#Biological data analysis

[drchristophedelongsblog]

The integration of artificial intelligence (AI) into medicine is profoundly transforming practices, and this raises important questions about the ability of geriatricians and general practitioners to adapt.

Here is an analysis of the issues

Growing complexity of medicine with AI

Preventive and predictive medicine

AI can analyze huge amounts of data to identify individual risks and predict disease occurrence.

This requires a deep understanding of algorithms and their interpretation.

Diagnosis

AI helps in interpreting medical images, analyzing biological data and detecting complex patterns.

This requires an ability to validate and integrate AI results into the clinical context.

Therapeutic

AI personalizes treatments based on individual patient characteristics.

This involves knowledge of AI-based therapeutic options and an ability to monitor their effectiveness.

Capacity of geriatricians and general practitioners

Continuing education

Continuing education is essential to keep physicians up to date with advances in AI and its applications in medicine.

Interdisciplinary collaboration

Collaboration with AI specialists, data scientists and other healthcare professionals is crucial for effective use of AI.

Decision support tools

AI can provide decision support tools to support physicians in interpreting data and making clinical decisions.

Specificities of geriatrics

Geriatrics, by its holistic nature, is particularly concerned with the management of multiple pathologies and fragility.

AI can be a valuable asset in synthesizing complex data and personalizing care plans.

The role of the general practitioner

The general practitioner, through regular monitoring of the patient, is on the front line to detect changes and refer to specialists.

AI can help refine its diagnosis and monitoring.

In summary

AI represents a challenge, but also an opportunity to improve the care of elderly patients.

Continuing education, interdisciplinary collaboration and the use of decision support tools are essential to enable geriatricians and general practitioners to adapt to this evolution.

General practitioners and geriatricians will have a key role in using AI as a decision-making tool.

Go further

[jcmarchi]

A protein found in human sweat may protect against Lyme disease

New Post has been published on https://thedigitalinsider.com/a-protein-found-in-human-sweat-may-protect-against-lyme-disease/

A protein found in human sweat may protect against Lyme disease

Lyme disease, a bacterial infection transmitted by ticks, affects nearly half a million people in the United States every year. In most cases, antibiotics effectively clear the infection, but for some patients, symptoms linger for months or years.

Researchers at MIT and the University of Helsinki have now discovered that human sweat contains a protein that can protect against Lyme disease. They also found that about one-third of the population carries a genetic variant of this protein that is associated with Lyme disease in genome-wide association studies.

It’s unknown exactly how the protein inhibits the growth of the bacteria that cause Lyme disease, but the researchers hope to harness the protein’s protective abilities to create skin creams that could help prevent the disease, or to treat infections that don’t respond to antibiotics.

“This protein may provide some protection from Lyme disease, and we think there are real implications here for a preventative and possibly a therapeutic based on this protein,” says Michal Caspi Tal, a principal research scientist in MIT’s Department of Biological Engineering and one of the senior authors of the new study.

Hanna Ollila, a senior researcher at the Institute for Molecular Medicine at the University of Helsinki and a researcher at the Broad Institute of MIT and Harvard, is also a senior author of the paper, which appears today in Nature Communications. The paper’s lead author is Satu Strausz, a postdoc at the Institute for Molecular Medicine at the University of Helsinki.

A surprising link

Lyme disease is most often caused by a bacterium called Borrelia burgdorferi. In the United States, this bacterium is spread by ticks that are carried by mice, deer, and other animals. Symptoms include fever, headache, fatigue, and a distinctive bulls-eye rash.

Most patients receive doxycycline, an antibiotic that usually clears up the infection. In some patients, however, symptoms such as fatigue, memory problems, sleep disruption, and body aches can persist for months or years.

Tal and Ollila, who were postdocs together at Stanford University, began this study a few years ago in hopes of finding genetic markers of susceptibility to Lyme disease. To that end, they decided to run a genome-wide association study (GWAS) on a Finnish dataset that contains genome sequences for 410,000 people, along with detailed information on their medical histories.

This dataset includes about 7,000 people who had been diagnosed with Lyme disease, allowing the researchers to look for genetic variants that were more frequently found in people who had had Lyme disease, compared with those who hadn’t.

This analysis revealed three hits, including two found in immune molecules that had been previously linked with Lyme disease. However, their third hit was a complete surprise — a secretoglobin called SCGB1D2.

Secretoglobins are a family of proteins found in tissues that line the lungs and other organs, where they play a role in immune responses to infection. The researchers discovered that this particular secretoglobin is produced primarily by cells in the sweat glands.

To find out how this protein might influence Lyme disease, the researchers created normal and mutated versions of SCGB1D2 and exposed them to Borrelia burgdorferi grown in the lab. They found that the normal version of the protein significantly inhibited the growth of Borrelia burgdorferi. However, when they exposed bacteria to the mutated version, twice as much protein was required to suppress bacterial growth.

The researchers then exposed bacteria to either the normal or mutated variant of SCGB1D2 and injected them into mice. Mice injected with the bacteria exposed to the mutant protein became infected with Lyme disease, but mice injected with bacteria exposed to the normal version of SCGB1D2 did not.

“In the paper we show they stayed healthy until day 10, but we followed the mice for over a month, and they never got infected. This wasn’t a delay, this was a full stop. That was really exciting,” Tal says.

Preventing infection

After the MIT and University of Helsinki researchers posted their initial findings on a preprint server, researchers in Estonia replicated the results of the genome-wide association study, using data from the Estonian Biobank. These data, from about 210,000 people, including 18,000 with Lyme disease, were later added to the final Nature Communications study.

The researchers aren’t sure yet how SCGB1D2 inhibits bacterial growth, or why the variant is less effective. However, they did find that the variant causes a shift from the amino acid proline to leucine, which may interfere with the formation of a helix found in the normal version.

They now plan to investigate whether applying the protein to the skin of mice, which do not naturally produce SCGB1D2, could prevent them from being infected by Borrelia burgdorferi. They also plan to explore the protein’s potential as a treatment for infections that don’t respond to antibiotics.

“We have fantastic antibiotics that work for 90 percent of people, but in the 40 years we’ve known about Lyme disease, we have not budged that,” Tal says. “Ten percent of people don’t recover after having antibiotics, and there’s no treatment for them.”

“This finding opens the door to a completely new approach to preventing Lyme disease in the first place, and it will be interesting to see if it could be useful for preventing other types of skin infections too,” says Kara Spiller, a professor of biomedical innovation in the School of Biomedical Engineering at Drexel University, who was not involved in the study.

The researchers note that people who have the protective version of SCGB1D2 can still develop Lyme disease, and they should not assume that they won’t. One factor that may play a role is whether the person happens to be sweating when they’re bitten by a tick carrying Borrelia burgdorferi.

SCGB1D2 is just one of 11 secretoglobin proteins produced by the human body, and Tal also plans to study what some of those other secretoglobins may be doing in the body, especially in the lungs, where many of them are found.

