#IT infrastructure components

[ajmishra]

How IT Infrastructure Can Make or Break Your Startup

Discover how IT infrastructure plays a crucial role in the success or failure of your startup. Learn the key components, challenges, and best practices to build a strong foundation that supports growth and scalability. Visit now to read more: How IT Infrastructure Can Make or Break Your Startup

[rahulp3]

What Are The Major Factors Driving Retinal Biologics Market Growth?

The Retinal Biologics Market is experiencing a surge in demand, fueled by advancements in eye disease treatments and a growing emphasis on vision health. According to a recent analysis by Future Market Insights (FMI), a leading market research firm, the market is currently valued at an impressive US$22.25 billion in 2022. Looking ahead, the market is projected to witness a remarkable Compound Annual Growth Rate (CAGR) of 11.1% over the next six years. This translates to a staggering market valuation of US$41.92 billion by 2028, highlighting the significant potential of retinal biologics in revolutionizing eye care.The remarkable expansion of the Global Retinal Biologics sector is fueled by advancements in technology, innovative research, and a growing demand for cutting-edge treatments. As the industry continues to evolve, it presents unprecedented opportunities for stakeholders, investors, and healthcare professionals alike.Key Retinal Biologics Market Insights:

Rising Prevalence of Diabetes-related Eye Disorders and Age-related Macular Degeneration (AMD) The prevalence of diabetes-related eye disorders and age-related macular degeneration is on the rise, underscoring the growing need for innovative solutions within the Retinal Biologics Industry.Substantial Investment in R&D for Biologics in Retinal Disorders The industry is witnessing a significant influx of research and development resources, aimed at advancing biologics for both infectious and non-infectious retinal disorders. This investment underscores the commitment to addressing unmet medical needs.

Emergence of Specific Biologic Molecules as Therapeutic Targets Specific biologic molecules are gaining prominence as highly promising therapeutic targets, offering new hope for patients with retinal conditions.Gene Therapy as a Solution for Monogenic Retinal Illnesses With a growing number of monogenic retinal illnesses, gene therapy is emerging as a pivotal component of the Retinal Biologics Market, presenting innovative solutions for these challenging conditions.

Request a Sample Copy of This Report Now.https://www.futuremarketinsights.com/reports/sample/rep-gb-8663

[silver-eater]

Started another rimworld playthrough bc I'm too sillay

This one is regular old mechanitor bc I have so many mods that add to em but I never play them. My main goals are to get a gestalt engine to manage the base so my mechanitor can go places, build a sleeve pod so I can put my mechanitor into a superior body, as well as make clones to eventually replace most mechs with hyperspecialized clones, freeing up bandwidth for warmechs (i was considering using androids but in my experience android mods kinda suck, theyre either inherently weaker than humans, stronger in a way that makes me compelled to use them exclusively and sucks all the fun out, or just rlly weird to use.) And collect lots of genes through immensely unethical means to make my clones even more powerful. The way I'll get them is wait for a human variant called a wretch to enter my base, this is doable bc a certain pirate faction can have them. Wretches have a gene that gives the host ten random genes every day, so I take that gene, make a xenogerm, and now any prisoner can be given the same gene. Now I put them in this extraction pod and every fifteen days or so I get a new random gene. There will be many garbage genes to toss, but in time it will make me super op.

[terakonide]

Just put together a 3-hour playlist specifically designed to wring my subconscious through a mach speed nonstop roller coaster of every single emotion I've ever felt. Psychotic, for sure, but I've never known anything other than going the full 100%. For everything, always.

[intelisync]

Decentralized Physical Infrastructure (DePIN) Explained

DePINs are transforming the way we build and manage infrastructure by leveraging blockchain technology. These networks ensure resilience, transparency, and security by decentralizing control and integrating blockchain-based systems.

Key components of DePINs include off-chain networks, token incentives, blockchain architecture, and physical infrastructure networks. These elements work together to facilitate secure and transparent transactions and automate agreements through smart contracts. However, DePINs face challenges like scalability, regulatory uncertainty, and environmental concerns. The DePIN Flywheel concept demonstrates how tokenization fosters network growth, creating a self-reinforcing cycle of development and innovation.

This innovative model enables seamless collaboration among various devices without relying on a central authority, thereby democratizing access to essential infrastructure resources.

DePINs operate through several key components, including off-chain networks, token incentives, blockchain architecture, and physical infrastructure networks. These elements work together to facilitate secure transactions, automate processes with smart contracts, and tokenize physical assets. This integration not only optimizes resource management but also fosters a more inclusive and participatory infrastructure ecosystem, empowering communities and individuals alike.

The future of infrastructure lies in the convergence of digital and physical elements, with DePINs leading the way. Intelisync offers tailored blockchain development solutions to help startups and small businesses embrace decentralized infrastructure. Connect with Intelisync today to explore the Learn more....

[little-p-eng-engineering]

Little P.Eng.'s Comprehensive Seismic Structural Services Aligned with ASCE 7-22 and NBCC Standards

In an era where architectural ambition pushes the limits of engineering, safeguarding structural integrity against natural calamities, particularly seismic activities, becomes paramount. This detailed exposé delves into the sophisticated seismic structural engineering services provided by Little P.Eng., a firm renowned for its compliance with the latest American Society of Civil Engineers (ASCE) 7-22 standards and the Canadian National Building Code (NBCC). Their work spans across Canada and the United States, encompassing a diverse range of buildings and non-structural elements, reflecting the pinnacle of safety, reliability, and innovation in modern construction.

1. Introduction

The unpredictable nature of seismic activities has long posed a significant challenge to the realms of construction and civil engineering. Within this volatile environment, Little P.Eng. has emerged as a beacon of reliability, offering cutting-edge seismic structural engineering services across Canada and the United States. Their adherence to the ASCE 7-22 and NBCC codes ensures not only the structural integrity of vast construction undertakings but also the safety and longevity of non-structural elements, affirming their position at the forefront of seismic resilience in contemporary infrastructure.

