#polycystic kidney disease

[iheartvmt]

When the two sweet, adorable little kitten siblings come in for their s/n surgeries, but the pre-anesthetic blood work shows mild renal dysfunction, so you do a U/A and it's chockablock full of renal cells and no sign of infection, and then the doctor finds out their breed is predisposed to polycystic kidney disease...

[kimmikreates]

W.T.F

Don't you just love it when you have to prove you're still disabled and that incurable things haven't magically cured over night🙄.

I deal with chronic pain 24/7 because of a kidney disease I inherited off my dad's side of the family, Polycystic kidney disease is something that has no cure and like other diseases affects people differently, for me thankfully for now my kidneys work just fine but are riddled inside and out with cysts which causes me crippling pain all day everyday, because of the medical neglect I received at the start of the pain 8 years ago, I now have other issues, and lets not get start on the mental lol.

Now I have to prove to PIP, AGAIN, that I have not magically gotten better, I understand people lie but they have all my medical proof off good doctors and hospitals.

Sorry just needed to get this off my chest so to speak.

[benne-basta-bauce]

bean soup blast? no, my wizard's spell gave you polycystic kidneys, dumbass

[im-always-the-problem-its-me]

the pain slices through me. i can't eat anything without pain again. (not such a bad thing honestly, the not eating, but the pain...) i don't know what to do other than take the pills i saved from when i had pancreatitis. i'm not a fan of pain meds but when it's bad, it's bad. i don't think i have an infection & i don't feel like going to the doctors just for them to tell me 'they don't know' or 'maybe it's an autoimmune disease' & then not tell me anything else or send me anywhere else to determine whether or not i do have something else.

they only care that i'm already chronically ill with things they've been able to diagnose. i even had a doctor say to me 'oh, well, you're already disabled, right?' like the only reason i go there is so i can collect payments or something? i didn't even bother to ask her what she meant by it. i don't bother to ask them much of anything anymore because their answers are either 'i don't know' or 'oh, you're fine.' i'm not fucking fine.

even my new doctor. i was concerned about how i couldn't get my cholesterol down considering my diet is insanely good & when i didn't eat any fat during the pancreatitis months my triglycerides got higher. she says, 'high cholesterol? *laughs* America, right?' WHAT THE FUCK?!

i have a kidney disease, assholes. i need to make sure things are being filtered properly. but no. they see 'well, you aren't losing function yet' & everything's just supposed to be fine. i'm exhausted just thinking about it.

so yeah, i'm just going to suffer til it passes as i always do. & be pissed off because i can't do anything other than lay in bed terrified to eat absolutely anything.

spring sucks. it's not even here yet & it's already bad

[lavender-0-menace]

[colinwilson11]

Rare Kidney Disease: An In-Depth Look

There are over a hundred rare diseases that can impact the functioning of the kidneys. Some of the less common renal diseases include Alport syndrome, Medullary cystic kidney disease (MCKD), Autosomal dominant polycystic kidney disease (ADPKD), and Nephronophthisis.

Alport syndrome is a genetic disorder characterized by kidney failure and hearing loss. It is caused by mutations in genes coding for type IV collagen, which is an important component of the glomerular basement membrane in the kidneys. Over time, the glomeruli are damaged, resulting in proteinuria and declining kidney function. Approximately 1 in 5000 individuals are affected by Alport syndrome worldwide.

Medullary cystic Rare Kidney Disease involves the development of cysts in the medulla of the kidneys, which are the inner regions. Two main types are MCKD type 1 and type 2. They are inherited in an autosomal recessive pattern. Cysts accumulate over time, leading to kidney enlargement and eventual failure. MCKD has a prevalence rate of about 1 in 50,000.

Autosomal dominant polycystic kidney disease is one of the most common life-threatening genetic disorders. It is caused by mutations in the PKD1 and PKD2 genes and is inherited in an autosomal dominant pattern. Multiple cysts form in both kidneys, enlarging them considerably. Symptoms include high blood pressure, kidney pain, urinary tract infections, blood in urine and late-stage renal failure. ADPKD has an incidence of about 1 in 1000-4000.

