#Medical Transplants

[reasonsforhope]

"The first modern attempt at transferring a uterus from one human to another occurred at the turn of the millennium. But surgeons had to remove the organ, which had become necrotic, 99 days later. The first successful transplant was performed in 2011 — but even then, the recipient wasn’t immediately able to get pregnant and deliver a baby. It took three more years for the first person in the world with a transplanted uterus to give birth. 

More than 70 such babies have been born globally in the decade since. “It’s a complete new world,” said Giuliano Testa, chief of abdominal transplant at Baylor University Medical Center.

Almost a third of those babies — 22 and counting — have been born in Dallas at Baylor. On Thursday, Testa and his team published a major cohort study in JAMA analyzing the results from the program’s first 20 patients. All women were of reproductive age and had no uterus (most having been born without one), but had at least one functioning ovary. Most of the uteri came from living donors, but two came from deceased donors.

Fourteen women had successful transplants, all of whom were able to have at least one baby.  

“That success rate is extraordinary, and I want that to get out there,” said Liza Johannesson, the medical director of uterus transplants at Baylor, who works with Testa and co-authored the study. “We want this to be an option for all women out there that need it.”

Six patients had transplant failures, all within two weeks of the procedure. Part of the problem may have been a learning curve: The study initially included only 10 patients, and five of the six with failed transplants were in that first group. These were “technical” failures, Testa said, involving aspects of the surgery such as how surgeons connected the organ’s blood vessels, what material was used for sutures, and selecting a uterus that would work well in a transplant. 

The team saw only one transplant fail in the second group of 10 people, the researchers said. All 20 transplants took place between September 2016 and August 2019.

Only one other cohort study has previously been published on uterus transplants, in 2022. A Swedish team, which included Johannesson before she moved to Baylor, performed seven successful transplants out of nine attempts. Six women, including the first transplant recipient to ever deliver a baby back in 2014, gave birth.

“It’s hard to extract data from that, because they were the first ones that did it,” Johannesson said. “This is the first time we can actually see the safety and efficacy of this procedure properly.”

So far, the signs are good: High success rates for transplants and live births, safe and healthy children so far, and early signs that immunosuppressants — typically given to transplant recipients so their bodies don’t reject the new organ — may not cause long-term harm, the researchers said. (The uterine transplants are removed after recipients no longer need them to deliver children.) And the Baylor team has figured out how to identify the right uterus for transfer: It should be from a donor who has had a baby before, is premenopausal, and, of course, who matches the blood type of the recipient, Testa said...

“They’ve really embraced the idea of practicing improvement as you go along, to understand how to make this safer or more effective. And that’s reflected in the results,” said Jessica Walter, an assistant professor of reproductive endocrinology and infertility at Northwestern University Feinberg School of Medicine, who co-authored an editorial on the research in JAMA...

Walter was a skeptic herself when she first learned about uterine transplants. The procedure seemed invasive and complicated. But she did her fellowship training at Penn Medicine, home to one of just four programs in the U.S. doing uterine transplants. 

“The firsts — the first time the patient received a transplant, the first time she got her period after the transplant, the positive pregnancy test,” Walter said. “Immersing myself in the science, the patients, the practitioners, and researchers — it really changed my opinion that this is science, and this is an innovation like anything else.” ...

Many transgender women are hopeful that uterine transplants might someday be available for them, but it’s likely a far-off possibility. Scientists need to rewind and do animal studies on how a uterus might fare in a different “hormonal milieu” before doing any clinical trials of the procedure with trans people, Wagner said.

Among cisgender women, more long-term research is still needed on the donors, recipients, and the children they have, experts said.

“We want other centers to start up,” Johannesson said. “Our main goal is to publish all of our data, as much as we can.”"

-via Stat, August 16, 2024

[healthcaretechnologynews]

Transplantation Market by Products (Tissue Products, Immunosuppressive Drugs), Application (Tissue Transplantation, Organ Transplantation), End User (Hospitals, Transplantation Centers) – Global Outlook & Forecast 2023-2031

According to the deep-dive market assessment study by Growth Plus Reports, the global transplantation market was valued at US$ 14.92 billion in 2022 and is expected to register a revenue CAGR of 9.47% to reach US$ 33.68 billion by 2031.

Transplantation Market Fundamentals

Transplantation, or organ transplantation, is a medical procedure in which a healthy organ or tissue is surgically removed from one person, known as the donor, and placed into another person, known as the recipient. Transplantation aims to replace a failing or damaged organ with a functional one, thereby improving or restoring the recipient's health and quality of life. Organ transplantation has become a life-saving option for individuals with end-stage organ failure, where other treatments have failed or are no longer effective. Common organs that can be transplanted include the heart, kidneys, liver, lungs, pancreas, and intestines. In addition, tissues such as corneas, skin, bone, and bone marrow can also be transplanted.

