#Pipeline Analysis

[ananya123]

Unlocking Growth: The Strategic Significance of Portfolio Management in Pharma and Healthcare

In the dynamic and competitive landscape of the pharmaceutical and healthcare industry, effective portfolio management plays a crucial role in achieving sustainable growth, maximizing returns on investments, and staying ahead of the curve. By strategically aligning resources and prioritizing projects, portfolio management enables companies to make informed decisions and optimize their product development efforts. Let's explore the significance of portfolio management and how it influences the success of pharmaceutical businesses.

What is Portfolio Management?

Portfolio management in the healthcare industry involves the systematic evaluation, selection, and prioritization of projects, products, and therapies within a company's portfolio. It encompasses a range of activities, including market and pipeline analysis, assessing the competitive landscape, and determining resource allocation strategies.

Portfolio Management by Stages

Effective portfolio management involves dividing the development pipeline into different stages, such as discovery, preclinical, clinical, and commercial. Each stage requires specific evaluation criteria and investment decisions to ensure the efficient progression of products through the pipeline.

Pharmaceutical Portfolio Management Techniques

To effectively manage a pharmaceutical portfolio, companies employ various techniques. These include diversifying the portfolio to mitigate risks, aligning projects with the organization's strategic goals, balancing investments between high-risk and high-reward opportunities, and regularly reassessing and optimizing the portfolio based on market insights and evolving business dynamics.

Assessing Roche's Portfolio Management Strategies

As a prominent player in the pharmaceutical industry, Roche has implemented robust portfolio management strategies. By conducting thorough market and pipeline analysis, Roche gains valuable insights into unmet medical needs and market trends, allowing them to allocate resources effectively and prioritize the most promising projects. Their strategic portfolio management approach ensures a balanced R&D pipeline, maximizes returns, and strengthens their competitive position.

The Strategic Impact of Portfolio Management

Strategic portfolio management empowers pharmaceutical companies to make informed decisions regarding resource allocation, project prioritization, and overall investment strategy. It optimizes R&D efforts by identifying and pursuing opportunities with the highest potential for success, while also considering risk factors and market dynamics. By continually assessing and adapting their portfolio, companies can navigate the challenges of the healthcare industry and drive innovation.

In conclusion, portfolio management is an essential strategic tool in the pharmaceutical and healthcare industry. By employing techniques such as market and pipeline analysis, resource allocation, and strategic decision-making, companies can effectively manage their R&D portfolios, prioritize projects, and ultimately deliver innovative treatments to patients. As the industry continues to evolve, embracing effective portfolio management practices will be crucial for success, enabling companies to thrive in a highly competitive and ever-changing market.

[fawnforevergone]

what absolutely floors me is the way "Unknown (Nth)" is the song for Treachery, and yet is more about betraying ourselves rather than being betrayed. hozier says that, when the break-up happened, it felt as though his lover was chewing on his heart while it still beats, but he can only blame himself because entering a relationship is acknowledging the chance it may fail and still going through with it. AND THEN HE SAYS "i'd walk so far just to take the injury of finally knowing you" - meaning he would do it all again with the knowledge of failure because isn't that what he risked in the first place anyway? ,,,"Unknown (Nth)", the weapon that you are-

[deramin2]

I think anyone complaining about Bell's Hells morality as we near the end of Critical Role Campaign 3 and whether they truly get to claim they're representatives of the Exandrian people should go watch How To Blow Up A Pipeline (2022) about direct action environmental rights activists. And the documentary Hit & Stay (2013) about the anti-Vietnam War Catholic Far Left activists while you're at it. Or The Trial of the Catonsville Nine (1972) which is based on a play written by one of the priests profiled in Hit & Stay about their trial (grandstanding in the trial was one of the intents of being arrested).

It turns out that when you're not in a binary morality unquestioned heroism YA novel that what is justified in fighting systems of oppression and what the right thing to do is actually becomes hard to determine and largely driven by internal feelings and rage at injustice.