Nephronophthisis is a tubulointerstitial kidney disease leading to end-stage renal failure during childhood or teenage years in most cases. It is inherited as an autosomal recessive or autosomal dominant trait. Tiny cysts form along the renal tubules as the disease progresses. Overall prevalence is estimated to be between 1 in 50,000 to 1 in 100,000.

Diagnosis And Management Challenges

Given the rarity of these disorders, diagnosing them accurately can prove difficult. Initial tests ordered by doctors usually include urine examination, ultrasound of kidneys, serum creatinine levels and creatinine clearance tests. However, definitive diagnosis requires specialist kidney biopsy in many cases to check for characteristic pathology changes under microscopy. Genetic testing is also important to confirm the specific type and mutation involved.

Lack of awareness about Rare Kidney Disease poses challenges in management. Patients often face delays before reaching specialist nephrologists. Limited published research means treatment protocols are still evolving for some conditions. Managing complications like hypertension, pain, infections etc. requires multidisciplinary teams. Coordinating long-term care and follow-up can be an issue as patients transition between pediatric and adult medical services.

Access To Novel Therapies

As understanding of disease pathways improves, new treatments are being developed for Rare Kidney Disease. For instance, antiviral drugs that block JC polyomavirus replication show promise against Nephropathia epidemica (a zoonotic infection causing tubulointerstitial nephritis). CRISPR gene editing is being explored as a curative approach for hereditary conditions. Drugs inhibiting ACE2/angiotensin pathways help slow ADPKD progression. Research is ongoing into stem cell therapy using patient-derived podocytes for Alport syndrome. Management of symptoms also incorporates dietary changes, lifestyle modifications and palliative care approaches. Government approvals have enabled access to orphan drugs for rare disorders in many countries.

The rare diseases impacting the kidneys remain an important public health problem due to their chronic nature and lack of standardized care protocols. Improving awareness, expediting diagnosis, streamlining multi-specialty management, facilitating clinical trials and making innovative therapies more affordable are some priorities. Coordinated global research programs are necessary to find new treatments and eventually cures for these challenging conditions afflicting patients worldwide.

Get more insights on this topic:  https://www.trendingwebwire.com/rare-kidney-disease-understanding-the-uncommon-causes-of-kidney-failure/

Author Bio

Vaagisha brings over three years of expertise as a content editor in the market research domain. Originally a creative writer, she discovered her passion for editing, combining her flair for writing with a meticulous eye for detail. Her ability to craft and refine compelling content makes her an invaluable asset in delivering polished and engaging write-ups. (LinkedIn: https://www.linkedin.com/in/vaagisha-singh-8080b91)

*Note: 1. Source: Coherent Market Insights, Public sources, Desk research 2. We have leveraged AI tools to mine information and compile it

[drpriya]

Polycystic Kidney Disease (PKD) is a genetic disorder characterised by the growth of numerous fluid-filled cysts in the kidneys. These cysts can vary in size and number, and as they grow, they can replace normal kidney tissue, leading to a decrease in kidney function. PKD is one of the most common genetic kidney diseases and can lead to serious complications, including kidney failure.

There are two main types of PKD:

Autosomal Dominant Polycystic Kidney Disease (ADPKD): This is the most common form of PKD and is typically diagnosed in adulthood. It is an autosomal dominant genetic disorder, which means that if one parent carries the mutated gene, there is a 50% chance that their child will inherit the disease. ADPKD progresses slowly, and cysts can develop in other organs, such as the liver and pancreas, in addition to the kidneys.

Autosomal Recessive Polycystic Kidney Disease (ARPKD): This is a rarer form of PKD that is usually diagnosed in infancy or childhood. ARPKD is caused by a mutation in a different gene than ADPKD and is inherited in an autosomal recessive manner, meaning that both parents must carry the mutated gene for a child to develop the disease. This form of PKD can be more severe, leading to kidney and liver problems in affected individuals.