2. Understanding Seismic Structural Engineering

2.1. The Science of Earthquake Engineering

Before delving into Little P.Eng.'s specialized services, one must understand the core principles of seismic structural engineering. This discipline focuses on making buildings and non-structural components resistant to earthquake shocks through specialized planning, design, detailing, and, subsequently, construction. It encompasses geological science, material engineering, and structural analysis to develop structures capable of withstanding seismic disturbances.

2.2. Evolution of Seismic Codes: From ASCE 7-10 to ASCE 7-22

Seismic building codes are dynamic, evolving in response to the continuous advancements in engineering research and catastrophic lessons learned from each seismic event. The transition from ASCE 7-10 to ASCE 7-22 is a reflection of this evolution, marking significant strides in risk reduction and structural robustness, emphasizing not just human safety but also post-earthquake functionality and rapid recovery for communities.

3. Little P.Eng.’s Integration of ASCE 7-22 in Seismic Structural Engineering

3.1. Innovations in Seismic Design Philosophies

Little P.Eng. employs a forward-thinking approach to integrate the innovations outlined in ASCE 7-22. These include state-of-the-art seismic design philosophies involving base isolation, energy dissipation devices, and performance-based seismic design (PBSD), allowing for structures that are more flexible, absorb and dissipate seismic energy, and maintain structural integrity during earthquakes.

3.2. Site-Specific Hazard Analysis and Geotechnical Considerations

One of the critical aspects of ASCE 7-22 is the emphasis on site-specific hazard analyses. Little P.Eng.'s engineers led by Meena Rezkallah carry out comprehensive geotechnical evaluations, considering soil-structure interaction, liquefaction potential, and site-specific seismic hazard assessments. By understanding the geological variances across different regions in North America, they ensure that each design is intrinsically aligned with its environmental context.

4. Adherence to NBCC Standards: Expanding Safety Parameters Across Canada

4.1. Bridging Policies between Countries

While their services in the United States predominantly adhere to ASCE standards, Little P.Eng. seamlessly bridges engineering policies between the U.S. and Canada by aligning their practices with the NBCC. This code compliance not only underscores their versatility in handling cross-border projects but also reflects their commitment to upholding the highest safety and professional standards in every geographical locale.

4.2. Understanding NBCC’s Seismic Provisions

The NBCC has distinct seismic provisions, necessitating specialized knowledge and an adaptive engineering approach. Little P.Eng.'s expertise in Canadian seismic codes ensures that structural and non-structural components comply with regional regulations, catering to Canada's unique seismic challenges, especially in high-risk provinces.

5. Comprehensive Services for Buildings and Non-Structural Elements

5.1. Diverse Building Typologies

Little P.Eng.'s portfolio encompasses a variety of buildings, from residential high-rises and expansive commercial complexes to critical facilities like hospitals and emergency response centers. Each building type presents unique challenges, and the firm’s nuanced, context-oriented approach to seismic retrofitting and sustainable design practices sets industry standards.

5.2. Protecting Non-Structural Components

Beyond the buildings themselves, Little P.Eng. extends its engineering prowess to safeguard non-structural elements. These components, often overlooked, can pose significant hazards during seismic events. From architectural elements to mechanical and electrical systems, the firm implements exhaustive strategies to enhance the safety of these components, thereby protecting human life and minimizing economic loss.

6. Future Directions and Continuous Advancements

6.1. Embracing Technological Innovations

As the field of seismic structural engineering advances, Little P.Eng. remains committed to incorporating new technologies, including artificial intelligence and machine learning, for predictive analysis, design optimization, and risk management. Their continual investment in technology positions them as a leader in future-proofing structures against earthquakes.

6.2. Contribution to Global Seismic Safety Standards

Harnessing Advanced Engineering: Little P.Eng.'s Comprehensive Seismic Structural Services Aligned with ASCE 7-22 and CNBCC Standards in North America

7. Conclusion

Little P.Eng.’s comprehensive seismic structural engineering services, grounded in the latest ASCE and NBCC standards, represent a confluence of scientific mastery, innovative engineering, and a deep commitment to safeguarding human lives and investments. Their work across diverse building typologies and non-structural components in Canada and the United States cements their stance as a pivotal player in shaping resilient, sustainable, and safe urban landscapes. As seismic activity remains an unpredictable threat, the foresight and innovation of firms like Little P.Eng. are society's best bet for a safer tomorrow.

References

[1] American Society of Civil Engineers. (2022). Minimum Design Loads and Associated Criteria for Buildings and Other Structures (ASCE/SEI 7-22). ASCE.

[2] National Research Council Canada. (2020). National Building Code of Canada.

Tags:

Little P.Eng.

ASCE 7-22

design optimization

earthquake resilience

energy dissipation

building codes

seismic design

advanced materials

non-structural components

CNBCC

technological innovations

cross-border projects

geotechnical considerations

mechanical systems safety

base isolation

sustainable construction

electrical systems safety

Seismic structural engineering

critical infrastructure

artificial intelligence

urban resilience

construction techniques

seismic retrofitting

site-specific analysis

predictive analysis

professional standards

safety regulations

risk management

performance-based design

global seismic standards

Engineering Services

Structural Engineering Consultancy

Seismic Bracing Experts

Located in Calgary, Alberta; Vancouver, BC; Toronto, Ontario; Edmonton, Alberta; Houston Texas; Torrance, California; El Segundo, CA; Manhattan Beach, CA; Concord, CA; We offer our engineering consultancy services across Canada and United States. Meena Rezkallah.

