Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised.
Every year, researchers try to predict the four influenza strains that are most likely to be prevalent during the upcoming flu season. And every year, people line up to get their updated vaccine, hoping the researchers formulated the shot correctly.
The same is true of COVID vaccines, which have been reformulated to target sub-variants of the most prevalent strains circulating in the U.S.
This new strategy would eliminate the need to create all these different shots, because it targets a part of the viral genome that is common to all strains of a virus. The vaccine, how it works, and a demonstration of its efficacy in mice is described in a paper published today in the Proceedings of the National Academy of Sciences.
“What I want to emphasize about this vaccine strategy is that it is broad,” said UCR virologist and paper author Rong Hai. “It is broadly applicable to any number of viruses, broadly effective against any variant of a virus, and safe for a broad spectrum of people. This could be the universal vaccine that we have been looking for.”
Nora AlMatrooshi, the first Emirati woman astronaut, worked as a piping engineer before becoming an astronaut candidate for the United Arab Emirates. https://mbrsc.ae/team/nora/
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What is the difference between a cathedral and a physics lab? Are they not both saying: Hello?
Paolo Giordano, “The Solitude of Prime Numbers” / Antonio Tonelli / Laura Giplin, “A Toast to the Alchemists” / Dennis Overbye, “Music of the Heavens Turns Out to Sound a Lot Like a B Flat” / Carina Nebula / Marie Howe, “Singularity” / Alan Bean, “Is Anyone Out There?” / Bill Bryson, “A Short History of Nearly Everything” / Garrett Lee, “Canyon” / Whit Bronaugh, “The Trees That Miss The Mammoths”
A snapshot of one morning, on a relaxed day with mild weather. Now imagine this when it's crowded or when it's raining or snowing.
Video description: POV from the lap of a wheelchair user. Very shaky. OP is going downhill on a fall day. Lots of trees and fallen leaves around. There are construction trucks to the left in the very beginning. Every now and then, you can see a German Shepherd on the left. Second obstacle shows a food robot crossing the sidewalk to drive in front of OP, but it stops suddenly and OP crashes into it. OP continues down the hill until she reaches another food robot, which is obstacle 3. This robot sits in the middle of the sidewalk while OP navigates around it. Then OP comes to a concrete ramp with iron railings, which is obstacle 3.5. It is very steep. After the ramp, OP goes to cross the street, where a black SUV blows through the crosswalk. Obstacle 4 is a ramp with red brick. OP struggles to move up and pauses at one point before continuing again to obstacle 5, where there is a big concrete building and manual doors. The German Shepherd service dog goes up to push the accessibility button multiple times to no avail. A student comes and opens the door, OP enters through two sets of doors into a hallway. Clip change to obstacle 6, OP is wheeling down a hallway and approaches a white elevator with out of order signs.
In 2016, years before long COVID was a thing, the US National Institutes of Health, the largest single public funder of medical research in the world, launched a study into a long-neglected and puzzling condition: chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis, or ME/CFS.
Eight years later, the results of that study are finally out. In one of the most thorough investigations to date, researchers took a deep dive into a small group of 17 people who developed ME/CFS after an infection and found distinct biological differences compared to 21 healthy controls.
"Overall, what we show is that ME/CFS is unambiguously biological, with multiple organ systems affected," neurologist Avindra Nath, lead researcher of the study and clinical director of NIH's National Institute of Neurological Disorders and Stroke (NINDS), said in an interview with JAMA.
For decades, many doctors had dismissed ME/CFS as a psychosomatic condition that was 'all in patients' heads'. Now there is little doubt: a host of biological changes underpin ME/CFS.