Symptoms of PKD can vary but may include:

Abdominal pain or discomfort

High blood pressure

Hematuria (blood in the urine)

Frequent urinary tract infections

Kidney stones

Kidney enlargement

Complications such as cyst infections, bleeding into cysts, or kidney failure

The management of PKD involves monitoring kidney function, controlling blood pressure, and addressing complications as they arise. In some cases, when kidney function declines significantly, kidney transplantation may be necessary to replace the diseased kidneys with a healthy donor kidney.

Because PKD is a genetic condition, it cannot be prevented, but early detection and medical management can help slow its progression and improve the quality of life for affected individuals. Genetic counselling and testing can be valuable for individuals with a family history of PKD to understand their risk and make informed decisions about family planning.

Here are some key aspects of PKD treatment:

Blood Pressure Management:

Controlling high blood pressure is crucial in PKD to slow down kidney damage. Medications such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are commonly prescribed to help lower blood pressure and reduce proteinuria (protein in the urine).

Pain Management:

Pain associated with enlarged kidneys or complications such as cyst infections or bleeding may require pain relief medications. In some cases, draining large cysts or performing surgery may be necessary to alleviate pain.

Cyst Infection Treatment:

If a cyst becomes infected, antibiotics are used to treat the infection. In some cases, drainage of the infected cyst may be required.

Dietary Modifications:

Maintaining a healthy diet low in sodium and protein can help manage blood pressure and reduce the risk of complications. Healthcare providers may also recommend limiting caffeine and alcohol intake.

Management of Complications:

Complications such as kidney stones, urinary tract infections, and cyst hemorrhages may require specific treatments, including pain management, antibiotics, or procedures to address the issue.

Kidney Function Monitoring:

Regular monitoring of kidney function through blood tests (creatinine, BUN) and urine tests (urinalysis) is essential to assess the progression of the disease and adjust treatment as needed.

Lifestyle Modifications:

Adopting a healthy lifestyle can be beneficial. This includes regular exercise, maintaining a healthy weight, and avoiding smoking or excessive alcohol consumption.

Kidney Transplantation:

In advanced stages of PKD when kidney function declines significantly and reaches end-stage renal disease (ESRD), kidney transplantation may be necessary. This involves replacing the diseased kidneys with a healthy donor kidney. Transplantation can provide a better quality of life and improved survival for individuals with ESRD due to PKD.

Supportive Care:

Supportive care, including access to support groups and counseling, can help individuals and families cope with the emotional and psychological aspects of living with PKD.

Individuals with PKD to work closely with their healthcare team, which may include nephrologists (kidney specialists), urologists, and other specialists, to develop and implement a personalized treatment plan. Regular follow-up appointments and adherence to treatment recommendations are critical to managing PKD effectively and preventing complications.

Additionally, genetic counseling may be recommended for individuals with PKD who are considering family planning, as the disease is hereditary, and there are genetic testing options available to assess the risk of passing PKD on to offspring. Know all about Kidney diseases and treatments at best hospitals like Indraprastha Apollo Hospitals.

[kimmikreates]

8 years ago my world stopped, out of nowhere a crippling pain starter, even though I know the cause sadly there is no cure.

Many times I get told that "You don't LOOK sick/in pain" "Are you sure its not just in your head?", due to pain I had to stop everything I enjoyed as I could not even sit in my chair for long.

Thankfully now I am at a doctors who care, who want to help me, who don't tell me to "Just get on with it", my pain will never no away but thanks to the caring doctors I can not sit and sew for a little while.

"Just get on with it" was from a 'specialist' who fobbed me off for 3 years at the start of the pain, thanks to him I have developed scoliosis due to how I was holding myself to tey and cope with the crippling pain, I did work at this time as well dragging myself in and getting talked down to or threatened to be fired because of my health.

It has taken so long to feel heard and fell like I am being listened to, taken seriously.

[healthydietme]

Explore detailed information about Polycystic Kidney Disease Symptoms, Causes, and Treatment.

[lavender-0-menace]

anyone know any yoga for beginners that helps with chronic pain? dm or reply

[colinwilson11]

[lexingtonrenalcare]

Nephrology is the subspecialty of internal medicine that focuses on the diagnosis and treatment of diseases of the kidney. Lexington Renal Care Physicians Services in Kentucky We provide services that help you with the prevention and treatment of kidney disease.