#broad institute

[jcmarchi]

Machine learning and the microscope

New Post has been published on https://thedigitalinsider.com/machine-learning-and-the-microscope/

Machine learning and the microscope

With recent advances in imaging, genomics and other technologies, the life sciences are awash in data. If a biologist is studying cells taken from the brain tissue of Alzheimer’s patients, for example, there could be any number of characteristics they want to investigate — a cell’s type, the genes it’s expressing, its location within the tissue, or more. However, while cells can now be probed experimentally using different kinds of measurements simultaneously, when it comes to analyzing the data, scientists usually can only work with one type of measurement at a time.

Working with “multimodal” data, as it’s called, requires new computational tools, which is where Xinyi Zhang comes in.

The fourth-year MIT PhD student is bridging machine learning and biology to understand fundamental biological principles, especially in areas where conventional methods have hit limitations. Working in the lab of MIT Professor Caroline Uhler in the Department of Electrical Engineering and Computer Science and the Institute for Data, Systems, and Society, and collaborating with researchers at the Eric and Wendy Schmidt Center at the Broad Institute and elsewhere, Zhang has led multiple efforts to build computational frameworks and principles for understanding the regulatory mechanisms of cells.

“All of these are small steps toward the end goal of trying to answer how cells work, how tissues and organs work, why they have disease, and why they can sometimes be cured and sometimes not,” Zhang says.

The activities Zhang pursues in her down time are no less ambitious. The list of hobbies she has taken up at the Institute include sailing, skiing, ice skating, rock climbing, performing with MIT’s Concert Choir, and flying single-engine planes. (She earned her pilot’s license in November 2022.)

“I guess I like to go to places I’ve never been and do things I haven’t done before,” she says with signature understatement.

Uhler, her advisor, says that Zhang’s quiet humility leads to a surprise “in every conversation.”

“Every time, you learn something like, ‘Okay, so now she’s learning to fly,’” Uhler says. “It’s just amazing. Anything she does, she does for the right reasons. She wants to be good at the things she cares about, which I think is really exciting.”

Zhang first became interested in biology as a high school student in Hangzhou, China. She liked that her teachers couldn’t answer her questions in biology class, which led her to see it as the “most interesting” topic to study.

Her interest in biology eventually turned into an interest in bioengineering. After her parents, who were middle school teachers, suggested studying in the United States, she majored in the latter alongside electrical engineering and computer science as an undergraduate at the University of California at Berkeley.

Zhang was ready to dive straight into MIT’s EECS PhD program after graduating in 2020, but the Covid-19 pandemic delayed her first year. Despite that, in December 2022, she, Uhler, and two other co-authors published a paper in Nature Communications.

The groundwork for the paper was laid by Xiao Wang, one of the co-authors. She had previously done work with the Broad Institute in developing a form of spatial cell analysis that combined multiple forms of cell imaging and gene expression for the same cell while also mapping out the cell’s place in the tissue sample it came from — something that had never been done before.

This innovation had many potential applications, including enabling new ways of tracking the progression of various diseases, but there was no way to analyze all the multimodal data the method produced. In came Zhang, who became interested in designing a computational method that could.

The team focused on chromatin staining as their imaging method of choice, which is relatively cheap but still reveals a great deal of information about cells. The next step was integrating the spatial analysis techniques developed by Wang, and to do that, Zhang began designing an autoencoder.

Autoencoders are a type of neural network that typically encodes and shrinks large amounts of high-dimensional data, then expand the transformed data back to its original size. In this case, Zhang’s autoencoder did the reverse, taking the input data and making it higher-dimensional. This allowed them to combine data from different animals and remove technical variations that were not due to meaningful biological differences.

In the paper, they used this technology, abbreviated as STACI, to identify how cells and tissues reveal the progression of Alzheimer’s disease when observed under a number of spatial and imaging techniques. The model can also be used to analyze any number of diseases, Zhang says.

Given unlimited time and resources, her dream would be to build a fully complete model of human life. Unfortunately, both time and resources are limited. Her ambition isn’t, however, and she says she wants to keep applying her skills to solve the “most challenging questions that we don’t have the tools to answer.”

She’s currently working on wrapping up a couple of projects, one focused on studying neurodegeneration by analyzing frontal cortex imaging and another on predicting protein images from protein sequences and chromatin imaging.

