#super effect

[kingofdoma]

best description of morgan spurlock's legacy ever

[lilianade-comics]

How does one live up to perfection?

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[kilometresrufflefuck]

hear me out the other day i woke up and was immediately hit in the face with "7 year gap narumitsu in europe where phoenix kisses edgeworth in a low moment and then tries to flee and edgeworth uses mind chess on him to get the truth out of him which is a completely normal and ordinary average way to discuss your relationship"

[soulstickerr]

Something about the sun, about how yellow is a color of the sun… Undertale Yellow��� something like that.

[casually-eat-my-soul]

Cop dad, criminal son, Stilinski coded. Like I love stiles but that man is not being a cop. He’s far too obsessed and cares to little about the law.

And to everyone thinking that sheriff Stilinski would be disappointed?? NOO, y’all have it sooo wrong.

That man loves his criminal son. THATS his wife’s son. Do you understand, that’s all Claudia. And yes I understand that the sheriff would also commit unspeakable crimes to protect his son, that criminality comes from Claudia. Stilinski’s protect their own. He doesn’t love stiles in spite of his behaviours but because of them.

Some random person: Stiles broke into the station again

Sheriff, Literally bursting with pride: I know, he’s just so smart, he was probably just bored and wanted something to do

Like everyone is side eyeing them because stiles commits crimes for enrichment and the sheriff is just like “tell me everything about how you got away with it”

I could go on about how Claudia haunts the narrative after years of being dead and everything but that’s for another post

[shaykai]

Still thinking about Gortash’s coronation and how smoothly he cuts a Durge off from their companions (and wishing we had a follow up with that)

The first words out of his mouth are that he cares about them- anybody else who remembers Durge has only distain for them, but not him- he’s happy to see them, he missed them, they’re his favorite assassin and he’s only glad to see them alive

And then he takes it a step further by providing insight into their past, something Ketheric refused to do for them- and Gortash isn’t dumb. He knows exactly how Durge’s companions will react, knows that he’s effectively outing Durge when he so easily could have pulled them to the side instead

And when their companions snap at them and refuse to look at them, Gortash is still smiling. Suddenly, he’s the nicest person in the room. Suddenly, everything is unstable and dangerous- but he likes you. He’s sitting there with open arms while the companions are rightfully so mad with Durge, but Gortash is more than happy to resume their alliance

He’s more than happy to be their sole source of comfort again, and isn’t he just so sweet for that?

[jaboody]

Super Shadow in Sonic the Hedgehog 3 (2024)

[carbon-corrie]

I had an idea for an AU where instead of immediately joining the Rex and the clone rebellion after he defects from the Empire, Wolffe instead has a brief run as a feared Crime Lord, and now I can’t stop thinking about it!

(The cloak was inspired by the amazing artworks by @catd3mon and @kokosnusslos!)

[remxedmoon]

so all you need to do right now is disappear.

HHHHAPPY ISATVERSARY EVERYONE. here’s redraws for every single battle cg in the game. 36 drawings this time around, with 11 of those being custom (though admittedly a good portion of those are edits). combined with the portrait redraws i made back in september, i’ve made 114 redraws for this project! jesus christ! just like those redraws, these are completely free to use!! as long as i’m credited and it’s not for commercial purposes, go wild!! do whatever you want!!!

no i didn’t make these for isat’s 1 year anniversary this is just wildly good timing.

i genuinely can’t fit all of these cgs in one post even with the 30 image limit on browser, but i’ll still try to fit Most of them below the cut (without making this post horrifically long), along with some notes that might be important 👍

okay! once again, i labeled all of the custom art as such in the drive(UPDATE. NNOT TRUE ANYMORE. reformatted file names to be easier to mod in auau. apologies!), but if you want a full list, the customs are hatless siffrin jackpot, bonnie jackpot, bonnie special attack, bigfrin attack, and a bunch of alts which are definitely not related to any projects i’ve been thinking about don’t worry about it. and out of those customs, only like. 3 of them are actually completely from scratch.

while i did my absolute best to keep the aspect ratios completely the same as the originals, there’s 3 exceptions that i just couldn’t get to work.

isabeau’s hair in his special attack cg wouldn’t fit in frame if i kept things completely accurate to the og, so i moved his cg down a bit. it shouldn’t cause any issues with modding or anything, it’ll just appear slightly lower than it does in game. alas…

isabeau’s sleeve and mirabelle’s hair made their jackpot sprites a little larger than the originals? i’m hoping this doesn’t have too much of an effect (since the jackpot sprites have inconsistent sizes) but i can’t test this myself unfortunately. aaa feel free to let me know on discord if any problems arise!!

i managed to fix these, so they aren’t going to cause problems now, but my original drawings for mirabelle and siffrin in the final attack scene were a pain in the ass to fix. mirabelle’s sprite was slightly too talk to fit in frame and siffrin’s hat whacked bonnie in the face while i was editing everyone together. i’m only mentioning this because it took like an hour and a half to fix them and finish the scene.