Transplantation has revolutionized medical care and significantly improved the survival rates and quality of life for many patients with organ failure. Efforts are ongoing to increase organ donation rates, promote organ sharing, and develop alternative approaches such as xenotransplantation and regenerative medicine techniques to address the shortage of organs.

Get Free Sample PDF including full TOC, Tables and Figures, and Available customizations: https://www.growthplusreports.com/inquiry/request-sample/transplantation-market/9283

Transplantation Market Dynamics

The prevalence of organ failure, such as end-stage renal disease, liver cirrhosis, heart failure, and lung disease, is rising globally. The growing incidence of these conditions fuels the demand for organ transplantation as a life-saving treatment option. According to the European Society of Cardiology, in the span of 1990-2017, the number of patients with heart failure doubled from 33.5 million to 64.3 million. Additionally, advances in surgical techniques, immunosuppressive medications, and organ preservation methods have improved the success rates of transplantation procedures. These advancements have made transplantation viable for a broader range of patients, increasing the demand for transplants and thus boosting the global transplantation market. Furthermore, efforts to expand the organ donor pool have contributed to the growth of the global transplantation market. This includes initiatives to increase deceased organ donation rates, living donor programs, and the use of extended criteria donors (ECDs) or marginal organs that may not have been considered suitable in the past.

However, the demand for organs far exceeds the available supply, leading to long waiting lists and significant challenges in organ allocation. The need for more organs restricts the number of transplantation procedures that can be performed and limits the market's growth potential. For instance, according to the Health Resources & Services Administration, each day, 17 individuals die while waiting for an organ transplant, and another person is added to the waiting list every 10 minutes. Transplantation procedures are complex and expensive, involving pre-operative evaluations, surgical procedures, post-operative care, immunosuppressive medications, and long-term follow-up. The high cost of transplantation can create financial barriers for patients, limiting access to transplantation and impacting market growth. Moreover, despite advancements in immunosuppressive medications, organ rejection remains a significant concern in transplantation. The recipient's immune system can recognize the transplanted organ as foreign and mount an immune response, potentially leading to organ failure. The need for lifelong immunosuppressive therapy can have side effects and complications, affecting patient outcomes. Additionally, organ shortage, rejection, and high procedure costs are some of the restraints impeding the overall market growth.

Transplantation Market Ecosystem

The global transplantation market is analyzed from the following perspectives: products, application, end user, and region. 

Transplantation Market by Products 

Based on the products, the global transplantation market is segmented into tissue products, preservation solutions, and immunosuppressive drugs.

The tissue products segment dominated the market with a principal revenue share of 55.4% in 2022. The increasing number of transplantation procedures, such as cochlear, heart valves, bone marrow, and orthopedic soft tissues, is attributed to the segment’s growth. Tissue products are the numerous forms of human tissues used for transplantation. Tissue transplantation involves specific tissues, such as corneas, skin, bone, tendons, and heart valves, rather than whole organs. These tissues are obtained from deceased donors and can be used to replace or repair damaged or diseased tissues in recipients. The availability of high-quality tissue grafts, advancements in tissue preservation techniques, and ongoing research and development in tissue engineering contribute to the segment's growth.

Transplantation Market by Application 

Based on the application, the global transplantation market is segmented into tissue transplantation and organ transplantation.

The organ transplantation segment accounted for a prominent share of the market. Organ transplantation focuses on the transplantation of whole organs from deceased or living donors to recipients in need of organ replacement. Organ transplantation is a complex medical procedure involving the surgical removal of an organ from a donor and its implantation into the recipient's body. Organ transplant surgeries involve the transplantation of a whole organ, such as a heart, liver, kidney, lung, or pancreas, from the donor to the recipient. Highly skilled transplant surgeons lead the surgical procedures, often assisted by a specialized surgical team. The surgical techniques and protocols vary depending on the organ being transplanted. The organs for transplantation are obtained from deceased individuals who have consented to organ donation or living individuals who voluntarily donate an organ. Donor evaluation includes medical history review, physical examinations, and various tests to assess the health and suitability of the organs for transplantation. These factors contribute to the growth of the organ transplantation segment.

Transplantation Market by End User

Based on the end user, the global transplantation market is segmented into transplantation centers, hospitals, and others.