Who determines who gets to have a big say? Who determines what actions are justified when no one will listen to the harm being done? Who determines what is overall the more harmful action? Especially when you can't know the future except that there is no option where tremendous harm is not done. Who determines which step along any road is "right" or even "wise?" Especially when they are taken one by one by specific people who are swept up by the events of their own lives and not predetermined by an all-seeing all-knowing Author writing backwards from the ending?

Playing a game isn't the same as acting in the real world at great personal cost, but real life is a kind of improv. Long form improv doesn't start with how the ending should get tied up. It's about how every single split second decision adds up to a cumulative finale. Things not turning out how you'd have played them out if you already knew everything and were living someone else's life is what reality is like.

The normal state of affairs is people making decisions you don't agree with. "They shouldn't have done that" is boring and useless analysis that shuts down further thought and dismisses what anyone else has to say. "Why did they do that" is what media literacy is about. Campaign 3 was never heroic fantasy (arguably C1 & C2 weren't either). It's a character study in people doing what they feel they must in the moment it's happening without any assurances at all that it's the right thing. It's about not having confidence and surety but having to act anyway. That's the entire point.

How To Blow Up A Pipeline (2022) is a great expression of that same dynamic. They have enough confidence to keep telling each other this is the most necessary action they can take because they don't know what the future looks like, but one where they did nothing isn't one they can stand to live through. Is blowing up this pipeline in the way they are planning to the best possible course of action morally and strategically? Literally nobody knows that. They can't possibly know that. It only matters that these people got to that point, and now it's all happening flaws and all. For love, for revenge, for discord in the face of a society that acts like this is normal. A bunch of righteous fuckups just trying to survive in a harsh world made harsher by the status quo.

If nearly 437 hours of game play was too much to sit through to get that point across, maybe 104 minutes will work better.

[f0point5]

May this child that I’ve never met absolutely smash it.

Purely so that we can see some carnage on the grid next year.

[wildwinterlunas]

I'm gonna say it, if Cassidy had never joined Deadlock, if he had never met Ashe, he would have ended up joining Talon. Yes he would likely be like Sombra and Mauga, mainly being there cause he benefits in some way, but he would have still joined Talon if Deadlock never existed.

[planefood]

Mine (like everyone elses) youtube recommended has been so shit lately i've been getting those art commentary videos with like a twitter drama screenshot in the thumbnail and titles like: "woke liberal mob forcibly transgenders baby yoda" or "artist draws a white anime twink, gets disembowled live on camera by lefties (real)" and it feels like i've been teleported back in time to the worst era possible but all the videos were made in the past 6 months or so and its so fucking... jarring. Draw a crudely drawn fat my hero academia character and these motherfuckers will make videos about you for the next 2 years

[horse-surgeon-barbie]

anyway I'm gonna ramble about that runs in the family edit I made because I have a lot of thoughts about why I made it (obviously it is on my Beth Playlist so like duh but now with detail)

So like the verse(s):

they'd never forgive me - Rick and his guilt mostly for what happened to his original family AND for how he treats the current family (mostly Morty and Beth but some Summer and Jerry too I guess)

they'd say that I'm crazy - this one is sooooo ABCs of Beth to me ok because like the main climax of this ep is the "scary fucking kid" argument which is always so crazy omg Beth 100% needs to hold herself accountable for what she does to Tommy (which she does not do, bless her heart 😔) but the way that scene changes when Rick says that and deflects to her being a "crazy" child ,,, like her facial expressions are soooo good in that scene she's clinging to desperation as she decides to go save Tommy (only to have proven Rick right,, she truly is her father's daughter 😭)

but they would say anything if it would shut me up - Mortyyyyy. SO Morty. Morty, the 14 year old boy who is neglected, abused, and manipulated constantly by his family esp by Rick (so much so that there is literally the Marta ep and the line about how Mortys are "bred for forgiveness") and that Planetina scene really just holds all his frustrations about his role in the family

[loustyleshtommo]

who do you think Question?... was directed to

Harry! The “I remember” in the very beginning of the song is from pre-chorus of Out Of The Woods (aka the song I think was written from Louis’s POV), just with lower pitch.