“The thing I’m most excited about is this idea that secretoglobins might be a class of antimicrobial proteins that we haven’t thought about. As immunologists, we talk nonstop about immunoglobulins, but I had never heard of a secretoglobin before this popped up in our GWAS study. This is why it’s so fun for me now. I want to know what they all do,” she says.

The research was funded, in part, by Emily and Malcolm Fairbairn, the Instrumentarium Science Foundation, the Academy of Finland, the Finnish Medical Foundation, the Younger Family, and the Bay Area Lyme Foundation.

[mangled-by-disuse]

I have such mixed feelings about the love languages thing specifically, because, like, gary chapman fucking sucks and there's no scientific validity to his work BUT

at the same time, i do think there's some value in recognising and discussing the fact that different people need different expressions of love in different amounts? Especially in relationships.

Like, I have just recently been having a discussion with my partner about how he really doesn't tend to express his affection through gifts, whereas (as someone who is mega-bad at expressing sincere feeling) I do rely heavily on giving gifts and doing things for people as a less scary way to express love. Joe doesn't like giving gifts, because he's scared he'll do it wrong, and is only so-so on receiving them. He prefers to express love through physical contact and saying nice things. I hate having nice things said to me unless I am allowed to immediately rebut them with a joke or sarcastic comment that makes them less scarily close to emotional honesty. too many words of affirmation and i will genuinely just start avoiding you because it is painfully awkward to me.

and none of that means we are fundamentally different categories of people, which is where the 5 Love Languages stuff falls into being absolute bollocks. but I have seen, and done, enough throwing the baby out with the bathwater on that to be a little defensive - I think reasonable applications of the concept are actually really quite valuable. and for me, the taxonomy Chapman suggests (words of affirmation, quality time, gifts, acts of service, physical touch) while not at all exhaustive or thorough, is a useful framework to hang those conversations on. bc, like, no, the way people communicate and receive affection is not universal, and from personal experience, assuming that it is can have really significant problems for a relationship.

...you could argue that this is parallel to BMI in terms of "tools being used in totally not the way they should be used" though, tbf.

I can't keep having the same conversations about love languages, mbti, iq, bmi, "brain fully formed at 25" and shit over and over again...

[kamalkafir-blog]

Driving generation and analysis of biological data for ML-based RNA design

Job title: Driving generation and analysis of biological data for ML-based RNA design Company: Inceptive Job description: engineers, software engineers, and translational experts to develop scalable data pipelines, automate analysis, and create…, and refine tools for efficient, reliable data analysis in collaboration with software engineers Collaborate on validation… Expected salary: Location:…

[airises]

"Revolutionizing Biotech: How AI is Transforming the Industry"

The biotech industry is on the cusp of a revolution, and Artificial Intelligence (AI) is leading the charge. AI is transforming the way biotech researchers and developers work, enabling them to make groundbreaking discoveries and develop innovative solutions at an unprecedented pace. “Accelerating Scientific Discovery with AI” AI is augmenting human capabilities in biotech research, enabling…

[reasonsforhope]

"Eavesdropping on whale songs over the last six years is providing new information vital to answering questions about these giants of the ocean.

The number of whale songs detected is associated with shifting food sources, according to the California scientists—and the number of days humpbacks have been singing has nearly doubled.

When monitoring baleen whale songs in the Pacific Ocean, researchers found year-to-year variations correlated with changes in the availability of the species they forage on.

In vast oceans, monitoring populations of large marine animals can be a “major challenge” for ecologists, explained Dr. John Ryan, a biological oceanographer at the Monterey Bay Aquarium Research Institute in California (MBARI).

Their team deployed underwater microphones called hydrophones to study and track baleen whales, which communicate over long distances through sound.

“Surprisingly, the acoustic behavior of baleen whales provides insights about which species can better adapt to changing ocean conditions,” said Dr. Ryan, a lead author of the study.

They also monitored songs from blue, fin, and humpback whales off the West Coast of the U.S. to see what the song data could reveal about the health of their ecosystem.

The findings, published in the journal PLOS One, showed “large” year-to-year variations in whale song detection.

“The amount of humpback whale song continually increased, with their songs being detected on 34% of days at the beginning of the study and rising to 76% of days after six years,” said Dr. Ryan.

“These increases consistently tracked improved foraging conditions for humpback whales across all study years—large increases in krill abundance, followed by large increases in anchovy abundance.

“In contrast, blue and fin whale song rose primarily during the years of increasing krill abundance.

“This distinction of humpback whales is consistent with their ability to switch between dominant prey. An analysis of skin biopsy samples confirmed that changes had occurred in the whales’ diets.”

He explained that other factors, including the local abundance of whales, may have contributed to patterns in song detections observed in some years, but changes in foraging conditions were the most consistent factor.

“Overall, the study indicates that seasonal and annual changes in the amount of baleen whale song detected may mirror shifts in the local food web.”

WHALES ON THE COMEBACK TRAIL: • Gray Whale, Extinct for Centuries in Atlantic, Is Spotted in Cape Cod • Sighting of Many Blue Whales Around Seychelles is First in Decades – ‘Phenomenal’ • Majestic Sei Whales Reappear in Argentine Waters After Nearly a Century

“The results suggest that an understanding of the relationship between whale song detection and food availability may help researchers to interpret future hydrophone data, both for scientific research and whale management efforts”, which could better protect endangered species."

-via Good News Network, March 1, 2025

[yogasblogyogaanitha]

Data-Driven Discovery - How Bioinformatics Empowers Biotechnology Research

What is the significance of bioinformatics in analyzing biological data? How do bioinformatics and data analysis companies contribute to biotechnology research? Bioinformatics plays a crucial role in analyzing biological data and has become an integral part of modern biotechnology research. Here are some key aspects of its significance and the contributions of bioinformatics and data analysis…

[blueiscoool]

A photo of the body casts of two adults and two children who died in what's now called the house of the golden bracelet in Pompeii. A new DNA analysis shows that these four people are not genetically related to one another. (Image credit: Archeological Park of Pompeii).

DNA Analysis Rewrites The Stories of People Buried in Pompeii

An ancient-DNA analysis of victims in Pompeii who died in Mount Vesuvius' eruption reveals some unusual relations between the people who died together.

Ancient DNA taken from the Pompeii victims of Mount Vesuvius' eruption nearly 2,000 years ago reveals that some people's relationships were not what they seemed, according to a new study.

For instance, an adult who was wearing a golden bracelet and holding a child on their lap was long thought to be a mother with her child. But the new DNA analysis revealed that, in reality, the duo were "an unrelated adult male and child," study co-author David Reich, a professor of genetics at Harvard Medical School, said in a statement.

In another example, a couple who died in an embrace and were "thought to be sisters, or mother and daughter, were found to include at least one genetic male," Reich said. "These findings challenge traditional gender and familial assumptions."

In the study, published Thursday (Nov. 7) in the journal Current Biology, Reich and an international team of researchers looked at the genetics of five individuals who died during the A.D. 79 eruption that killed around 2,000 people.