[wilwheaton]

At Steve Jackson Games, we are actively assessing what this means for our products, our pricing, and our future plans. We do know that we can't absorb this kind of cost increase without raising prices. We've done our best over the past few years to shield players and retailers from the full brunt of rising freight costs and other increases, but this new tax changes the equation entirely. Here are the numbers: A product we might have manufactured in China for $3.00 last year could now cost $4.62 before we even ship it across the ocean. Add freight, warehousing, fulfillment, and distribution margins, and that once-$25 game quickly becomes a $40 product. That's not a luxury upcharge; it's survival math. Some people ask, "Why not manufacture in the U.S.?" I wish we could. But the infrastructure to support full-scale boardgame production – specialty dice making, die-cutting, custom plastic and wood components – doesn't meaningfully exist here yet. I've gotten quotes. I've talked to factories. Even when the willingness is there, the equipment, labor, and timelines simply aren't. [...] We want to be transparent with our community. This is real: Prices are going up. We're still determining how much and where. If you're frustrated, you're not alone. We are too. And if you want to help, write to your elected officials. Ask them how these new policies help American creators and small businesses. Because right now, it feels like they don't. We'll keep making games. But we'll be honest when the road gets harder, because we know you care about where your games come from – and about the people who make them.

Daily Illuminator: Tariffs Are Driving Up Game Prices Now

[virtualizationhowto]

Terragrunt vs Terraform: Battle of DevOps tools

Terragrunt vs Terraform: Battle of DevOps tools @vexpert #homelab #terraform #terragrunt #infrastructureascode #cloudinfrastructuremanagement #devops #terragruntconfiguration #dependencymanagement #remotestatemanagement

Infrastructure as Code (IaC) has become widely adopted by many, including in production environments, developers, and home lab enthusiasts to deploy infrastructure. Terraform is arguably one of the top tools used by DevOps professionals. However, there is another tool you may not have heard about called Terragrunt. What is Terragrunt? What about Terragrunt vs Terraform? Are they competing…

[electronalytics]

Explosion-proof Circuit Breaker Market Share, Size, Type, Demand, Overview Analysis, Trends, Opportunities, Key Growth, key points, Development and Forecasts by 2032

Market Overview:

The explosion-proof circuit breaker market refers to the segment of the circuit breaker market that caters to hazardous or potentially explosive environments. Explosion-proof circuit breakers are designed to prevent the ignition of flammable gases, dust, or other hazardous substances in order to ensure the safety of personnel and equipment in such environments.

The global Circuit Breaker market size was valued at USD 5427.73 million in 2021-2022 and is expected to expand at a CAGR of 6.91% during the forecast period, reaching USD 8105.33 million by 2030.

Key Factors: Several key factors are driving the growth of the explosion-proof circuit breaker market:

severe safety laws: Businesses operating in risky areas, such as those in the oil and gas, chemical, mining, and manufacturing sectors, must adhere to severe safety laws. To reduce the risk of explosions and guarantee worker safety, these standards require the use of explosion-proof circuit breakers.

Industrialization and infrastructure development are progressing at an accelerated rate, which is driving up demand for explosion-proof circuit breakers. Businesses in hazardous environments including oil refineries, power plants, chemical plants, and mining activities need effective circuit protection solutions.

Technological developments: The market for explosion-proof circuit breakers has grown as a result of the development of sophisticated technologies in circuit protection, such as improved arc quenching mechanisms and improved insulating materials.These technical developments provide improved performance and dependability in risky circumstances.

Demand: The increased focus on safety in dangerous areas is predicted to drive up demand for explosion-proof circuit breakers. Explosion-proof circuit breakers are being adopted by industries across all sectors, including oil and gas, chemical, mining, and manufacturing, in order to adhere to safety laws and safeguard their operations.

Explosion-proof circuit breakers that meet the strict safety standards and regulations of diverse industries should be the primary focus of manufacturers and suppliers in this industry. To meet the changing needs of the market, they should also emphasise the strength, dependability, and simplicity of maintenance of their products.

Referrals to our Stringent datalytics, trade journals, and websites that focus on market reports are encouraged. These sources frequently include thorough research, market trends, growth projections, competition analysis, and other insightful information about this market.

You can investigate the availability of particular reports linked to this market by going to our website or getting in touch with us directly. We offer thorough and in-depth information that might be helpful for firms, investors, and individuals interested in this industry, but these reports frequently need to be purchased or subscribed to.

“Remember to look for recent reports to ensure you have the most current and relevant information.”

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Market Segmentations:

Global Explosion-proof Circuit Breaker Market: By Company

• Phoenix Contract

• Connecticut Electric

• Murrelektronik

• Eaton

• Siemens

• ABB

• Culter-Hanmmer

• Westinghouse

• Schneider

• Blue Sea Systems

• IDEC

• Carling Technologies

• Bussman

• AudioPipe

• Buyers Products

• ITE

• Panduit

• Powerwerx

• Stinger

• Federal Pacific

• Murray Feiss

Global Explosion-proof Circuit Breaker Market: By Type

• High Voltage

• Medium Voltage

• Low Voltage

Global Explosion-proof Circuit Breaker Market: By Application

• Petrochemical

• Military Industry

• Others

Global Explosion-proof Circuit Breaker Market: Regional Analysis

The regional analysis of the global Explosion-proof Circuit Breaker market provides insights into the market's performance across different regions of the world. The analysis is based on recent and future trends and includes market forecast for the prediction period. The countries covered in the regional analysis of the Explosion-proof Circuit Breaker market report are as follows:

North America: The North America region includes the U.S., Canada, and Mexico. The U.S. is the largest market for Explosion-proof Circuit Breaker in this region, followed by Canada and Mexico. The market growth in this region is primarily driven by the presence of key market players and the increasing demand for the product.

Europe: The Europe region includes Germany, France, U.K., Russia, Italy, Spain, Turkey, Netherlands, Switzerland, Belgium, and Rest of Europe. Germany is the largest market for Explosion-proof Circuit Breaker in this region, followed by the U.K. and France. The market growth in this region is driven by the increasing demand for the product in the automotive and aerospace sectors.

Asia-Pacific: The Asia-Pacific region includes Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, China, Japan, India, South Korea, and Rest of Asia-Pacific. China is the largest market for Explosion-proof Circuit Breaker in this region, followed by Japan and India. The market growth in this region is driven by the increasing adoption of the product in various end-use industries, such as automotive, aerospace, and construction.