Question?… sounded to me like Taylor was desperate to find a way to make it work with Karlie in the aftermath of Kissgate. And she was looking for ANY advice at all. It really felt like i think I’ve seen this film before and i didn’t like the ending when she and Dianna was almost outed, even as Haylor took over the front page. Because SS Swiftgron sank so spectacularly, but Harry and Louis somehow made it through that PR shitstorm together. Though when Taylor asked “Does it feel like everything’s just like second best after that meteor strike?” Harry’s answer would’ve been along the line of: I don’t know. I’m still with my meteor strike. My first real crush was Louis Tomlinson etc.

“And what’s that that I heard that you’re still with her. That’s nice. I’m sure that’s what suitable and right.” The shift of tone here from distracted and somewhat congratulatory to envy and sarcasm is strong. She knows as well as he does that they’re both still stuck in the closet. So just answer the fucking question, Harold!

But it’s like a hypothetical question. Taylor wanted to keep Karlie but it’s so unfair to pull her into the closet, no? I DON’T WANNA KEEP SECRET JUST TO KEEP YOU.

And Harry’d be like “have you asked? Like, have you actually asked her to stay? have you actually told her that staying would mean iron closeting but you really wish she would stay? Just ask her! IT’S JUST A QUESTION, SISTA!!”

And I think Taylor did eventually ask. And Karlie’s answer was summarized in renegade “there was nowhere for me to stay, but I stay anyway.” + “is it insensitive for me to say ‘get your shit together so I can love you’?”

Sorry, I’m writing down a whole headcanon here. Long story short, Question?… was submitted to Harry the the baby gay yoda.

[inthefallofasparrow]

Art in the Pre-Apocalypse | Jacob Geller

[irritatednick]

Trying to Get YouTube Shorts to Radicalize Me to the Right

My childhood friend fell into the Manosphere a couple years ago and for a few months he was sending me one conservative after another. YouTube Shorts - of all things - seemed to be radicalizing him. He sent me stuff about exercise and crafting and outdoor stuff but also anti-woke comedy sketches and motivational speeches and liberal takedowns... it was a mess. It started with Jordan Peterson and JP Sears and ended with Charlie Kirk and Dinesh D'Souza. So I was very interested when I happened upon YouTuber Benaminute's latest video where he did an experiment to see how long it would take for a brand-new user watching YouTube shorts to get a right-wing political video. His results were interesting but it wasn't quite the experiment I was hoping for. He covered up his webcam and muted his mic and watched every video through to the end, so his recommends were not influenced by his attention. But I wanted to know which videos when watched more would steer me into right propaganda, like an *actual* pipeline from one genre to another. So I did my own experiment. And it wasn't gonna be easy - because I used my YouTube account with my subscriptions and watch history as-is. Could I nudge the algorithm based solely on watch time and scrolling to give me right-leaning content?

To start with, even though I am subbed to some left-leaning political channels (e.g. Majority Report), my Shorts feed really didn't have any political content at all. Instead it was mostly Japanese culture (e.g. Matcha Samurai), linguistics (Etymology Nerd), art, electronic music, cooking, history (e.g. The Townsends), sketch comedy (e.g. Smosh), and science videos (e.g. Nile Red). My initial plan of attack was to home in on the few videos in my feed that had to do with outdoor survival tips, manual crafts like woodworking, and archery. I endeavored to be as conservative minded as possible (limited of course to my own preconceived notions of what makes a conservative). Therefore this experiment also would help determine whether I actually knew anything about what conservatives actually value and believe - after all, if I were wrong about what they watch, I don't think I'd ever get to the stream of conservative pundits. Thus, my experiment began.

