#anti depressants are good

[a-little-bit-poss]

.

[super-nova5045]

sylvia plath, todd anderson and virginia woolf (aka ACTUAL tortured poets) watching taylor “im breaking up with my boyfriend for his intense depression and blaming it on him, im dating a racist who enjoys watching woc being brutalized and harasses young woc artists, i sent my fans out on a hate train to attack a young woc actress for a line she had to say as part of her job to show how mentally ill her character was, im dating a maga supporter, i refuse to say anything about a current genocide despite being the most influential person in the world right now, i am a billionaire, i fly 13 minute flights and have the highest carbon emission of any celebrity, i am a known white feminist who only speaks about issues when it affects me and has constantly let my fans get away with extreme racism and even encouraged it by associating myself with known racists” swift call herself a tortured poet (her writing sounds like a bunch of thesaurus words slapped over gabba hanna and rupi kaur-esque poetry that was created purely as a trinket for an edgy pinterest board)

[isbergillustration]

Stocked up on my fave sketchbooks (seawhite of brighton 140gsm a5 soft my beloveds) and it's. Good.

[showtoonzfan]

“That’s it? That’s the Hazbin hotel season one finale?”

[reasonsforhope]

"One in five Americans will experience major depressive disorder in their lifetime, and many will not find relief from current therapies. But now researchers have identified an unexpected source of the problem: inflammation.

Inflammation in the body may be triggering or exacerbating depression in the brains of some patients. And clinical trial data suggests that targeting and treating the inflammation may be a way to provide more-precise care.

The findings have the potential to revolutionize medical care for depression, an often intractable illness that doesn't always respond to conventional drug treatments. While current drug treatments target certain neurotransmitters, the new research suggests that in some patients, depressive behaviors may be fueled by the inflammatory process.

It appears that inflammatory agents in the blood can break down the barrier between the body and the brain [and specifically the blood-brain barrier], causing neuroinflammation and altering key neural circuits, researchers say. In people at risk for depression, inflammation may be a trigger for the disorder.

Research suggests that only a subset of depressed patients - roughly 30 percent - have elevated inflammation, which is also associated with poor responses to antidepressants. This inflammatory subgroup may be a key to parsing out differences in underlying mechanisms for depression and personalizing treatment...

The inflamed body and the depressed brain

...A number of studies show that depressed patients tend to have increased inflammation compared with non-depressed subjects, including more inflammatory cytokines and C-reactive protein — which is produced by the liver in response to inflammation — circulating in the blood. Patients with autoimmune diseases have inordinately high rates of depression. And postmortem brain samples from people who died by suicide showed more activation of the brain’s immune cells, which release inflammatory agents.

Crucially, pro-inflammatory drugs can induce people to become depressed, which suggests a causative link. In one seminal study published in the New England Journal of Medicine, Miller and his colleagues conducted a double-blind study of 40 cancer patients undergoing treatment with interferon-alpha, an inflammatory cytokine.

Though none of the patients had depression to begin with, the inflammatory agent had a striking effect: Many became depressed, a finding that has been consistently replicated.

"The patients recognize pretty much immediately that, 'Hey, you gave me something, and now I feel this way. I don't know why I feel this way,'" Miller said.

Can treating inflammation treat depression?

If inflammation can induce or exacerbate depression and its symptoms, then reducing inflammation could provide relief.

Even if inflammation is a disease modifier rather than the cause of the problem, “you have to take care of it in order for you to be able to get your therapeutics working to restore your circuitry and what’s happening in the mind,” said Eleonore Beurel, a professor of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine.

Anti-inflammatory drugs, used alone or in conjunction with a standard antidepressant, may help some depressed patients. A 2019 meta-analysis encompassing almost 10,000 patients from 36 randomized clinical trials found that different anti-inflammatory agents, including NSAIDs, cytokine inhibitors and statins, could improve depressive symptoms...

“We’ve come to the tipping point,” Miller said. “And we know enough at this point to begin to target the immune system and its downstream effects on the brain to treat depression. We are there.”

