#e-learning accessibility
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imrovementcompany · 1 year ago
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Unlock the Power of Continuous Learning with Udemy's Frequent Sales
In today’s fast-paced world, continuous learning has become a necessity. Udemy, a leading provider of online education, embraces this principle by offering a variety of sales throughout the year, making a vast selection of courses accessible to learners worldwide. Since its inception in 2010, Udemy has dramatically expanded its course offerings, now boasting over 155,000 courses taught by 70,000…
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edwardian-girl-next-door · 1 year ago
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The thing I love about Victorian and Edwardian fashion is that even if I don't like a piece of clothing, even if it's an affront to God and the most unfortunate combination of colours and drapery, I am ALWAYS stunned into appreciation when I see the details. The amount of minute, manual attention paid to each square centimetre of cloth is mindblowing. I can just imagine someone stooping over that corner of sleeve sewing on each individual bead or lining up the waist tape in a work dress or arranging the frills with a host of finicky pins. I wish each piece of my clothing was as unique and full of dedication and character
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clonerightsagenda · 3 months ago
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Faculty fear me: every time a student tells me an instructor keeps blowing them off I look up the relevant division chair's name and give it to them
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oreolesbian · 2 years ago
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does… does dave filoni know that the whole “anyone can be force sensitive if they put their mind to it” bullshit fundamentally shatters the entire core of star wars world-building around force users? like - does he understand that?
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volfoss · 2 years ago
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I cannot recommend enough starting game series from the start. Both because if you get used to the clunky gameplay of earlier ones, the later ones will be easier (from experience, going the other way just makes the originals seem IMPOSSIBLE) and also bc it does in fact help w understanding the story. Also because honestly old games are so cool
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timelesstricksteraltar · 6 days ago
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Discover the Future of Digital Education with LSDB
Discover LSDB's self-paced online education, driving digital business innovation with flexible e-learning modules and adaptive platforms. Access 24/7 expert-led courses in business management and digital transformation frameworks, supported by a domain-focused consultancy panel.
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sed-official · 3 months ago
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i saw this post and decided that i had some time spare, i could give AI another go. (link to post https://www.tumblr.com/dibelonious/778852078032404480/now-that-ai-made-troubleshooting-ridiculously. dont harass the poor old sod obviously.)
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i hear a lot of people irl at uni and some online say ai is great for coding, and so every couple months i try it out. sometimes with a very small project in a popular language (python or c, usually. though im forgiveful with c as everyone fucks up c.), sometimes with something simple (i.e. a couple lines tops with a naive approach if written idiomatically) but in a more unusual language with full documentation online. (like sed! yay!)
but every single time i come to the conclusion that even with being handheld chatgpt could not do what it was asked to do. even if someone tells it every issue in its outputs, itll remember for only one prompt. even if someone tells it the solution, itll find a new way to fuck it up.
below the cut is me trying to get chatgpt to make a working sed script that prints "meowwwwwwwwwwwwwwwww..." (long post warning)
(if anything reads weirdly, this was originally a reblog to the screenshotted post, then i decided to make it its own post. so that may be why.)
i cant remember the last time i ran into an issue that i couldnt fix in like ... 5 minutes. but knowing what chatgpt is like, any ask i give it will give me issues to troubleshoot. (yes this example is code, not linux proper. but its more of the same doing that.)
the other day i decided to write "meowwwwwwwwwwwwwwwwwwwwwwwwwwwww....." in many different languages, after seeing @brainfuck-official do it in BF. (link to post https://www.tumblr.com/brainfuck-official/773510105608192000) as is my blog, i asked it to do this in sed.
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great! this script doesnt work! it doesnt even come *close* to working, giving me plenty to try out chatgpt's troubleshooting skills! it also just doesnt make much sense. why the shebang but not making it executable? and why are the flags different (ones -f, ones -nf). also a counter? why though? thats not what im asking for? (you can see tags for a brief explanation on how to add a counter)
after telling it the script doesnt work (and why, something someone troubleshooting likely wont know) it just adds in a P. a command that prints a damn newline. but it lies about it printing a newline.
