#is because the majority of the time SSRIs work

[pokeybananas]

Just this is 1000% true. I am always here and open to receive any one of the queerstake folks or questioning people.

I remember when my mom told me that my brother was gay. I was making pasta from scratch (I'm still this person tbh) and, even though we had family over, abandoned my starchy friend and sat in the bathtub and cried for like two hours. I was completely heartbroken. My heart aches for 16 year old me. Its so hard to be a teen. I'm truly so proud of the queer youth for figuring these things out about themselves.

Now I'm, like 14 years out from that, been out for like 3 years now (it certainly feels longer than that), in my own queer journey, just got divorced from a man, and turned 30.

My one piece of advice is***: don't deny who you are so you can fit into other people's expectations of you. I spent so long trying to please others **** (as I was raised to in the church) and my 20s were full of anxiety and loneliness (thank heavens for SSRIs). * Regardless of where your journey is or where it leads to, making major life decisions only to try and please others, or fit into some sort of ill-defined mold is nothing but misery. There is community outside of the church, there is found family too. To end on one of my favorite quotes: "the time will pass anyway."

*to anyone who thinks "people who left the church are lazy learners" or any of that other stuff, they are some of the bravest people I know. Would you like to try and completely redefine your belief system, lose your community, and work through all toxic ideas of ones self that the church teaches?

**If you don't count the not being involved with the church at all (i live in a kinda rural area and I see the missionaries at least one a week, why are there so many out here?) and the occasional sip of tea, and the tithing thing (the church has $250 BILLION, they're fine, they make more interest in 2 weeks than you probably ever will in your life)(for context, a million seconds ago was around 2021, a billion seconds ago we were in the middle of the Roman empire), I'm still completely temple worthy

*** I have many other pieces of advice, including "don't get married before your 25 at least, because like, I didn't realize I was gay until 29, and that came as a huge shock and I was married to a man for 7 years by that point", "when you first leave the church, you will have a realization, that not having substances and such never gave you a chance to really practice or observe self control. Bring $15 to the bar and call it early" "people are inherently good (for the most part)", "let people prove to you that you can trust them", "seriously have someone with experience with the substances that you TRUST help gauge how high/drunk you are" "start saving for retirement early" " you don't have to be busy every second of every day in order to be successful" "in the end, your knowledge and health are all you have", "choose and chase joy, but stalking is creepy", "find more exmormons if you want, they understand more of what you're going through" "just because you leave the church doesn't mean you also have to leave all the friends you've made behind" "

****my dad once home taught a guy who was gay and married to a woman. Can you imagine what misery that was not only for the husband, but especially for the wife? AND THEY HAD KIDS We already have women falling on so many swords in this faith, don't make them do it more

***** is my ADHD showing?

I just went browsing the queerstake tag for a little while, just, you know, curious about what's going on in there.

But I couldn't do it for very long. Very nearly every post is just.... pain. Mormon kids who want to do the right thing but also feel the need to be true to themselves. People who are struggling, who don't understand how the people that are supposed to be their community can treat them the way that they do.

Sometimes there are little posts of joy and acceptance, happiness among themselves. They've found some small community here on tumblr, and for that I am glad.

But it just reminds me of the weeks before I stopped being Mormon. It didn't feel like a process, not really. I believed, full stop, I knew the church was true. But I also knew that love was love and that it was good for people to live by how they felt inside, be that sexuality or gender. I knew that people deserve to be happy in this life and spend their days with a partner and in a body that they love.

And it really was just a step off a cliff when I suddenly realized that I just... didn't believe the same things as the church anymore. That my beliefs of kindness and understanding and love were things the church could not and would not accept or change for, and that if it did change for them, then it wasn't the true church anyway.

It was a relief, more than anything, to let go of the pain and confusion the church was putting me through.

It was a relief, to know that there were people and communities out there who would share that love and understanding I wanted, without any strings attached.

And if any queer mormons are reading this, just... please, know that there are other communities out there. Better ones. Kinder ones. You won't be alone, if you make that jump.

[walkawaytall]

I really wish there was more interest in how to handle ADHD other than just addressing the symptoms that affect the people around us.

Like, the best pharmaceutical treatment we have right now is stimulants, and I agree that being on stimulants 24 hours a day, 365 days a year is probably not good for your body. Hell, I’m on a less-than-ideal dose of my medication from a concentration perspective because the ideal dose had my resting heart rate sitting at a cool 115BPM. I know taking med holidays is important. I know all of this.

But because ADHD isn’t just an attention problem (or may not actually be an attention problem at all at its core), it sucks that the only time period medical professionals seem to be concerned about treating are the “important” times: the length of a school or workday. Forget the fact that ADHD affects executive function, forget the fact that people with ADHD often experience chronic and unending anxiety and/or depression as a result of the ADHD, forget that there are important times that have nothing to do with an 8-hour school or work day, forget the rejection sensitivity dysphoria, the sensory issues that make things like clothing, food, and group situations a nightmare to try to navigate, the household stuff that has to be taken care of outside of the 8-hour school or work day. It feels like none of that matters because it doesn’t affect a group of fifteen or more people.

On top of ADHD, I have been plagued with anxiety-related issues for the majority of my life. I likely have a form of OCD and I have a history with a restrictive eating disorder; both of those conditions are very closely associated with high levels of anxiety. I’ve been on anxiety medications before. I was first given an as-needed medication that took the edge off but also made everything feel a little fuzzy, like there was a pane of glass between me and the rest of the world; I was put on an SSRI that somehow made my OCD-related intrusive thoughts about 50x worse than usual and had me wondering at one point if I should be hospitalized; and I’m currently on buspirone, which is doing what it’s supposed to do without the side effects of the others thankfully. But nothing, and I mean nothing, has reduced my anxiety as much as my ADHD medication.

Two hours after my first stimulant dosage, I just suddenly didn’t feel on-edge any more. I estimate that being on ADHD medication has reduced my anxiety by about 70% (buspirone’s for the other 30%). I started taking it in the summer of 2020 and I remember, in 2021, when I saw my boss in person for the first time since lockdown, he remarked on how much more confident I seemed, how I was more likely to speak up in meetings, etc. And I was like…yeah, man, it’s a wonder what not feeling anxious every second of every day will do for someone.

ADHD affects so much more of my life than just attention and anxiety, too. I have sensory issues with mine, which is pretty common, and they make eating — an already sometimes-complicated task due to the ED history — difficult at times because, while I can eat foods that I don’t particularly like, if something is what I call “the bad texture”, I will gag no matter how hard I work to overcome it (believe me, I’ve tried). And my brain sometimes decides that foods that were previously fine are now “the bad texture” and they may or may not shift back to being okay eventually; I don’t know.

The sensory issues affect me socially. My therapist and I have recently come to the conclusion that I’m probably not actually an introvert, but if I’m around larger groups, that means noise and movement and probably being touched, and too much of that causes my brain to either freak out or shut down. I used to always say, “I love people, but when I’m done, I’m done.” And that was likely because the overstimulation was building and building in the background, and at a certain point, my brain would just be like, “We gotta get outta here.” I was Queen of Irish Goodbyes for a very long time because of this.

And the executive dysfunction affects…well..everything? Not just work, not just school (but also those because if my environment is chaotic, my brain feels chaotic, and it is difficult to maintain a non-chaotic environment if you keep getting stuck on order of operations when picking up a room).