How to manage your own inflammation

Experts agreed that people should not take anti-inflammatories without talking with their health-care provider. Your doctor can order a C-reactive protein blood test to measure your level of inflammation.

“There are so many patients who do not respond to antidepressants,” said Ole Köhler-Forsberg, a physician and associate professor of psychiatry at Aarhus University who has given anti-inflammatory drugs to his patients in addition to antidepressants. “So there is the issue of how can we improve the individual outcomes.” Tailoring treatment for each individual on a holistic basis may add some benefit.

More clinical tests for inflammatory markers may be a way to differentiate the effectiveness of antidepressant treatment. If confirmed, it would “be the first actual biomarker in psychiatry,” Raison said. “I mean, we’ve been looking for biomarkers for 50 years and had zero luck. And it’s ironic that it’s not a brain chemical.”

In the meantime, “you get much more mileage out of the lifestyle changes than you would out of supplements or any other over-the-counter drugs at this point,” Miller said."

-via The Washington Post (via Yahoo News), February 24, 2023

[raviollies]

Wanted to give a quick update on my mental health since I think it's important to share the positives, especially as someone with Bipolar type II, and since I have been negative on here before.

I feel GREAT, like genuinely, I feel fantastic mentally. I have been doing exercises daily, I have been meal prepping and eating mindfully (Cutting back on carbs since they make me tired, upping my vegetables and trying to make food I love healthier by subbing ingredients) - In fact, I feel ENERGETIC. It's not the out of this world feeling of mania, but a consistent feeling of being able to tackle tasks that were very difficult for me before (exercise, dishes, cooking meals ahead of time so I have something to eat during and after work, eating veggies I used to hate, keeping my room tidy). I've had unlucky, bad things happen and it didn't make me want to crawl into a hole and die, I actually...was able to react calmly? Was able to shrug it off without collapsing into a pile?

It's genuinely...life-changing and not somewhere I thought I'd be several years ago. I could not fathom how I could live at a constant mood scale of not simply chugging through the day - and you guys have played a role in that. Comments that I love responding to, tags on my art, just engaging with my OCs as they've been a huge form of creativity for me and just loving art again (I'm proud of tackling more and more complex pieces).

So thank you! I hope to continue like this and also prove that having this life isn't just...out of the realm of possibility for those struggling with mental illness.

[yvesolade]

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[hikarry]

So, while I was sick I was cooking up some ideas so let me throw this imagine at you. I won't be as nice as the others because jello brain, but follow me!

After Season 3, like, way way way after. 30 years after, perhaps. Let's pretend Crowley and Aziraphale didn't destroy Heaven and Hell or turned (argh) humans and that Gabriel is having his happily ever after with Beez, yes? Crowley and Aziraphale are living in the South Downs, Muriel is taking care of the bookshop and Michael is the new supreme archangel, yes? Fantastic. Let's go.

So, Aziraphale is in the workshop working on some book and Crowley is yelling at his plants outside the window when someone calls. Crowley quickly lifts his head and looks at Aziraphale through the window. The angel just waves his hand and goes to the living room where his old phone still is. It was Muriel, once again asking for help.

"Of course, dear. I'll be there in a jiffy." He answers, as per usual. "Crowley, my dear?"

"Yes, angel?" He yells from the garden.

"Can you take a quick break and take me to the bookshop?"

"Argh. You have a bloody license."

"...Do you...want me to drive her?"

"...Gimme a minute!"

It's just the time for Crowley to clean himself and fix his hair (took longer than he would ever admit. Aziraphale was expecting it), and off they went, back to Soho.

"Will you come in, dear?"

"Nah. With luck, it's the same problem as last time and it will take you both hours. I'll make a reservation at the Ritz, go to that bakery you like and-"

"Oh, yes! Please buy some-"

"Chocolate croissants, I know. Anyway, I might pass by the plant nursery and then I'll come back. It takes me a maximum of half an hour. Would you like something to drink?"