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(if you dont believe it prints a trailing newline and believe the AI instead, just try echo -n foo | sed -n 'P ; P')
anyways it alternated between no print statements and printing with newlines for the next ... 8 prompts, by which time i felt sorry for the poor bugger and told it to use e to print without a newline.
all the while it was trying to be more useful and add a count - making it print my string after n repeats instead of the infinite that i asked for. it was trying to subtract 1 with effectively s/[0-9]+/&-1/ which just appends the string "-1" to a number!
anyways, i tell it to use "the e command". there are three different versions of the e command in sed, and only one of them makes sense here. which did chatgpt use? none! it used the e regex modifier! which executes your pattern hold, then turns the output into the new pattern hold. and does not print anything.
ill just screenshot the last couple interactions minus only the useless exposition it adds to every response so you can see how stupid it is
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ignoring sed's requirement for an input this is equivalent to the python
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to be fair i never said there shouldnt be infinite meows, and this does have infinite Ws. but come the fuck on. this is clearly not whats being asked for.
#linux is best - yes. but learn to troubleshoot properly.#blindly copying code online without understanding it isnt troubleshooting.#regardless if that code came from stackoverflow or chatgpt.#anyways maybe it wouldve been better to write the equivalent in C with gotos and labels?#but at least everyone knows python#and i dont need to write c this way#also decided to see if it could find any info about me if i give it my name and county of origin#which is identifiable information but its outdated as ive changed my name (trans :3) and moved away.#anyways it thought i was from l*nd*n.#i told it where i was from (West Country. Very Much Not london.) and it thought i was a londoner. what in the hell.#yes if i said the name of most counties to an american online theyd probably think its in london.#but thats before they google the damn place! and this bot has access to the whole internet!#(for the yanks: it did the equivalent of calling an appalachian a californian)#(or at least i think thats close enough. im not really all that sure about what happens over the pond. and i like my ignorance here.)#wait the documentation tells you how to make a counter. at least twice.#IT COULD COPY CODE FROM THE INFO PAGES FOR THE COUNTER AND IT STILL GOT IT WRONG EVEN AFTER BEING TOLD WHY ITS WRONG#oh my god.#anyways in the docs they wanted to print the number. you can just hold n chars and remove one each loop#then break the loop when your hold is empty.#thats the easiest way ive found of looping n times (if you need the hold do this on a prepended line)#(not efficient but you can make it more efficient if you want. the docs explain how to! but its more effort and easy to fuck up soooooo...)#printing n ws though? just use e printf like it bloody demonstrates itself#no need to do inefficient shit in sed when someones written it in c for you.
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dtplabsservices · 7 months ago
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DTP Labs has a full-fledged multimedia department, offering multimedia engineering services to diverse clients. Utilizing cutting-edge editing tools, this department is staffed with a skilled team capable of managing media engineering for presentations, animations, e-learning courses, and product demonstrations. https://www.dtplabs.com/localization-of-e-learning-content/
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publishingservice · 10 months ago
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Transform Learning with Amnet's Unique E-Books!
Amnet's e-books provide interactive, multimedia-rich information suited to digital learning. Our adaptable digital textbooks improve accessibility and engagement, allowing for a variety of learning styles in modern institutions. Discover Amnet's cutting-edge e-books and enhance the reading experience. Check It Out
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transcriptioncity · 1 year ago
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Translation Services and Subtitling Services for Online Tutorials
Online learning has seen a significant rise, especially post-pandemic. Accessible and effective communication is crucial in online education. Key tools like transcription, translation, subtitling, live captioning, and note-taking enhance the learning experience. The Rise of Online Learning The shift to online learning accelerated during the pandemic. Many institutions and learners had to adapt…
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latest-info · 1 year ago
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The Role of Technology in Unveiling Knowledge Horizons
Introduction In today’s rapidly evolving world, technology plays a pivotal role in reshaping the horizons of knowledge. The unprecedented pace at which technology advances enables us to access, analyze, and disseminate information like never before. This article delves into how technology is unveiling new knowledge horizons, transforming education, research, communication, and societal…
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elearningmania · 1 year ago
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 e-book reading experience MagicBox.