I’m not saying that I want to be on longer-lasting stimulants or that I want to be on the higher dose that I know helps my concentration more, cardiovascular system by damned. What I’m saying is, I wish treatment research had been more holistic rather than just figuring out what would give teachers and managers an easier time despite what the person with ADHD might be dealing with as soon as their meds wear off.

Maybe current research is working on it; I don’t know. I just know that, the older I get, the more frustrated I am with my brain and the more apparent the deficiencies I used to be able to counteract with pre-chronic-illness energy and crushing perfectionism become, and I wish there was an answer to this that actually helped me most of the time rather than forcing me to pick which parts of my day/week is “important” and making sure I’m medicated for those parts.

[rollingblakely]

Hey there, welcome to the chaos. ✨I'm disabled, chronically ill, neurodivergent, and proudly intersex—and if you're any of those things too, I hope you feel seen here. 🫶🏻

Dynamic As Hell 😎

I'm an incomplete paraplegic with dynamic disabilities-meaning some days I can pivot off a foot with assistance, and other days I can't scoot myself up on the couch because my arms are like "bestie no." | use a manual chair with power assist when I can and a power chair when I can't. (Shoutout to my Quantum Edge 3-coming soon to a hallway near me.)

My very unsexy but educational medical resume:

Congenital Myasthenic Syndrome (CMS): A rare neuromuscular disorder where my muscles and nerves straight up ghost each other, causing muscle weakness, loss of sensation, fatigue and joint subluxations (my joints out here freelancing).

Glycogen Storage Disease: My body stores energy like a toxic ex- inefficiently and with long-term consequences.

Dysautonomia (IST): My heart rate is the only thing about me that knows how to hustle.

Also living with: ME/CFS, cluster headaches (ow), fibromyalgia, incontinence (fun!), Hashimoto's, skeletal abnormalities in my spine (lost the genetic lottery) and chronic pain so consistent it's basically a roommate.

Intersex + Gender Is A Journey, Baby! 😮‍💨

I'm intersex and nonbinary, a proud blend of both. l've had male characteristics since I was 9, and when I got my medical records as an adult, I learned my original birth certificate just said "O." I don't fit in any binary box-so I don't try to. I'm both. I'm neither. I'm a little beard, a little glitter, and a lot of "what gender feels correct today?" I never know if I'm gonna wake up feeling like a glam queen or an Adam Sandler character. Either way, I always slay. 😉

Raw Dogging Mental Health:

I'm healing out loud after a childhood of abuse that started at 9 that contributed to my C-PTSD, ADHD, OCD, autism spectrum disorder, and agoraphobia.

I can't take SSRIs, atypical antidepressants, or antipsychotics due to my conditions and genetics-so l'm rawdogging my mental health journey and somehow thriving anyway?!? 👀

I'm at the gym 3-4x a week (yes, even in a wheelchair-accessibility is radical), exposure therapy, shadow work, and finding the delicate balance between respecting my body's limits and pushing through executive dysfunction. I’m unlearning all the cruel ways of thinking my parents taught me growing up, and learning to be comfortable with being uncomfortable. Some days the healing looks like deep inner work. Some days look like watching reality TV and crocheting until mv hands cramp.

It's messy. It's magical. It's all mine.

Breaking News: There’s No “Bad” Foods After All.

I'm healing my relationship with food. After years of chaos and a major health crash last year, I've lost 80 lbs total-12 of those since getting back on track. Now that my partner is my legal caregiver, l've got the support I need, and my body finally feels like it's starting to work with me, not just against me. I'm not chasing thinness-I'm chasing peace when I make a meal or shop for groceries.

My Little Joys

• Crochet: If it's practical, chunky, or a granny square, l'm in. Currently obsessed with amigurumi but forever starting five new projects before finishing one.

• Reality TV: Yes, I watch 1000lb Sisters, Teen Mom, and Sister Wives. No, I will not apologize. The tea is PIPING. ☕️🐸

• Financial Literacy: My partner and I watch Caleb Hammer while eating dinner. We paid off $10k in debt last year, and now that I have been approved for SSDI I'm able to support myself for the first time in years-and it feels so damn good.

• Art + Gaming: I love painting, drawing, and chill cozy games on the Switch (Paleo Pines, Cozy Garden, anything where I can grow fake plants and pet fake cows).

• Music: Raised by my grandparents = 60s-80s classics. Mom gave me 90s-2000s R&B/pop. Godfather gave me Latin music. Stepdad gave me Bob Marley. Theater kid brain gave me musicals. If I'm conscious, music is playing.

✨ He/They Pronouns ✨

✨ 27 ✨

This space is for disabled joy, queer magic, healing energy, and a lot of chaos. Hope you’re hungry, cause baby I’m serving. 💖

[koyaildoesstuff]

So this one’s going to be a bit of a heavier post, but I just need to kinda ramble about my physical and mental health. My mood swings fueled this. If this post disappears after you read it, I’ve probably privated it.

I’m just going to let my adhd take us wherever it does, so I’ll add trigger warnings as I go, but I know it’s probably going to mention self harm, depression, dysmorphia, loss of weight, nausea, eating disorders, and sexual assault (while we were both minors). Huge Tw for that one

Please do not feel like you have to reply to this post if it gets really dark. I really don’t know where it is going to go, but if it is heavy on the depression or other hard stuff, just know that I am in no danger currently. Please prioritize your own mental health 💜

So if you saw my other posts, you can tell I’m in over my head. I can already feel myself slipping into an episode. I was doing so good too. I just want to be happy.

I’m starting an ssri tomorrow. I hope it does something. I’m so used to taking medication and it just not working so I’m just taking a side effect pill. I wanted to get off of my current “mood stabilizer” which isn’t doing anything. She isn’t taking me off of it either, but she at least heard my concerns and gave me a valid reason why she didn’t want to take me off of it. Some of my other doctors haven’t been so nice. I hate hospitals. The brain fog makes it so hard to get anything done there, because I simply can’t remember. I feel so stupid all the time.

I’m also starting birth control for periods. Hopefully it doesn’t fuck me up too much.

Lastly, I was prescribed an anti-nausea medication. I was prescribed this in the past, when I was very sick and couldn’t eat, despite wanting to. I kinda just put two and two together that I haven’t eaten all 3 meals consistently for a few months now, and it’s gotten worse recently. I haven’t been able to eat full meals without gagging or having to stop before I can finish what I know I can eat, or need to eat. I hope it helps. I don’t know how gradually this happened, but I lost weight. I know it’s because of this, but it’s still kinda of worrisome. I want to be able to eat. I have a past of binge eating, and I’m worried that I might get in such a bad place mentally that I go the other way and start starving myself. I struggle heavily with dysmorphia, so I often stay away from a scale, but this also means I often think I’m heavier than I am. But I want weight loss to be on my terms, and honestly, I just want to be happy in my own body currently. But I’m not. Plus, I’ve had doctors not take my concerns with eating seriously before, telling me that I don’t need to eat all three meals (basically implying I should lose weight).

I really hope the ssri helps. I don’t know the last time I was happy. I started showing symptoms of depression in 2019. I was diagnosed with major depressive disorder two years ago. I spend more time in episodes than out of them too. I’ve struggled with self harm in that time too, especially this last year when the impulses to actually cut, instead of hurt myself other ways, got to the point where I had to avoid the bathroom, because I knew where the razor was.