When Mount Vesuvius erupted, it covered the surrounding area in a deadly layer of volcanic ash, pumice and pyroclastic flow, burying people alive and preserving the shapes of many bodies beneath the calcified layers of ash. The remains of the city were rediscovered only in the 1700s. In the following century, archaeologist Giuseppe Fiorelli perfected his plaster technique, in which he filled in the human-shaped holes left after the bodies had decomposed to create casts of the victims.

The casts of two people who died about 2,000 years ago in the house of the cryptoporticus in Pompeii. A new DNA analysis found that one individual was biologically male, but the sex of the other could not be determined. (Image credit: Archeological Park of Pompeii).

The casts allowed scholars to study the victims in their last moments and make hypotheses about their identities based on details such as their locations, positions and apparel. The problem with this approach, however, was that their interpretations were influenced by modern-day assumptions — for instance, that the four people at the house with the golden bracelet, which included the adult holding the child, were two parents with their children, when in reality none of them were genetically related, the researchers wrote in the study.

For their research, the team analyzed 14 casts and extracted DNA from fragmented skeletal remains in five of them. By analyzing this genetic material, the scientists determined the individuals' genetic relationships, sex and ancestry. The team concluded that the victims had a "diverse genomic background," primarily descending from recent eastern Mediterranean immigrants, per the statement, confirming the Roman Empire's multiethnic reality.

The cast of a person who died in the villa of the mysteries in Pompeii in A.D. 79. (Image credit: Archeological Park of Pompeii).

Our findings have significant implications for the interpretation of archaeological data and the understanding of ancient societies," study co-author Alissa Mittnik, an archaeogeneticist at Harvard Medical School and the Max Planck Institute for Evolutionary Anthropology in Germany, said in the statement. "They highlight the importance of integrating genetic data with archaeological and historical information to avoid misinterpretations based on modern assumptions."

It's possible that past misconceptions led to the "exploitation of the casts as vehicles for storytelling," meaning that curators may have manipulated the victims' "poses and relative positioning" for exhibits, the team wrote in the study.

Sex misassignment is "not uncommon" in archaeology, Carles Lalueza-Fox, a biologist at the Institute of Evolutionary Biology (CSIC-UPF) in Barcelona who specializes in the study of ancient DNA but was not involved with the study, said in an email.

"Of course we look at the past with the cultural eyes of the present and this view is sometimes distorted; for me the discovery of a man with a golden bracelet trying to save an unrelated child is more interesting and culturally complex than assuming it was a mother and her child," Lalueza-Fox said.

By Margherita Bassi.

[drchristophedelongsblog]

The integration of artificial intelligence (AI) into medicine is profoundly transforming practices, and this raises important questions about the ability of geriatricians and general practitioners to adapt.

Here is an analysis of the issues

Growing complexity of medicine with AI

Preventive and predictive medicine

AI can analyze huge amounts of data to identify individual risks and predict disease occurrence.

This requires a deep understanding of algorithms and their interpretation.

Diagnosis

AI helps in interpreting medical images, analyzing biological data and detecting complex patterns.

This requires an ability to validate and integrate AI results into the clinical context.

Therapeutic

AI personalizes treatments based on individual patient characteristics.

This involves knowledge of AI-based therapeutic options and an ability to monitor their effectiveness.

Capacity of geriatricians and general practitioners

Continuing education

Continuing education is essential to keep physicians up to date with advances in AI and its applications in medicine.

Interdisciplinary collaboration

Collaboration with AI specialists, data scientists and other healthcare professionals is crucial for effective use of AI.

Decision support tools

AI can provide decision support tools to support physicians in interpreting data and making clinical decisions.

Specificities of geriatrics

Geriatrics, by its holistic nature, is particularly concerned with the management of multiple pathologies and fragility.

AI can be a valuable asset in synthesizing complex data and personalizing care plans.

The role of the general practitioner

The general practitioner, through regular monitoring of the patient, is on the front line to detect changes and refer to specialists.

AI can help refine its diagnosis and monitoring.

In summary

AI represents a challenge, but also an opportunity to improve the care of elderly patients.

Continuing education, interdisciplinary collaboration and the use of decision support tools are essential to enable geriatricians and general practitioners to adapt to this evolution.

General practitioners and geriatricians will have a key role in using AI as a decision-making tool.

Go further

[alltoomaples]

Speed of Science🧬💻💌

I'm dating a STEM girlie and you're not (F1 Edition)

a/n: and im baaaaaacccckkkkk (like anyone even missed me lmao) with the long overdue request! life of a postgrad StEm girlie here and the struggle is really realll af. but besides that, I'm writing this down as a headcanon for the drivers requested on this poll i had posted long back here. I've always wondered how there's soo minimal povs/ocs where they are a scientific researcher, analyst, etc. sooo i dedicate this one to all the STEM F1 girlies out theree <33

alsoo quick shoutout to my girlieee @smoooothoperator for inspiring and motivating me to get back at writing!🥹🫶🏼 check out her lastest ongoing work 'What Was I Made For? ' its amazing and thats a FACT!! do check her works! its absolutely amazing❤️

check out my works: until i found you masterlist | other works

Scientific Art Illustrator - Charles Leclerc

As a Scientific Art Illustrator, you specialize in creating visually captivating and scientifically accurate illustrations that depict complex biological, astronomical, or technological subjects.

Charles first discovered you through your works at an exhibition where their stunning illustrations of Formula 1 cars caught his eye. Impressed by their attention to detail and artistic talent, they struck up a conversation about their mutual love for precision and creativity.

During a peaceful weekend afternoon, Charles suggests a spontaneous visit to a local art supply store. Excitedly exploring aisles stocked with vibrant paints, fine brushes, and specialized papers, the two of you engage in discussions about artistic techniques and innovative tools. Amidst laughter and shared enthusiasm for creativity, you bond over your mutual appreciation for the intricacies of art and science, making the afternoon a cherished memory of their shared passions.

After being away from home during race season, Charles always finds a framed series of sketches by you for the races you couldn't make it, capturing his most memorable racing moments. Each sketch is intricately detailed, depicting not only the speed and intensity of the races but also the emotions and determination etched on Charles' face. Touched by the thoughtful gesture, Charles hangs the sketches in his study, a constant reminder of your support and admiration for his passion.

...

Data Scientist - Lando Norris

A Data Scientist specializes in analyzing large volumes of data using statistical methods and machine learning techniques to extract insights and make data-driven decisions.

You and Lando first connected through a mutual fascination with racing data at a technology symposium focused on sports analytics. Your presentation on advanced predictive modelling in motorsports caught Lando's attention for its innovative approach to enhancing race strategies.

During a cosy evening at home, Lando playfully challenges you to a friendly data analysis competition using real-time telemetry from previous races. Their banter and shared excitement over dissecting racing data create a lighthearted and memorable bonding experience.