Middle East and Africa: The Middle East and Africa region includes Saudi Arabia, U.A.E, South Africa, Egypt, Israel, and Rest of Middle East and Africa. The market growth in this region is driven by the increasing demand for the product in the aerospace and defense sectors.

South America: The South America region includes Argentina, Brazil, and Rest of South America. Brazil is the largest market for Explosion-proof Circuit Breaker in this region, followed by Argentina. The market growth in this region is primarily driven by the increasing demand for the product in the automotive sector.

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Reasons to Purchase Explosion-proof Circuit Breaker Market Report:

• To obtain insights into industry trends and dynamics, including market size, growth rates, and important factors and difficulties. This study offers insightful information on these topics.

• To identify important participants and rivals: This research studies can assist companies in identifying key participants and rivals in their sector, along with their market share, business plans, and strengths and weaknesses.

• To comprehend consumer behaviour: these research studies can offer insightful information about customer behaviour, including preferences, spending patterns, and demographics.

• To assess market opportunities: These research studies can assist companies in assessing market opportunities, such as those presented by possible new goods or services, emerging markets, and trends..

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[charliejaneanders]

You cannot claim to oppose fascism *and* defend the purveyors of anti-trans misinformation.

Scapegoating is a key component of fascism, and the "reasonable, just asking questions" "moderates" are vital to the fascist infrastructure.

[weemietime]

i am asking this in good faith

If the Bosnian Genocide is has been ruled a genocide and the death count was 33,071 people, how is what is happening in Gaza not a genocide when the number has been surpassed

Because genocide is not about the number of people being killed. Genocide is a specific legal term, and it has to have two components: 1) obviously people have to be murdered -- but this must be done systemically, as a policy (either written or unwritten) of the belligerent party. AND 2) there has to be genocidal intention to murder said people. Genocidal intention means that Party A (Israel) murders Party B (Palestinians) specifically because those people belong to Party B (Palestinians). There is no evidence that Israel has a genocidal intention. In fact, the October 7th massacre was actually a genocidal act on behalf of Hamas - Hamas committed the genocidal action and has been committing genocidal actions for over 20 years, because they specifically want to murder Jews for being Jewish. They also meet the first criteria because this is a systemic policy that is present in the Hamas Charter.

This is very important to distinguish because whilst genocide is a war crime, not all war crimes are genocide. Israel has committed war crimes, including murdering civilians, and even intentionally allowing civilians to be killed (such as bombing a house with a Hamas member in it and killing his family members). But this is not sufficient to rise to the criteria of genocide. We could make the argument that there is ethnic cleansing, because the vast majority of the people being evacuated are of a single ethnicity, Palestinian. However, again, ethnic cleansing alone is not sufficient to rise to the definition of genocide.

Crucially, the ICJ has not ruled that there is a genocide ongoing. They have ruled prima facie that 1) South Africa has the right to accuse Israel of genocide, and 2) that the ICJ itself is fit to hear and rule on the accusation. They have also ordered Hamas to release the civilian hostages, so if Hamas is saying they want to abide by the ICJ, they have already disregarded the ICJ ruling.

Genocide is not based on vibes. It's not based on bad feelings. It's not based on videos and images of dead kids, or destroyed rubble. Genocide is a specific legal term that can only be applied to the above scenario, and it cheapens our language when we levy it in circumstances where it does not apply. It especially cheapens our language when we engage in Holocaust inversion by claiming Israel is doing to Palestine what Germany did to the Jews, which is categorically false.

Beyond this, it belittles the groups that are involved in this conflict, particularly Hamas, to treat them like they are innocent civilians when they are in fact a very well-outfitted military brigade and the official armed forces of the Gazan government with over 40,000 fighters strong, who repeatedly and loudly say "death to Israel, we want to annihilate Israel, we will commit October 7th again and again until Israel is destroyed." They are being funded by the IRGC, they are being used as a proxy for Iran, and innocent Palestinian civilians are suffering as a result. Hamas has openly said that the "blood of martyrs fuels our resistance," they have openly said they hope Palestinian civilians die in droves while they steal aid and resell it at absurd mark-ups, while they flee to Egypt and Qatar so that they don't have to get their hands dirty. They recruit and brainwash young children to fight their "holy war" to murder as many Jews as possible.

And in terms of the death toll, you have to understand that this war is being fought in an urban environment where the belligerents are embedded purposely in the civilian population, in tunnels all throughout the civilian infrastructure. Violating the Geneva Conventions by using hospitals and schools as military bases, refusing to wear uniforms, and intentionally shooting their own people and blaming Israel.

These people even play tapes pretending to be hostages shouting in Hebrew "don't shoot," which is one of the reasons why a hostage was accidentally killed by the IDF, which is then turned around to show how evil the IDF is without understanding the context that these events happen in. In normal urban warfare the ratio of civilian to combatant death is around 9:1. In Gaza, the ratio is, according to Hamas's own numbers, 4:1. Literally twice as low as the average. So, yeah. War crimes are happening. Yes. Absolutely. Genocide is not happening, at least, it's not happening to the Palestinians.

[fatliberation]

Anti-Obesity Drugs in Sociopolitical Context

Abstract

This literature review critically examines the use of Body Mass Index (BMI) as a diagnostic tool for obesity, highlighting its historical and scientific flaws. The diagnosis and treatment of obesity is heavily stigmatized and reflects deeper socio-economic and racial biases. Fatphobia, or anti-fatness, is deeply rooted in white supremacy and colonial history. I argue that anti-fatness and weight-based discrimination significantly impact health outcomes, rather than body fat percentage alone. The way that the medical system focuses on body size rather than the overall health of patients perpetuates harm and yields even poorer health outcomes. To genuinely improve the lives of fat individuals, we must dismantle anti-fat systems and remove barriers to healthcare, job equity, and basic infrastructure by implementing legal protections, rather than simply promoting weight loss. This review emphasizes the need for a holistic approach to health that considers socio-economic factors and systemic discrimination.