"No, love." He leans over and kisses Crowley on the cheek. "I believe Muriel has a lot of tea inside. Mind how you go."

Crowley nods and gives him a quick kiss before Aziraphale leaves the car.

Once inside, with Crowley gone, the bookshop was darker than he expected.

"Muriel?"

He took a couple more steps when the bookshop's doors closed with a burst of wind and the unforgettable smell of ozone invaded, right before Michael, Muriel, Uriel and Sandalphon appeared in front of him. Muriel looked terrorized. Aziraphale tried to move in their direction but found his hand hit against an invisible wall. A trap, really? He opened his mouth to talk, but after Uriel snapped her fingers he fell unconscious.

Aziraphale woke up in some sort of old building. He was laying on the floor and his head hurt considerably. He tried to move his hands to try and help himself to his feet, but felt a sharp pain on his wrists.

Right.

Demonic handcuffs.

Original.

By that logic, he couldn't touch any of his power or call for his wings.

Great. So stay on the floor he would.

Bellow him there was an angel trap, with his sigil on it. Which made this much more complicated indeed.

Aziraphale managed to get on his knees and finally saw a window on the other wall in front of him. From this perspective, he was surely not on the first floor. He started banging with his chains on the invisible wall in front of him. It wouldn't do anything, obviously, but he would be damned if he just stayed there doing nothing.

Putting demonic chains on him was a low low blow, even for them.

After a while he started getting tired and sat back on his legs, sighing

"Mr. Fell?" A whisper came from the closed door.

"Muriel?"

"Yes. It is me. I'm so so so so sorry I tricked you. I tried to say no but...the supreme archangel asked. Are you...alright?"

"It's alright, dear. I'm...fine, considering."

"The supreme archangel is infuriated. She yelled at everyone and said that she would punish you at nightfall. I'll try to get some help."

"No, don't do that! They will punish you if they find out! I can handle them!"

"After I let them take you like that? I can't. I'm sorry, Mr. Fell. I feel too guilty. I need to help you."

"...How long have I been gone from the bookshop?"

"...3 hours, I believe."

Aziraphale took a deep breath.

"Right. Crowley is probably panicking flying around like a blind eagle. If you can get to a phone, try to reach him. If not, run. Go to Nina and Maggie's or to our house, alright, dear? Don't let them catch you. Don't get in trouble."

It was less than 2 hours when the doors opened. The first to walk in was Michael, followed by her two minions.

"Very well, Aziraphale. Are you prepared to return to Heaven?" Michael said.

Aziraphale chuckled.

"You must have lost your mind, certainly. Crowley and I made sure you all would leave us alone. So-"

"That's because we didn't have other choice." Uriel interrupted. "Now we have the Programmer." Aziraphale raised an eyebrow in confusion. "We can reprogram other angels to their original position and manipulate their memories."

Aziraphale got to his feet and flinched back. Now, that wouldn't do.

"We have already lost Gabriel, Metraton. We need you back. Especially away from that demon pet of yours. You're too powerful together, as shown by the way you almost blasted the whole of Heaven."

"And the machine is running, ready for you-" Sandalphon entering the circle, and held him by the arm. "-my dear." A fist was raised, but before it could collapse into its target, there was a very loud screech outside.

The angels looked amongst themselves and Sandalphon left to check on all the noise with Michael.

They listened to multiple voices outside. They were speaking so loud none was really distinguishable.

"You are going, not even if I have to take you myself!"

Uriel crossed the circle, making the lil mistake of erasing a part of the circle with her shoe. Enough to let Aziraphale go. He stepped out of the circle, but Uriel followed him, grabbing him by the lapels and pushing him against the window, that broke against his elbows and back.

Now the voices were more clear, and one of them was, without mistake, Crowley. He took a quick peek outside and there he was, fighting both the archangels.

Right. He had to get a wiggle one.

"I'm sorry, dear girl." He swung the chains towards Uriel and she fell to the floor, sluggish.

Quickly, he turned around and looked down. He was on the third floor with two archangels and a demon blocking the exit.