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cartoonistcoop · 2 years ago
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The #ConnectingGaza campaign supplies E-Sims to people on the ground in Gaza, allowing them to circumvent internet disruption/blackout during the siege and continue connecting with the wider internet. A digital SIM card (called an e-SIMs) works the same as a physical SIM Card, providing data and SMS for a phone number. E-Sims are one of few resources that can be directly accessed without blockage by people on the ground in Gaza.
Artists will be offering art in exchange of the value of the donated e-SIMs. Visit https://cartoonist.coop/esims4gaza to learn more.
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goatgoesmbe · 4 months ago
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tw : sexual theme, stalking, 141 being a creep
A series : part 2 of Discord shenanigans
AO3
Word count: 2031
rated: E
Poly!141 x f!reader
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The New Member
The server wasn’t meant for public in the first place.
It was just something quick Johnny made just to have a little corner to hang out when they were on leave.
They rarely used it at first, finding no reason to communicate outside of work, they were busy with their own life anyway.
That was, until Johnny started sending pictures of literally anything in his daily life. It started with scenery, dogs he saw during walks, and selfies. Soon enough, Simon joined in with his own blurry pictures, then Kyle’s award-worthy photography, and John who sent the most normal pictures of some nice views worth sharing.
Eventually, interacting through the server became so regular that they started using it when they got back on base too– They never talk about something confidential in it of course, they were still professionals after all.
The gaming session was Kyle’s idea (Well, actually it was Johnny but he couldn’t convince them to play among us), they started playing various FPS games before settling for the popular one.
Kyle played casually, Johnny played competitively (and sucked at it compared to the others), John played it rarely but was pretty decent at it, while Simon was effortlessly good at it (Which he was so smug about).
The members consisted of people they knew from their jobs, so imagine their surprise when there was a notification about a new member.
You.
They welcomed you in a friendly manner, showing no suspicion despite John telling Kyle to do a background check immediately. And oh do they like what they see.
Pretty thing that you are, messy hair, pouty lips, dark bags under your eyes that only made you look more adorable rather than off-putting, like a sleepy panda. You always wore comfortable clothes oversized shirts or hoodies on colder days while your legs were bare, sitting crosslegged in your gaming chair with a big plushie in your lap. Johnny wondered if you wore anything underneath which made them go silent. made them think.
Fuck.
It was illegal and immoral, but really– everything they had ever done was all of those things and more, so what’s a bit of hacking into the webcam of a bonnie thing like you? It was done for their own safety after all, keeping their secrets as members of a highly classified military task force. It was only normal for them to check for any individuals that got into their space. Just in case.
Sure, they could just drop it when they found out that you were just a harmless civilian, but they also learned that you were just a sweet thing.. they immediately took a liking to you, adored you, so of course they had to keep an eye on you because they wanted to make sure you were alright. Keeping a civilians safe was part of their job, right?
You live alone, which made sense as to why you have CCTVs around your place. Smart girl, looking after your security seriously. Adorable.
Was it creepy for them to have access to those CCTVs? They just cared about your safety is all, was it wrong?
Well, they didn’t really care if it was, they were in too deep already, addicted to watching you in your own world, from your pretty face looking adorable as you focused on the game you were playing, the chime of your giggle when Johnny sent something stupid, to the way those innocent eyes showed no suspicion when one of them slipped up.
“Not as bonnie as you ;)” Johnny sent one time.
“You don’t even know what i look like XD”
Fortunately, you were oblivious. But still, they need to be more careful in the future. Johnny had a limp the next day and his body was covered in marks that peeked from the t-shirt he wore. But from how he barely covered them and how he still had that smirk on his face, it looked like he would definitely do it again if it would have John sending Simon to punish him.