“There are still many unanswered questions,” she says. “I want to pick questions that are biologically meaningful, that help us understand things we didn’t know before.”

[rottmnt-residuum]

Wym it starts when i go back to tgerapy

Is this a sign

i- i hope not?? i dont think theres anything really therapy worthy in the first update... hmmmm. i guess looking at it right now, it might be a little upsetting? very low grade, though

[needlesandnilbogs]

Every time I see people responding to less than perfect institutional responses to their demands by scrawling “I’M NOT READING THAT” over them (either on the paper or in photo edits) I want to shake them

[shinobicyrus]

“Nevertheless, the interpassive simulation of participation in postmodern media, the network of narcissism of MySpace and Facebook has, in the main, generated content that is repetitive, parasitic, and conformist. In a seeming irony, the media class’s refusal to be paternalistic has not produced a bottom-up culture of breathtaking diversity, but one that is increasingly infantilized...The reason that focus groups and capitalist feedback systems fail, even when they generate commodities that are immensely popular, is that people do not know what they want. This is not only because people’s desire is already present but concealed from them (although this is often the case). Rather, the most powerful forms of desire are precisely cravings for the strange, the unexpected, the weird. These can only be supplied by artists and media professionals who are prepared to give people something different from that which already satisfied them; by those, that is to say, prepared to take a certain kind of risk...to wager on the strange and our appetite for it.”

–Mark Fisher, Capitalist Realism: Is There No Alternative?

[daggersandarrows]

just remembered about the "friend" who called me an idiot and stopped talking to me because i refused to include nurses in acab.

like...yeah these two groups have power over the vulnerable that they will abuse. yes nurses can and will harm people. tell me. which one of these groups has state sponsored guns, riot gear, and legal invulnerability against being brought to justice??? which one of these professions was invented to recapture escaped slaves????

[lilliankillthisman]

Page 124 and we're finally playing the hits!

[adamsvanrhijn]

I'm sorry nobody knows what a tumblr job is

if you aren't missing a comma or a "but" there. thank u i love u

if i had unlimited characters and thought people would bother reading context associated with a poll, (i am pretty sure they usually do not) and also had some foresight about some of the specific things people would interpret differently than i intended, here's what this would have looked like:

[begin post]

[begin poll]

which of these listed tumblr job types is yours?

retail, grocery, consumer-facing service and sales (excludes call centers and food service)

food service (includes restaurants, cafes, coffee shops, bars, cafeterias, food trucks, commercial kitchens, food kitchens, etc; cooking + serving + hosting)

teacher, professor, tutor, teaching assistant, childcare provider, but not educational administrator, if you do another kind of education read the rest of the options first because one of them might be a better fit

engineer, developer, technical designer, data or computer scientist, not including technical writers

parks and wildlife, outdoor research, animal care (including animal boarding and veterinary care), animal keeping (such as zoos or aquariums), animal husbandry, farming, ranching, environmental conservation, gardener or plant nursery worker (but not florist), field archaelogist, equine therapist, outdoor camp counselor if you work with and have knowledge around plants and/or animals

librarian, archivist, docent, tour guide, curator, patron-facing researcher, consultant historian or sociologist, community educator at a cultural or knowledge (probably nonprofit) institution (including but not limited to historical reenactors); reception or guest services related to any of the previous, excepting food service, which is the food service option

writer - content, technical, proposal, marketing, fiction, nonfiction, educational, research, including editing, but has to be actively working and receiving pay from a company, an organization, and/or clients/commissioners including publications/publishers, even if income is inconsistent or not received at regular intervals. does not include captioning or transcription. translators use your best judgment

artist, illustrator, graphic designer, but has to be actively working and receiving pay from a company, an organization, clients/commissioners including publications and galleries, may include visual marketing but does NOT include ad sales, also does not include video editing unless you do like, speed paints or show off your art in videos

patient healthcare, caregiving, and advocacy. does not include animal care, pharmaceutical research or dispensing, or medical coding/billing

you are not currently working as / do not currently have any of the Tumblr Jobs listed above

[end poll]

a "Tumblr Job" is decided based on the following criteria, which is based on my own dashboard/Tumblr experiences, and tumblr searches:

either many Tumblr users have or have had that job, OR, one to a few high-profile Tumblr users have or have had that job

posts are made about that job, either about the day-to-day work itself (positive or negative), as an appeal to authority ("librarian here!"), or about the concept and/or vibes of the job or having that job

posts are reblogged about that job, and reach an audience of people who do not have that job; posts go viral about that job, even