"Crowley!" The demon's head snapped up in between the confusion that was him and the archangels.

Aziraphale climbed on the window and sat on it. He still couldn't use his wings so all he could hope for was Crowley's pristine timing. With his eyes closed, he took a final last breath and leapt out of the window. Within seconds he felt arms holding him and the unmistakable sounds of wings flapping.

"Are you insane?! You could have been discorporated! What would have happened if I didn't catch you, eh?! There's no other corporation, angel! You have to stop-" Aziraphale giggled, wrapping his arms around Crowley's neck, trying to get in a better position. "What?"

"Thank you for the timely rescue. Again."

"Why are you laughing? This isn't a laughing matter! I'm gonna kill those-"

"Crowley." The angel put his hands on his face, forcing him to slow down and face him. "Let's just go home, yes, my dear? There's a lot to discuss and I need a cup of tea for that." Crowley took a deep breath and smiled down at the angel. "Muriel found you?"

"Yes, they called. I told them to go to the cottage and stay put. I came as fast as I could but they literally dragged you to the middle of nowhere."

"Oh!" Aziraphale looked over Crowley's shoulder. "What about the Bentley?"

Crowley laughed, looking in front once again and picking up speed.

"She's on her way back home, obviously. She ran as soon as I caught you."

Of course she was. Why was he even surprised, he thought with a chuckle.

[shitty-check-please-aus]

The thing about SAD is that it's a very real, sometimes debilitating condition, but it also makes me feel so silly.

Like I was born and raised here and still I've got a brain that's like "holy shit it's way too cold and dark, we absolutely cannot make any of the good chemicals until we fix that" and I'm like "until we fix... the existence of winter? the thing we've experienced 28 times already?" and my brain is like "exactly"

and THEN it feels even sillier to be like "well if I want my brain to make any good chemicals for about 7 months of the year, I need to plug in a special lamp and sit in front of the special lamp every single morning, because if I don't I get extra sad"

[veone]

weed vs coke

[drowsydregon]

they don't know that my fanseason project is basically cancelled

[sailor-cerise]

the difference between doing chores or errands on a good day vs a bad day is stunning.

Sometimes on days that are ok physically but bad mentally, I forgot how starkly different it can be.

I start to believe that I'm lazy or not trying hard enough or that I cut myself too much slack or make too many excuses or feel too sorry for myself and really I just need to do better.

And then I have a rare day like today where I am able to easily start and focus on an important, tedious paperwork-related task for two hours, getting it done, and not feel awful afterwards. The amount of willpower it takes is laughably small in comparison to most days.

No crying or bursts of anger or overwhelming exhaustion or inchoate anxiety.

Instead: a moderate sense of satisfaction, and pleasant relief that I'm done.

I feel like a different person. I know it won't last, but even that realization doesn't feel that bad. Because things are pretty good right now.

And I remember:

It's not supposed to be so hard all the time.

That I'm NOT exaggerating or imagining just how ridiculously fucking hard it is to do every-day things.

This is what it should feel like.

~* It's not supposed to feel like the world is ending because I need to open my mail. *~

What did I do differently to make today happen?

I let myself rest. For as long as I needed. For weeks.

I stopped pushing myself so fucking hard all the time, and protected my body and respected my limits and let things go.

It doesn't always give me a magic day. My exchange rate is like, 2 weeks of aggressively resting and setting boundaries for 1-2 days of doing what I want and need.

But it reminds me that pushing through is not the way to get what I want.

Maybe taking care of myself and being kind to myself will get me that day or afternoon or hour of magic, maybe it won't -- but running myself into the ground never does.

[eyestrain-addict]

[kaedeichinose]

people trying to spin the ruby situation into being about medication/therapy/whatever already sound like theyre on insane levels of cope but if any of the writers try to pull that shit i'll be so mad

"it wasnt a terrible suicide allegory it was actually a DIFFERENT terrible allegory and we just used suicide imagery and framing for pure shock value and a cliffhanger!" i think thatd be worse actually

[moeblob]

Chris works in a different room than Right, Brent, and Karen so he just pops in and is like "Karen why does it feel so tense in here and it's dead silent please help me" and Karen is just done with the two guys so she's just "this is my work environment now thanks for noticing".