You two would watch old races and analyze historical racing data together, playfully debating optimal pit stop strategies and analyzing driver performance trends, their shared passion for racing and data fostering a deep connection and mutual admiration.

...

Oceanographer/Marine Biologist - Oscar Piastri

An Oceanographer or Marine Biologist studies marine life, ecosystems, and ocean processes to understand and protect marine environments and resources.

You and Oscar crossed paths during a research expedition to study coral reefs in a remote location. Your expertise in marine biology and passion for conservation impressed Oscar, sparking their connection.

Amidst the hectic F1 season, Oscar surprises you with a weekend getaway to a coastal retreat, where they explore tide pools and participate in a beach cleanup together, reaffirming their commitment to environmental stewardship.

You gave Oscar a custom-made charm bracelet featuring miniature charms of marine animals they've discussed during their beach walks and conservation talks. Each charm represents a meaningful moment in their relationship, from their first discussion about oceanography to their shared admiration for marine life. Oscar wears the bracelet during race weekends as a reminder of you and all the love and support you give, both on and off the track.

...

Mechanical Engineer - Daniel Riccardo

You are a passionate Mechanical Engineer, specializing in advanced automotive design and performance optimization.

Daniel first encountered you at a technical conference organized by one of the team sponsors where you presented groundbreaking research on aerodynamic innovations that caught his attention.

Often, while you meticulously draft engineering schematics at their home office, he makes sure that you have your "engineering emergency kit" beside your workstation, which is a tray of snacks and their favourite coffee – ensuring they're fueled for their late-night brainstorming sessions. For when he's away for races, he stacks them up with small cute notes.

Before Daniel heads to a crucial race, you surprise him with a meticulously crafted miniature replica of his race car, complete with detailed decals and a personalized message of encouragement engraved on the base. Touched by the thoughtful gesture, Daniel proudly displays it in his motorhome, a reminder of the reader's unwavering support both on and off the track.

...

Statistician - George Russell

A Statistician specializes in collecting, analyzing, and interpreting numerical data to help organizations and individuals make informed decisions.

You and Russell first crossed paths during a university seminar on advanced statistical modeling in sports. Your insightful analysis of Formula 1 race data caught George's attention, sparking a lively discussion that led to mutual admiration for each other's analytical skills and shared passion for racing statistics.

During a particularly demanding race weekend, the reader surprises George with a meticulously prepared statistical analysis report highlighting his strengths and areas for improvement based on recent race data. This thoughtful gesture boosts George's confidence and motivation, showing the reader's support in his pursuit of excellence.

During a weekend getaway, you guys stumble upon a local go-kart track. George, always up for a challenge, suggests they have a friendly race. Knowing George's competitive spirit, you secretly calculate his optimal strategy and surprise him by winning with a perfectly executed last-minute overtaking maneuver. George is impressed by the your strategic thinking and playfulness, and they share a lighthearted and joyous moment celebrating their shared love for racing and friendly competition.

...

Astrophysicist - Logan Sargeant

An Astrophysicist studies the physical properties, behavior, and evolution of celestial objects such as stars, planets, galaxies, and the universe as a whole, using principles of physics and astronomy.

Logan and you first crossed paths during an expedition to study a rare astronomical event—a comet passing close to Earth. Both passionate about astrophysics, you found yourselves sharing a telescope at a remote observatory, marveling at the comet's beauty and discussing its celestial significance late into the night. Their shared awe and intellectual connection sparked a mutual admiration that grew into a deep bond over their shared passion for exploring the wonders of the cosmos.

During a quiet evening at home, Logan excitedly shows you a new telescope he acquired for stargazing during race weekends, expressing his eagerness to learn more about the cosmos together and sharing their enthusiasm for both racing and astrophysics in equal measure.

Before a critical race weekend, the reader surprises Logan with a personalized star chart that maps out the night sky above the upcoming race venue during the race weekend. Each star on the chart is marked with a heartfelt message of encouragement, reminding Logan of their unwavering support and belief in his abilities on and off the track. Touched by the thoughtful gesture, Logan treasures the star chart as a symbol of the reader's love and encouragement throughout his racing career.

...

Climate Scientist - Lance Stroll

A Climate Scientist studies climate patterns, environmental changes, and their impacts on Earth's ecosystems, using data analysis and modeling to understand and address global climate challenges.

Lance crossed paths with you at an eco-friendly racing event where Lance was advocating for sustainable practices in motorsport. Being a respected climate scientist, you caught Lance's attention with your insightful presentation on the environmental impact of racing and innovative solutions for reducing carbon footprints in the sport. Their shared passion for sustainability sparked an immediate connection and admiration for each other's dedication to making a positive impact on the environment.

One weekend, Lance surprises you with a homemade dinner featuring sustainably sourced ingredients, proudly showcasing his culinary skills while discussing ways to reduce your carbon footprint. His earnest commitment to sustainability and your shared vision for a healthier planet melts your heart, making this a cherished moment you both treasure.

You, being deeply involved in climate science, often spends late nights analyzing data or writing research papers. One evening, Lance bring him a cozy blanket and a mug of your favorite hot beverage, quietly sitting beside him as he works. You look up from your laptop, touched by his thoughtfulness, and pulls him into a warm embrace, grateful for his unwavering support and understanding of your demanding but vital work.

...

taglist: @lndonrris @thatgirlmj @lwstuff @dannyramirezwife-f1dump @moonypixel tysm for your suggestions! apologies on taking this long to write😅🫶🏼

a/n: hope y'all enjoyed reading this! this was my first time writing a headcanon and for f1 drivers beside charles and lando so hope i did justice to all.

i'm being wanting to read some good domestic bliss, sweet, adorable and lovey dovey blurbs, fics of lando (i talked abt it here) soo maybe i'll work on some drafts at some point cause i'm currently in the middle of project work of my masters degree soo don't know when i'll be posting soo until next time, see yaaa and going back to read mode 👋💓✨️

check out my works: until i found you masterlist | other works

[moonyskarma]

𝒯𝙝𝔢 𝒮𝙝𝔞𝚍𝙤𝚠 𝒮𝙥𝔦𝚍𝙚𝔯

◀ FILE ACCESSED: LEVEL 9 REQUIRED ► METAHUMAN DOSSIER: SPIDERMAN A.R.G.U.S. REGISTRY CODE: X-319J-CH-VOID

ALIASES: Spiderman / Shadow Spider / The Spider CIVILIAN IDENTITY: West, Charles "Charlie" Calloway AGE: 23 KNOWN AFFILIATIONS: Flash (Charles Leclerc), Team Flash, CCPD LOCATION TRACKED: Central City CURRENT STATUS: Active

PHYSICAL PROFILE: • Height: 5'8' • Build: Athletic, high muscle density (noted for enhanced strength) • Eyes: Dark brown • Identifying Marks: Minor scar, left oral commissure (non-inhibitory); mask conceals facial identity effectively. • Movement Style: Agile, non-linear; often utilizes vertical terrain. Confirmed enhanced reflexes. • Suit: Matte black adaptive suit with web-distribution technology and reinforced under layer. Not A.R.G.U.S.-issued.