I finally told my therapist that the self harm is still there. I lied to it with my doctor tho, because I kinda forgot I had a few moments this week. And I’m more worried with telling her those things. My therapist is no longer a mandatory reporter however, so I could finally tell her that I know damn well why I struggle with it, and that it never really went away. I think I’ve been clean since April. Well, mostly. I have had some moments where I’ve scratched my arm red. I have dermographia, so it doesn’t take long for that to happen or cause irritation. That happened like last week again I think. I can’t remember.

It was my first solo doctors appointment too, which was nice because I didn’t have to deal with my mom trying to speak for me, or if I bring something up, not have her be like “you didn’t tell me that.” I was able to tell my gp I have been sexually active in the past.

I haven’t told either her or my therapist that I was sexually assaulted, and that’s the other reason I wanted to go on birth control. My therapist kinda knows, because I did mention a Medusa drawing I was asked to make for my ex who did it. I mentioned I might get a tattoo at some point, then backpedaled hard because she would have to legally report that to my parents as a mandatory reporter. I have had quite a hard time validating my experiences, convincing myself that I wanted it too. She coerced me, and I didn’t realize it wasn’t consent until we had the local domestic abuse shelter come and talk to us about consent. It still doesn’t feel like I can even call it assault, when I know it is. And I don’t want to take any action, because she is still a minor, and could easily turn the narrative. I have no clue if this has affected me mentally. Tho I was in a very bad place when she did it, and the end of that relationship was the breaking point for me, and I developed anxiety tics. And now that I think about it, it kinda has. I haven’t been able to do anything with anyone else without regretting it afterwards. I would enthusiastically consent (as well as a teen could, which still shouldn’t be considered consent, but we were both still minors with my other two relationships as well), but then would feel icky down the line, even if there was aftercare. There’s just a lot of icky feelings surrounding all that. Which is about the time I wished I was ace and not aro. Because the romantic attraction just isn’t there, and I sometimes wish the sexual would have that same disconnect and I could have my romantic back.

I don’t know why I talked about that honestly. Kind of just one of those things, get it out to a bunch of strangers online (love you guys tho) and see if it helps.

I’m worried about my physical health. With the amount of stress I’m under, I’m going to go into training in a crash, I can tell it. I am also worried I’m going to fail my lifeguard certification. I’m going to be so tired, and now all the excitement I had for camp has turned into anxiety. Which is why I’m also worried I’m going to go to camp in the middle of a depressive episode. While trying new meds. And still being on meds that don’t do shit. And my headaches and migraines have been really bad the last few weeks. My migraine abortive med doesn’t work either. And the injection hasn’t started helping. And even once it does, I still need a working abortive, because it won’t stop them all. God, it’s just so much. I don’t even know why I wrote this. It will probably be turned onto private or deleted once I wake up.

If you read this, thank you. Especially if you’re a blog I interact with frequently. You guys make everyday a little easier. I’m off to bed, so I won’t see any notifications for a bit. Hopefully tomorrow goes well. This rant helped honestly. I have a hard time crying because of my meds, so I just end up emotionally numb, and this helped release some of that. Anyhoo, back to the regularly scheduled chaos and humor.

For those of you who don’t know, Borahae- the saying I use at the end of my fics or longer posts like this, means I purple you. It means I love you. So, Borahae and I love you peeps 💜

[mostremote]

Reflecting on 2024 and goals for 2025

personal longpost

Another year gone by! Last year I set myself the single goal of making an effort to publish the novel I was then working on. I finished that novel and did indeed 'make an effort' to publish it. I was not successful, but I learned a lot in this process about how the industry works and most importantly I learned that my first novel, while there is much I like about it, was in many ways more of an exercise than a great output. I would quite like to rewrite it from scratch now that I know more about what I want to write, but for now I am going to set it aside. I am writing a different novel now which is 1/3 complete, and thus far it has proved a much more cohesive and mature project. So, one goal for 2025 will be to finish that novel and, I hope, secure a literary agent.

My other more relaxed goal for 2025 is to read 50 non-academic books. This year I quit one of my academic service roles which required reading loads of academic books I didn't care about, and now I will be free to read as much as I want. I'm also breaking out of my academic niche to research and teach on works more interesting to me, so being able to read whatever I want will be a great boon.

My other big life plan is to move cities, get a mortgage, and buy a house (no more 8 hour commute!!). I'm not going to set this as a "goal" since it's almost guaranteed to happen and if it doesn't it'll be because, idk, I end up in a coma or something. But it'll be a big life change to look forward to!

2024 had lots of good things happen. Most importantly my second academic book came out with [major publisher] so that was exciting! But in the most remote.txt thing of all time, at the book launch everyone wanted to congratulate me and i just kind of waved them off so i could make a beeline for Hot Old Man and drink and talk about erotic literature w him all evening instead....... god i'm a parody of myself

Another important thing this year was making a very good close new friend, which is hard to do in your 30s, and I am immensely grateful for her intelligence, verve, and influence on me. There are few things I cherish more from 2024 than gaining her friendship.

Last year I was also very manic and that has, thankfully, much calmed down. My Big Emotional Change has endured; I've lost all interest in my previous addictive behaviours (mostly excessive & harmful sexual habits & video games) and have just been incredibly centred and soothed and happy. Writing The Shivering Season and basically canonising Donald Sutherland allowed me to process certain things about my trauma and abuse that have transformed me into a different person. I also finally got into proper long term therapy and that's been very good for me. Granted those who follow my trauma/MH side blog can see I've still been a bit insane in some ways, but it has genuinely been so much better than it was. Just feeling very calm and happy (certainly the SSRIs have helped with that lol) and good about where my life is and where it will be. Bring on 2025! And don't fuck that Hot Old Man

[roguetelepaths]

"depression is ALWAYS a PHYSICAL PROBLEM IN THE BRAIN and if you had bad side effects from SSRIs it just means you were on the wrong one" okay how about you eat my entire ass lol

Every single SSRI I've ever tried has either done nothing for me, made me dangerously unstable, or turned me into a literal zombie. Every. Single. Fucking. One. They are not a class of medication that works well for me. Neither are any of the other psychiatric medications I've been put on. Because the vast majority of my specific problems stem from the long-term effects of continuous trauma and poverty, and there isn't yet a chemical that can give me a non-abusive childhood and a thriving wage.

(5-HTP— serotonin's chemical precursor— works much better for me, which leads me to believe that if there is a structural neurochemical thing going on with me, it's that my brain isn't making enough of the good shit in the first place, not that it's sucking it back up too fast. Which kind of makes sense to me as an adaptation of a brain that's been in survival mode since birth, but I'm not a neuroscientist, I'm just some dirtbag with a blog.)

Do I think that SSRIs do that to everyone? No. Emphatically, absolutely not. I know several people including my partner who I love dearly for whom they're life-saving. I can't feel anything on Prozac, but my partner can't feel anything without it. Brains are weird and they work differently from one another and scientific models of neuropsychology aren't nearly as universal as they pretend to be.

People with bad psychiatric experiences need to be listened to and welcomed as part of the greater community of psychiatrically disabled people. We DO NOT need comic sans powerpoints telling us to try different medications and saying shit like "u made the meds sad by spreading misinfo :(". If someone is saying their bad psychiatric experiences are universal, then yeah, absolutely call that shit out. But like, your GOOD experiences aren't any more universal. Informed consent requires both perspectives.