Watching you had become a group routine. When they weren’t in the same room, they just hopped on the hidden channel Johnny made just to ping each other whenever you were doing something that would pique their interest.
Kyle enjoyed watching you go about with your routine, waking up at noon, cooking up something simple for yourself before you lock into your PC to do your freelance job then hopped into video games. His favorite was when you did your skincare, hand went down to cup the bulge in his pants as he watched you putting on lotion all over your body. His eyes darkened at the thought of him doing it instead, sliding his hand up your legs, lathering them nicely, and perhaps sneaking an opportunity for a feel of your clothed pussy when he reached your inner thighs.
Johnny likes to watch your reaction whenever you two interact, relishing your flustered expression from his relentless flirting. He wondered if you would also be shy under him, squirming as you tried to hide your face while he took off your clothes. He would click his tongue as he pried your hands off your face and gripped both of your wrists in one hand before pinning them above your head, one knee lodged between your legs to prevent you from closing them.
John’s favorite part of your day was when you were working. Tongue peeking out slightly in concentration, your doe eyes shifted and looked sharper when you were focused. He was there when you were in an online meeting with your employer, even though noone noticed. As he watched you talk, he liked to imagine that you were working for him instead. Talking formally unlike how you usually were when you were talking to them, he imagined you calling him sir like how you called your current boss. The bastard that made you uncomfortable with the way he leered at you, making innuendos while you tried your best to keep the conversation professional. You poor thing, don’t worry, John will teach him a lesson or two about respecting you. And yes, he was a hypocrite since he was lazily pumping his shaft under the desk as he watched you doing your job.
Simon rarely said anything about it, but out of everyone in the server, he was a constant presence with how the view count never went below one. He wasn’t picky, he liked watching you doing anything, even when you were just sleeping, he’d fuck his fist messily at the view of you being so vulnerable and oblivious before shooting his cum all over the screen with your face displayed on it. He was the one who would ping the others to notify them when you were doing something he knew they would be interested in.
Like right now.
It had been a long week, you barely had time to do your hobby. Projects after project that got you awake until two am before a quick wink of rest until you had to wake up again at five. When you were looking forward to doing something fun but then finding yourself too tired to even play your favorite game. And then you’d feel bad for neglecting your hobby as you continued to be enslaved under capitalism.
You were tired, sleep-deprived, stressed, and pent-up. At times like this, you were glad that you worked from home. You couldn’t imagine yourself not snapping at people if you work in an office with coworkers. Couldn’t even find the energy to open the server these past few days since you didn’t want to interact with anyone.
So naturally, they would miss you. Naturally, they were very excited when Simon pinged all of them in the hidden channel.
The light in your room was dimmed, but they could see your figure just fine. Panting on the bed on your back, legs spread wide with your hand between them while your other hand was clutching a pillow which you use to hide your face. 
John growled, fingers twitching as he thought of taking it off you so he could see what kind of expression you were making. Instead, he gripped Kyle’s dick as the younger man rolled his hips with the Captain bottoming out in his ass as they were both settled on the couch.
Johnny pulled away from Simon’s cock with a lewd pop. “She could fit mair than that..” he panted before Simon shoved his dick back in the scot’s mouth, gloved hand gripping at his mohawk.
His words got them zeroed in on your cunt which was stuffed with your fingers deep to your knuckles. Wet squelching noises combined with your needy whines echoed around the rec room from the cheap speakers as the stream was displayed on the wall from the projector. Johnny was right, you could take more than that. And from the way you desperately bucked your hips as you moved your fingers that fast, they could tell that you wanted to take more either.
“Does she not have a fucking toy?” Kyle groaned as he jacked off with the same tempo as your fingers as he continued to move in John’s lap.
“No” Simon responded curtly. He would know, he was the one who always kept an eye on you more than anyone else after all.
He knew you didn’t have a partner and never brought anyone home. You rarely go out and when you do, you’ll be back soon enough. A quick trip to the grocery stores or some shops, as shown by the trackers he put in your phone. Low possibility of you seeking out to anyone. Perhaps it was odd for some people but he wasn’t complaining, because he was only willing to share you with the men he trusted his life with.