Journal Summary

Recently, two anti-obesity medications, Ozempic and Wegovy, which are primarily prescribed for type 2 diabetes mellitus (T2DM), have shown promise in causing weight loss. The 2022 scientific journal “Ozempic and Wegovy for Weight Loss, Pharmacological Component and Effect” by Abdullah Mohammed, et al explores the pharmacological components and effects of these medications on weight reduction, summarizing findings from existing clinical studies.

Ozempic is a glucagon-like peptide-1 (GLP-1) receptor agonist primarily used to manage T2DM. Clinical studies indicate that semaglutide can also promote significant weight loss. Ozempic's mechanism involves binding to GLP-1 receptors in the brain, reducing food intake and increasing feelings of fullness. This leads to a decrease in body weight and improvement in glycemic control. Wegovy, also a GLP-1 receptor agonist, is the same drug as Ozempic but two times the dose, specifically approved for weight loss for fat people even without T2DM. Administered as a weekly injection, Wegovy has shown effectiveness in inducing sustained weight loss. The STEP trials demonstrated that participants using Wegovy experienced an average weight loss of 15.8% over 68 weeks. Wegovy's pharmacokinetics involve prolonged activation of GLP-1 receptors, enhancing satiety and reducing hunger. GLP-1 receptor agonists like semaglutide mimic the action of the natural hormone GLP-1, which regulates appetite and blood sugar levels. By slowing gastric emptying and promoting a feeling of fullness, these medications reduce caloric intake. Clinical trials have shown that GLP-1RAs, including semaglutide, can result in weight loss from 5% or up to 10-15% of body weight. However, sustained weight loss requires ongoing lifestyle modifications, as discontinuation of the medication leads to weight regain. Common side effects of GLP-1 receptor agonists include gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation. Other potential side effects include increased heart rate, fatigue, headaches, and changes in thyroid function.

Obesity as a Disease

How does one get an obesity diagnosis? There is one single criterion used for diagnosing someone with this disease: The Body Mass Index (BMI). A person’s BMI is their weight in kilograms divided by the square of their height in meters, rounded to one decimal place. It does not account for muscle mass versus body fat. For these reasons, the BMI has been widely proven to be an ineffective health measure. The BMI was also never intended to be a measure of health in the first place.

The BMI was created in the 1800s by a statistician named Adolphe Quetelet, who did not study medicine, to gather statistics of the average height and weight of specifically white, European, upper-middle-class men to assist the government in allocating resources. It was never intended as a measure of individual body fat, build, or health (Karasu, 2016). Quetelet is also credited with founding the field of anthropometry, including the racist pseudoscience of phrenology. Quetelet’s L’homme Moyen would be used as a measurement of fitness to inspire, and as a scientific justification, for eugenics (Eugenics archive).

Studies have observed that about 30% of "normal” weight people are “unhealthy," whereas about 50% of "overweight" people are “healthy” (Rey-López, et al, 2014). Thus, using the BMI as an indicator of health misclassifies 75 million people in the United States alone. “Healthy*” lifestyle habits are associated with a significant decrease in mortality regardless of baseline body mass index (Matheson, et al, 2012).

*I put “healthy” in quotation marks here because the definition of an individual’s health is oversimplified and depends on many socioeconomic factors.

While epidemiologists use BMI to calculate national obesity rates, the distinctions between weight classes can be arbitrary. Ever notice that the weight classes on the BMI are nearly intervals of five? In 1998, the National Institutes of Health lowered the overweight threshold from 27.8 to 25—making roughly 29 million Americans "overweight" overnight—to match international guidelines (Butler, 2014). Critics have also noted that those guidelines were drafted in part by the International Obesity Task Force, whose two principal funders were companies making weight loss drugs.

Jackie Scully, Senior Research Fellow at the Unit for Ethics in the Biosciences, University of Basel, in her scientific journal titled “What is a Disease?” states the following: “As the business literature shows, new clinical diagnoses are often welcomed primarily as opportunities for market growth (Moynihan et al, 2002). One recent example of this is female sexual dysfunction (FSD). The huge commercial success of sildenafil (Viagra) for erectile dysfunction in men provides a strong motivation for drug companies to identify an equivalent market (that is, condition) in women. And some ethicists feel that drug companies were, to put it mildly, over-involved in the medical consensus meetings held between 1997 and 1999 that effectively drew up very inclusive clinical criteria for the definition of FSD (Moynihan, 2003)."

How can one diagnose a person with a disease and sell them medications solely based upon an outdated measure that was never meant to indicate health in the first place, especially when obesity has no proven causative role in the onset of any chronic condition? (Kahn, et. al., 2000), (Cofield, et al, 2010).

This is why the term “obese” is recognized as a slur by fat communities. It's a stigmatizing term that medicalizes fat bodies even in the absence of disease. The word directly translates to "having eaten oneself fat" in Latin. Obesity, as a medical diagnosis, doesn’t have much ground to stand on. Aside from being overtly incorrect as a medical tool, the BMI is used to deny certain medical treatments and gender-affirming care, as well as insurance coverage. Employers still often offer bonuses to workers who lower their BMI. Although science recognizes the BMI as deeply flawed, it's going to be tough to get rid of. It has been a long-standing and effective tool for the oppression of fat people and the profit of the weight loss industry.

To treat obesity, patients must eat less. Making someone smaller still means they will be healthier, right?

Fatness and Mortality

The idea that obesity is unhealthy and can cause or exacerbate illnesses is a biased misrepresentation of the scientific literature that is informed more by bigotry than credible science (Medvedyuk, et al, 2017). Fatphobia existed long before fatness became medicalized. Yes, obesity is correlated with conditions such as cardiovascular disease, hypertension, and diabetes, but some scientists are looking into possibilities that don't equate correlation with causation. Obesity has no proven causative role in the onset of any chronic condition (Kahn, et al, 2000), (Cofield, et al, 2010) and its appearance may be a protective response to the onset of numerous chronic conditions generated from currently unknown causes (Lavie, et al, 2009), (Uretsky et al, 2007), (Mullen, et al, 2013), (Tseng, 2013). A portion of these correlated conditions are likely brought on by the stress of being part of one or more marginalized groups with little to no support or basic access in society. Weight stigma itself is deadly. Research shows that weight-based discrimination increases risk of death by 60% (Sutin, et al, 2014).

