Interesting Reviews for Week 4, 2024
Cognition from the Body-Brain Partnership: Exaptation of Memory. Buzsáki, G., & Tingley, D. (2023). Annual Review of Neuroscience, 46(1), 191–210.
Prefrontal Cortical Control of Anxiety: Recent Advances. Mack, N. R., Deng, S., Yang, S.-S., Shu, Y., & Gao, W.-J. (2023). The Neuroscientist, 29(4), 488–505.
Neural Circuits for Emotion. Malezieux, M., Klein, A. S., & Gogolla, N. (2023). Annual Review of Neuroscience, 46(1), 211–231.
Recent Insights on Glutamatergic Dysfunction in Alzheimer’s Disease and Therapeutic Implications. Pinky, P. D., Pfitzer, J. C., Senfeld, J., Hong, H., Bhattacharya, S., Suppiramaniam, V., … Reed, M. N. (2023). The Neuroscientist, 29(4), 461–471.
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Interesting Papers for Week 30, 2023
Adult-born neurons inhibit developmentally-born neurons during spatial learning. Ash, A. M., Regele-Blasco, E., Seib, D. R., Chahley, E., Skelton, P. D., Luikart, B. W., & Snyder, J. S. (2023). Neurobiology of Learning and Memory, 198, 107710.
Behavioral origin of sound-evoked activity in mouse visual cortex. Bimbard, C., Sit, T. P. H., Lebedeva, A., Reddy, C. B., Harris, K. D., & Carandini, M. (2023). Nature Neuroscience, 26(2), 251–258.
Exploration patterns shape cognitive map learning. Brunec, I. K., Nantais, M. M., Sutton, J. E., Epstein, R. A., & Newcombe, N. S. (2023). Cognition, 233, 105360.
Distinct contributions of ventral CA1/amygdala co-activation to the induction and maintenance of synaptic plasticity. Chong, Y. S., Wong, L.-W., Gaunt, J., Lee, Y. J., Goh, C. S., Morris, R. G. M., … Sajikumar, S. (2023). Cerebral Cortex, 33(3), 676–690.
An intrinsic oscillator underlies visual navigation in ants. Clement, L., Schwarz, S., & Wystrach, A. (2023). Current Biology, 33(3), 411-422.e5.
Not so optimal: The evolution of mutual information in potassium voltage-gated channels. Duran-Urriago, A., & Marzen, S. (2023). PLOS ONE, 18(2), e0264424.
Successor-like representation guides the prediction of future events in human visual cortex and hippocampus. Ekman, M., Kusch, S., & de Lange, F. P. (2023). eLife, 12, e78904.
Residual dynamics resolves recurrent contributions to neural computation. Galgali, A. R., Sahani, M., & Mante, V. (2023). Nature Neuroscience, 26(2), 326–338.
Dorsal attention network activity during perceptual organization is distinct in schizophrenia and predictive of cognitive disorganization. Keane, B. P., Krekelberg, B., Mill, R. D., Silverstein, S. M., Thompson, J. L., Serody, M. R., … Cole, M. W. (2023). European Journal of Neuroscience, 57(3), 458–478.
A striatal circuit balances learned fear in the presence and absence of sensory cues. Kintscher, M., Kochubey, O., & Schneggenburger, R. (2023). eLife, 12, e75703.
Hippocampal engram networks for fear memory recruit new synapses and modify pre-existing synapses in vivo. Lee, C., Lee, B. H., Jung, H., Lee, C., Sung, Y., Kim, H., … Kaang, B.-K. (2023). Current Biology, 33(3), 507-516.e3.
Neocortical synaptic engrams for remote contextual memories. Lee, J.-H., Kim, W. Bin, Park, E. H., & Cho, J.-H. (2023). Nature Neuroscience, 26(2), 259–273.
The effect of temporal expectation on the correlations of frontal neural activity with alpha oscillation and sensory-motor latency. Lee, J. (2023). Scientific Reports, 13, 2012.
Describing movement learning using metric learning. Loriette, A., Liu, W., Bevilacqua, F., & Caramiaux, B. (2023). PLOS ONE, 18(2), e0272509.
The geometry of cortical representations of touch in rodents. Nogueira, R., Rodgers, C. C., Bruno, R. M., & Fusi, S. (2023). Nature Neuroscience, 26(2), 239–250.
Contextual and pure time coding for self and other in the hippocampus. Omer, D. B., Las, L., & Ulanovsky, N. (2023). Nature Neuroscience, 26(2), 285–294.
Reshaping the full body illusion through visuo-electro-tactile sensations. Preatoni, G., Dell’Eva, F., Valle, G., Pedrocchi, A., & Raspopovic, S. (2023). PLOS ONE, 18(2), e0280628.
Experiencing sweet taste is associated with an increase in prosocial behavior. Schaefer, M., Kühnel, A., Schweitzer, F., Rumpel, F., & Gärtner, M. (2023). Scientific Reports, 13, 1954.
Cortical encoding of rhythmic kinematic structures in biological motion. Shen, L., Lu, X., Yuan, X., Hu, R., Wang, Y., & Jiang, Y. (2023). NeuroImage, 268, 119893.
Mindful self-focus–an interaction affecting Theory of Mind? Wundrack, R., & Specht, J. (2023). PLOS ONE, 18(2), e0279544.
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We found a new antibiotic target in bacteria!!
It took almost 4 years, but the fruits of my postdoc research are finally here! In our paper (with me as the first author), just published in Nature Communications, we decipher a working mechanism of an antibiotic that targets the membrane of bacteria in an unprecedented way!
enhanced PDF: https://rdcu.be/dgj2d
web version: https://lnkd.in/eRpxr4jg
And how does it work?
The antibiotic AMC-109 first self-assembles into stable aggregates with a cationic surface. These aggregates then specifically target bacteria cells and insert into their membrane.
You can see the process how we simulated it in a computer on the figure below. Grey-Blue is the antibiotic, Red-Yellow are lipids that together form a membrane.
@jmelcr did this awesome simulation work! You are an amazing scientist, jmelcr! I love you and it seems our collaboration did not ruin our marriage. Not yet, anyway 😄.
After insertion into the bacterial membrane, the antibiotic dissolves membrane nanodomains affecting membrane function without formation of any pores or holes in the membrane.
Below is the series of high-speed atomic force microscopy images that shows the process of dissolution of membrane nanodomains. Yellow are the membranes extracted from bacteria laying flat on a hard surface (black). The membranes contain nanodomains (bright yellow) that are important in living bacteria for its survival. Addition of antibiotic dissolves them.
More studies will follow that use this new target in bacteria giving us an advantage over untreatable superbugs. I will keep you posted. And... keep your fingers crossed. It's research after all, so we never know if and how well it's going to work.
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