You rarely pleasure yourself either, which made a moment like this more special. At first, he expected you to whimper out someone’s name, a crush they didn’t know about perhaps. Fortunately, that never happened. You seem content with yourself like this, eyes closed as you focus on the way you curl your fingers and grind your palm against your clit.
But they could tell you wanted more. They agreed that you deserved more. They could give you more.
Your whole body tensed, a shudder rippled through your body as heat built in waves. Breath hitching as you gasped, soft at first before breaking into a moan, raw and unrestrained. Fingers clutching at your pillow, muscles tightening as pleasure peaked, your back arching instinctively.
A flush spread across your skin, a sheen of sweat caught the light. Eyes fluttered to a close, lips parted, as a final tremor coursed through your body before you melted into the afterglow, breathless and trembling.
Yet, your cunt still clenched around your fingers as you pulled them out, like it didn’t want to let them go, because you still wanted more. You whined, and they groaned at the expression on your face. Unsatisfied, but too tired to do anything about it.
After a moment of gathering your jumbled mind, you got up and headed to the bathroom for a shower. And while they knew it was impossible, they wished you had a camera there too.
As the men chased their own pleasures, they thought to themselves about how they could help. You were physically nowhere near them at the moment, and they didn’t want to scare you by being too upfront in the server. Didn’t want you to know what they had been doing behind your back.
The next day, an onslaught of sex toy ads kept popping up when you turned on your PC. It obviously pissed you off at first (especially with how one appeared when you share your screen during a work meeting), but eventually it made you consider getting one. And if you got a transfer to your bank account in the same amount you spent on it right after, if you received four dildos instead of one, they totally had nothing to do with it. Nope, they totally didn’t send you the exact copies of their cocks.
Next (soon)
A/N: I remember someone saying 'How are you gonna get a guy if you never leave your house' and this is my answer to that also, this series was supposed to be fun silly online friends story, so idk what happened here, I swear the story wrote itself I had nothing to do with it
open taglist : @partiallysame, @niazrzl, @iiriam, @sweetlike-sugarplum, @mordacioust, @boogeysmoth, @little-mini-me-world, @sxnshinebxcky, @lady-red-night-1234, @theycallmevalen, @z-wantstowrite, @c-moon20-12, @glitteryarcadefart, @purple-snowfox, @shylahstarzz, @mestrecadumaverick, @thereofrin, @crappity-craps-crap, @rottensage, @sirbonesly, @shinebright2000, @kittygonap, @savas-q1, @just-pure-trash, @sheep-from-rad, @wolfbc97, @dont-mind-me-just-existing-sadly, @lucienofthelakes
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cameronsbabydoll · 3 months ago
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NSFW ALPHABET — BLUE COLLAR RAFE CAMERON
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A — Aftercare ⟢ Rafe isn’t the most openly affectionate guy, but after sex, he’s all about making sure you’re okay—even if it’s in his own gruff way. He’ll pull you against his chest, rub a rough hand down your back, maybe even murmur a low, “You good, baby?” If he really wore you out, he’ll force himself to get up and grab you water, even if he groans about it. He likes seeing you fucked-out and satisfied, though, so don’t expect him to leave you alone too long—he’ll be running his hands over your body again in no time.
B — Body part ⟢ On himself? His arms. He knows he’s strong, and he loves how easily he can manhandle you with them. On you? Your thighs. Whether they’re wrapped around his waist, shaking beneath his touch, or pressed tight together while you try to act all innocent—he’s obsessed. Loves to squeeze them, grab them, spread them apart. If you’re wearing shorts? Good luck.
C — Cum ⟢ He’s messy, and he likes it that way. Loves to see you covered in it, whether it’s dripping between your legs or smeared on your stomach after he’s pulled out. If he finishes in your mouth, he’s watching, making sure you swallow—or else. But his favorite? Pumping you full and keeping you there, too big and heavy for you to squirm away.