Dieting also poses serious health risks. The reason that these weight loss drugs are so successful by comparison is that dieting is unsustainable and does not lead to prolonged weight loss. Over 50 years of research conclusively demonstrates that virtually everyone who intentionally loses weight by manipulating their eating and exercise habits will regain the weight they lost within 3-5 years, and 75% will regain more weight than they lost (Mann, et al, 2007). Evidence suggests that repeatedly losing and gaining weight is linked to cardiovascular disease, stroke, diabetes, and altered immune function (Tomiyama, et al, 2017). If most fat people have historically tried to lose weight their whole lives through dieting, this has major implications on overall health. Prescribed weight loss is also the leading predictor of eating disorders (Patton, et al, 1999).

Another factor that may be impacting fat people’s rate of mortality is that they are being mistreated at the doctor’s office. I have personally heard dozens of stories about doctors refusing to treat or investigate a problem that a fat person came in for until they lost a certain amount of weight, only to discover years later that the problem was unrelated to their weight and has progressed severely because it went untreated. Fat people are often mistreated and looked at with disgust and disdain in medical settings, leading them to avoid going to the doctor in shame or fear of abuse. This can seriously worsen health issues. Fat stigma in the medical establishment (Puhl, et al, 2012) and society at large arguably (Engber, 2009) kills more fat people than fat does (Teachman, et al, 2003), (Chastain, et al, 2009), (Sutin, et al, 2015). This impact is too significant not to be taken under consideration.

Anti-Fatness as Anti-Blackness

The issue of anti-fat bias is directly rooted in white supremacy. The ideal thin body was constructed as a marker of whiteness and “purity” before any of this was ever made to be about health. Dr. Sabrina Strings has spent her career studying this history. In her book, Fearing the Black Body: The Racial Origins of Fat Phobia, Dr. Strings discusses how constructions of race led to the thin ideal. “Over the decades, the rise in biracial children would break down the way that slave owners saw Blackness and whiteness. To combat the hypocrisy they created, owners invented new ways to dehumanize the enslaved population. They made a calculated decision to start putting more value on white physiques versus Black ones. In her research, Strings found that Black women’s bodies were otherized even more than Black males. For colonizers who hadn’t seen diverse body types before, they quickly categorized the Black female figure as ‘deviant,’ ‘greedy,’ and ‘overtly sexual.’ The fact that we still use these terms to describe fat bodies today is all the evidence we need to understand that fatphobia is directly linked to racism, not health. This mindset was also strengthened by Protestantism. Slave owners looked for any way to prove their power over the enslaved people, and they frequently used religion as ‘proof’ of their racist superiority. Additionally, Protestant belief encouraged various ways to become closer to God, which included eating as little as possible. This would resonate the most with white women. They had as much to do with perpetuating fatphobia as their husbands. White women were desperate to show their own power against Black women on the plantation, and the difference between their bodies was the perfect rift. And so began the centuries-old belief that thinness is beautiful, and fatness is ugly” (Sassenrath, 2023).

Revisiting the Journal with Context

Thinness has been an important value throughout history in the United States. Our positive associations with thinness and negative associations with fatness have led to a collective schema that is black and white, good versus bad, beautiful versus ugly, healthy versus unhealthy, and life versus death. This has led the FDA to approve Wegovy as a weight loss drug with haste, after just sixteen months of testing. It is known that going off the drug will result in rapid weight regain, so patients are expected to be on it for the rest of their lives when there have been no long-term studies. We do not yet know if the drug will have long-term effects, yet it has been approved for kids as young as twelve (FDA, 2021). As of July 2024, Novo Nordisk has a market cap of $633.01 billion (Marketcap). 

Wegovy is prescribed along with diet and exercise, which has been proven to lead to weight regain and eating disorders. Patients are being prescribed Wegovy and Ozempic when they are fat, but otherwise metabolically healthy. If this drug is truly a game changer for public health, we should be measuring how patients' health improves over the long-term rather than how much weight they lose. For example, if these drugs improve heart health, they should be prescribed as a heart health medication for patients with heart disease, rather than prescribed as a weight loss fix based on body size alone. With the evidence we have, we know it is possible to be fat and healthy, so these drugs may be solely cosmetic in many cases.

Future

If we want to improve the lives of fat people, we will remove barriers to care, not try as hard as we can to make all fat people disappear. That will never happen. If we truly cared about the well-being of fat people and not their disappearance, we would work to dismantle the systems that oppress them and abolish anti-fatness. 

Currently, fat people have next to no legal protections for being discriminated against (NAAFA, 2023). Fat people are denied housing, (Kariss, 1977) jobs, and receive less pay and promotions legally because of their size (The Economist). They are denied access to clothing, seating, transportation, and other human rights because infrastructure has been designed to exclude them. Fat people have less likelihood of receiving a fair trial (Beely, 2013), and are denied necessary surgeries (Barrett, 2022) ––but not weight loss surgery that amputates the digestive tract. Fat people are denied gender-affirming care (Conley, 2023), in vitro fertilization and reproductive healthcare (Muir, 2024), even adopting children (Carter, 2009). Fat children have been removed from their loving parents because when their diets failed, it was seen as neglect (Badshah, 2021). Fat people have disproportionately high suicide rates (Wagner, et al, 2013), and are facing medical malpractice and mistreatment (Kolata, 2016).

Can a drug fix that?

References

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“Quetelet, Adolphe.” Eugenics Archive, www.eugenicsarchive.ca/connections? id=5233cb0f5c2ec5000000009c. Accessed 5 July 2024.

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Butler, Kiera. “Why BMI Is a Big Fat Scam.” Mother Jones, 25 Aug. 2014, www.motherjones.com/politics/2014/08/why-bmi-big-fat-scam/.