Tumblr users might aspire to have that job, or be studying toward it

it might require a high level of interest and/or personal investment with limited positions available, OR, it might be a very common job in the world

the job is NOT one that many Tumblr users would perhaps complain and/or rant and/or criticize about other people having

the job is NOT one commonly associated with things Tumblr tends to skew away from, like industries known to contribute to climate change or jobs that tend to be associated with ultra high earners with wealth inequality in the same industry (editing to plug my other poll that 6 & 7 apply to that nobody is taking)

a "Tumblr Job" is NOT just a job anybody on tumblr might have or even a job most people or many people on tumblr might have. it's not even a job that is necessarily common on tumblr (common on tumblr != common tumblr job), that's something i am interested in finding out via the poll.

just because tumblr users you know also have your job doesn't mean it Is a tumblr job. and just because your job type isn't listed doesn't mean it is Not a tumblr job. there are only 9 job hodgepodge types here. there are more jobs in the world than this and there are more tumblr jobs on tumblr than this. these are also not and are not intended to be standard industry classifications. they are grouped by tumblr vibes, not necessarily by job role or duties.

if you do not have a job at this time, you do not currently right now have one of the listed tumblr jobs. being unemployed or being a student, even if you once had one of these jobs or are studying to obtain one of these jobs, are not jobs for the purpose of this poll.

the purpose of the poll is to see how many respondents actually have and are doing these specific jobs that i have identified as "tumblr jobs". nothing more and nothing less!

[end post]

but nobody is gonna fucking read all that & tumblr polls have character limits. if the poll was as specific as i wanted it to be it would not have however many thousands of votes it currently has. curse of my autisms <3

[zorrxchicle]

apparently I have several thoughts on the issue the previous post is really about. the infantilization of younger women, specifically in the context of intimate relationships with an age difference. trying to sum them up: 1. A 20something yo woman is not a minor. 2. The use of "minor" as a category to denote a type of person defined by being incapable of having agency in their own life is very insidious and makes my teeth hurt. 3. Patriarchy is a prison structuring all our lives, thoughts, behaviors and possibilities and it'll have women shackling themselves to a life of paid and unpaid labor for a man that has not yet realized he can become a full person when they should be at the club. so it's complicated

[halfdeadwallfly]

the only thing getting me through is the thought that i don't have physics lab next week

[idkhowtopickausername]

I can already tell this one course is going to really frustrate me

[jcmarchi]

Student spotlight: Victory Yinka-Banjo

New Post has been published on https://thedigitalinsider.com/student-spotlight-victory-yinka-banjo/

Student spotlight: Victory Yinka-Banjo

This interview is part of a series from the MIT Department of Electrical Engineering and Computer Science featuring students answering questions about themselves and life at the Institute. Today’s interviewee, Victory Yinka-Banjo, is a junior majoring in MIT Course 6-7: Computer Science and Molecular Biology. Yinka-Banjo keeps a packed schedule: She is a member of the Office of Minority Education (OME) Laureates and Leaders program; a 2024 fellow in the public service-oriented BCAP program; has previously served as secretary of the African Students’ Association, and is now undergraduate president of the MIT Biotech Group; additionally, she is a SuperUROP Scholar; a member of the Ginkgo Bioworks’ Cultivate Fellowship (a program that supports students interested in synthetic biology/biotech); and an ambassador for Leadership Brainery, which equips juniors/leaders of color with the resources needed to prepare for graduate school. She recently found time to share a peek into her MIT experience.

Q: What’s your favorite building or room within MIT?

A: It has to be the Broad Institute of MIT and Harvard on Ames Street in Kendall Square, where I do my SuperUROP research in Caroline Uhler’s lab. Outside of classes, you’re 90 percent likely to find me on the newest mezzanine floor (between the 11th and 12th floor), in one of the UROP [Undergraduate Research Opportunities Program] rooms I share with two other undergrads in the lab. We have standing desks, an amazing coffee/hot chocolate machine, external personal monitors, comfortable sofas — everything, really! Not only is it my favorite building, it is also my favorite study spot on campus. In fact, I am there so often that when friends recently planned a birthday surprise for me, they told me they were considering having it at the Broad, since they could count on me being there. 