In conclusion maybe don't take medical advice from fucking comic sans powerpoints. I mean, don't take it from me either. I'm just some asshole on the internet, as we've established. But I'm also not out here trying to GIVE medical advice. There's a world of fucking difference between "here's what these drugs do to me every time I try to take them" and "well you just need to keep trying new drugs, sweaty :)"

[askgothamshitty]

hello! sorry if this is a strange ask but i was filtering the search through my following on twitter to see if anyone has said anything about SSRIs and tricyclics as i’ve just started taking them and your tweet from 2022 showed up, i was wondering if you still take SSRIs and tricyclics and what is/was your experience with those meds? (for reference, i am taking them for OCD and anxiety)

I’ve taken SSRIs since I was in middle school for anxiety/panic disorder and they, along with therapy, have been central to my success in managing my symptoms. I have not experienced any major side effects. There were two times, however, where I switched SSRIs because it seemed like the previous ones stopped working. I’ve heard this is common. However, I’ve been on my current medication for probably the longest time out of all of them and they are showing no signs of stopping.

As for tricyclics, I added those to my regimen more recently when I started developing symptoms of OCD. Together with my SSRIs, they work wonders. I don’t experience any anxiety symptoms, and while there have been times where my OCD-related urge to ruminate has emerged, it is 100% manageable and not disruptive to my life.

I do deal with side effects as a result of these two drugs: heat intolerance and increased sweating. But for me, these are manageable and worth the benefit of not dealing with virtually any symptoms.

LMK if you have any more questions!

[shoesofthefishermanswife]

In med school and also preparing for my exam. I have to learn a whole course about antidepressants so here it goes I guess !

Hi! I'm sure that the majority of this will be pretty basic review but let's talk about it!

The first generation of antidepressants were monoamine oxidase inhibitors (MAOIs). They were originally invented to treat tuberculosis but in 1953 Iproniazid was developed and patients taking it showed improvements in their depression symptoms. As their name suggests, they function by inhibiting the breakdown of monoamine neurotransmitters (serotonin, dopamine, norepinephrine, ect) by the enzyme monoamine oxidase, and this leaves more neurotransmitters available for synapse. The problem with this method is that there are monoamines in our food. Patients taking MAOIs have to be careful eating foods that contain lots of tyramine because it can't be broken down. High levels of tyramine can cause sudden increases in blood pressure and even cerebral hemorrhage! Understandably, MAOIs aren't prescribed very often anymore.

The next generation of antidepressants, known as tricyclic antidepressants, was developed in the late 50s. These work by inhibiting both serotonin and norepinephrine reuptake. They are also antagonists for postsynaptic adrenergic α1 and α2 receptors, muscarinic receptors, and histamine H1 receptors. Reuptake inhibition is the mechanism found in a lot of our current antidepressants, but they're a little bit more focused.

In the late 80s, Fluoxetine was finally approved by the FDA and SSRIs continue to dominate the antidepressant landscape. SSRI stands for Selective Serotonin Reuptake Inhibitors, and they do what their name suggests, inhibiting the serotonin transporter (SERT) at the presynaptic axon terminal. This leaves more serotonin (5-HT) available for synapse. Additionally, SSRIs target the 5-HT1A autoreceptors. This seems counter productive at first, because the autoreceptor activation slows 5-HT production and release. But over time, this builds autoreceptor tolerance. Generally, autoreceptors can shut off signaling when there's too much and is a main contributor to building drug tolerance. But since the autoreceptor is now being activated, that shut off function loses efficacy and the extra 5-HT in the synapse from SERT inhibition doesn't cause tolerance to be built up (as much). This is why it takes SSRIs weeks to kick in because the two processes do cancel each other out until the autoreceptors have gotten tolerant. There is variety within SSRIs. Fluoxetine (Prozac) has a half life much longer than Sertraline (Zoloft) and takes longer to get peak plasma concentration.

Serotonin-Noradrenaline reuptake inhibitors work very similarly, they just also inhibit norepinephrine reuptake. (Say what you will about anti-depressants, at least they're named straightforwardly lol). Some patients respond better to SSRIs, some respond better to SNRIs. Unfortunately, a lot of patients don't respond well to either and they can come with difficult side effects.

Moving on from depression, let's talk a little about anxiety and anxiolytics. One of the key brain changes in general anxiety is reduced PFC inhibitory control, associated with reduced GABA(A) receptors. This is coupled with amygdala overactivity. Benzodiazepines help regulate anxiety by increasing GABA control. They do so without nearly as many side effects as the previous barbiturates, and took off in the 1960s. But because they act on GABA, mixing benzodiazepines with alchohol (also acts on GABA) creates lots of abuse potential (think of the Valium + martini housewife). The positive side to this is that benzodiazepines can be used to help someone with alcohol withdrawal, which is otherwise very dangerous. Second generation anxiolytics are partial agonists for 5-HT1A receptors. Moving away from GABA reduces the abuse potential, but also makea the drugs less effective. Generally, SSRIs are prescribed for anxiety before other classes of drugs.

Hope that was a good basic review!

[nobrain-nothoughts]

Okay I really dont wanna start a fight under your reblog, but I also think the methodology behind this is pretty interesting, so wanted to share it. I read the article you linked, and I read the papers that they linked, and im sorry to say

The data is trash. It really is.

So the article you linked, links to 3 research articles (and a nhs internet page on what depression is and common treatments, for obvious reasons I didnt investigate that). I read them, and their data just isnt that good. They just cant really prove that walking or exercise works to prevent depression. Now im not saying that walking is not good for your mental health: im a big fan of walking and running to avoid The Void myself. But it is actually important that scientifically the data isnt there yet.

The headline of the article implies that walking treats depression, and the subheader says that walking prevents depression. Those are 2 very different things. Neither are really supported by this evidence.

Okay, back to those 3 articles.

The first one is a metastudy, which compares and collects studies done on a specific topic. This one is on prevention: it proves a link between steps/day and rates of depression. So thats what they have data on: that people who who have a higher stepcount, have lower rates of depression. They've proven association, but cannot, with this data, prove causation, or more importantly, the direction of that causation.

To say that otherwise, they might have proven that people that walk a lot get less depression. They might also have proven that depressed people dont walk that much. Which seems very logical: one of the main symptoms of depression is fatigue and difficulty with activities of any kind! They dont have the data to say with certainty anything about cause and effect.

The second study is about treatment: again a metastudy. It looks at a lot of studies done on the effect of exercise versus other treatments. Because of the way this is set up, with exercise as an intervention (people with depression didnt do it and in the study, they started) here we can do causation. However. There are 2 major problems with this study. 1. The data sucks. They say this themselves. All of their correlations and effects have a low certainty. The field just does not have great evidence. 2. This one is more of an impact related thing. Halfway trough their results section they mention autonomy. Their study finds that the more autonomy someone had, the less the intervention worked. The idea of the researchers was that if they could, they would choose a less strenuous exercise and it wouldnt work that much. But what that means for the conclusion of the paper (doctors should offer exercise as a treatment option if ssris are off the table for whatever reason) is that this will likely only work if people are in some way forced to do exercise. As mentioned before, not wanting to do anything and low motivation are symptoms of depression. The people in the original studies were likely heavily followed up on: trials are very expensive and the last thing you want is for all of the data to be useless because of low adherence. These people probably couldnt go 3 days without some research assistant going

this intense followup is not availability for depressed people: you gotta do it on your own, which according to this data heavily reduces your chances. Doctors need to be able to offer more than just advice. The intervention of telling a depressed person to go do yoga has been tested a thousand times, it does not work. As long as there are no frameworks to actually help depressed people do this, this study and its result are useless.