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Medvedyuk, S., Ali, A., & Raphael, D. (2017). Ideology, obesity and the social determinants of health: a critical analysis of the obesity and health relationship. Critical Public Health, 28(5), 573–585. https://doi.org/10.1080/09581596.2017.1356910

Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. 2000 Aug;106(4):473-81. doi: 10.1172/JCI10842. PMID: 10953022; PMCID: PMC380258.

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Mullen JT, Moorman DW, Davenport DL. The obesity paradox: body mass index and outcomes in patients undergoing nonbariatric general surgery. Ann Surg. 2009 Jul;250(1):166-72. doi: 10.1097/SLA.0b013e3181ad8935. PMID: 19561456.

Tseng CH. Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus. Atherosclerosis. 2013 Jan;226(1):186-92. doi: 10.1016/ j.atherosclerosis.2012.09.004. Epub 2012 Sep 21. PMID: 23040832.

Sutin, A. R., Stephan, Y., & Terracciano, A. (2015). Weight Discrimination and Risk of Mortality. Psychological Science, 26(11), 1803-1811. https://doi.org/10.1177/0956797615601103

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Mann T, Tomiyama AJ, Westling E, Lew AM, Samuels B, Chatman J. Medicare's search for effective obesity treatments: diets are not the answer. Am Psychol. 2007 Apr;62(3):220-33. doi: 10.1037/0003-066X.62.3.220. PMID: 17469900.

Patton GC, Selzer R, Coffey C, Carlin JB, Wolfe R. Onset of adolescent eating disorders: population based cohort study over 3 years. BMJ. 1999 Mar 20;318(7186):765-8. doi: 10.1136/bmj.318.7186.765. PMID: 10082698; PMCID: PMC27789.

Puhl, Rebecca, and Kelly D. Bronwell. “Bias, Discrimination, and Obesity.” Obesity Research, 6 Sept. 2012. doi.org/10.1038/oby.2001.108

Engber, Daniel. “Glutton Intolerance: What If a War on Obesity Only Makes the Problem Worse?” Slate, https://slate.com/technology/2009/10/the-health-effects-of-discrimination-against-fat-people.html 5 Oct. 2009.

Teachman, B. A., Gapinski, K. D., Brownell, K. D., Rawlins, M., & Jeyaram, S. (2003). Demonstrations of implicit anti-fat bias: The impact of providing causal information and evoking empathy. Health Psychology, 22(1), 68–78.

Chastain, Ragen. “So My Doctor Tried to Kill Me.” Dances With Fat, https://danceswithfat.org/2009/12/15/so-my-doctor-tried-to-kill-me/ 15 Dec. 2009.

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Sassenrath, Jenna. “Anti-Blackness Is Anti-Fatness in ‘Fearing the Black Body.’” Bookstr, bookstr.com/article/anti-blackness-is-anti-fatness-in-fearing-the-black-body/ 26 July 2023.

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Commissioner, Office of the. “FDA Approves New Drug Treatment for Chronic Weight Management, First since 2014.” U.S. Food and Drug Administration, FDA, www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014. 5 July 2024.

Karris, L. (1977). Prejudice against Obese Renters. The Journal of Social Psychology, 101(1), 159–160. https://doi.org/10.1080/00224545.1977.9924002

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naafa.org/sizefreedom. 5 July 2024.

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Elizabeth Beety, Valena (2013) "Criminality and Corpulence: Weight Bias in the Courtroom," Seattle Journal for Social Justice: Vol. 11: Iss. 2, Article 4. https:// digitalcommons.law.seattleu.edu/sjsj/vol11/iss2/4

Berrett, Martyn. “More Obesity Discrimination: The NHS Will Deny Non-Urgent Surgery to Obese Patients.” Healthier Weight, 24 Nov. 2022, www.healthierweight.co.uk/blog/more-obesity-discrimination-the-nhs-will-deny-non-urgent-surgery-to-obese-patients/.

LaRosa, John. “U.S. Weight Loss Industry Grows to $90 Billion, Fueled by Obesity Drugs Demand.” Market Research Blog, The Freedonia Group, Inc., 2 May 2024, blog.marketresearch.com/u.s.-weight-loss-industry-grows-to-90-billion-fueled-by-obesity-drugs-demand.

Conley, H. “Studies Show Top Surgery Is Safe for FAT Patients, but Some Surgeons Still Mandate Weight Loss.” STAT, 25 July 2023, www.statnews.com/2023/06/02/top-surgery-safe-fat-patients/.

Muir, Becca. “Opinion: Women with Obesity Are Often Restricted from IVF. That’s Discriminatory.” NPR, 14 Jan. 2024, www.npr.org/sections/health-shots/2024/01/14/1224546666/opinion-women-with-obesity-are-often-restricted-from-ivf-thats-discriminatory.

Carter, Helen. “Too Fat to Adopt - the Married, Teetotal Couple Rejected by Council Because of Man’s Weight.” The Guardian, Guardian News and Media, 13 Jan. 2009, www.theguardian.com/society/2009/jan/13/adoption-rejected-couple.

Badshah, Nadeem. “Two Teenagers Placed in Foster Care after Weight Loss Plan Fails.” The Guardian, Guardian News and Media, 11 Mar. 2021, amp.theguardian.com/society/2021/mar/10/two-teenagers-placed-in-foster-care-after-weight-loss-plan-fails.

Wagner B, Klinitzke G, Brähler E, Kersting A. Extreme obesity is associated with suicidal behavior and suicide attempts in adults: results of a population-based representativesample. Depress Anxiety. 2013 Oct;30(10):975-81. doi: 10.1002/da.22105. Epub 2013 Apr 10. PMID:23576272.

Kolata, Gina. “Why Do Obese Patients Get Worse Care? Many Doctors Don’t See Past the Fat.” The New York Times, The New York Times, 26 Sept. 2016, www.nytimes.com/2016/09/26/health/obese-patients-health-care.html.

[ayeforscotland]

What is Dataflow?