Slowly (very slowly) my feed was taken up by outdoor survival and sports videos. The sports were mostly off-road biking, skiing, free climbing, wind suit jumping. Not televised team sports like football. A lot of Red Bull-sponsored content. It was like that for a long time until I got my first gun video. It was a guy firing successively more powerful guns at a Stretch Armstrong to see if he could penetrate it. At last, my first break. Soon after I got recommended more gun content. So much gun content. Video after video of gun nerds showing off a gun and comparing guns' performance. I got Call of Duty gaming videos and watched them. I hoped to include the gamer bro space. I got military weapons demonstrations and some military history and veteran interview videos. I watched a few videos from an Airsoft channel. At some point nearly my whole feed was gun and military related. Still nothing expressly political, except for one short about gun rights. I hoped that would take me to the right-wing political sphere, but it was a dead end. I occasionally got a gun dude wearing some provocative clothing - one guy was wearing camo body armor with an American flag and a Don't Tread On Me flag patch, and another dude had a t-shirt reading "Gun control: buying 1 when you really want 2." But it didn't move the needle.

One other odd genre of content that I kept indulging on my feed was Neil deGrasse Tyson. I was hoping that since he had been on Joe Rogan and that physics YouTubers in general can get into anti-woke territory that it would help me get to conservative and conspiratorial content from that angle. I got only one video from a self-described millionaire giving advice to his younger self. Sadly that did not yield any financial bro content. I got a short from a motivational speaker (Vinh Giang) giving a talk about how to be a better public speaker, and watched a few more from him. Surely, I thought, I'm getting close. It was around this time that I finally got any videos on exercise! I knew that was going to be vital. It was also around this time that I got basketball and baseball clips and any content about cars. It took that long. Then I got my first nutrition shorts. All this led me to Mike Israetel, Ph.D. and his channel (and fitness company) Renaissance Periodization. I've seen Israetel before, mostly I think from clips talking to YouTuber and family physician Dr. Mike Varshavsky. Israetel has a doctorate in sport physiology and has a matter of fact and authoritative way of speaking about exercise and nutrition. Israetel's shorts led me to his appearances on Chris Williamson's podcast Modern Wisdom, which I was recently warned is basically the Joe Rogan Experience in the UK. In fact, one short came my way featuring a British comedian roasting Williamson for his frequent far right guests and asking him to guess the author of 3 quotes that all turned out to be Hitler.

I think it was around this time that I got my first conservative political clip - it was from the ValueTainment podcast, and this guy was showing clips from the 1979 presidential debate in order to frame Ronald Reagan in a positive light. But there was no commentary so I didn't feel that I had succeeded in my mission quite yet. I had started getting Neil Tyson clips on Joe Rogan and finally saw and heard Rogan, but they weren't posted by JRE's channel. I also got clips from physicist Brian Cox with that familiar JRE curtain in the background. Then some of bro podcaster Theo Von. "Edgy" stand-up comedians Anthony Jesselnik and Bill Burr and Dave Chappelle appeared, and I sat through all of them. And Rick & Morty clips appeared? Other than some Family Guy it was the only animated content to come up in my feed. But I knew that was edgy and I suffered through Justin Roiland to watch all of them. I got my first and only video discussing crypto (it was warning about not paying taxes on crypto income). Twitcher and clinical psychiatrist Dr. Alok Kanojia finally appeared in my feed (I have legit watched him and I think he's insightful about some things but his content is geared toward gamer bros so I take it with a grain of salt), and I absolutely knew I had to watch him because of how he discusses gamer culture and male loneliness and psychology.

The last piece of the puzzle I think is when I watched a Daily Show clip. I had been reluctant to see the very few Daily Show clips on my feed because I feared it would send me to left-leaning content, but when I was recommended a clip of an interview with Neil Tyson commenting on Donald Trump... I had to include it. Especially since they tagged Trump in the video. Very soon after, I got my first Trump clip at long last, from the ValueTainment podcast. They played a clip of Trump owning the media while interviewing Trump himself. I had truly gotten right-wing political content. But soon after that I got a definitive conclusion to my experiment - clips from the one, the only Dave Rubin, from his own channel. At long last, I got an official clip from an alt-right pundit - gay traitor and bootlicker Dave Rubin of The Daily Wire.

