#ExpertiseR

[poorly-drawn-mdzs]

Expertise can't help you here.

[demoprepmtl]

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[mynnthia]

was talking with a friend about how some of dunmeshi fаndom misunderstands kabru's initial feelings towards laios.

to sum up kabru's situation via a self-contained modernized metaphor:

kabru is like a guy who lost his entire family in a highly traumatic car accident. years later he joins a discord server and takes note of laios, another server member who seems interesting, so they start chatting. then laios reveals his special interest and favorite movie of all time is David Cronenberg's Crash (1996), and invites kabru to go watch a demolition derby with him

[im-ignoring-canon]

This isn't even a hot take, but Percabeth weren't smart x dumb. They weren't even book smart x street smart. They were strategic x strategic. Their minds worked in very similar ways that complimented eachother. It's why they were such great friends, it's why they were a formidable team, hell, it's why they could fight a war against a deity with an army of forty fricking kids and win. They shared their braincells, in the most beautiful sense of the phrase and THAT'S why, for me, they're perfect together.

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[w1f1n1ghtm4r3]

i need mpop to be real so much

[spidertroupeart]

Good morning sonadow nation

[theabigailthorn]

"Good" Acting

i have a theory that a lot of people say acting is "good" when they're emotionally moved by it, and a lot of cishet white people have a lifelong habit of not listening or empathising when minoritised people speak, so minority actors get called "bad" even when they display some pretty fucking amazing technical skill

[lolababyelf]

Violet: *Glares*

Bodhi *flinches*: Xaden’s been rubbing off on you Sorrengail

Ridoc: *snorts* I bet he has

[maydayway]

derek morgan’s career history pre bau is crazy, so much expertise i wish they’d used it more

[fluentisonus]

not an uncommon idea to come across but I'm so fascinated by how much about this view of ancient history/culture/myth tradition is unintentionally & straightforwardly revealed by the phrase "and therefore the origin" here -- not just the assumption that these things exist in a strictly linear progression ("greece" exists then "rome" exists) where "greece" and "rome" are the only players (where does pre roman italy fit into this worldview? what room is there here for the influence of ancient north africa and west asia on greece? these places are effectively erased off the map), but the idea of greece as an "origin" of "art and mythology", that in greece it somehow developed whole cloth & completely undiluted by the sort of "cultural borrowing" they perceive the romans are doing. I always find this sort of view of greece as contextless & devoid of movement and trade until it comes time to pass the things they've apparently independently invented on to rome (or have it stolen as some would see it) frustrating, as well as the view of rome as a sort of copy pasted greece with no other influence or separate or preexisting traditions, really frustrating & honestly occasionally kind of sinister tbh

[prokopetz]

My knowledge of superhero comics isn't deep so much as it is frustratingly eclectic. Like, I might well completely fail to recognise a character who's been a regular member of the X-Men for thirty years, but if you need somebody to explain from unprompted memory the complete plot of Spanner's Galaxy, I'm your guy.

[mischievous-thunder]

Logan's two moods when it comes to Wade:

Meanwhile Wade's a simple lover:

[biggest-gaudiest-patronuses]

i will never understand why more people in their 80s don't commit felonies. you reach that age and surely there's something illegal you always wanted to do but didn't bc Consequences

dammit, GO FORTH GRANNIES!!! rob an armored car! hold up that bank! tunnel your way into fort knox! what are they gonna do, sentence you to 20 years? good fuckin luck with that

[yeoldenews]

I'm not sure if you'll know the answer to this, but for the regency era, how common are contractions in letters and speech? Not the "Wm." for William kind, but your standard "couldn't," "wouldn't" and "shouldn't?" Thanks!

All common English contractions did exist by the Regency period. However, there is very limited period documentation or scholarly research as to whether they were viewed as "proper" English or not at the time.

Contractions were first used in the English language sometime in the last half of the 16th century, and by the late 17th and early 18th centuries were approaching what most people today would probably consider over-use.

By the time the Regency era rolled around however, many older uses of contractions had already fallen, or were in the midst of falling, out of favor. 'Tis, 'twas, ne'er, e'er, e'en, tho', thro', etc., were mostly confined to poetry by the early 19th century (though 'tis seems to have hung on a little bit longer than the others).

The last half of the 18th century had also already seen the almost complete disappearance of the most common use of English contractions in the 17th and early 18th centuries - using 'd in place of -ed - as seen here in an example from the 1736...

The frequency of use of contractions in the Regency period specifically, seems to have varied greatly from person to person. Jane Austen herself used very few contractions in her novels compared to some of her contemporaries. Couldn't, wouldn't and shouldn't do not appear at all in Pride & Prejudice, Sense & Sensibility or Emma, and all other contractions were used very sparingly.

In P&P, I counted one appearance of "I'm", one of "you'll", one "won't", two "can't"s, three "shan't"s and six "don't"s.

I compared this to Evelina, by Frances Burney (published in 1778) which (just in Volume One) includes: 14 occurrences of can't, 4 of won't, 35 of don't (vs only 15 of 'do not') and 11 of shan't (3 spelled shan't and 8 sha'n't).

Though couldn't, wouldn't and shouldn't all appear in Evelina as well (in an archaic forms which included a space between the modal verb and n't: could n't, would n't, should n't), I did notice they are used much more by lower class characters than by upper.

There seems to be some evidence that negative contractions (those ending in n't) began to be considered improper English in the latter half of the 18th century, and subsequently generally fell out of favor with the upper classes.

The Grammatical Wreath... by Alexander Bicknell, published in 1790, specifically cautions against using contractions in correspondence with social superiors.

"And be careful in not omitting any letter belonging to the words you write; as, I've, can't, don't, shou'd, wou'd, &c. instead of I have, cannot, do not, should, would; for such contractions not only appear disrespectful and too familiar, but discover ignorance and impudence."

This very interesting paper (which you can view in full if you have a free JSTOR account) analyzes the grammatical trends found through 50 years (1730s-1780s) of the correspondence of writer Elizabeth Montagu. The author marked a significant falloff in the use of negative contracted modal and auxiliary verbs over the course of Montagu's letters. In the 1730s Montagu used un-contracted negatives 62% of the time and contracted 38%, but by the 1780s Montagu used no contacted negatives at all.

Granted these are only the letters of a single person and, as the author notes, could have many other explanations (age, change in social class, familiarity with the correspondent, etc.), it does seem to reflect what I've personally observed in writing from this period.

So the answer to your question is - yes, contractions existed and yes, they were in fairly common use - with the asterisk that how they were viewed by society is not terribly well documented for the Regency period.

So I'd personally say feel free to use them in any Regency era stories you may be writing, but do so sparingly with very proper or upper class characters.

If you're aiming for very authentic period flavor, you could also try throwing in some contractions that have fallen out of use over the past two centuries - shan't, mustn't, needn't, mayn't, etc. I'd especially recommend using 'shan't' in place of 'shouldn't' where appropriate, and also remembering that if you're using 'can not' instead of 'can't' it is always one word - cannot.

One thing that is period authentic, but I won't personally recommend to any Regency era writers (unless you want to throw some meta commentary on the chaos that is the English language into an epistolary) - is that no one really agreed where to put the apostrophe in wouldn't/couldn't/shouldn't until well into the 19th century. It's very common to see the n't separate as in the examples from Evelina, but I've also seen wou'd'n't, would'nt, wou'd'nt, etc. etc. etc., sometimes multiple different ways within a single paragraph.

Hope some of that was helpful. I had fun digging into it!