The hospitals segment is a key player in the transplantation market, with the largest revenue share of 51.2% in 2022, being the primary treatment center for the transplantation procedure. Hospitals play a crucial role in all aspects of the transplantation process, from patient evaluation and pre-transplant care to surgical procedures, post-operative care, and long-term follow-up. Hospitals that have specialized transplant centers are at the forefront of transplantation services. These centers typically have multidisciplinary teams consisting of transplant surgeons, transplant physicians, nurses, anesthesiologists, social workers, and other healthcare professionals collaborating to provide comprehensive care to transplant patients. Hospitals perform transplantation surgeries involving donor organs or tissue implantation into the recipient's body. Transplant surgeons lead the surgical procedures, working with a specialized surgical team to ensure the successful transplantation of the organ or tissue. Hospitals must maintain state-of-the-art surgical facilities and adhere to strict surgical protocols. These overall factors contribute to the growth of the hospital segment. 

Transplantation Market by Region

Geographically, the global transplantation market has been segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. 

North America dominated the global transplantation market with the largest revenue share of 41% in 2022, attributed to advanced healthcare infrastructure, robust research and development activities, and a high prevalence of transplantation procedures. For instance, according to the Organ Procurement and Transplantation Network, in the United States, 42,887 organ transplants were performed in 2022, setting a record. North America has well-established transplantation programs and centers of excellence that have significantly contributed to the field. These programs have extensive experience in organ transplantation, advanced surgical techniques, and comprehensive post-transplant care. The region has many transplant centres in academic institutions and private hospitals, providing various transplantation services. 

Additionally, regional companies are continuously involved in partnerships, mergers, and acquisitions, which are also expected to improve the transplantation market outlook. For instance.  North America is at the forefront of technological advancements in transplantation. The region has witnessed the development and adoption of innovative techniques, including minimally invasive surgeries, robotic-assisted surgeries, improved organ preservation methods, and advanced immunosuppressive therapies. These advancements have contributed to improved patient outcomes, shorter hospital stays, and reduced complications.

Transplantation Market Competitive Landscape

The prominent players operating in the global transplantation market are:

Arthrex, Inc.

Astellas Pharma

Zimmer Biomet

21st Century Medicine

Veloxis Pharmaceuticals Inc.

BiolifeSolutions, Inc. 

Orthofix Medical Inc.

Amnio Technology

Transplantation Market Strategic Developments

In July 2022, Precise Bio partnered with Carl Zeiss Meditec to develop and commercialize tissue-based implants for ophthalmology. The firms will collaborate to create 4D bio-fabricated corneal transplants for patients requiring endothelial keratoplasty and natural lenticular transplants to treat keratoconus and vision correction.

In February 2022, Amnio Technology, a global pioneer in the development and marketing of amniotic tissue allografts, introduced two new PalinGen membrane products, PalinGen Dual-Layer Membrane and Dual Layer PalinGen X-Membrane. Like the whole PalinGen membrane product line, the novel allografts are minimally modified, analogous in usage, and devoid of the chorion. The dual-layered structure of the allografts allows for unidirectional application with two epithelial sides facing outward. The PalinGen membranes are manufactured using the patented Advantek technology, which retains the extracellular matrix components and regulatory proteins found in amniotic tissues. Keeping the properties of natural tissue helps in wound treatment.

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[morbidology]

A man holding his old heart after a successful heart transplant.

[hometoursandotherstuff]

This image shows a decellularized heart, stripped of all native cells, leaving behind an intact vascular system and a scaffold that has been infused with stem cells.

One of the greatest limitations to organ transplantation derives from organ rejection caused by antibodies of the transplant recipient reacting to donor antigens on cell surfaces within the donor organ.

By re-cellularizing an decellularized organ with a patient’s own cells, the adverse immune response is eliminated.

[swervesbar]

Mandroid was looking ROUGH this last batch of episodes.

[anuninterestingperson]

today is my 20th bone marrow birthday, aka the anniversary of my bone marrow transplant! on this day every year i like to remind people to check out their local bone marrow registry. signing up for a bone marrow registry is simple, and while it more often than not doesn't result in you being called to donate, having options available is the best way possible to make sure that people who need bone marrow transplants can get them. i'm only alive today because of a person who signed up at a drive and was willing to donate after, and i am eternally grateful to her and to everyone who registers!

big global registry here: https://bethematch.org/

worldwide list of registries here: https://wmda.info/find-your-registry/

thank you for listening and thank you thank you to anybody who's ever signed up~

[popsartattic]