PRIMARY ABILITIES: • Enhanced Physiology: Superhuman strength (class 10), stamina, reflexes, and healing factor. • Wall-Crawling: Adhesive grip via neuro-responsive extremities. • Spider-Sense: Extrasensory awareness of immediate threats. • Web Deployment: Internally engineered, wrist-mounted cartridges. Customizable web types (standard tensile, impact dispersal, ensnarement) • Combat Training: Improvised street combat, acrobatic evasion, and pressure-point targeting.

SKILLSET & SPECIALIZATIONS: • Forensic profiling, behavioral analysis (certified) • Tactical intelligence and urban reconnaissance • High proficiency in field improvisation and stealth pursuit • Access to CCPD crime scene data and surveillance through internal credentials (flagged by ARGUS audit; under review)

PSYCHOLOGICAL PROFILE & BACKSTORY: Psychological Profile: • Subject exhibits patterns of trauma-rooted hyper-independence. Displays marked reluctance to delegate or rely on others—early case files indicate complete operational solitude for first phase of activity. • Notably anti-lethal but not pacifistic; engages targets with calculated brutality when deemed necessary. Repeated field reports highlight consistent use of force intended to incapacitate rather than eliminate. • Maintains high tactical intelligence and demonstrates combat-specific hyperfocus, especially in urban terrain. Emotional triggers noted: child endangerment, abuse of power, institutional failure. Exhibits signs of complex trauma and internalized guilt response—subject is a classic moral absolutist operating in moral grey. • Behavioral alignment: Anti-heroic, trending toward cooperative vigilante. • Integration into Team Flash has promoted marked behavioral shifts—less isolation, increasing reliance on allies (notably Flash and Cisco Ramon). Subject remains emotionally reserved but is capable of deep loyalty once trust is established.

Background Summary: • Subject was adopted as a young child into the West family under sealed circumstances; birth records list "Calloway" as original surname. Details regarding biological parents remain classified or unknown, though metahuman lineage is suspected. • Early adolescence marked by above-average intelligence, academic aptitude in forensic science and behavioral criminology, and notable disciplinary issues related to authority resistance. Currently employed by CCPD as a criminologist. • Initial vigilante activity predates official metahuman registrated by ~10 months. Operated nocturnally under masked alias "The Spider", avoiding detection while targeting individuals who eluded legal consequence. Patterns consistent with personal vendetta overlaying systemic justice response. • Following first contact with The Flash, subject's strategy evolved—shifted from solo vigilantism to tactical cooperation in metahuman apprehension efforts. • Subject remains unregistered in the official Central City vigilante database, though Team Flash records identify him as a consistent field agent in meta-level incidents.

THREAT ASSESSMENT: • Threat Level: Yellow (Conditional Watchlist) • Subject poses no direct threat to civilians or sanctioned meta operations under typical parameters. Actions are guided by a strong internal moral code, though not always in alignment with ARGUS or CCPD protocol. • Tactical efficiency, unpredictability, and emotional volatility under specific triggers (e.g., child endangerment, abuse of power, sexual abuse) warrant continued surveillance • Field Classification: Containment Risk Tier II — Standard intervention protocols apply; use of lethal force not authorized unless subject breaches metahuman containment policy. • Despite cooperative stance, subject has not submitted to full ARGUS evaluation.

SECURITY CLEARANCE NOTES: Access to full dossier contents restricted to Level 9 operatives and above. Any unauthorized attempts to duplicate, transmit, or disseminate subject data will trigger immediate lockdown protocol [Ref. ARGUS Regulation 16.3c]. Subject's full metahuman potential remains under evaluation; redacted portions accessible only by Director Waller or ARGUS Field Oversight Division.

[SECTION REDACTED – 03.16.XX / AUTHORIZATION: W. WALLER] Biological origin and medical anomalies flagged for meta-genetic analysis. Subject denies knowledge of pre-adoption trauma. Further investigation pending.

. . . back to the circus 🎪

[evidence-based-activism]

IOC Study on Transgender Athletes Severely Flawed

So, to a certain extent, the question of "should transwomen be able to compete female sports?" is an ideological question (i.e., "should identity supersede reality?").

That being said, there's a recent report [1], funded by the IOC, that is being used to "prove" that transwomen do not have a biological advantage over non-trans women. This report is severely flawed and does not actually lend support to the idea that transwomen have no biological advantage in sports over female people.

(I will mimic the language used in the report (e.g., using "ciswomen").)

Significant differences noted by the report that do NOT support transwomen's inclusion in women's sports:

Transwomen were substantially taller than ciswomen

Transwomen had more lean/fat-free mass than ciswomen

Transwomen had better lung function than ciswomen, as measured by forced vital capacity, forced expiratory volume in one second, and peak expiratory flow. (See the next section for a discussion on the ratio.)

Transwomen had greater hand grip strength (a proxy for overall strength measurement)

Transwomen had higher absolute peak power (lower extremity) compared to ciswomen. (See next section for a discussion on the relative measure.)

Transwomen had the same "absolute strength" as cismen

The data showing no significant difference between transwomen and ciswomen has substantial flaws:

The sample size was too small to reliably determine differences in bone mineral density

For lung function only the FEV1:FVC ratio was lower for transwomen, but the values are generally within the normal range for both groups. The impact of this difference is therefore questionable, as the transwomen have greater absolute values on each measurement and the ratio is not showing any abnormalities. In addition, the effect size (size of the difference) is much smaller than the effect size of the absolute differences described above. The conclusion here is simply that the participants do not have any obstructive respiratory diseases, and the transwomen have greater absolute lung function. (Although there are better tests for this.) There is also one outlier in the transwomen group that is likely driving this relationship in the ratio; unfortunately they do not perform the expected control analyses to demonstrate the retention of results without the outlier. [2]

The researchers decided to examine power in the lower extremities relative to lean/fat-free mass, which yielded a lower result for transwomen compared to ciswomen. However, this methodology make absolutely no sense. We have already established that transwomen have significantly greater lean/fat-free mass, and this paper is interested in determining equitably in sport performance. In general, sports aren't divided out by mass (and certainly not by lean mass), therefore we are interested in absolute differences, not in differences adjusted by some other factor. (Particularly not when that factor is established to be significantly different between transwomen and ciswomen!)

The same criticism applies to their analysis of cardiac function. But even more importantly, "the most crucial variable influencing VO2_max was not assessed in the present study" which is a significant oversight given the stated goals of this paper.

There are numerous other limitation and issues with this report:

This study is of "cross-sectional design, making it challenging to establish causation or examine if the performance of athletes changes as a result of undergoing GAHT"

"The athlete training intensity was self-reported. Therefore, the results may suffer from selection and recall bias." [emphasis mine] -> In other words, these results may be "comparing apples and oranges" with varying rates of fitness impacting the results.

