#adrenitis

[intersex-support]

Help an intersex family in Gaza!

Hi everyone. I'd like to share about a fundraiser that is very important to me. A good friend of mine is in contact with the organizers.

(Described in alt).

Their story:

"Hello, my name is Abeer. I'm organizing this fundraising campaign from Belgium on behalf of my family, who currently live in Gaza. 

Since October 7, all families in Gaza have been subjected to genocide. My family is one of those families that has had to flee its own home several times because of the threat of regular attacks. 

After two months, my family decided to return home and take the risk of being bombed at any moment rather than stay in the street. Our 4-floor building now contains over 100 people who have fled from different parts of Gaza. We always open our hearts for our own people, but we can't do it without your help and support. 

My parents, Kamal (53) and Moukaram (51), are suffering from the war because of their age and health. My brother Suliman, his wife Rawan Abualnaja and their two-year-old daughter Bisan are trying to stay strong, but it's complicated by their little daughter's enormous needs. My other siblings who are not married are Mohammed 25, Inas 22, Ibrahim 17, Abdallah 15.

My family medical condition during the war:

My father suffers from delusional disorders. He can't work or help my family financially. Mohammed and Ibrahim suffer from a chronic disease, congenital adrenal hyperplasia. It is difficult for them to obtain medication in Gaza. One of their medicines has not been available in Gaza for two years. During the war, they couldn't get their medicines because they simply didn't exist anymore. My family members are still suffering. They don't want to be potential victims. They want to escape death and live like other families on the planet.

 On 01/01/2024, they attacked the local mosque and the missile failed to explode and ended up in front of my family's house. My family is in danger and the missile will explode any second.

Since then, my family has decided to be evacuated from Gaza because of the senseless attack on our city. Please help me evacuate my family to Egypt so that they can rebuild their lives in peace.

I've been in Belgium for over five years. I feel useless because I haven't been able to do much except try to help them with their daily living expenses. That's why we created this campaign. We're raising funds to evacuate my family to Egypt, a place that offers a glimmer of hope and stability. However, the cost of the evacuation is high, hence our call for crowdfunding.

Every contribution makes a difference The funds we raise will be used for :

- Evacuation from Gaza for both families (Rafah border crossing fees for 9 people total)  - Two months of temporary living expenses in Egypt, including food, shelter, and transportation  - Passport fees  - Food expences untill they leave Gaza 

No matter how small your contribution, it can make all the difference in breaking the cycle of violence and uncertainty. By supporting our campaign, you are offering a lifeline to our families so that they can rebuild their lives, heal from their trauma and make a fresh start in a safe and secure environment. Please leave a comment and share our campaign with your friends, so we can reach more people and make a bigger impact. Together, we can make a difference!"

They are using a French platform called Papayoux Solidarite instead of GoFundMe. Abeer also has a Paypal account for non European donors.

They are currently at 33 588,78 €/ 50,000 €.

Let's see if we can get them to 34,000 today. Any donation matters, even $1 or $2 donations can add up.

We need to help them meet their goal. Intersex liberation means intersex liberation everywhere--it is so important that we show up in solidarity. Those of us living with CAH know how dangerous salt wasting crises are without medication, and how important it is to urgently help Mohammed and Ibrahim get access to the medications they need to support their CAH. Intersex solidarity means that we need to show up and support intersex people facing genocide.

If you can't donate, please share. Consider doing an art raffle to raise money. Do whatever you can to help this family because it is urgent, and we need to act in solidarity with them now and make sure that the intersex community is here to support them!

[homeofhousechickens]

Chickens likely domesticated themselves the same way wolves did which is basically by hanging around our settlements and eating our refuse.