Commissions Open

Hey all, my cat is sick and his vet bills have been pretty high so I'm opening up commissions again. I'll draw your OC or favorite character for you! I can do multiple styles, but my main four are a simple cutesy style, a cartoony style, anime style, or a slightly more complex semi-realistic style. Prices for most styles are the same but the cutesy style ones are cheaper because they're quicker and easier to draw. Anyway, here's the pricing-

CUTESY STYLE

HEAD/BUST:

Lineart - $10 Flat Color - $15 Shaded - $22 FULLBODY: Lineart - $18 Flat Color - $28 Shaded -$35

ALL OTHER STYLES

HEAD/ BUST:

Lineart - $18 Flat Color - $25 Basic Shading - $30 Fully Rendered -$40

HALFBODY:

Lineart - $25 Flat Color - $35 Basic Shading - $42 Fully Rendered - $50

FULLBODY: Lineart - $35 Flat Color - $55 Basic Shading - $65 Fully Rendered - $85

EXTRAS

Backgrounds/Props: $5-$50 depending on complexity. Simple gradient backgrounds or very simple patterns are free.

Extra Characters: 2/3 of base commission cost per character

All prices are subject to change and open to negotiation within reason (I'm willing to work with you, so long as you're negotiating in good faith). Prices will not change for an individual commission once a price has been agreed upon, of course. I reserve the right to add an extra charge for designs with excessive detail.

I currently have ten commission slots open.

I look forward to drawing your OCs and/or blorbos!

[freshestsquid]

a head transplant in three parts

[mindblowingscience]

A team of surgeons in New York has performed the world's first transplant of an entire eye in a procedure widely hailed as a medical breakthrough, although it isn't yet known whether the man will ever see through the donated eye. The groundbreaking surgery involved removing part of the face and the whole left eye – including its blood supply and optic nerve – of a donor and grafting them onto a lineworker from Arkansas who survived a 7,200-volt electric shock in June 2021. Aaron James, 46, suffered extensive injuries including the loss of his left eye, his dominant left arm above the elbow, his nose and lips, front teeth, left cheek area and chin. He was referred to NYU Langone Health, a leading medical center for facial transplants, which carried out the procedure on May 27. Transplanting an entire eye has long been a holy grail of medical science, and though researchers have had some success in animals – where they have restored partial vision – it's never before been performed in a living person.

Continue Reading.

[eldritch-muppetshow]

finally a semi-normal tf2 oc lmao. might adjust his design a little when i draw him again but w/e i’m happy with this ref rn

[reasonsforhope]

"In a highly-anticipated world-first, the Texas Heart Institute has successfully implanted an artificial titanium heart that uses the same technology as bullet trains to pump blood mechanically throughout the body.

Called the Total Artificial Heart (TAH), the feat is seen as a major step in keeping people alive for longer and longer periods while they wait for heart transplants.

Texas Heart partnered with the medical tech company BiVACOR to create the TAH. It’s a titanium-constructed biventricular rotary blood pump with a single moving part that utilizes a magnetically levitated rotor that pumps the blood and replaces both ventricles of a failing heart.

The benefit of using magnetic levitation is that none of the moving parts ever scrape or slide against each other, reducing friction, and dramatically increasing the longevity of the device. But what’s really cool is the TAH can pump blood at a rate of 12 liters per minute, enough to allow an adult male to engage in exercise.

The first-in-human clinical study, overseen closely by the FDA, aims to evaluate the safety and performance of the BiVACOR TAH as a bridge-to-transplant solution for patients with severe bi or univentricular heart failure. Following this first implantation completed at Baylor St. Luke’s Medical Center in the Texas Medical Center, four additional patients are to be enrolled in the study.

“The Texas Heart Institute is enthused about the groundbreaking first implantation of BiVACOR’s TAH. With heart failure remaining a leading cause of mortality globally, the BiVACOR TAH offers a beacon of hope for countless patients awaiting a heart transplant,” said Dr. Joseph Rogers, President and Chief Executive Officer of The Texas Heart Institute and National Principal Investigator on the research.

“We are proud to be at the forefront of this medical breakthrough, working alongside the dedicated teams at BiVACOR, Baylor College of Medicine, and Baylor St. Luke’s Medical Center to transform the future of heart failure therapy for this vulnerable population.”

Heart failure is a global epidemic affecting at least 26 million people worldwide, 6.2 million adults in the US, and is increasing in prevalence. Heart transplantations are reserved for those with severe heart failure and are limited to fewer than 6,000 procedures per year globally. Consequently, the US National Institutes of Health estimated that up to 100,000 patients could immediately benefit from mechanical alternatives.

The successful implantation of BiVACOR’s TAH highlights the potential of innovative technologies to address critical challenges in cardiac care, such as long transplantation waitlists.