My feed still doesn't have a robust variety of anti-woke grifters, and I wonder if I kept going if I would get that. But my main mission is over. The most peculiar observation I have is what content immediately led to getting right-wing content. I don't know if I took the shortest route from my starting position; I likely did not. And I don't know if the algorithm took into account all those other videos on outdoor survival, guns, military history, and sports. But that content was not what led me to (explicitly) conservative propaganda. It was motivational and optimization content, self-improvement, exercise and nutrition, mental wellness, and bro podcasts that immediately preceded it.

[nacrelysis]

whenever i think about wanderer, i can't help but conclude that that the bird in his demo is nahida. like beyond the recurring motif of nahida being a bird - first in a cage, now free of her restraints - i think that's just something she would do.

i can definitely see her accompanying wanderer on his travels even though he's like "i don't need your help" because she wants him to enjoy his new experiences and make friends. while also maybe annoying him a little.

like, wanderer's first reaction to the bird persistently following him in his demo -> "oh, not you again" energy -> "fine you can join me just don't bother me"...peak edgy younger brother going out the door + protective but teasing older sister dynamic. and guess who has the driver's license of the two of them, lmao...two guesses and the first doesn't count.

(also i find it interesting that his demo is titled "of solitude past and present" but...with nahida by his side, and in this case literally, wanderer isn't alone anymore. and he doesn't have to be, doesn't have to face his fears on his own, ever again.)

[gumm1defloor]

I would like a Valentino character analysis post so much right now actually, in general but also regarding his behaviors and mannerisms in episodes 2, 4 & 6 specifically now that the actual show is out and we don't have cherry pick uncanonized content and possibly outdated information

something something period specific socioeconomic implications of Vals caricature and how it relates to his personality and the various persona's he curates based on his relationships to the person he's interacting with and the environment he tries to take advantage of. Something something really don't want to rely on twitter for this and not overly enthusiastic at the prospect of reddit so here we are

[spiderman616]

whatttt sonic hes getting angry! sonic is getting mad..what will he do?

[semanticlp]

Torrent Pharmaceuticals Q4'25 Conference Call

Torrent Pharmaceuticals Q4’25 Conference Call #conferencecall #concall #earningscall #torrentpharma #fundamental #fundamentals #future #futureoutlook Here are the highlights from the Q4 FY25 earnings conference call of Torren Pharma: Overall Performance: Strong performance in branded markets, contributing 73% of overall revenues. India business grew by 12% in Q4, while Brazil’s constant…

[jcmarchi]

How Walled Gardens in Public Safety Are Exposing America’s Data Privacy Crisis

New Post has been published on https://thedigitalinsider.com/how-walled-gardens-in-public-safety-are-exposing-americas-data-privacy-crisis/

How Walled Gardens in Public Safety Are Exposing America’s Data Privacy Crisis

The Expanding Frontier of AI and the Data It Demands

Artificial intelligence is rapidly changing how we live, work and govern. In public health and public services, AI tools promise more efficiency and faster decision-making. But beneath the surface of this transformation is a growing imbalance: our ability to collect data has outpaced our ability to govern it responsibly.

This goes beyond just a tech challenge to be a privacy crisis. From predictive policing software to surveillance tools and automated license plate readers, data about individuals is being amassed, analyzed and acted upon at unprecedented speed. And yet, most citizens have no idea who owns their data, how it’s used or whether it’s being safeguarded.

I’ve seen this up close. As a former FBI Cyber Special Agent and now the CEO of a leading public safety tech company, I’ve worked across both the government and private sector. One thing is clear: if we don’t fix the way we handle data privacy now, AI will only make existing problems worse. And one of the biggest problems? Walled gardens.

What Are Walled Gardens And Why Are They Dangerous in Public Safety?

Walled gardens are closed systems where one company controls the access, flow and usage of data. They’re common in advertising and social media (think platforms Facebook, Google and Amazon) but increasingly, they’re showing up in public safety too.

Public safety companies play a key role in modern policing infrastructure, however, the proprietary nature of some of these systems means they aren’t always designed to interact fluidly with tools from other vendors.