I think the most beautiful thing about this building, apart from the beautiful view of Cambridge we get from being on one of the highest floors, is that when I was applying to MIT from high school, I had fantasized working at the Broad because of the groundbreaking research. To think that it is now a reality makes me appreciate every minute I spend on my floor, whether I am doing actual research or some last-minute studying for a midterm. 

Q: Tell me about one interest or hobby you’ve discovered since you came to MIT.

A: I have become pretty involved in the performing arts since I got to MIT! I have acted in two plays run by the Black Theater Guild, which was revived during my freshman year by one of my friends. I played a supporting role in the first play called “Nkrumah’s Last Day,” which was about Ghana at a time of governance under Kwame Nkrumah, its first president. In the second play, a ghost story/comedy called “Shooting the Sheriff,” I played one of the lead roles. Both caused me to step way out of my comfort zone and I loved the experiences because of that. I also got to act with some of my close friends who were first-time stage actors as well, so that made it even more fun. 

Outside of acting, I also do spoken word/poetry. I have performed at events like the African Students Association Cultural Night, MIT Africa Innovate Conference, and Black Women’s Alliance Banquet. I try to use my pieces to share my experiences both within and beyond MIT, offering the perspective of an international Nigerian student. My favorite piece was called “Code Switch,” and I used concepts from [computer science] and biology (especially genetic code switching), to draw parallels with linguistic code-switching, and emphasize the beauty and originality of authenticity. This semester, I’m also a part of MIT Monologues and will be performing a piece called “Inheritance,” about the beauty of self-love found in affection transferred from a mother. 

Q: Are you a re-reader or a re-watcher — and if so, what are your comfort books, shows, or movies?

A: I don’t watch too many movies, although I used to be obsessed with all parts of “High School Musical;” and the only book I’ve ever reread is “Americanah.” I would actually say I am a re-podcaster! My go-to comfort-podcast is this episode, “A Breakthrough Unfolds”, by Google DeepMind. It makes me a little emotional every time I listen. It is such an exemplification of the power of science and its ability to break boundaries that humans formerly thought impossible. As a computer science and biology major, I am particularly interested in these two disciplines’ applications to relevant problems, like the protein-folding problem discussed in the episode, which DeepMind’s solution for has caused massive advances in the biotech industry. It makes me so hopeful for the future of biology, and the ways in which computation can advance human health and precision medicine.

Q: Who’s your favorite artist?

A: When I think of the word ‘artist,’ I think of music artists first. There are so many who I love; my favorites also evolve over time. I’m Christian, so I listen to a lot of gospel music. I’m also Nigerian so I listen to a lot of Afrobeats. Since last summer, I’ve been obsessed with Limoblaze, who fuses both gospel and Afrobeats music! KB, a super talented gospel rapper, is also somewhat tied in ranking with Limo for me right now. His songs are probably ~50 percent of my workout playlist.

Q: It’s time to get on the shuttle to the first Mars colony, and you can only bring one personal item. What are you going to bring?

A: Oooh, this is a tough one, but it has to be my Brass Rat. Ever since I got mine at the end of sophomore year, it’s been nearly impossible for me to take it off. If there’s ever a time I forget to wear it, my finger feels off for the entire day. 

Q: Tell me about one conversation that changed the trajectory of your life.

A: Two specific career-defining moments come to mind. They aren’t quite conversations, but they are talks/lectures that I was deeply inspired by. The first was towards the end of high school when I watched this TEDx Talk about storing data in DNA. At the time, I was getting ready to apply to colleges and I knew that biology and computer science were two things I really liked, but I didn’t really understand the possibilities that could be birthed from them coming together as an interdisciplinary field. The TEDx talk was my eureka moment for computational biology. 

The second moment was in my junior fall during an introductory lecture to “Lab Fundamentals for Bioengineering,” by Professor Jacquin Niles. I started the school year with a lot of confusion about my future post-grad, and the relevance of my planned career path to the communities that I care about. Basically, I was unsure about how computational biology fit into the context of Nigeria’s problems, especially because my interest in the field is oriented towards molecular biology/medicine, not necessarily public health. 

In the U.S., most research focuses on diseases like cancer and Alzheimer’s, which, while important, are not the most pressing health conditions in tropical regions like Nigeria. When Professor Niles told us about his lab’s dedication to malaria research from a molecular biology standpoint, it was yet another eureka moment. Like, Yes! Computation and molecular biology can indeed mitigate diseases that affect developing nations like Nigeria — diseases that are understudied, and whose research is underfunded. 

