Glial cells are like an unsung network of city support workers – regulating traffic, sweeping streets, keeping things orderly and hygienic in our brain and nervous system. Their shape is key to how they interact with brain cells, but current techniques to assess this morphology are limited. A new imaging tool, GliaMorph, combines different modules to in turn quantify texture, segmentation, and other features at the individual cell and global scale. Researchers turned GliaMorph’s focus to zebrafish Müller glia – cells important to eye health. They were able to measure Müller glia development, observing the growing complexity and rearrangement (pictured, at 72 - top - and 120 - bottom - hours post fertilisation) – with the original image on the left followed left to right by segmentation, structural edges, distance between elements, and the cellular skeleton highlighted. They then measured changing protein positioning in a mouse model of glaucoma, showing the approach’s direct potential for revealing the precise morphology of human disease.
Written by Anthony Lewis
Image from work by Elisabeth Kugler and colleagues
Institute of Ophthalmology, University College London, London, UK
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in Development, February 2023
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Breast milk is often referred to as “liquid gold” due to its numerous benefits for babies. One of the critical components of breast milk is its high protein content, which provides essential building blocks for infants’ growth and development. In this blog article, we will explore the importance of proteins in breast milk and how they contribute to the bricks of life.
What are proteins, and why…
Steve being convinced (read: forced) by the highschool drama teacher to play the part of "King" in a production, not a speaking role, his job is to just... look the part, look down upon his subjects from a throne, sit above them, powerful, regal, with the side note that he has to maintain that air of disinterest through the whole thing until he's 'assassinated/usurped'.
he only says yes because he was promised an automatic pass if he did it, as no-one else could really fit and maintain the look the teacher had envisioned.
and Eddie Munson, playing the role of court jester, putting his whole jestussy into making Steve crack both his character, and a smile.
because Steve wouldn't get his automatic pass if he broke character, and Eddie feels it's his sworn duty to not let King Steve coast through school on his good looks.
1. Gazing: The character's eyes move slowly across a scene or object, taking in the details. This movement can indicate curiosity, interest, or observation.
2. Darting: The character's eyes quickly shift from one point to another, often indicating nervousness, suspicion, or alertness.
3. Winking: One eye briefly closes while the other remains open, often used to convey playfulness, flirtation, or a shared secret.
4. Rolling eyes: The character's eyes move upward or to the side, indicating annoyance, disbelief, or sarcasm.
5. Narrowing eyes: The character's eyes become slits or squinted, suggesting suspicion, scrutiny, or concentration.
6. Widening eyes: The character's eyes open wider than usual, indicating surprise, shock, or fear.
7. Glancing: The character's eyes quickly move in a specific direction, often used to check for danger or to communicate a message without words.
8. Staring: The character's eyes fixate on a specific point or person for an extended period, often indicating intensity, fascination, or intimidation.
9. Flickering eyes: The character's eyes flicker rapidly between different objects or individuals, suggesting indecisiveness, confusion, or distraction.
10. Blinking: The character's eyes momentarily close and open, mimicking a natural blinking pattern. This movement helps to convey realism and prevent the eyes from appearing static.
Dp x dc twin au where Danny and Damian were in fact conjoined/siamese twins, but the most dangerous type - one head, two bodies.
Their early removal from talia being because their shape would not have allowed for natural birth, they were written off but talia begged for the chance to send them off in the lazarus pit.
By some bizarre miracle, before she turned to leave, two small bodies bobbed to the surface - identical in every way, except for the eyes. The previous blue eyes now split in two, one left, one right, and the new eyes, pit created, a bright green.
She took her child, her two children, and together, they survived.
Being removed prematurely, their early years were tough, but soon they blossomed into promising heirs for the league. In sync with every step, the closest of brothers, the league was certain the old fairy tale of twins being telepathic had been granted by the pit that separated them, the remnants of being born as one mind, one brain, one skull.
But then Danny had to flee, and leave his other half behind. Stretched by distance for the first time, the bond grew thin and stretched, and Damian grieved his brother as dead. When he started being sent on public missions, he hid his distinctive heterochromia, choosing the green in memory of the pit that had given him and his brother life.
Danny, hiding his pit aura in the ocean's worth that was Amity park, took to blue, the colour that he and Damian were born with.
Damian moves to Gotham, and continues to mourn his brother as dead, right until one day when he is twelve, when he learns what the death of your other half truly feels like.
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Their reunion is a thing of family legend. Violence runs hot in both bloodlines, ghosts are highly emotional and prone to fighting a the drop of a hat for bonding, playing, testing, every reason under the green sun. Their training and play often consisted of friendly spars, competitive spars, furious spars, venting spars. Both have been exposed to unhealthy amounts of ecto since before their birth.
There is a long, long minute of staring, before they rip themselves away and lunge at each other like wolves.
The bat family are horrified by their brutally efficient youngest suddenly barreling towards a clone (?) and trying to claw his throat open with his bare hands while openly sobbing.
It ends with them wrapped around each other crying into the others shoulder as their minds finally meet again and relax from the painful stretch for the first time in years.
last night the dentist (faggy) was adjusting the cuff on my arm for the blood pressure machine and said "i'm making this tighter, i've been too nice to you" and like oh my god. oh my god. oh my god
If you look at a clear blue sky it’s possible to see the blood vessels in your own eyes. But researchers demanding a closer look have been working on ways to visualise the full complex network of vessels that permeate our eyeballs. Previous genetic and experimental attempts in mice have tended to look at one sub-section of vessels at a time. A new approach has represented the complete vasculature of the mouse eye at various stages of development (video, with different sections of vasculature digitally coloured). A process to make the eye material transparent is followed by high resolution microscopy and digital analysis. With this technique, the researchers observed how the iris vasculature (yellow) is remodelled during development just after disconnection from the early supply network. They also analysed the impact of injury on vascularisation, showing the platform’s potential for analysing eye disease impacts and treatments on a whole-eye scale.
Written by Anthony Lewis
Video by Luc Krimpenfort and colleagues
Div. of Vascular Biology, Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Stockholm, Sweden
Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in bioRxiv, December 2022 (not peer reviewed)
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