Living with chickens in this sort of way was likely happening way before the estimated times of 8,000- 10,000 years ago. The relationship was likely already long established it was just during that time some chickens started developing smaller/weaker adrenal glands which caused them to become much easier to raise and handle which eventually lead to the domesticated chicken we know of today (and how that happened so suddenly is a completely different but very interesting topic)

Also due to this you could argue that there isn't any true wild red jungle fowl left untouched and uninfluenced by humans anymore. Not only due to constant cross breeding with domestic chickens but because red jungle fowl are still doing what their ancestors did in their current range, if there is a town or village nearby the bravest junglefowl will still choose to intermingle with the village and eat the refuse, agricultural byproducts, and waste. People will still catch and care for these "wild" birds like their ancestors did. This isn't to say we shouldn't try our best to preserve the wild red jungle fowls wild genetics, their should be populations left to be in their natural environment but it's likely they are not truly same wild birds they once were thousands of years ago and honestly that's OK because thats how its been for thousands of years.

[evilwriter37]

Laying in bed with no energy is really fucking boring, y’all.

[daughterofsarenrae]

Snuggled? ✅️

Cozed? ✅️

Comfy? ✅️

Soft? ✅️

Fluffy? ✅️

Cute? ✅️

Pre-sleep checks complete

[dhddmods]

Some intersex flags! (Part 2)

Part 2 of making flags for intersex traits and variations that were flagless! (Part one is here.) There will be a part 3 & 4 and then all the main intersex traits/variations will officially have flags.

Please read (and reblog) our intersex guide. It is so important to understand intersex people, their bodies, and their health!

Accessory Ovary

The flag is based on the uterus didelphys and polyorchidism flags. The A is meant to represent the name of this variation. The three circles are meant to represent ovaries. The plus symbol is meant to stand for people who have more than one accessory ovary (aka 3+ ovaries.)

Supernummary Ovary

The flag is based on the uterus didelphys and polyorchidism flags. The S is meant to represent the name of this variation. The three circles are meant to represent ovaries. The plus symbol is meant to stand for people who have more than one accessory ovary (aka 3+ ovaries.)

Cervical Duplication

The flag is based on the uterus didelphys flag. In the center of the flag, the shape is meant to vaguely resemble a uterus with two cervixes.

Cervical Duplication + Uterus Didelphys

The flag is based on the uterus didelphys flag, with the shapes being changed to vaguely resemble two uteruses with cervixes.

Cervical Agenesis

The flag is based on the MKRH Syndrome flag. The symbol is meant to represent a uterus with an X over where the cervix would be.

Cervical Hypoplasia

The flag is based on MKRH Syndrome flag. The symbol is meant to represent a uterus with a minus symbol over where the cervix would be, representing its smaller size.

Uterine Hypoplasia

The flag is based on MKRH Syndrome flag, with a minus with a minus symbol, representing its smaller size.

Anorchia

The flag is based on the ovarian agenesis flag. The circle with the X represents a lack of gonads.

Monorchidism

The flag is based on the ovarian agenesis flag. The circle in the symbol represents the testicle itself. The 1 represents how there is only one gonad, and the M represents the name of this variation.

Unilateral Ovarian Agenesis

The flag is based on the ovarian agenesis flag. The circle in the symbol represents the ovary itself. The 1 represents how there is only one gonad, and the U represents the name of this variation.

Aromatase Excess Syndrome (AEXS/AES)

The flag uses the hyperestrogenism symbol, as it is a form of hyperstrogenism. The shades of pink represent the feminizing effects of the variation. The rainbow and monochrome coloring represents the gender spectrum, and how any gender can have this variation.

Classic CAH (Simple-Virilizing)

The flag is based on the CAH flag. The SV represents the name of this variation.

Classic CAH (Salt-Wasting)

The flag is based on the CAH flag. The SW represents the name of this variation.

Nonclassic CAH

The flag is based on the CAH flag. The NC represents the name of this variation.

Leydig Cell Hypoplasia (LCH)

The shades of blue represent the masculinizing effects of testosterone. The grey represents hypoandrogenism, and low levels of androgens. The grey circle represents the testes, and the underdeveloped/absent leydig cells within them.