Since his talk, I found a renewed sense of purpose. Grad school isn’t the end goal. Using my skills to shine a light on the issues affecting my people that deserve far more attention is the goal. I’m so excited to see how I will use computational biology to possibly create the next cure to a commonly neglected tropical disease, or accelerate the diagnosis of one. Whatever it may be, I know that it will be close to home, eventually.

Q: What are you looking forward to about life after graduation? What do you think you’ll miss about MIT?

A: Thinking about graduating actually makes me sad. I’ve grown to love MIT. The biggest thing I’ll miss, though, is Independent Activities Period (IAP). It is such a unique part of the MIT experience. I’ve done a web development class/competition, research, a data science challenge, a molecular bio crash course, and a deep learning crash course over the past three IAPs. It is such an amazing time to try something low stakes, forget about grades, explore Boston, build a robot, travel abroad, do less, go slower, really rejuvenate before the spring, and embrace MIT’s motto of “mind and hand” by just being creative and explorative. It is such an exemplification of what it means to go here, and I can’t imagine it being the same anywhere else. 

That said, I look forward to graduating so I can do more research. My hours spent at the Broad thinking about my UROP are always the quickest hours of my week. I love the rabbit holes my research allows me to explore, and I hope that I find those over and over again as I apply and hopefully get into PhD programs. I look forward to exploring a new city after I graduate, too. I wouldn’t mind staying in Cambridge/Boston. I love it here. But I would welcome a chance to be somewhere new and embrace all the people and unique experiences it has to offer.

I also hope to work on more passion projects post-grad. I feel like I have this idea in my head that once I graduate from MIT, I’ll have so much more time on my hands (we’ll see how that goes). I hope that I can use that time to work on education projects in Nigeria, which is a space I care a lot about. Generally, I want to make service more integrated in my lifestyle. I hope that post-graduation, I can prioritize doing that even more: making it a norm to lift others as I continue to climb.

[a-god-in-ruins-rises]

Well maybe now congress will actually do its job and pass laws.

that's a HUGE maybe. congress is dysfunctional and inefficient and unwieldy. it is constantly mired in petty politics, mindless bickering, and perpetual gridlock. Really smart leaving the day-to-day regulations that govern the nation up to them! Then, when they eventually do get around to passing oppressively narrow regulations y'all will complain about how impossible it is to remove said regulations.

[ravenkings]

my problematic opinion regarding the kate middleton conspiracies is that seeing how "the firm" dealt with and continues to deal with the prince andrew x jeffrey epstein situation (among many other things) i find it very difficult to muster much sympathy or trust for the british monarchy as an institution

[pttedu]

Welding Repair Guide Techniques For Perfect Welds

Explore effective troubleshooting techniques in our welding repair guide. Fix common repair issues with expert insights and tips to get that perfect weld.

[bluelockmaniac]

prisonguard!jjkmen X prisoner!reader ★ slight suggestiveness + gn!reader

prisonguard!satoru who shamelessly makes out with you, unbothered by the agape mouths of the prisoners in the surrounding cells. he shoots them a menacing glare, silently threatening them to keep their tongues locked in their mouths if they know what's best for them. he then gently pulls your curious (and slightly aroused) face closer to his, until your cheeks pressed against the cold metal of the iron bars. despite the barrier, he was able to capture your sweet lips fervently, slightly nibbling on the soft, addictive flesh.

prisonguard!nanami who openly delivers the warmest meals and the comfiest clothes directly to your cell, ignoring the envious gazes of covetous prisoners who were painfully aware of the privileges you had, that they lacked. the other guards held him in high regard due to his intimidating reputation, so when they caught him hauling a thick mattress, coupled with a fluffy pillow and blanket, slung effortlessly over his broad shoulder just for you, they immediately casted you in a new light— surely you were wronged, right?

prisonguard!sukuna who plays a dangerous game, sneaking into your cell late at night in a vulgarly obtrusive manner, as if he held no interest in the possibility of rousing all the vile convicts from their deep slumber. he settles himself homely on the edge of the wooden plank you called your ‘bed’, and while you couldn’t see his face properly due to the dimmed lighting, you can practically feel the smirk forming on his lips as he pulls you onto his lap, whispering temptations laced with a certain bittersweetness, promising that he’ll get you out of here one day—but not yet. he still wants to use you.