Okay third study is back to prevention. This is one study, but its very large, 6042 participants. They get their data from a major database or something that people can share their fitbit data with. Their population is out of wack, 73% is female, 84% is white, 71% has a college degree. They try to control for the cause and effect problem by determining that the diagnosis of depression must have happened after the 7year long study has been going for 6 months, but I am not convinced that this works. The paper itself also says that "causation should not be inferred. We acknowledge the potential for reverse causation in which the existence of a condition leads to taking fewer steps rather than the reverse."

So yeah. Conclusion: go on a stupid mental health walk. Its good for you. Go see some fukin birds or whatever. But the scientific data about it? Sucks. And what is there, is being used for ineffective public policy. Sorry.

[manovaidyaayurveda]

OCD Treatment in Delhi: Latest Therapy Techniques That Work

Obsessive-Compulsive Disorder (OCD) is a kind of mental disorder that may be overwhelming and puzzling. People with OCD tend to have unwanted thoughts (obsessions) and must repeat certain habits (compulsions) to manage or reduce anxiety.

The best part is—OCD can be treated. With appropriate care and assistance, most people can manage their symptoms and live normal, healthy lives. If you, or someone close to you, are looking for OCD treatment in Delhi, you can find out the latest therapy techniques employed and where you can consult experienced professionals from this guide.

What Is OCD?

OCD is not just about tidiness or being too careful. It involves patterns of distressing thoughts and behaviors that a person feels they must follow, even though they know it is not logical.

Telltale symptoms include:

Endless checking (doors, locks, switches)

Excessive hand washing due to phobia of germs

Unwanted thoughts triggering guilt or anxiety

Obsession with ordering things in a specific order

Difficulty concentrating because of incessant rumination

If these habits start interfering with your work, life, or relationships, then it may be time to take a visit to a mental health expert at a Delhi, NCR-based clinic.

Modern OCD Treatment in Delhi There are numerous treatments available for treating OCD in Delhi. Mental health professionals utilize research-backed, science-supported approaches customized to each client. These are most effective and most used therapies:

Cognitive Behavioural Therapy (CBT) CBT is the most effective treatment for OCD. It alerts you to the connection between your thoughts, emotions, and behaviors. Under therapy, you become able to stop unwanted thoughts and reduce the need to perform compulsions.

This form of mental well-being therapy in Delhi is available at the majority of good clinics and provides very good long-term results.

Exposure and Response Prevention (ERP) ERP is one form of CBT that works well for OCD. During the therapy, patients are exposed to their fears in a safe and controlled environment gradually. This helps them eventually confront the anxiety without resorting to rituals or compulsions.

For instance, if a person has an aversion to germs, ERP could consist of touching a doorknob and not washing hands immediately.

Medication Support In certain cases, psychiatrists also prescribe selective serotonin reuptake inhibitors (SSRIs), an antidepressant that alleviates OCD symptoms. Medication treatment is typically combined with therapy for best results.

Delhi, NCR mental health clinics have trained psychiatrists who carefully regulate dosage and side effects for treatment in a safe manner.

Mindfulness and Relaxation Techniques Mindfulness techniques help you stay in the present. Meditation, relaxation training, and breathing exercises are often used in conjunction with CBT to help with anxiety and stress levels.

Some Delhi clinics also offer yoga therapy sessions, which may also help with emotional control and general health.

Online Therapy Options For the person who values privacy or cannot travel often, the majority of clinics now also have online OCD treatment sessions. These are effective and can be done from home.

How to Choose the Ideal Mental Health Clinic When looking for OCD treatment, choose a clinic that understands your needs and offers good care.

Choose a clinic that has:

Certified psychiatrists and psychologists

Personalized therapy plans

A calm and private environment

In-person and online session availability

Follow-up and progress tracking support

There are several well-known Delhi, NCR-based mental health clinics that specialize in OCD and other anxiety disorders and offer the latest in therapy techniques for long-lasting relief.

When to Seek Help If OCD symptoms are getting in the way of your daily routine, work, social relationships, or mood, don't wait. Treatment can stop the condition from worsening and improve your quality of life.

Common indications it's time to seek help:

Spend over one hour a day on ritualistic ideas or habits

Avoid trips to particular locations, individuals, or activities

Get caught in a pattern of thought or behavior

Stressed out and unable to sleep, concentrate, or relax

Final Thoughts OCD does not have to control your life. With the right treatment from the right professionals, you can take back control. Whether you are thinking about talk therapy, medication, or both, you have qualified assistance available to you.

Reach out to a mental health clinic in Delhi, NCR and ask about what is being offered currently to treat OCD in Delhi. First, is just taking that first step—and from there, the healing begins.

[patienttalonsolace]

vyvanse

Vyvanse and Anxiety: Your Real Takeaway

For the condition of attention deficit hyperactivity disorder (ADHD), Vyvanse (lisdexamfetamine dimesylate) is used for moderate as well as severe episodes of binge eating.. In studies of the drug, Vyvanse appears to have augmented attention and impulsivity as well as help binge eating... Thus, health care providers are eager to understand its effects on anxiety, a common condition experienced with ADHD..

Here in this blog, we’re going to talk about the interaction of Vyvanse with anxiety and its potential side effects, risks, and some things you should consider if you are taking both conditions.

Does Vyvanse Produce Anxiety?

Vyvanse is a stimulant. So it triggers certain neurotransmitters in your brain ( like dopamine and norepinephrine ), which in turn can make you more focused or energized. But in some people, it can cause anxiety ( which could never have happened if you didn't have any ) if you did have it in the first place.

Nervousness

Restlessness

Racing heart

Insomnia

Jitteriness

These signs and symptoms may be more present when you first start the medication (or even after you increase the dosage). Not everyone who takes Vyvanse has anxiety, but in some people, overall anxiety goes down with treatment of their ADHD, especially when the anxiety is because it is part of the distress caused by uncontrolled ADHD symptoms.

Vyvanse and Coexisting Anxiety Disorders

Some people with ADHD also have Generalized Anxiety Disorder (GAD), panic attacks, or social anxiety. It's very hard to treat both conditions at the same time. While Vyvanse may help reduce the symptoms of ADHD, it may not help relieve – and sometimes even worsen – the root anxiety if it isn't taken with care.

When anxiety is a major issue, physicians may opt to:

Begin with a lower dose of Vyvanse and titrate up

Track the patient's anxiety symptoms vigilantly

Consider combining Vyvanse with an anti-anxiety drug (such as an SSRI)

Suggest therapy (CBT is particularly effective for ADHD and anxiety)

Can Vyvanse Help with Anxiety?

This is a decent question, as some people have said that they get more focused and calm taking Vyvanse. If anxiety is primarily executive dysfunction (generalized panic attacks about being disorganized, running late, forgetting things, etc. ), taking ADHD medication like Vyvanse would probably reduce anxiety indirectly.

That said, I would like to point out that Vyvanse is not indicated for treating anxiety disorders as a whole. One should never take it for anxiety by itself, and one needs to make the distinction between anxiety as a whole condition and anxiety as a side effect of ADHD symptoms.

Tips for Coping with Anxiety on Vyvanse

No, I 'm not on Vyvanse. I have high levels of anxiety.. Tips for dealing with it

Track your symptoms: Keep track of when and what triggers your anxiety.

Adjust the timing: If you take Vyvanse in the morning, it may help reduce nighttime anxiety.