D — Dirty secret ⟢ He’s thought about bending you over at the construction site more times than he’d ever admit. Even in broad daylight, even with his crew around. The idea of fucking you somewhere risky, where he could get caught with his pants down (literally), is a fantasy that plagues him. And yeah, he’s stolen a pair of your panties before. Just once. Maybe twice.
E — Experience ⟢ He’s been around, no doubt about it. He’s had his fair share of flings, girls drawn in by his rough hands and cocky smirk, but none of them mattered until you. He knows what he’s doing—he knows exactly how to touch you, exactly how to pull sounds from you that no one else ever has. And if there’s anything he doesn’t know? He’ll learn. Fast.
F — Favorite position ⟢ Anything that gives him control. He loves bending you over, watching his cock disappear inside you as he grips your hips. But if he really wants to ruin you? Missionary, so he can see your face, watch every little reaction as he stretches you out. And he definitely loves having you ride him—nothing gets him off faster than watching you struggle to take him.
G — Goofy ⟢ He’s not goofy, but he is cocky. Smirks when you whimper, teases you when you get all shy. If you accidentally moan too loud? “Damn, baby. Didn’t know you liked it that much.” But the second you try to turn it back on him, acting all sweet and playful? He’s flipping you over and showing you who’s really in charge.
H — Hair ⟢ He’s not meticulously groomed, but he keeps it in check. A little bit of hair, nothing crazy. As for you? He doesn’t care, as long as he’s got full access to you. And if he notices you cleaned up for him? That cocky smirk comes out in full force. “Went all pretty for me, huh?”
I — Intimacy ⟢ He’s more intense than romantic. He shows his affection through possession—gripping your jaw, pressing his forehead against yours, growling low praises when you take him so well. It’s rough, needy, overwhelming. But there are moments, quiet moments, when he softens. Like when he kisses your temple after, or holds you just a little tighter than necessary.
J — Jack off ⟢ He tries not to. He really does. But sometimes he’s stuck on a long job, or you’re teasing him without even knowing it, and he has to take care of it. Usually in the shower, thinking about you—about your body, your moans, the way you whimper his name when you’re close. If he’s desperate? He’ll use your panties.
K — Kink ⟢ Possession. Rafe is territorial as hell. Loves marking you—hickeys, bruises, his cum dripping from between your thighs. Also has a major thing for power imbalance. He’s older, stronger, more experienced—and he loves reminding you of it. Loves when you get all flustered, playing the innocent little thing while he ruins you.
L — Location ⟢ Anywhere he can get away with it. The truck is a favorite—he’ll pull you into the backseat without a second thought.
M — Motivation ⟢ You, obviously. Doesn’t matter what you’re doing—looking too good in your work clothes, biting your lip without realizing, laughing in a way that makes his stomach tighten. The second you get a little shy, a little flustered? It’s over for you.
N — No ⟢ He’s not into anything that makes you uncomfortable. Won’t share, won’t degrade you in a way that actually hurts. He likes you a little embarrassed, a little helpless under him, but he’s never truly cruel.
O — Oral ⟢ Loves giving. Could spend hours between your thighs, lapping you up until you’re too sensitive to handle it. But he’s greedy, too—loves watching you on your knees, pretty lips wrapped around him. And if you look up at him? He’s gone.
P — Pace ⟢ Usually fast and rough, but he knows when to take his time. If he really wants to make you beg? Slow, deep, agonizing.
Q — Quickie ⟢ Loves them. He’ll pull you into a supply closet, the back of his truck, his own construction site, anywhere he can take the edge off.
R — Risk ⟢ High. He gets off on knowing someone could catch you. Even if he’d kill anyone who tried.
S — Stamina ⟢ Insane. Blue-collar work keeps him strong, and he can go for multiple rounds without breaking a sweat.
T — Toys ⟢ Doesn’t need them. He’s enough. But if you want to try something? He’ll allow it. As long as he’s in control.