"The athletes participating in the present study represented a variety of different sports, and this would have undoubtedly impacted the results of the study as different sports stress different training and sports modalities." [emphasis mine] -> This is a significant limitation, as comparing the strength of a ciswoman weight lifter to a transwomen distance runner (or vice versa) is meaningless. It's true that measures of fitness tend to correlate, but comparing across sport disciplines for highly competitive sports (where they are focusing on improving specific characteristics) distorts the results. (They explicitly note this: "Exercise type, intensity and duration all have an impact on physiological responses and overall laboratory performance metrics.")

"Social media recruitment leaves this study open to sample bias"

"The gender-affirming treatment of the transgender athletes was not controlled"

"The participants were not screened by a clinician before participation, and any medical conditions were self-reported"

The transwomen in this study all suppressed testosterone to ciswomen's levels and increased oestradiol above ciswomen's levels. This is a limitation because this degree of success in hormone suppression is uncommon, meaning that even these these poorly-supportive results are likely inapplicable to the majority of transwomen. [3]

There is a significant conflict of interest: this study was funded by the IOC after they had already changed the rules to remove the "hormone suppression" requirement [4]

All in all, this study is a classic case of researchers misrepresenting their data in the study's abstract. The data they actually collected shows that transwomen on hormone suppression maintain significant advantages over ciswomen. Further, the flaws in the study limit the applicability of their results.

---

In addition, there are other studies that contradict this result:

This review [3] discusses numerous sources describing "the inherent male physiological advantages that lead to superior athletic performance and then addresses how estrogen therapy fails to create a female-like physiology in the male"

This review [5] found "the performance gap between males and females becomes significant at puberty and often amounts to 10–50% depending on sport" and that "longitudinal studies examining the effects of testosterone suppression on muscle mass and strength in transgender women consistently show very modest changes, where the loss of lean body mass, muscle area and strength typically amounts to approximately 5% after 12 months of treatment. Thus, the muscular advantage enjoyed by transgender women is only minimally reduced when testosterone is suppressed."

This study [6] found that transwomen "generally maintained their strength level" during "gender-affirming therapy".

This study [7] found that all physical advantages were present after one year and that some are retained even after years on hormone suppression. They also specifically hypothesized that "gender dysphoria could stimulate the opposite behaviour [differences in exercise habits] in transwomen, decreasing push-up performance and explaining why transwomen performed fewer push-ups than [cismen] prior to starting oestrogen." This motivation difference likely won't apply to elite athletes, which further supports the idea that transwomen athletes should not be competing with female athletes.

As this position statement [8] indicates we know that there are substantial differences in athletic performance for male and female people.* However, there is little high-quality, definitive evidence concerning the effects of hormone suppression/replacement on people's athletic performance. The current state of evidence suggests that hormone suppression/replacement fails to bridge the physiological gap between male and female people, but we need further higher-quality evidence to definitively prove this.

(That being said, the burden of proof here is on the people attempting to initiate a change; that is equitably between transwomen and female people should be (have been) established prior to eliminating biological sex-separation.)

*Before anyone jumps on this: this is not a moral difference. There is absolutely no reason why running faster or lifting heavier things would make someone "better". The biological difference in performance exists, but it does not in anyway suggest superiority of men over women. Beyond that, it is unsurprising that men outperform women on traditional sports given that sports were designed by and for men. In sports that cater to women's physiological advantages (e.g., endurance, flexibility), women outperform men. [9]

---

So, given all this, what would we actually need to make determine transwomen's relative advantage over female people?

The "perfect" study would involve (at least) these elements:

Random selection from the desired population(s) of transwomen (e.g., top-ranked athletes in a specific sport, non-athletic, etc.) with matched (for population) non-trans female and non-trans male controls

Observation (not self-report) of activity level prior to, during, and following a standardized treatment (hormone suppression/replacement) initiation

Continual measurement of various physical and athletic performance, preferably with a range of laboratory (e.g., spirometry, body measurements) and naturalistic (e.g., actual sports competitions) tasks along with monitoring the treatment and clinical/health issues in all participants (again, not via self-report)

Large enough sample sizes to allow for sufficiently powered tests of all groups/differences of interest

A double-blinded assessment approach (or "placebo" controlled) such that both the researcher assessing the participants and the participants do not know what is being evaluated until the study is complete. For example, you may tell one half the transwomen participants that you are tracking the long term health effects of the intervention (hormone therapy), while you tell the other half that you are assessing differences in athletic performance as a result of the intervention. This will allow for the evaluation of demand characteristics like the ones impacting [7].

There are likely even more factors I have not currently thought of. Of course, completing the "perfect" study would likely be almost impossible. It would certainly be impossible to do for every population of interest (e.g., Olympic weight-lifters, adolescent track and field athletes, sedentary office workers) at the same time.

That being said, a study that fails to include all of these factors (particularly the blinded approach, matching of control participants, and sample size) is not going to meet the standard of evidence needed to make decisions of this magnitude (i.e., choosing to change the priority from biological categorization to ideological categorization). In reality, we would likely need many studies that individually evaluate each group of interest (e.g., transwomen olympic-level weight-lifters vs female olympic-level weight-lifters), each applying as many of the ideal study characteristics as possible.

In conclusion, the IOC has failed to perform their stated duty to regulate and ensure fair competition in sports. There is no current evidence suggesting that transwomen have lost their male-advantage in sports, much less any evidence suggesting they are at a disadvantage.

References below the cut:

Hamilton, B., Brown, A., Montagner-Moraes, S., Comeras-Chueca, C., Bush, P. G., Guppy, F. M., & Pitsiladis, Y. P. (2024). Strength, power and aerobic capacity of transgender athletes: a cross-sectional study. British Journal of Sports Medicine, 58(11), 586-597.

Al-Ashkar, F., Mehra, R., & Mazzone, P. J. (2003). Interpreting pulmonary function tests: recognize the pattern, and the diagnosis will follow. Cleveland Clinic journal of medicine, 70(10), 866-881.

Heather, A. K. (2022). Transwoman elite athletes: their extra percentage relative to female physiology. International Journal of Environmental Research and Public Health, 19(15), 9103.

“International Olympic Committee Issues New Guidelines on Transgender Athletes.” NBC News, 3 Jan. 2024, https://www.nbcnews.com/nbc-out/out-news/international-olympic-committee-issues-new-guidelines-transgender-athl-rcna5775.

Hilton, E. N., & Lundberg, T. R. (2021). Transgender women in the female category of sport: perspectives on testosterone suppression and performance advantage. Sports Medicine, 51, 199-214.

Wiik, A., Lundberg, T. R., Rullman, E., Andersson, D. P., Holmberg, M., Mandić, M., ... & Gustafsson, T. (2020). Muscle strength, size, and composition following 12 months of gender-affirming treatment in transgender individuals. The Journal of Clinical Endocrinology & Metabolism, 105(3), e805-e813.

Roberts, T. A., Smalley, J., & Ahrendt, D. (2021). Effect of gender affirming hormones on athletic performance in transwomen and transmen: implications for sporting organisations and legislators. British journal of sports medicine, 55(11), 577-583.