prisonguard!toji who couldn't care less about concealing his painfully obvious favoritism towards you. while he cruelly forces the inmates to do all the labour, having them sweep the dirty floors of the institution, scrub the filthy metal toilets of each cell, and handle the reeking laundry, you were innocently seated on his spread lap, in his office. you giggle softly as he plants kisses with blatant intentions on your hair, trailing down to your nape, all while you flip through the brand-new magazine he had bought exclusively for you.

prisonguard!choso whose careful footsteps echo down the walkway early in the morning, drawing closer to your cell as he does every single day. he enters quietly, a smile spreading across his face when he sees you waiting for him on the edge of your dented bed, wide awake, with the scalpel he had gifted you resting lightly in your grip. you quickly stand and move to the cement wall where dates, names, and vulgarity were carved. sighing happily, you feel him standing behind you, his chest pressing against your back. he gently guides your hand with the scalpel to the wall, slowly chipping away at the concrete to write a number. three. you glance back at him with a smirk, which he responds with a ticklish pinch on the plush of your waist. three more days till he gets you the fuck out of here.

prisonguard!suguru who flashes you one of his notorious smiles, your eyes immediately drawn to the prison guard’s uniform hanging from his arm, then to the scarlet-tinted baton he held carelessly in his other hand. your lips curl upwards into a grin of delight, laughing as you fathom the fact that he actually followed through on his promise. you quickly loop your arms around his neck, kissing him softly, before taking the slightly oversized uniform and dressing up while no one, prisoner or guard, was watching. after you were finished, he walked confidently down the hallway with you by his side. no guard bothered to question the unfamiliar face beside him. he didn’t even have to use the excuse of patrol duty. ultimately, he was able to successfully orchestrate your escape. but not to worry, he has you safely and comfortably hidden in his apartment after a search for you was later launched that day.

© 2024 bluelockmaniac — do not repost, copy, translate, modify, etc my work on any platform !

[artbyblastweave]

So I don't really think that it's a secret that Boston has a significant Minotaur problem. It's a pretty common situation for older American cities on the East Coast- centuries of poorly-documented cowpath-style urban growth providing an ideal nesting ground, widespread electrification and plentiful steam tunnels that compensate for the loss of the temperate Mediterranean climate that they're used to. And all this on top of limited institutional knowledge of proper containment tactics at least up until the Greek diaspora started to really blow up in the 20th century. You only have to fuck up the safety checks on one cargo steamer coming in from the broad area of old Minoa and then basically any import controls you put in after that point are closing the barn door after the bulls are loose. So yeah, no secret, it's an issue.

I do think, though, that we've kind of let the specific narrative surrounding the issue get away from us in the usual fashion, the problem people picture when they hear "Minotaur" isn't anywhere close the to the problem as it exists on the ground. I mean people's minds immediately jump to the 1949 Boylston massacre, but let's be real, even though that was really politically useful for finally getting the exit fares on the T removed, that was still a black-swan event, right? Basically every mayor since, like, Hynes has lived in mortal terror of having to manage a repeat of something like that during the mass media era, let alone the smartphone era. So we've got these Theseus kill-teams with their titanium-composite ropes and souped-up cattle prods and bolt guns, we have these constant "track replacement" stoppages on the orange line, and it's fine. It's fine! There hasn't been a serious Minotaur thing within walking distance of a T stop since, like, 2006, which again you can mostly chalk up to the chaos surrounding the dig.

No, the actual danger zones, the silent killers are the exurbs, like West Roxbury, Roslindale, parts of Hyde Park. Relatively dense foliage, bad sightlines, far enough from the urban center that the response times are bad, foot traffic that's basically nonexistent for big parts of the workweek because everyone's either commuting or hunkered down working from home. And, of course, a steady stream of delivery drivers with no political ties to the area. Which is an important element, right? I mean it's kind of baked into the Minotaur's nature, that they have a very finely tuned instinctual awareness of the politics of their situation. Start snagging homeowners, there might be a ruckus. But Amazon does steady business everywhere, and Minotaurs are smart enough to cover their bases, to wait until after the drivers have dropped off your package or delivered your food. So yeah, watch yourself out there. One eye on the treeline at all times. And if you see an Amazon van left idling, get ready to run faster than the driver could.