all that aside, these were a fucking BLAST to work on. apparently this ended up taking 57 hours over exactly 10 days. which is a little worrying if you do the math on that but somehow i have not burnt myself out. i will be doing enemies at some point!!! but probably not for a little bit. i think my friends will actually kill me if i don’t take a break.

once again, happy birthday isat. you’ve ruined my life and i wouldn’t have it any other way (silly).

also, on an actual serious note, this little timeloop game has genuinely changed my life for the better? you guys are probably sick of hearing it at this point (or maybe not, i don’t talk about myself That Much. i hope), but i was practically a ghost for about 2 years before joining this fandom. it’s a little surreal to suddenly have friends (plural!!!) and people who Care about me, or even know i exist, honestly. it’s weird!! in a good way!!!

i don’t think i would’ve ever come back to social media if this community wasn’t so welcoming. i’ve met a lot of really great people through this game!!! so, uh, thank you isat, i guess. here’s to another year.

[akanemnon]

Deus ex Chara

FIRST - PREVIOUS - NEXT

MASTERPOST (for the full series / FAQ / reference sheets)

[ginpotts]

DOCTOR WHO series one ✧ 2005 — inspiration

christopher eccleston as the ninth doctor 🌌

[aucrowne]

(´｡• ᵕ •｡`) Nirei wants to piggyback too -`♡´-

➺ More windbreaker fanart

➺ More wbk silly comics

[gingerswagfreckles]

It's also a little bit funny that other people are calling the guy who shot a healthcare CEO with bullets that said "deny defend depose" and was carrying a manifesto about how corporate America is evil a "Nikki Haley Republican" or part of the "center right." I guess based on the fact that he went to an expensive private school was messing around in Hawaii pretending to develop a video game as work until recently? Like. This guy left a goodreads review about how the Unibomber was an "extreme political revolutionary." While also traveling around the world on the money his parents made off of real estate and owning a chain of senior rehabilitation facilities.

I think a lot of you are really uncomfortable with how common champagne socialism is and frankly I think a lot of this is projection. This guy is very obviously someone who considers themselves a leftist revolutionary, and yet everyone is kind of re-framing him as a "Nikki Haley Republican" because they're uncomfortable with acknowledging that far leftists are often very privileged and hypocritical people. I've been talking about this for a long time, but a lot of the left (at least on the internet) is quite in denial about the fact that a lot of their beliefs aren't widely shared by the working class. That often, the loudest voices in the movement are those belonging to the wealthy, who are at the end of the day cosplaying and are more interested in acting out heroic fantasies than improving life for the working class.

[deadsetobsessions]

It’s been months since he’s settled into life at Wayne Manor. It’s hilarious that they don’t think he knows about their obvious nightlife (and that’s coming from someone whose hero name was just their last name spelled differently) but they don’t know anything about his own past as a vigilante. To be fair, a dimensionally displaced Ghost King wasn’t really on the board for reasonable guesses. Danny Fenton blinked innocently at Duke, blue eyes watery and oh-so-trusting of his adopted older brother when Duke claimed that his bruising came from getting caught in Ivy’s attack on the busses today.

(“Oh my god he’s so trusting and pure what the hell?” He heard Steph whisper to Dick, who nodded emphatically.)

“Oh man, you should get some rest. You guys are seriously unlucky, you know? Do you need to go to the hospital?” Danny asked Duke, his core trilling as he allowed himself to fuss over a member of his ‘fraid.

“Nah, man. I’m good. I think I’ll take a nap and sleep it off.”

“Okay. Oh, here!” Danny fumbled for his bag, grabbing his prescribed pain meds- for his chronic pain, but they don’t actually do anything for him since his ectoplasm burns away most of it- and handed it to Duke. “Take one, and only one. Those bruises look nasty.”

And then Danny gave him the puppy dog eyes and Duke folded, because Danny knew that he wasn’t supposed to hand his meds out but these situations were kind of the reason he claimed chronic pain to being with (even if it was true and his hands shook with aftershocks).

“Thanks, Danny. I feel like death warmed over.”

Danny laughed, the opportunity to mess with the family sparking in his head. “Yeah, I’ve died before. Wouldn’t recommend it.”

With that, Danny threw Duke an easy going smile and walked towards his room, bag on his back.

From his peripherals, Danny watched Jason drop his bowl of snacks, Dick’s pale face, and the concerned and shocked look of everyone else. Except Damian, who just kind of scowled thoughtfully. Tim looked like he was going to rip Danny apart like an interesting puzzle, Cass sat up straight (and he made sure every micro expression he caught on others stayed unconcerned on his own body), and Duke froze.

He snickered- well out of regular earshot- as whispers and whispered shouts rung out after he left the room.

He can’t wait to drop the “I know you’re vigilantes” bomb on them. It’ll be hilarious.

[technikki]

HAPPY 18 YEARS TO THEFUCKING GAME OF ALL TIME