Pitsiladis, Yannis MMedSci, PhD, FACSM; Harper, Joanna MS; Betancurt, Jonathan Ospina; Martinez-Patino, Maria-Jose; Parisi, Attilio MD; Wang, Guan; Pigozzi, Fabio MD, PhD. Beyond Fairness: The Biology of Inclusion for Transgender and Intersex Athletes. Current Sports Medicine Reports 15(6):p 386-388, 11/12 2016. | DOI: 10.1249/JSR.0000000000000314

Ro, Christine. The sports where women outperform men. (2024). From https://www.bbc.com/future/article/20240731-the-sports-where-women-outperform-men

[reasonsforhope]

"In an unprecedented transformation of China’s arid landscapes, large-scale solar installations are turning barren deserts into unexpected havens of biodiversity, according to groundbreaking research from the Chinese Academy of Sciences. The study reveals that solar farms are not only generating clean energy but also catalyzing remarkable ecological restoration in some of the country’s most inhospitable regions.

The research, examining 40 photovoltaic (PV) plants across northern China’s deserts, found that vegetation cover increased by up to 74% in areas with solar installations, even in locations using only natural restoration measures. This unexpected environmental dividend comes as China cements its position as the global leader in solar energy, having added 106 gigawatts of new installations in 2022 alone.

“Artificial ecological measures in the PV plants can reduce environmental damage and promote the condition of fragile desert ecosystems,” says Dr. Benli Liu, lead researcher from the Chinese Academy of Sciences. “This yields both ecological and economic benefits.”

The economic implications are substantial. “We’re witnessing a paradigm shift in how we view desert solar installations,” says Professor Zhang Wei, environmental economist at Beijing Normal University. “Our cost-benefit analysis shows that while initial ecological construction costs average $1.5 million per square kilometer, the long-term environmental benefits outweigh these investments by a factor of six within just a decade.” ...

“Soil organic carbon content increased by 37.2% in areas under solar panels, and nitrogen levels rose by 24.8%,” reports Dr. Sarah Chen, soil scientist involved in the project. “These improvements are crucial indicators of ecosystem health and sustainability.”

...Climate data from the study sites reveals significant microclimate modifications:

Average wind speeds reduced by 41.3% under panel arrays

Soil moisture retention increased by 32.7%

Ground surface temperature fluctuations decreased by 85%

Dust storm frequency reduced by 52% in solar farm areas...

The scale of China’s desert solar initiative is staggering. As of 2023, the country has installed over 350 gigawatts of solar capacity, with 30% located in desert regions. These installations cover approximately 6,000 square kilometers of desert terrain, an area larger than Delaware.

“The most surprising finding,” notes Dr. Wang Liu of the Desert Research Institute, “is the exponential increase in insect and bird species. We’ve documented a 312% increase in arthropod diversity and identified 27 new bird species nesting within the solar farms between 2020 and 2023.”

Dr. Yimeng Wang, the study’s lead author, emphasizes the broader implications: “This study provides evidence for evaluating the ecological benefit and planning of large-scale PV farms in deserts.”

The solar installations’ positive impact stems from several factors. The panels act as windbreaks, reducing erosion and creating microhabitats with lower evaporation rates. Perhaps most surprisingly, the routine maintenance of these facilities plays a crucial role in the ecosystem’s revival.

“The periodic cleaning of solar panels, occurring 7-8 times annually, creates consistent water drip lines beneath the panels,” explains Wang. “This inadvertent irrigation system promotes vegetation growth and the development of biological soil crusts, essential for soil stability.” ...

Recent economic analysis reveals broader benefits:

Job creation: 4.7 local jobs per megawatt of installed capacity

Tourism potential: 12 desert solar sites now offer educational tours

Agricultural integration: 23% of sites successfully pilot desert agriculture beneath panels

Carbon reduction: 1.2 million tons CO2 equivalent avoided per gigawatt annually

Dr. Maya Patel, visiting researcher from the International Renewable Energy Agency, emphasizes the global implications: “China’s desert solar model could be replicated in similar environments worldwide. The Sahara alone could theoretically host enough solar capacity to meet global electricity demand four times over while potentially greening up to 20% of the desert.”

The Chinese government has responded by implementing policies promoting “solar energy + sand control” and “solar energy + ecological restoration” initiatives. These efforts have shown promising results, with over 92% of PV plants constructed since 2017 incorporating at least one ecological construction mode.

Studies at facilities like the Qinghai Gonghe Photovoltaic Park demonstrate that areas under solar panels score significantly better in environmental assessments compared to surrounding regions, indicating positive effects on local microclimates.

As the world grapples with dual climate and biodiversity crises, China’s desert solar experiment offers a compelling model for sustainable development. The findings suggest that renewable energy infrastructure, when thoughtfully implemented, can serve as a catalyst for environmental regeneration, potentially transforming the world’s deserts from barren wastelands into productive, life-supporting ecosystems.

“This is no longer just about energy production,” concludes Dr. Liu. “We’re witnessing the birth of a new approach to ecosystem rehabilitation that could transform how we think about desert landscapes globally. The next decade will be crucial as we scale these solutions to meet both our climate and biodiversity goals.”"

-via Green Fingers, January 13, 2025

[covid-safer-hotties]

Also preserved in our archive

By Samantha Fields

When Charlie McCone got COVID in March 2020 in San Francisco, he was 30, otherwise healthy and fit, not considered high-risk. His doctors told him he’d get better in a couple of weeks. He didn’t.

Eventually, weeks into being sick and with no real answers from his doctors, he turned to that place many of us turn to for medical information: the internet.

“I found a Facebook group with thousands of other people asking what’s going on, and I was like, ‘Oh my God,’” he said, “‘This is happening to so many other people.’”

It was already becoming clear then, in spring of 2020, that COVID could cause serious, lasting issues, including debilitating fatigue and brain fog, among many other symptoms. Because there was so much attention on COVID at the time, McCone said, “there was a lot of hope about the response to long COVID, I think, the first two years.”

Then in late 2020, Congress allocated over $1 billion to the National Institutes of Health for long COVID research. “There was this feeling that we’re going to have answers here in a few years,” he said.

But now it is a few years later, and that feeling has changed.

McCone is still sick. He’s not working anymore and can’t walk much more than a block. Roughly 20 million people in the U.S. are now estimated to have long COVID, maybe more. And that initial $1.15 billion NIH got for the RECOVER program — which stands for Researching COVID to Enhance Recovery — has yielded few answers and zero approved treatments so far.

“There’s been a lot of disappointment in terms of the program moving slowly and also focusing a lot on the kind of observational side of things,” said Betsy Ladyzhets, co-founder and managing editor of the Sick Times, a nonprofit news site focused on long COVID.

Most of the research money has gone into trying to learn more about what long COVID is — into clinical research, data collection and analysis and studies of electronic health records.