[feralboo-the-weirdo]

BARBIE SPOILERS. if you have not seen it and you don't want spoilers, just skip over this. Unless you would like some prior warning for it. :)

This is honestly the only summery of the Barbie movie I can give without going into a giant rant:

Spoiler: Yes. They pushed both. I just couldn't get the other meme to work.

dang, I have a feeling this is going to garner quite a bit of hate, but as a disclaimer before I go into what I will try to keep a tiny rant-- I understand there are people who did like it and I want to like it, because it's you know, it's Barbie and the old movies were wonderful, but... the movie made itself irredeemable to me.

Yes, it was satire, but it was honestly hard to tell what was satire and what they proclaimed was truth. I hated it. Every moment I spent in the theater I wanted to leave it.

why was how they broke the brainwashing reminding women how mistreated they are? Like. HOW. DOES. THAT. FIX. ANYTHING? was it satisfying for a bit? admittedly yes, the initial rant the mom gave was satisfying.... and then they dragged out the bit and it was just like "what on earth is this?" why is this what unbrainwashes them?

Also, I know people are going to get onto the "well they were white so that explains everything" No. no it does not.

Also everything they brought up they did not go deep into. like Ken being hurt by the Patriarchy too. they spent about five minutes (if that) on it and then were like "yay! problem solved, it's barbie land again." Also mental health. Was handled VERY poorly. it's not a joke. as someone who deals with mental health struggles on the daily I did not appreciate how they presented it.

The "only baby dolls" thing. This should not have made me hate this movie so much because it's (MAYBE???) satire. But still. They have not been the only doll to exist ever.

This movie hated both genders equally but tried to make it seem like they loved women.

Also. I hated the extremes they went to in the real world. Not every man is Evil. there are some that definitely should not be allowed around women or other people yes, but not all of them are evil. And not all women are good either.

No one, the barbie movie: women are so mistreated, woah is us!

Also the barbie movie: eck! we're so powerful we can't stand it!

But mostly, I just hated it because I was promised a happy movie of Barbie having a midlife crisis and Ken coming along for the ride and instead it was like Tik tok. in movie form.

This movie did not make me feel anymore comfortable with my gender. if anything it made me feel worse. I left the theater feeling like I should have been empowered, but I just felt gross. Overall, this is probably the last post I will ever make for this movie because I want it to fade into the background and be ignored. The worst insult I could give this movie is ignoring it's existence entirely.

Does anyone else miss when movies just had strong CHARACTERS instead of it being a strong gender? like it wasn't "LOOK A FEMALE WHO IS A CHARACTER!!!" and "oh, a guy character, gross." Why does it have to be so extreme? Like I appreciate there are more female protagonists out there but I also miss when they weren't all hot headed, arrogant, jerks, and when they were FEMININE. like. what. is wrong. with. being soft??? also I miss smart male protagonists. and male protagonists in general who were good characters not comic relief. (unrelated, but semi related note: I will never forgive the Harry Potter Movies for what they did to Ron to make Hermione smart. Ron is SMART TOO. My boy deserved better!)Like there was a while there where women and men both had equal roles in stories and they were good because they were good characters and now... it's just politics. and I'm sick of it.

I don't know what Barbie was supposed to be but it was not what I wanted to see when I went to see it. I had low expectations, but somehow, it failed them. failed them hard. Honestly, I don't know how anyone likes it, and I'm still to angry at it to look for reasons why people did. Maybe in a few years after my anger at what this movie was actually about subsides.

In conclusion, I finally remembered why I don't go see movies anymore. I want a story, not a message. Barbie provided a message. a very dark undertone that hid under "discover yourself and your role in the world :)"

P.S. If you liked Barbie and wish to tear me to shreds, please remember I was not the target audience, I did not "get it" as those in the target audience did.