Try some relaxation techniques. Deep breathing, meditation, and exercise might be what you need.

Talk to your doctor: Do not change your dose or stop taking Vyvanse without the doctor's advice.

Final Thoughts

Vyvanse is a good medication for ADHD and BED, but not without its kinks, particularly anxiety. The best way to accurately evaluate the balance between anxiety-lowering and anxiety-worsening is to work with your healthcare provider closely, and best of all, I encourage you to have a professional assess your health if you are looking at treatment or have serious side effects of Vyvanse.

[butts-bouncing-on-the-beltway]

Anxiety disorders (of many kinds) and ADHD are a super common combination! And they can often blur together, particularly if you're someone who struggles with recognizing and/or interacting with your emotions. That's part of why it can be really important to differentiate between which thoughts/symptoms/experiences are associated with which part of the mental health experience.

Also, depending on your therapist's qualifications, they may or may not be licensed to diagnose ADHD, meaning the better they clarify the difference between anxiety and ADHD, the better your odds of getting an accurate diagnosis from someone who is (this is the charitable outlook. You do not have to choose to apply it to your providers. Some providers genuinely just fail to understand or accept ADHD in it's many forms).

If taking stimulents is supportive but causes additional anxiety, your med prescriber may discuss a number of options with you. PLEASE NOTE I HAVE NO PHARMACEUTICAL TRAINING AND PLEASE DO NOT ADJUST YOUR MEDS WITHOUT THE SUPPORT OF SOMEONE WHO DOES, THANK YOU.

Some of these options may include:

1) behavioral recommendations to your therapist to help you develop specific strategies for this extra anxiety

2) adding a medication to manage the side effect

3) switching you from a stimulent med to a non-stimulent ADHD medication

For example, my wife's med protocol is Adderall with an SSRI added for anxiety and depression. My med protocol is a combination of SNRIs and SSRIs without a stimulent, because we're not sure what the stimulent would do with my autoimmune symptoms/heart condition. I've also known folks who combine a stimulent with an SNRI or with an anti-anxiety med. It is rare to see both benzos and stinulents tho, so the anti-anxiety meds are sometimes a bit limited, and rely heavily on off-label prescriptions like vaso-dialators.

Generally, I suggest folks with ADHD work with ADHD-specific informed providers, and if that's not available, try to find a trauma-informed provider team, as they'll be the best equipped to help you manage a hyperactive autonomic system (that's what the H(yperactive) in ADHD is referring to btw, not to PHYSICAL hyperactivity, altho physical hyperactivity can certainly be one part of the presentation of a hyperactive autonomic system) via behavioral and medical interventions.

I will say that I've known a few people who reacted poorly to SSRIs and/or SNRIs *before* being put on stimulents/the right combination and dose of SNRIs. Especially those with the anxiety/ADHD profile because a lot of the time anxiety disorders are (mal)adaptive for thise of us with ADHD. Basically, we've developed anxious habits and cognitions as a way of covering for our executive dysfunction. Treat the anxiety without treating the executive function, and some people become much more dysregulated because now they also have lost a major strategy for maintaining the infrastructure of their life. But once both were treated simultaneously, the same meds that had made them feel wretched before ended up being really helpful.

Anyway, meds are weird, and so are brains, but we're still learning a lot about how neurology shows up in the world!

When a person with ADHD complains of severe anxiety, I recommend that the clinician not immediately accept the patient’s label for her emotional experience. A clinician should say, “Tell me more about your baseless, apprehensive fear,” which is the definition of anxiety. More times than not, a person with ADHD hyperarousal will give a quizzical look and respond, “I never said I was afraid.” If the patient can drop the label long enough to describe what the feeling is like, a clinician will likely hear, “I am always tense; I can’t relax enough to sit and watch a movie or TV program. I always feel like I have to go do something.” The patients are describing the inner experience of hyperactivity when it is not being expressed physically.

At the same time, people with ADHD also have fears that are based on real events in their lives. People with ADHD nervous systems are consistently inconsistent. The person is never sure that her abilities and intellect will show up when they are needed. Not being able to measure up at the job or at school, or in social circles is humiliating. It is understandable that people with ADHD live with persistent fear. These fears are real, so they do not indicate an anxiety disorder.

holy SHIT

[bisluthq]

Hey Nat, do you ever get scared starting new meds? Because I'm getting new ones tomorrow that I'll probably start tomorrow and Ive had some bad experiences - like some I've been allergic to, some made my symptoms much worse and I could tell because I was more anxious, depressed or paranoid, one made me act out but I FELT AMAZING lmao so I was annoying and scaring everyone else and way more impulsive but I felt so free and uninhibited (because I was but in the worst way possible lmao). A couple gave me physical side effects like headaches and nausea but I was told to push through and get used to them, they didn't help and then the withdrawal symptoms were so bad I wanted to go to hospital. I don't have bipolar fwiw but I've been on most categories of psychiatric meds and I've gone from being excited to try new meds because they sounded promising, to having an almost panic attack. Idk my brain is exhausting to be around. But do you ever feel that way?

I mean I don't know what they're medicating you for because you haven't told me (and you don't have to). I'm fortunate in that I've never really felt any major side effects (I do get warned about them) except weight gain on Wellbutrin but at the time I didn't really care about that because I was just like "I need something that makes this depression go away" (I do, and again this is very much another side of "my brain isn't quite right" do generally, as a rule, avoid meds that have weight gain as a side effect because I don't like to be bigger than a Size 8 eekkk and I know that's like also not quite normal of me but it is what it is and when I'm struggling with the other stuff I also don't want to be stressing about trying to overexercise or manage it to not be bigger). My biggest issue when trying new meds is "will this work" because so many haven't? Like I've been on every possible SSRI (by itself and with other stuff), I've been on Cymbalta, one doc prescribed Norpramin which like really did fuck all, I've been on every anti-anxiety med from Xanax (which I guess sorta works in that it feels nice I guess but it doesn't really help my symptoms), Espiride (does fuck all for me), Valium (really useful because I had a prescription for that when I went through a hectic party phase and self-medicated with those to come off the party drugs, which was a big w but I don't think that's what the doc prescribed them for) (also I kept saying to the docs like I don't think you need to treat the anxiety, like I don't think I'm ANXIOUS I think I'm just concerned and with the new diagnosis like I think they were treating hypomania as anxiety), one wack ass doc put me on Lyrica (gabapentin) which I think may have been weirdly enough shooting in more of the correct direction but he did that to reduce my drinking but all those med were, again, fairly useless at actually treating what's wrong with me. So my biggest concern when starting new meds, for me personally, is major skepticism. I'm like "how is this one/this combo different from the other seventy things I've been on since I was sixteen/seventeen?"