17-KSR Deficiency

The purple and yellow represents that this variation is a form of intersex. The shades of grey surrounding the blue represents the "barrier" preventing androstenedione from converting into testosterone. The Ks and 17 represents the name of this variation.

Aromatase Deficiency

The purple and yellow represents that this variation is a form of intersex. The shades of blue represents the hyperandrogenism, and the pink surrounded by grey represents hypoestrogenism. The AD represents the name of this variation.

Mild Androgen Insensitivity Syndrome (MAIS)

The flag is based on the AIS flag. The M represents the name of this variation.

Partial Androgen Insensitivity Syndrome (PAIS)

The flag is based on the AIS flag. The Ps represents the name of this variation.

Complete Androgen Insensitivity Syndrome (CAIS)

The flag is based on the AIS flag. The Cs represents the name of this variation.

[whatshouldwecallchronicillness]

When I forget how to have a normal conversation...

[hellyeahsickaf]

Be careful with adrenal supplements it turns out that shit makes you produce adrenaline and my ass got paranoid that I had mad cow disease (I'm a vegetarian) and I almost threw up realizing a bear could fit through my window if he wanted (I live in a major city)

[sciderman]

Is Lamar still with us? 🙏

unfortunately so!! 😔😩 - my surgery was originally planned for june - got pushed for tomorrow, and now it’s been pushed again for next week - so I’m quite lamarful at the moment. hes still bunking with me, but… sighs. soon. I really hope so soon. he’s two months overdue, already…

[defsteria]

I should make a compilation of the times he changes the lyrics. In all seriousness they should’ve released an explicit version of “Let’s Get Rocked” this is hilarious!

[intersex-support]

hi! im questioning if im intersex (sorta. im like. 98% sure i am lol) but i cant quite find any variations that fit perfectly, though i know that you dont necessarily have to fit Every criteria for a variation. but i also might have EDS, or rather. probably absolutely do, but i missed One criteria in the hEDS diagnostic thing (my skin isnt Super elastic, just a little, but otherwise i am hypermobile) and wasnt diagnosed w hEDS specifically. i also wasnt able to get in with a geneticist to confirm EDS that way (i was pointed in their direction right when covid started so they werent accepting new patients)

anyways my point is, ive heard of CAH X, i think was the name? and from what i could tell its kind of a mix of CAH and EDS symptoms? but i couldnt find anything about it that wasnt super medical so i couldnt really understand it. is it possible you have some information on it? if not thats fine! ty for your time!

Hi anon!

Disclaimer that we cannot diagnose or provider medical advice, but I can absolutely share some information about CAH X.

So, CAH X is a subset of CAH where people have both CAH and Ehlers Danlos Syndrome. Research has only been done on patients with the most common type of CAH, 21-hydroxylase deficiency, and there isn't any info yet about the other rarer CAH subtypes.

CAH X is caused because the gene mutation that causes CAH is located next to another gene that can cause some kinds of EDS. The gene that causes CAH is called CYP21A2. Right next to CYP21A2 is a gene called TNXB, which encodes a protein called Tenascin-X (TNX). Severe TNXB mutations can cause a subtype of EDS called classical-like EDS, and milder mutations can cause hypermobile EDS. So in about 14-15% of people with CAH, there is essentially an overlapping mutation where the genes that cause CAH and the genes that can cause some types of EDS are both mutating at the same time and causing both diagnoses.

In the studies they've done about CAH X, they've found a range of symptoms and clinical presentations, both in terms of CAH and in EDS. There were patients in the study that had NCAH, CAH simple virilizing, and CAH salt wasting. Patients in the study ranged from having hEDS and just having joint hypermobility and joint dislocations, to having cardiac valve problems, gastrointestinal problems, to having clEDS. Most of the studies so far have found that almost all CAH X patients have elastic skin.

In the study, they found that having both CAH and EDS tended to make the impact of EDS worse. They found this out by comparing the people with CAH X compared to their relatives who just had EDS without CAH.