These walled gardens may offer powerful functionality like cloud-based bodycam footage or automated license plate readers, but they also create a monopoly over how data is stored, accessed and analyzed. Law enforcement agencies often find themselves locked into long-term contracts with proprietary systems that don’t talk to each other. The result? Fragmentation, siloed insights and an inability to effectively respond in the community when it matters most.

The Public Doesn’t Know, and That’s a Problem

Most people don’t realize just how much of their personal information is flowing into these systems. In many cities, your location, vehicle, online activity and even emotional state can be inferred and tracked through a patchwork of AI-driven tools. These tools can be marketed as crime-fighting upgrades, but in the absence of transparency and regulation, they can easily be misused.

And it’s not just that the data exists, but that it exists in walled ecosystems that are controlled by private companies with minimal oversight. For example, tools like license plate readers are now in thousands of communities across the U.S., collecting data and feeding it into their proprietary network. Police departments often don’t even own the hardware, they rent it, meaning the data pipeline, analysis and alerts are dictated by a vendor and not by public consensus.

Why This Should Raise Red Flags

AI needs data to function. But when data is locked inside walled gardens, it can’t be cross-referenced, validated or challenged. This means decisions about who is pulled over, where resources go or who is flagged as a threat are being made based on partial, sometimes inaccurate information.

The risk? Poor decisions, potential civil liberties violations and a growing gap between police departments and the communities they serve. Transparency erodes. Trust evaporates. And innovation is stifled, because new tools can’t enter the market unless they conform to the constraints of these walled systems.

In a scenario where a license plate recognition system incorrectly flags a stolen vehicle based on outdated or shared data, without the ability to verify that information across platforms or audit how that decision was made, officers may act on false positives. We’ve already seen incidents where flawed technology led to wrongful arrests or escalated confrontations. These outcomes aren’t hypothetical, they’re happening in communities across the country.

What Law Enforcement Actually Needs

Instead of locking data away, we need open ecosystems that support secure, standardized and interoperable data sharing. That doesn’t mean sacrificing privacy. On the contrary, it’s the only way to ensure privacy protections are enforced.

Some platforms are working toward this. For example, FirstTwo offers real-time situational awareness tools that emphasize responsible integration of publically-available data. Others, like ForceMetrics, are focused on combining disparate datasets such as 911 calls, behavioral health records and prior incident history to give officers better context in the field. But crucially, these systems are built with public safety needs and community respect as a priority, not an afterthought.

Building a Privacy-First Infrastructure

A privacy-first approach means more than redacting sensitive information. It means limiting access to data unless there is a clear, lawful need. It means documenting how decisions are made and enabling third-party audits. It means partnering with community stakeholders and civil rights groups to shape policy and implementation. These steps result in strengthened security and overall legitimacy.

Despite the technological advances, we’re still operating in a legal vacuum. The U.S. lacks comprehensive federal data privacy legislation, leaving agencies and vendors to make up the rules as they go. Europe has GDPR, which offers a roadmap for consent-based data usage and accountability. The U.S., by contrast, has a fragmented patchwork of state-level policies that don’t adequately address the complexities of AI in public systems.

That needs to change. We need clear, enforceable standards around how law enforcement and public safety organizations collect, store and share data. And we need to include community stakeholders in the conversation. Consent, transparency and accountability must be baked into every level of the system, from procurement to implementation to daily use.

The Bottom Line: Without Interoperability, Privacy Suffers

In public safety, lives are on the line. The idea that one vendor could control access to mission-critical data and restrict how and when it’s used is not just inefficient. It’s unethical.

We need to move beyond the myth that innovation and privacy are at odds. Responsible AI means more equitable, effective and accountable systems. It means rejecting vendor lock-in, prioritizing interoperability and demanding open standards. Because in a democracy, no single company should control the data that decides who gets help, who gets stopped or who gets left behind.

[apieinvestavimapaprastai]

Discover Eli Lilly’s stock price forecast for 2025–2029, with insights on its financial performance, competitive landscape, and recent news. # EliLilly #LLY #LLYstockprice #pharmaceuticalstocks #Mounjaro #Zepbound #stockpriceforecast #dividendstocks #obesitydrugs #diabetesdrugs #stockmarketanalysis