So those are actually the questions I ask now. "What makes this different to the other drugs?" and then I also ask for the specific biological/pharmacological ways it works so that I really, really understand what the goal of the drug is. I do ask about side effects (which you've done). I ask how long I should wait before it takes effect/I worry (because for example SSRIs are usually +/- 6 weeks so there's no reason to go back until you've been on it for 6 weeks unless you just like throwing money at docs lol and if you're in public then I don't even think they'll see you before the 6 week mark). I'm not really excited these days - even with the Lamotrigine like I wouldn't say I was excited, I just think they're medicating the right thing now but I suspect I may have to go onto Lithium because my clinical psych said so (she can't prescribe obviously but her take is because I mask it so well - which we do know and the psychiatrist was aware/did mention that - I haven't been put on strong enough meds and the dosage she thinks from her experience, and again she can't prescribe, is WAY too low considering how bad my Bipolar actually is). Also after having these chats with the docs I ALWAYS ALWAYS ALWAYS do my own research. Obviously not like health.com or whatever lmao but like I actually read up on studies and stuff and what these things are meant to do/where they're used/what countries don't use them and why (because with psych meds some countries always ban certain things I've found) and just make sure I know what's going on as much as possible as not a doctor. I think that's super important because as I've said before when people here ask me, *we* know better what's wrong with us than the docs do a lot of the time and *we* will have to live with it. Like the docs know the meds/solutions but they actually don't have to live with it and they actually don't know what we feel day to day because in an hour appointment there's no way we can cover everything going on lol. So yea. Ask lots of questions, do your own research from reputable sources, check how long it's meant to take to work and if it doesn't work in that time go back and be like "ok homie this didn't work, what's the next thing we can try???"

Also with psych meds always be sure you're not JUST relying on meds and are doing therapy of some sort and exercising (I know it's annoying when you get told this but you really do have to exercise unless there's a VERY good physical reason for you not to be and even then I'd see if maybe you can do SOMETHING like light stretching or chair yoga or something) and eating sensibly because like if... you're not eating (what I sometimes do) or eating complete junk and if you're using mood altering substances (alcohol, THC, anything more hectic than that OBVIOUSLY even more so unless the THC/psilocybin/K has been prescribed and you're using medical grade/medicinal doses but like alcohol like obviously no one will prescribe to you) recreationally lbr besties like whatever you're on is probably not gonna work correctly lmao. Like you can't take MDMA and then the next day be like ":((( my SSRI isn't working" like maybe it's not but let's cut the MDMA first.

[tittyinfinity]

adhd meds update

only gripe I have about the new adhd medication so far is that if I'm in too much physical pain to do anything, they make me super antsy and overstimulated because I'll have the will and motivation to do stuff, but can't. it's been cloudy for the past week and my knees have been KILLING me. not only that, but I just ran out of my pain medication until friday and I didn't realize how much the vyvanse makes my upper back hurt like HELL. gotta constantly massage my neck and jaw to make sure I'm not clenching anything.

BUT DESPITE ALL OF THAT, my threshold for "too much pain to do anything" has raised significantly; I can actually push through the pain until it's at like, a 6 or 7, instead of being useless while my pain is at a 3 or 4. I never understood how others could just "push through it." welp, it turns out that my chronic pain was pretty much my biggest distraction! I was hyperfocusing on the pain! and now that I can pay attention to ~other things~ I don't notice the pain until it gets really bad.

I'm in a hell of a lot of pain today, but as I was walking through my doctor's office earlier, I got hit with the sudden realization that I had no problem showing up to the appointment and walking around while in this much pain. usually I'd cancel bc just driving would hurt me too much. granted I do feel better today than I did a couple of days ago when a storm rolled in – I don't think I could have done it on that day. but still.

I did have a couple of days where I cried nearly all day long. But it was a GOOD cry. I felt excitement and motivation for the first time in years and I didn't even realize I had lost the ability to feel those things. feeling those butterflies in my stomach felt like a punch to the gut. I spent a couple of days going over my emotions to figure out which other parts of myself I had been suppressing. still working on that, actually.

I keep thinking about how I told my psychiatrist that I believe that the 6+ different SSRIs that I had tried over the years didn't work because the root cause of my depression was my ADHD. I kept getting into shitty situations because of my forgetfulness, executive dysfunction, and impulsivity. I was constantly missing deadlines, showing up late to places, forgetting about extremely important things, and not thinking before making decisions or reacting to situations. this led me into a never-ending spiral of guilt. I couldn't stop hating myself for how often I screwed shit up. And yeah, I was right. My anxiety has been reduced significantly now that I'm actually being productive instead of sitting around hating myself.

I mean, I'm still dealing with depression. I've been diagnosed with major depressive disorder and complex PTSD, and a few weeks of new medication isn't gonna suddenly undo all of that. not to mention the fact that being poor and disabled is fucking depressing. but I haven't been just sitting there thinking about how sad I am all day long like I was. the biggest thing that's fucking me up right now is the whole realization deal.

I found out the hard way that you should NOT drink coffee before your meds kick in. Especially not 2 cups of coffee. there have been a few days where I drank some coffee forgetting that I had already taken my meds and it fucked me uuuuppp. makes my heart rate spike like crazy and then I can't do anything bc everything becomes too overstimulating to me.

I wasn't expecting the post to be this long or to go on 20 tangents lmao. the adhd can't be completely wiped away. I probably need a higher dose than 20mg to fully help, but I'm not sure if I want a higher dose considering the whole back pain deal. but yeah it feels nice to type out my progress, and typing helps me organize my thoughts instead of having word salad in my brain, so. wee

[fildenaprofessional]

How does Cenforce D influence the treatment of erectile dysfunction in patients with Parkinson's disease?

Erectile dysfunction (ED) is a condition that affects many men, particularly as they age. However, when combined with a neurological disorder like Parkinson’s disease (PD), the treatment of ED becomes more complex. Parkinson’s disease, a neurodegenerative disorder, affects motor control and can result in a range of sexual health problems, including erectile dysfunction. Among the treatment options for ED in Parkinson’s patients, Cenforce D has shown promise. This article explores the role of Cenforce D in treating ED in patients with Parkinson's disease, the mechanisms behind its effectiveness, and important considerations for its use.

Erectile Dysfunction in Parkinson's Disease

Erectile dysfunction in Parkinson's disease is more common than many realize. Research suggests that more than 50% of men with PD experience ED, a significantly higher rate than the general population. The condition arises due to a combination of factors inherent in Parkinson’s disease.

PD is primarily a disease of the central nervous system that affects dopamine-producing neurons in the brain. Dopamine is critical not only for motor control but also for sexual function. As the disease progresses and dopamine levels decrease, patients often experience difficulties with arousal and achieving or maintaining an erection. Additionally, the physical symptoms of Parkinson’s, such as tremors, stiffness, and bradykinesia (slowness of movement), can impact sexual performance and intimacy.

Psychological factors also play a role in the development of ED in Parkinson’s patients. Depression, anxiety, and other emotional struggles that come with chronic illness can further hinder sexual desire and function. As such, addressing ED in Parkinson's disease is a critical part of improving quality of life.

What is Cenforce D?

Cenforce D is a combination medication containing two active ingredients: Sildenafil and Dapoxetine. Sildenafil is a well-known phosphodiesterase type 5 (PDE5) inhibitor used primarily to treat erectile dysfunction. It works by increasing blood flow to the penis, which helps men achieve and maintain an erection when sexually stimulated. Dapoxetine, on the other hand, is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat premature ejaculation by delaying ejaculation and increasing control over sexual function.

Cenforce D, with its dual action, is particularly useful for men who suffer from both ED and premature ejaculation. This combination makes it an attractive treatment option for Parkinson’s patients, as they often experience a range of sexual health issues beyond just erectile dysfunction, including premature ejaculation.

How Cenforce D Works in Parkinson’s Disease

In patients with Parkinson’s disease, Cenforce D has the potential to address both the erectile dysfunction caused by dopaminergic dysfunction and the premature ejaculation that can accompany it.

Sildenafil, the PDE5 inhibitor, is effective in treating ED in Parkinson’s patients because it enhances blood flow to the penis. Since Parkinson’s disease often leads to reduced blood flow due to the loss of dopaminergic function, sildenafil helps counteract this issue by promoting smooth muscle relaxation in the blood vessels of the penis, allowing more blood to flow during sexual stimulation.