This post is inspired by another post about the Crowd Strike IT disaster and a bunch of people being interested in what I mean by Dataflow. Dataflow is my absolute jam and I'm happy to answer as many questions as you like on it. I even put referential pictures in like I'm writing an article, what fun!

I'll probably split this into multiple parts because it'll be a huge post otherwise but here we go!

A Brief History

Our world is dependent on the flow of data. It exists in almost every aspect of our lives and has done so arguably for hundreds if not thousands of years.

At the end of the day, the flow of data is the flow of knowledge and information. Normally most of us refer to data in the context of computing technology (our phones, PCs, tablets etc) but, if we want to get historical about it, the invention of writing and the invention of the Printing Press were great leaps forward in how we increased the flow of information.

Modern Day IT exists for one reason - To support the flow of data.

Whether it's buying something at a shop, sitting staring at an excel sheet at work, or watching Netflix - All of the technology you interact with is to support the flow of data.

Understanding and managing the flow of data is as important to getting us to where we are right now as when we first learned to control and manage water to provide irrigation for early farming and settlement.

Engineering Rigor

When the majority of us turn on the tap to have a drink or take a shower, we expect water to come out. We trust that the water is clean, and we trust that our homes can receive a steady supply of water.

Most of us trust our central heating (insert boiler joke here) and the plugs/sockets in our homes to provide gas and electricity. The reason we trust all of these flows is because there's been rigorous engineering standards built up over decades and centuries.

For example, Scottish Water will understand every component part that makes up their water pipelines. Those pipes, valves, fitting etc will comply with a national, or in some cases international, standard. These companies have diagrams that clearly map all of this out, mostly because they have to legally but also because it also vital for disaster recovery and other compliance issues.

Modern IT

And this is where modern day IT has problems. I'm not saying that modern day tech is a pile of shit. We all have great phones, our PCs can play good games, but it's one thing to craft well-designed products and another thing entirely to think about they all work together.

Because that is what's happened over the past few decades of IT. Organisations have piled on the latest plug-and-play technology (Software or Hardware) and they've built up complex legacy systems that no one really knows how they all work together. They've lost track of how data flows across their organisation which makes the work of cybersecurity, disaster recovery, compliance and general business transformation teams a nightmare.

Some of these systems are entirely dependent on other systems to operate. But that dependency isn't documented. The vast majority of digital transformation projects fail because they get halfway through and realise they hadn't factored in a system that they thought was nothing but was vital to the organisation running.

And this isn't just for-profit organisations, this is the health services, this is national infrastructure, it's everyone.

There's not yet a single standard that says "This is how organisations should control, manage and govern their flows of data."

Why is that relevant to the companies that were affected by Crowd Strike? Would it have stopped it?

Maybe, maybe not. But considering the global impact, it doesn't look like many organisations were prepared for the possibility of a huge chunk of their IT infrastructure going down.

Understanding dataflows help with the preparation for events like this, so organisations can move to mitigate them, and also the recovery side when they do happen. Organisations need to understand which systems are a priority to get back operational and which can be left.

The problem I'm seeing from a lot of organisations at the moment is that they don't know which systems to recover first, and are losing money and reputation while they fight to get things back online. A lot of them are just winging it.

Conclusion of Part 1

Next time I can totally go into diagramming if any of you are interested in that.

How can any organisation actually map their dataflow and what things need to be considered to do so. It'll come across like common sense, but that's why an actual standard is so desperately needed!

[probablyasocialecologist]

The supply chain capitalism of AI. This image partially captures the supply chain of AI as a global and complex phenomenon. Natural resources, components and materials to build AI infrastructure are extracted, shipped, manufactured and produced across the globe. For instance, NVIDIA obtains tungsten from Brazil; gold from Colombia and tantalum from Kazakhstan. Minerals are assembled to manufacture GPUs by TSMC. NVIDIA sells GPUs across data centres in the world. Given the refresh rates of these materials, data centres sent their components to recycle plants or dumps. The human labour wrapped-up in this chain includes, data labellers, logistics drivers, data scientists, miners, data centre operators and electronic waste dismantlers, who are also scattered across different geographies. Source: NVIDIA (2022) and fieldwork.

The supply chain capitalism of AI: a call to (re)think algorithmic harms and resistance through environmental lens

[intelisync]

Decentralized Physical Infrastructure (DePIN) Explained

What if infrastructure could be managed without central control, ensuring security and transparency? Enter Decentralized Physical Infrastructure Networks (DePINs).

DePINs are transforming the way we build and manage infrastructure by leveraging blockchain technology. These networks ensure resilience, transparency, and security by decentralizing control and integrating blockchain-based systems.

Key components of DePINs include off-chain networks, token incentives, blockchain architecture, and physical infrastructure networks. These elements work together to facilitate secure and transparent transactions and automate agreements through smart contracts. However, DePINs face challenges like scalability, regulatory uncertainty, and environmental concerns. The DePIN Flywheel concept demonstrates how tokenization fosters network growth, creating a self-reinforcing cycle of development and innovation.

This innovative model enables seamless collaboration among various devices without relying on a central authority, thereby democratizing access to essential infrastructure resources.

DePINs operate through several key components, including off-chain networks, token incentives, blockchain architecture, and physical infrastructure networks. These elements work together to facilitate secure transactions, automate processes with smart contracts, and tokenize physical assets. This integration not only optimizes resource management but also fosters a more inclusive and participatory infrastructure ecosystem, empowering communities and individuals alike.

However, the path to widespread DePIN adoption is not without its challenges. Issues such as scalability, regulatory uncertainties, technological hurdles, and environmental impacts need to be addressed. Despite these obstacles, the potential benefits of DePINs are immense, offering a more resilient, efficient, and sustainable infrastructure future.

To harness the power of decentralized solutions for your business, reach out to Intelisync and start your blockchain journey today.

The future of infrastructure lies in the convergence of digital and physical elements, with DePINs leading the way. Intelisync offers tailored blockchain development solutions to help startups and small businesses embrace decentralized infrastructure. Connect with Intelisync today to explore the potential of Learn more....