Nipocalimab Trial Highlights Promise for Treating Rare Blood Disorders in Pregnancy 🧪👶
Recent clinical trials suggest that nipocalimab could revolutionize the treatment of haemolytic disease of the foetus and newborn (HDFN) 🩸, a rare but serious blood disorder. Data from the Phase II UNITY study demonstrate that nipocalimab may benefit foetuses, newborns, and expectant mothers by delaying or preventing anemia and reducing the need for intrauterine blood transfusions in high-risk pregnancies 🤰.
Insights from the Phase II Study:
The study included pregnant women who had previously experienced foetal loss or required early intrauterine transfusions due to HDFN. After administering intravenous nipocalimab between 14 and 35 weeks of gestation, 54% of participants achieved a live birth at or after 32 weeks without the necessity for transfusions 👶. Additionally, some newborns did not require post-birth transfusions, and none developed foetal hydrops, a severe complication of HDFN 💉.
Potential and Future of Nipocalimab:
Johnson & Johnson confirmed that nipocalimab is currently the sole therapy in clinical development specifically for HDFN 🧬. Dr. Kenneth Moise Jr., the lead investigator and a professor at Dell Medical School at The University of Texas at Austin, emphasized nipocalimab's potential to treat various alloimmune conditions affecting foetuses, such as foetal/neonatal alloimmune thrombocytopenia and immune-mediated congenital heart block 🧠.
Dr. Moise Jr. added that if further research supports nipocalimab's use in treating HDFN, it could significantly improve the safety and ease of managing such pregnancies 🩺. The promising results from the Phase II trial were published in the New England Journal of Medicine 📄, paving the way for a larger Phase III study. If approved, nipocalimab would represent the first non-surgical treatment option for high-risk pregnancies affected by HDFN 🔬.
In related news, the National Institute for Clinical Excellence (NICE) recently recommended a new drug for haemolytic anemia patients, marking progress in the field of blood disorder treatments 💊.
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6061 aluminum vs 7075 aluminum
What Is 6061 Aluminum Grade?
Aluminum grade 6061 is one of the most commonly used aluminum alloys. it is the most famous member of the 6000 series of aluminum alloys. Due to the perfect balance of hardness and machinability, 6061 aluminum alloy is referred to as structural aluminum. it is Composed primarily of aluminum(97.9%) and magnesium, silicon, copper, chromium, and a tiny amount of other elements.
What Is 7075 Aluminum Grade?
Aluminum 7075 is a high-strength heat-treatable aluminum alloy used for highly stressed structural parts. it is a member of the 7000 series aluminum alloys. As a primarily zinc-based aluminum alloy, It contains 5.6% zinc, 2.1% magnesium, and 1.2% copper.
Differences Between Aluminum 6061 and 7075
6061 Vs. 7075 Aluminum: Chemical Composition Comparison
Below is a table to show the Chemical Composition of both materials and you will find how each Chemical affects the performance of the materials.
6061 vs. 7075 Aluminum: mechanical properties comparison
A comparison table is below for the mechanical properties of both materials.
Tensile Strength
This property measures a material’s resistance to a longitudinal pulling force. Aluminum 7075 is very good in this aspect, making it ideal for applications where high strength is critical, such as aerospace components.
Yield Strength
Yield strength indicates the point at which a material begins to deform plastically. Aluminum 7075 has a higher yield strength compared to 6061, which means its superior ability to withstand deformation.
Hardness
Hardness means a material’s resistance to surface indentation or abrasion. Aluminum 7075’s hardness is higher than that of aluminum 6061, making it more resistant to wear and damage.
Elongation
Elongation measures how far a material can stretch before breaking. Aluminum 6061 is more ductile in this aspect, meaning it can deform significantly before reaching its breaking point compared to 7075.
Young’s Modulus(Modulus of Elasticity)
This property defines a material’s stiffness and its ability to return to its original shape after deformation. Both alloys have similar values, but 6061 is slightly more elastic, making it better suited for applications requiring flexibility.
Thermal Conductivity
It means how efficiently a material conducts heat. Aluminum 6061 has higher thermal conductivity, making it suitable for heat dissipation applications like heat sinks.
Electrical Resistivity
This property quantifies a material’s opposition to electrical current flow. 7075 has slightly lower electrical resistivity, making it better for electrical conductivity applications.
Elasticity
Elasticity reflects a material’s ability to deform and regain its original shape under applied stress. Aluminum 6061 has higher elasticity, allowing it to flex more without permanent deformation.
Temperature Resistance
This property indicates how well a material can withstand elevated temperatures. Aluminum 7075 is better in high-temperature environments due to its higher melting point.
Corrosion Resistance
6061 vs. 7075 Aluminum: machinability comparison
CNC Machinability
Aluminum 6061 is easy to machine, and used for producing longer, continuous chips during CNC Aluminum machining. On the other hand, Aluminum 7075 is also machinable, but it generates shorter, segmented chips. so, for CNC machinability, 6061 aluminum will be better.
Weldability
In terms of weldability, Aluminum 6061 is better. It is adaptable to various welding techniques, including TIG and MIG welding with a good result. Although Aluminum 7075 is weldable, it demands more expertise and careful control of welding parameters.
Bending
For bending operations, Aluminum 6061 is highly formable and can be bent to various angles without the risk of cracking or distortion. In contrast, Aluminum 7075 is less ductile and possible to crack during bending.
Sawing
Both alloys can be cut effectively, but Aluminum 6061 is easier to cut. Standard sawing equipment can easily cut 6061, ensuring precise and clean cuts. Aluminum 7075 requires specialized sawing equipment for optimal cutting results.
EDM (Electrical Discharge Machining)
Wire EDM is not commonly used on Aluminum 6061 due to its excellent machinability using conventional methods. For Aluminum 7075, EDM is a viable option, especially in cases demanding high-precision components.
Tool Wear
Tool wear is a key consideration during machining. Aluminum 6061 shows low tool wear. Aluminum 7075, while still machinable has high tool wear due to its high hardness.
Surface Finish
Aluminum 6061 generally delivers a smooth surface finish, making it an excellent choice when aesthetics is important. Aluminum 7075 can also achieve a satisfactory surface finish, but it may require more effort due to its high hardness.
6061 VS 7075 Aluminum: How To Choose?
With the answer to the following three questions, you will know how to choose.
Which One is Stronger: 6061 or 7075 Aluminum?
7075 aluminum alloy has a higher yield strength compared to 6061 aluminum, So it can withstand impacts better than 6061.
Which One is Easier to Machine: 6061 or 7075 Aluminum?
6061 aluminum has lower tensile strength and hardness compared to 7075 aluminum. So, 6061 aluminum is easier to machined and shaped.
Which One is More Cost-Effective?
The raw material cost and machining expenses for 7075 are higher. So Aluminum 6061 is more cost-effective.
When to choose: 6061 or 7075 Aluminum
According to the comparison above, we summarize a when list to help you decide how to choose.
Aluminum 6061 can be considered for use in the following situations:
When parts require a lot of welding process.
When there’s a high demand for corrosion resistance.
When a lower cost is a priority.
7075 aluminum is more suitable for the following situation:
When achieving a high strength-to-weight ratio is needed.
When parts need to withstand high temperatures.
When parts will be subjected to high stress.
When the budget allows for higher material costs.
Conclusion
6061 and 7075 Aluminum alloys are both wonderful in the machining process. if you can not decide well, Contact a professional aluminum machining supplier. KUSLA is a manufacturer of precision aluminum machining in China. Feel free to get in touch with us for your aluminum machining projects.
You may also interested in other comparisons:
Titanium vs Aluminum
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