sclerosis

A dubious amount of sclerosis

The possibilities are endless.

[mymanysituations]

Shin spints and people suck.

Lately, I am really focusing on being positive in bettering myself and my health while trying not to let symptoms stop me (at least entirely. ) I walked really well yesterday at the recreation center, and so I decided after my i.o.p class today that I would go again. I believe that due to my muscle weakness , the shin splints I got today were from overuse. I ran into an acquaintance who I saw yesterday as well. He walked up to me and said, "You look like hell, there is no way you can be in so much pain today. I saw you yesterday and you were completely fine. Not wanting to waste my energy and needing to get off of my feet, I made it short and simple and said yes, I was really just looking for sympathy, that's why I came here.

[aaliyahunleashed]

#OnThisDay Friday, November 14th, 1997

(From left to right) China Chow, Gwen Stefani, Kidada Jones, Aaliyah, and Rashida Jones attending the 5th Annual Race to Erase MS Gala & Fashion Show at the Century Plaza Hotel, Los Angeles, CA.

Race to Erase MS ( @racetoerasems ) is a non-profit organization dedicated to the treatment and ultimate cure of Multiple Sclerosis.

The foundation has gained the support of many key individuals in the fashion and entertainment worlds, including Tommy Hilfiger who supported and sponsored the organization since its inception. In April 2015, Tommy Hilfiger was honored with the Medal of Hope from the organization.

[wipeoutms]

This looks like a unique and fun MS fundraising. Good luck to all the participants.

[lifestyle-healths-blog]

Genetics’ Role in Chronic Disease

Could your genes hold the secret to chronic disease? As older adults face many long-term health issues, the role of genetics is getting more attention. Twin studies have shown that genes play a big part in diseases like heart disease, diabetes, and Alzheimer’s. But just how much do our genes affect these health challenges?

Genome-wide association studies (GWAS) have made it easier to see how likely someone is to get certain diseases. These studies give us a peek into a person’s genetic risk for certain conditions. But we still don’t know much about how these genetic risks affect our long-term health and social status. Exploring how genes, environment, and health interact is key to understanding chronic disease.

[scienceblogs]

🧬 MicroRNAs: Revolutionizing Early Diagnosis in Neurodegenerative Diseases

By Hafiz Muhammad Husnain Azam Researcher, Brandenburg University of Technology Cottbus-Senftenberg 📘 Published 🔗 Read Full Review on Frontiers

The Neurodegenerative Crisis: A Call for Precision Diagnostics

As the global population ages, the incidence of neurodegenerative diseases (NDs)—such as Alzheimer’s, Parkinson’s, ALS, MS, and Huntington’s—is projected to rise sharply. Yet early diagnosis remains elusive, often occurring only after irreversible neuronal damage has already taken hold.

In our newly published review, we explore microRNAs (miRNAs) as next-generation diagnostic tools—unlocking their power to detect neurodegenerative diseases early, non-invasively, and with molecular precision.

What Makes MicroRNAs Game-Changers?

MiRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level, acting as master switches for cellular behavior. Their dysregulation is intimately linked to key neurodegenerative processes including:

Protein aggregation (e.g., amyloid-beta, tau, alpha-synuclein)

Neuroinflammation and oxidative stress

Synaptic plasticity and neuronal survival

Post-translational modifications (PTMs) such as ubiquitination and phosphorylation

Key Highlights from the Review:

🔬 Pathway Regulation MiRNAs are involved in modulating tau and amyloid-beta synthesis, dopamine signaling, and neuroimmune responses—making them sensitive indicators of early neurodegenerative change.

🧠 Aging & Disease Progression Aging alters miRNA profiles in the brain, impacting neurogenesis, synaptic function, and protein homeostasis—factors critical in both healthy aging and disease onset.

🧪 PTMs and Protein Homeostasis We examine how miRNAs affect proteins central to the ubiquitin-proteasome system, a key pathway in preventing toxic protein accumulation.

💉 Non-Invasive Biomarkers MiRNAs are detectable in blood, CSF, and saliva, allowing for minimally invasive diagnostics that can detect NDs before clinical symptoms appear.

📈 Clinical Applications & Limitations We review key candidate miRNAs (e.g., miR-34a, miR-146a, miR-132) and discuss the current challenges in standardization, sensitivity, and specificity in clinical practice.

Why It Matters

MiRNA-based diagnostics could redefine the clinical approach to neurodegenerative diseases—enabling earlier interventions, better patient stratification, and personalized treatment strategies. This marks a pivotal step toward precision neurology.

Next Steps: Translating Research into Clinical Reality

Our review calls for:

Standardized miRNA panels for clinical testing

Advanced detection technologies (e.g., NGS, qPCR, microarrays)

Cross-disciplinary collaborations to move from lab to clinic

📖 Explore the full article: Frontiers in Molecular Neuroscience 🔗 Nature Shortlink: go.nature.com/3FSQrke

https://doi.org/10.3389/fnmol.2024.1386735

[thetimmermansmethod]

The weather didn't make it easy, but 𝐒𝐞𝐡𝐞𝐫 𝐒𝐢𝐧𝐠𝐡 made us proud at the MS Walk Run + Roll in Sydney! 🌧️

Using her COGY wheelchair, she tackled the course with more power and determination than last year 💪.

A heartfelt thank you to support multiple sclerosis research. You are part of the change!

MS Society UK MS Society SA & NT

[neurologyassociatesva]

Common Misconceptions about Multiple Sclerosis | Neurology Associates Lansdowne VA

There are common misconceptions about multiple sclerosis (MS) including one that it is a terminal disease, which it is not. While multiple sclerosis currently has no definitive cure, there are various medications, treatments, and strategies to manage its symptoms and quality of life. Schedule an appointment with a neurologist in Leesburg VA to diagnose and treat this chronic condition.

Read more at https://neurologyassociatesva.com/common-misconceptions-about-multiple-sclerosis/