The discovery of CAH X is still very recent, so there's not a ton of research on it yet. I think they're going to keep finding more out about CAH X over the next several years, and keep refining the genetic testing and clinical diagnosis profiles for it.

So overall, CAH X is a subset of CAH where people have both CAH and EDS, and the symptoms of both diagnoses. Here's links to two research papers if people want to read to learn more!

[thechronicpaingame]

Today I learned about achenbach syndrome! Ive always had this weird thing with my hands where I get this like spiky pain and it hurts to touch the skin and later on it's bruised (on the inside of my fingers). So when it happened today I decided to have a Google and voila! It's nothing exciting, I just find it so interesting when I find something that's like, oh yeah it's definitely that haha. Medical stuff is my specialist interest and I think always will be haha.

[tea-and-spoons]

If you made a mistake (or two or five or hundreds) in your medical care, you are still a good person. You still deserve care, you still deserve to feel better 💙

[i-love-def-leppard]

i love when he wears tight pants 🤭😝

[hiiragi7]

Wondering why PCOS is not considered medically to be under the CAH umbrella (since CAH is a group of conditions involving hyperandrogenism), does anyone happen to know the reason?

Is it the vagueness regarding the cause of PCOS, is it the amount of misunderstanding and misinformation surrounding PCOS, is it intersexism and misogyny? Or even a combination of these?

Looking at the literature, PCOS is indistinguishable from CAH without extensive bloodwork, and often CAH is misdiagnosed as PCOS due to less widespread knowledge of not only CAH's existence (despite it being extremely common) but also due to doctors rarely ever testing for anything that is not 21-OHD, if they decide to run tests at all. (Many PCOS patients are diagnosed without any tests or with only an ultrasound to check for ovarian cysts, which is not actually useful as any kind of evidence towards a PCOS diagnosis at all)

In fact, 3bHSD CAH at one point was even considered to be a type of PCOS rather than CAH. If the two are so similar, and CAH is already an umbrella term, why the distinction between PCOS and CAH at all?

If it's due to treatment implications, that doesn't seem to work because treatment implications are different even within different variations within the CAH umbrella and even further within the same CAH variation. My treatment needs and goals are different from someone with another CAH enzyme deficiency, because the location of the deficiency on the steroid pathway changes a lot about what your symptoms are and how to manage it. Someone with 3bHSD CAH may build up pregnenolone, while someone with 21-OHD CAH may build up progesterone, for example, and these can cause very different outcomes for physical health and needs. There's also vastly different implications between classic, non-classic, and salt-wasters.

Us all being lumped under CAH has never stopped us from accessing the different treatment we need for whichever variation we have. Being grouped under an umbrella label does not mean we are all suddenly the exact same and have the same needs. This is true across all umbrella diagnoses and across spectrum disorders, and CAH is not any different.

A person with XY chromosomes and 3bHSD CAH may have ambiguous genitalia while a person with XX chromosomes and 3bHSD CAH may have completely "typical-appearing" or only slightly virilized genitals, some people with CAH may be infertile while others have no issues with fertility, some have ovarian cysts and some do not, some will go through "typical" puberty and others will have ambiguous or "opposite-sex" puberty, so on.

What vast amount of differences are there between PCOS and CAH that are not present between 21-OHD and 3bHSD, 11-beta, and StAR? PCOS and NCAH can even be more alike to each other than CAH variations can be to other CAH variations.

When we have studies which struggle to differentiate PCOS from CAH even on a biochemical level, why are we so confident in saying that PCOS is not yet another CAH presentation, or that it does not belong underneath that umbrella?

TERFs don't touch this post, I don't want to hear your shit today.

[quixoticanarchy]

bestowing my medical problems on an oc is like. hi I just think you could use this. it’s not an honor it’s also not a curse I just need you to hold onto it for me ok?

[whatshouldwecallchronicillness]

When I meet someone with my condition who is stable and lives a mostly normal life...