“This achievement would not have been possible without the courage of our first patient and their family, the dedication of our team, and our expert collaborators at The Texas Heart Institute,” said Daniel Timms, founder and CTO of BiVACOR."

-Article via Good News Network, August 1, 2024. Video via 7News Australia, July 26, 2024.

[lifewithaview]

Sela Ward and Hugh Laurie in House (2004) The Mistake

S2E8

Chaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.

*At the beginning of the episode, Kayla's daughters tell her that Sally Ayersman has been teasing them, to which Kayla responds, "If Sally's mean to you again, I'm just gonna have to key her daddy's new convertible." However, later in the episode, House blackmails a surgeon into doing Kayla's liver transplant. The surgeon is a Dr. Ayersman, whose wife, getting an "anonymous" tip about her husband's cheating, decides to key his new convertible. In House's words, "Enough irony for us all."

[purplefiction-ao3]

Processing medical trauma through fanfic? Yes, please.

This fic is super personal to me and feels quite like I’m baring my soul to everybody. I’ve never been quite so open with my medical journey but it’s helping me dissociate from my current severe pain, and helping me organize my thoughts about my trauma. So that’s nice.

If you read it, I’d love to hear any thoughts or questions you have! 💜

[addictsitter]

chambers (2019) | episode two: "right to know"

[bihansthot]

I’m probably not going to be around much today lovelies, as I mentioned earlier in the week it’s the 25th anniversary of my heart transplant and ngl it’s weird. I’m in a weird place today, I’m trying really hard not to be sad or upset or think about how traumatic that night was. I don’t remember a lot about the night but I remember the phone ringing late at night maybe just after midnight and I remember going into my parents bedroom, they didn’t have to come get me, and I said “it’s time”, I just knew it as soon as I heard the phone and they confirmed it and we relatively calmly got our stuff and drove to the hospital. I had no idea what I was getting into and had I known, I would have not reacted as calmly as I did. I remember they had to draw blood before the procedure to use during the operation, I remember it taking over 25 attempts to get all the blood they needed and I was sobbing, I was in so much pain and I absolutely hated getting my blood drawn as a kid and while 14 isn’t exactly a little kid anymore it’s certainly not an adult either. I still remember the nurse who was there with us, she had a very distinct, raspy voice despite being quite young and to this day people with that type of voice bring back this very unpleasant memory. I don’t remember anything after the blood draw, they give you medication to help you forget traumatic operations and it doesn’t get much more traumatic than a heart transplant. I don’t really remember much of recovery either, I do remember how painful it was when they made me walk though. I wanted to go home and they said I had to walk to the end of the hall to go home and if I couldn’t do it they would keep me at the hospital another day. You better believe I dragged all my various IVs and monitors down that hallway in an instant. My incision was bleeding afterwards and I felt like I was going to collapse but I held that shit together like the stubborn ass I am and gave them a smile and told them it was nothing and I was ready to go. Shockingly they didn’t notice the bloody incision or my clear exhaustion and I was allowed to go home after only 7 days which at the time was a record. The weeks and months that followed were absolute agony, a heart transplant is a ridiculously painful procedure the only time I’ve ever been in more physical pain is when I threw up from my painkillers after having my tricuspid valve replaced 10 years ago. It was awful, I couldn’t even wash myself, I had to have my mother give me a bath like I was a five year old and that was humiliating but I couldn’t do anything about it, it was just too painful to move my arms to wash myself when my whole sternum had been ripped open and was now held together by twist ties and super glue. Then there was the near constant pain from the weekly biopsies to check for rejection, they basically jam a catheter into your neck and then rip little chunks of your heart out to check to make sure your body isn’t rejecting the organ. On top of all that I gained so much weight from the medications and steroids I was on and my mother was an absolute monster about it. We had a very bad very toxic relationship during this time, she ridiculed me constantly but I depended on her for so much that I couldn’t do anything about it. I was so miserable and wanted nothing more than to die. I don’t want to get to into it though but it was really hard so trying to think positively about today is really difficult but on the positive side of things I’m still here. I made it through all that hardship, all that struggle, all that physical and mental anguish. I survived. For 25 years I have survived and while everyday hasn’t been easy, I didn’t give up. I guess I deserve to celebrate that at least even if I don’t like dwelling on all the misery I’ve endured. So, happy anniversary me, you’ve done the best you could and deserve a nice celebration. I know a lot of you lovelies aren’t going to read this but if you do, thank you, I appreciate you taking the time to get to know me outside of being a horny Bi-Han fangirl. 💙