U — Unfair ⟢ Loves teasing. Runs his hands over you, pulls away when you try to grind against him. “Patience, baby.”
V — Volume ⟢ Low, deep grunts. Filthy praises. A little growl when he’s close. If you’re loud? He loves it.
W — Wild card ⟢ He has, at some point, stolen your underwear just to keep in his truck. For reasons.
X — X-ray ⟢ Big. Thick, a little curved, and he knows how to use it.
Y — Yearning ⟢ Insatiable. He wants you constantly. If he had his way, he’d keep you in bed all day.
Z — Zzz ⟢ Falls asleep eventually. But only after making sure you’re completely spent, totally satisfied, and pressed up against his chest.
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reasonsforhope · 7 days ago
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"Canadian scientists have developed a blood test and portable device that can determine the onset of sepsis faster and more accurately than existing methods.
Published today [May 27, 2025] in Nature Communications, the test is more than 90 per cent accurate at identifying those at high risk of developing sepsis and represents a major milestone in the way doctors will evaluate and treat sepsis.
“Sepsis accounts for roughly 20 per cent of all global deaths,” said lead author Dr. Claudia dos Santos, a critical care physician and scientist at St. Michael’s Hospital. “Our test could be a powerful game changer, allowing physicians to quickly identify and treat patients before they begin to rapidly deteriorate.”
Sepsis is the body’s extreme reaction to an infection, causing the immune system to start attacking one’s own organs and tissues. It can lead to organ failure and death if not treated quickly. Predicting sepsis is difficult: early symptoms are non-specific, and current tests can take up to 18 hours and require specialized labs. This delay before treatment increases the chance of death by nearly eight per cent per hour.
[Note: The up to 18 hour testing window for sepsis is a huge cause of sepsis-related mortality, because septic shock can kill in as little as 12 hours, long before the tests are even done.]
[Analytical] AI helps predict sepsis
Examining blood samples from more than 3,000 hospital patients with suspected sepsis, researchers from UBC and Sepset, a UBC spin-off biotechnology company, used machine learning to identify a six-gene expression signature “Sepset” that predicted sepsis nine times out of 10, and well before a formal diagnosis. With 248 additional blood samples using RT-PCR, (Reverse Transcription Polymerase Chain Reaction), a common hospital laboratory technique, the test was 94 per cent accurate in detecting early-stage sepsis in patients whose condition was about to worsen.
“This demonstrates the immense value of AI in analyzing extremely complex data to identify the important genes for predicting sepsis and writing an algorithm that predicts sepsis risk with high accuracy,” said co-author Dr. Bob Hancock, UBC professor of microbiology and immunology and CEO of Sepset.
Bringing the test to point of care
To bring the test closer to the bedside, the National Research Council of Canada (NRC) developed a portable device they called PowerBlade that uses a drop of blood and an automated sequence of steps to efficiently detect sepsis. Tested with 30 patients, the device was 92 per cent accurate in identifying patients at high risk of sepsis and 89 per cent accurate in ruling out those not at risk.
“PowerBlade delivered results in under three hours. Such a device can make treatment possible wherever a patient may be, including in the emergency room or remote health care units,” said Dr. Hancock.
“By combining cutting-edge microfluidic research with interdisciplinary collaboration across engineering, biology, and medicine, the Centre for Research and Applications in Fluidic Technologies (CRAFT) enables rapid, portable, and accessible testing solutions,” said co-author Dr. Teodor Veres, of the NRC’s Medical Devices Research Centre and CRAFT co-director. CRAFT, a joint venture between the University of Toronto, Unity Health Toronto and the NRC, accelerates the development of innovative devices that can bring high-quality diagnostics to the point of care.
Dr. Hancock’s team, including UBC research associate and co-author Dr. Evan Haney, has also started commercial development of the Sepset signature. “These tests detect the early warnings of sepsis, allowing physicians to act quickly to treat the patient, rather than waiting until the damage is done,” said Dr. Haney."
-via University of British Columbia, May 27, 2025
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