Dapoxetine, the second active ingredient, targets serotonin levels in the brain. Men with Parkinson’s disease often experience changes in serotonin regulation, which can contribute to premature ejaculation. Dapoxetine helps extend the time before ejaculation, thus improving the sexual experience and satisfaction for both partners.

The combination of sildenafil and dapoxetine in Cenforce D addresses two major sexual health concerns in PD patients: the inability to achieve or sustain an erection and premature ejaculation. It is especially beneficial since many Parkinson's patients face both of these issues simultaneously, which can significantly affect their sexual health and relationships.

Safety and Effectiveness in Parkinson’s Disease Patients

When considering Cenforce D for Parkinson’s patients, it is important to weigh the safety and effectiveness of the treatment. Clinical studies have shown that PDE5 inhibitors like sildenafil are generally safe and effective for treating ED in individuals with PD. However, PD patients must use these medications cautiously because they may have underlying conditions that affect how their body responds to treatment.

One key concern is that Parkinson's medications, particularly dopaminergic drugs like levodopa, can interact with sildenafil, leading to potential side effects such as low blood pressure or dizziness. As such, patients taking medications for PD should always consult with their healthcare provider before starting Cenforce D.

The effectiveness of Sildenafil in PD patients is also dependent on the individual’s stage of Parkinson’s disease. In early to mid-stage PD, where motor function is less affected, patients may find Cenforce D more effective in managing both ED and premature ejaculation. However, as the disease progresses and motor symptoms worsen, the challenges in sexual health may become more complicated, and other treatment approaches may be needed.

Role of Healthcare Providers in Managing ED in PD

Managing erectile dysfunction in Parkinson’s disease requires a tailored approach. Healthcare providers, including neurologists, urologists, and sexual health specialists, must work together to create a comprehensive treatment plan. The patient's overall health, current medications, and the stage of Parkinson's disease should all be considered when prescribing Cenforce D.

Since Cenforce D combines two drugs that can impact serotonin and dopamine levels, monitoring is crucial. Patients should be regularly assessed for any side effects, including dizziness, headaches, and changes in mood, which could be indicative of serotonin-related issues or interactions with other PD medications.

Adjusting the dosage of Cenforce D is also essential. In some cases, patients may require lower doses to minimize the risk of side effects, especially if they are on other medications for PD. Open communication between patients and healthcare providers is critical to ensure the best possible outcomes.

Conclusion

Cenforce D offers a promising solution for managing erectile dysfunction and premature ejaculation in patients with Parkinson's disease. By addressing the two key aspects of sexual dysfunction—ED and premature ejaculation—Cenforce D can significantly improve the sexual health and quality of life for many men living with PD. However, it’s important for patients to work closely with their healthcare team to ensure that the treatment is both safe and effective, taking into account the complexities of Parkinson’s disease and its impact on overall health. With proper care and monitoring, Cenforce D can help restore confidence and intimacy in PD patients, improving their overall well-being.

[fedorahead]

for a fun follow-up to this post

consider what all of this means for medications; how we digest them, what they actually need to do to be considered food within our body so that we will break them down and achieve the desired results

i learned a few years ago that the majority of supplements and vitamins aren't even bioavailable for the average person. this is largely dependent upon genetics, but an even bigger problem is that since supplements and vitamins are not regulated by the FDA, many (most?) of them are not bioavailable to any person.

chlorophyll supplements, for example, have zero definitive research on whether the human body even processes the chlorophyll. and people pay for this.

meanwhile, people with a homozygous mutation of the mthfr gene (known as the "motherfucker mutation") don't use folate as quickly because their liver cannot process it from many sources. even 90% of folic acid supplements aren't bioavailable at all to people with this gene because they're processed using a pathway their liver doesn't have. i have a heterozygous mthfr, which is a factor in my depression, chronic pain, gut issues, brain fog, and it probably contributed to my mom's hypothyroidism, if she's the one i got it from. people with these mutation have to get extra folate from extra sources because we just don't process most of them.

we know very little about most precription medications. ssris, for instance, aren't even proven to work let alone effect the brain chemistry in the specific ways shared cultural knowledge claims they do.

anything we swallow our body is going to try to digest, which means that medications are being processed the same way as nutrients, at least at first. so maybe we would have better understanding of medications, how they work, and what they really do if we studied them with that understanding from the start.

what medication choices would i have made differently if i knew how my body might break them down and that that might to do different parts of me? i don't mean the "may cause liver damage" nonsense, i mean does it leave a chemical burn? does it process so slowly it backs other important things up? does it bond with random liver molecules and steal them? does it fundamentally alter the way my liver will work every time it goes through it? will it leave residue, forever stuck in my liver, that scientists in the future will cut up and point to and exclaim "aha, z was on ssris, no wonder their liver has this purple spot!"

i've done a lot of drugs, things doctors told me would help xyz problem. interestingly, nobody thought i might be vitamin deficient until adulthood, nobody noticed i had the mthfr gene or a chronic b12 deficiency.

actually, i'm the one who figured out the b12 thing because my blood was always on the lowest acceptable levels* every time i had a blood draw, which is a pretty weird place to be for someone who is consuming b12 enriched energy drinks 3 or 4 times a day, right?

* (acceptable by the computer... if you look up the actual numbers, i was at severe risk of psychosis which answers quite a few questions.)

i would feel our scientific exploration and curiosity in these fields are gatekept to education, but i've been listening to a podcast recently ("Just Eat Normally" with Dr Rachel Evans) where nutritionists and dieticians have come on and talked about how hard it is even in that field of education to get into the details of what our bodies genuinely need without a "weight loss is good, actually" blanketed approach. the classes that cover bigger bodies are specialty and cost more. and so much of it is treated with a one size fits all approach.

as an aside, i have a terrible immune system. i catch every passing cold and flu and have had covid twice, the two times i was really exposed by someone in my house. i've posted on here before, i think, how my bad immune system was part of how i feel so far behind in school i had to test out, because i was missing up to 3 months a year from strep, the flu, rhinovirus, allergies, etc.

i've been trying to eat incredibly healthy recently because i hate having so many disturbances in my life from my weight and all of the nutritional imbalances that got me to this weight. i've been eating as wide a variety of foods as i can manage, in smaller portions but including impulse buying vegetables that look pretty, fruit that's easy to pick at for a few hours, different types of noodles and breads... besides losing nearly 30 lbs, i've had another strange effect.

everyone in my house has covid right now and i'm fine.

maybe i brought it home and didn't feel it, maybe my recent malaise was covid. maybe i'm coming down with it right now. but this is notable and weird because historically, i catch things immediately from exposure, i incubate them pretty quickly, and i'm physically devastated by them. my partner has been out of comission since monday, and this week i've been energetic and feeling fine. i never feel fine, even on good days; i have severe allergies and chronic, disabling illness. even if i get sick, there is no timeline that makes sense based on my norms.

having a wider variety of foods, and more of the macro *and* micronutrients that i've never really had the education to seek out or even realize i needed, purely by accident has changed how my body is responding to exposure to an illness i already know i'm particularly susceptible to.

even while i've been eating less overall.

Why are agriculture classes the first time I've learned extremely basic info about nutrition and how digestion works. Why isn't this stuff in health textbooks or any easily accessible resource about healthy eating.