“Rather than what many people in the patient community and also the research community really want, which is focus on treatments, clinical trials,” Ladyzhets said.

There’s good reason for the focus on observational research, according to Dr. Serena Spudich, a neurologist and researcher at Yale who’s working with the RECOVER program.

“There has to be a very, very strong urgency for finding treatments,” she said. “And at the same time, we will only find treatments if we understand the condition properly.”

And understand what’s causing the many different kinds of symptoms people are having.

“Because long COVID is not one condition, it’s a very heterogeneous condition,” Spudich said. “And it’s very, very possible, I would even say likely, that different forms of long COVID — for example, the more neurologic forms versus something like severe shortness of breath or problems with the heart rate — those may actually be due to different types of biologic mechanisms that need different treatments.”

Outside researchers agree that these kinds of observational studies and data collection are critical, but some feel the NIH didn’t need to spend nearly $1 billion on them.

Dr. Ziyad Al-Aly, director of the Clinical Epidemiology Center and chief of the Research and Education Service at the VA St. Louis Health Care System, said his team and others did similar research earlier in the pandemic, “for peanuts, a few hundred thousand dollars that generated evidence much more robustly, faster, years ahead of RECOVER, for a small, small, small, small fraction of the funds.”

At this point, more than four years in, “NIH should be laser-focused, laser-focused on finding treatment for long COVID,” he said.

That will be a bigger focus going forward. NIH got another $515 million this year for RECOVER and plans to put much of it toward clinical trials.

This fall, it held a kickoff meeting for the next phase of the RECOVER program, called RECOVER-TLC, which stands for Treating Long COVID. Now, Joseph Breen at the National Institute of Allergy and Infectious Diseases at NIH said it’s in the process of soliciting ideas for drugs and other treatments to trial.

“We have every intention of getting started as soon as possible,” he said. “In reality, we’re probably into next year.”

David Putrino, director of rehabilitation innovation for the Mount Sinai Health System in New York, has been doing long COVID research since 2020. He said how the clinical trials are designed will be critical.

“What we need to be doing is rapidly testing as many drug targets as possible, rather than taking big swings,” he said. Meaning that instead of putting all the funding into a few big, expensive trials of a couple of drugs, RECOVER could do a bunch of smaller trials.

“For a couple million dollars apiece, they could be testing 100 drugs. And they could be logging the responses of those 100 drugs, and they could be moving into more sophisticated clinical trial strategies,” Putrino said. “That is where I think we should be applying the money.”

Many long COVID patients and advocates are cautiously optimistic about this next phase of research. Charlie McCone, who has become something of an expert in his own illness and now volunteers with the Patient-Led Research Collaborative, was at the kickoff meeting and left feeling a little more hopeful.

“The NIH can do this right, they have to do this right,” he said. “And they need to do it fast, which we know is possible.”

But no matter what comes of this current slate of funding, he said more is going to be needed. “No disease is solved with a one-time investment. And so, just because this first billion dollars didn’t produce much does not mean the next billion and the next billion won’t.”

Some legislators are already pushing for additional funding. Sen. Bernie Sanders, a Vermont Independent, along with several Democratic senators, introduced the Long COVID Research Moonshot Act in the Senate, and a companion bill has been introduced in the House. The Moonshot Act would provide $1 billion a year for 10 years for long COVID research. It has yet to be brought to the floor for a vote.

[bykalopsia]

Considerations Regarding the Experimental Subject's Evolution - Suga Kenzo Character Song EN Lyrics

*rough translation, apologies for any mistakes! **bolded lyrics were originally in english

Acid way In the corner of a dark room, glowing faintly A secret is locked up inside the glass I'll exhaust all means to perfect this Let's give this a shot— Break it, fix it up, see you tomorrow Acid way It's still not enough, talilalila A sweet trap, the statistics I'm seeking I'd love to know, let me let me know It's uncharted territory from here on out Won't you give it a try? For the sake of carrying out my ambition Sleep, sleep Fill in the evolution program The entwined molecules, I get it, for next time's sake— Carefully write down the deciphered figures The derived hypothesis, the possibilities are endless Let's put it to the test, this unknown technology Acid way It's still not enough, talilalila Give me a more detailed sample I've got it! Bake it bake it hot Reach a hand out towards that unknown realm The light that disappeared The scent that burns in the darkness Circulate, circulate It's embedded, a program of hope Yo! Analysis that continues deep into the night Intellectual stimuli that fills in the void Step by step, fit in the pieces Day by day, the data's enormous! The research subject's biological reactions, moreover, the consequent emotions Let's fill in even the meager variations Before I could notice, I'm already on my seventh cup of coffee! It's still not enough, talilalila Logic that surpasses all common sense No matter how far, deep deep dive Shall we create an even larger impact? Won't you give it a try? For the sake of carrying out my ambition Bet it all, towards the other side of humanity Search, investigate, put it to the test, even if I'm wrong I'm going towards the realm of dreams A program that continues even higher "Well then, why don't we move on to the next step?"

[myalgicencephalomyelitiscfstom]

Summary that was posted on social media:

1) Here it is, our overview of the most interesting ME/CFS studies of 2024. If you think we’re missing an important one, feel free to post it as a comment below

https://mecfsskeptic.com/2024-looking-back-on-a-year-of-me-cfs-research

2) A recent preprint used data from the UK Biobank and showed that there are many differences in the blood between ME/CFS patients and controls. Their analysis suggests that these differences are not due to inactivity or deconditioning.

3) The Intramural NIH study did the most extensive set of biological measurements ever conducted in ME/CFS patients but because of the low sample size (n = 17) and focus on ‘effort preference’ it has mostly led to disappointment.

4) The MCAM study recruited patients from 7 ME/CFS specialty clinics and assessed cognitive functioning in more than 200 patients. Accuracy was relatively normal but information processing speed was significantly lower in patients versus controls.

5) This year, the largest study on repeated cardiopulmonary exercise testing in ME/CFS was published. Although there were small to moderate effects, there was a large overlap between patients and controls. It is unclear if this procedure can be used as a diagnostic test.

6) 2024 also saw two big rehabilitation trials for children with ME/CFS: MAGENTA and FITNET-NHS. Both had null results suggesting that GET and online CBT (FITNET) are unlikely to be cost-effective.

7) We also had a new prevalence estimate using statistics data for NHS Hospitals in England. Extrapolating the highest rates to the entire UK would mean that 390.000 people (0.585%) get ME/CFS in their lifetime.

A Norwegian study showed how wages dropped dramatically and sickness benefits increased before and after an ME/CFS diagnosis.

9) Honourable mention: following the tragic death of Maeve Boothby O’Neill, Prof. Emeritus Jonathan Edwards wrote a paper on managing nutritional failure in people with severe ME/CFS, including suggestions that can supplement the NICE Guideline.

====== comment: Another excellent blog from this account. Note that the social media summary only highlights a few of the many studies that are discussed in the post. Saying that, I didn’t find it overly long either. Highly recommended.