#How to test for MTHFR mutation

[mehmetyildizmelbourne-blog]

MTHFR Gene Mutation: Why It Matters & How to Get Tested

Discover the Role of the MTHFR Gene, the Impact of Its Mutations on Your Health, & How You Can Get Tested to Understand Your Genetic Risk Factors You may not have heard of MTHFR, but this enzyme plays a vital role in our body’s ability to process folate (vitamin B9) and maintain your DNA. Related to another critical B vitamin, I recently wrote a story about the global B12 epidemic.  Analyzing…

[onehealthassist]

How Methylated Multivitamins Help with Energy, Brain Fog & Immunity

You eat clean, sleep deep, and still feel drained. The brain fog lingers. The spark? Gone. You’re doing everything “right,” so why is your body still begging for more?

Table of Contents

Why Are They Important for Your Body’s Energy and Wellness?   How Do Methylated Vitamins Work Differently Than Regular Ones?   Who Needs Methylated Multivitamins the Most?   How Can You Tell If You Have a Methylation Deficiency?   How Do Methylated Multivitamins Support Energy, Mood, and Focus?   What Should You Look for When Buying Methylated Multivitamins? 

Why Are They Important for Your Body’s Energy and Wellness?

Picture this: It’s 3 p.m., and you’re dragging yourself through the day, feeling like you’re running on fumes. You’ve eaten a balanced breakfast, avoided junk food, maybe even squeezed in a quick workout—but your energy is nowhere to be found.

Maybe your digestion has been off. Or you’ve caught colds more often. Or perhaps your mood feels like a rollercoaster. Sound familiar?

This was me last year—juggling work deadlines, family dinners, and endless to-do lists—only to realize that my body wasn’t keeping up. After trying everything from sleep hacks to yoga, I stumbled across methylated multivitamins. Within weeks, the fog lifted. My energy returned. My digestion improved. If you’re wondering why your healthy lifestyle isn’t working, this could be the missing link.

How Do Methylated Vitamins Work Differently Than Regular Ones?

Methylated multivitamins aren’t just another supplement—they’re bioactive powerhouses. Unlike regular vitamins that your body must convert to work, methylated forms like methylfolate (B9) and methylcobalamin (B12) are ready to use immediately.

Here’s how they can transform your health:

Energy Unleashed

Methyl-B12 fuels ATP production, giving your cells the energy they need to power through the day.

Say goodbye to 3 PM crashes and low stamina.

Mental Clarity Boost

5-MTHF folate helps produce serotonin and dopamine—key neurotransmitters for focus and emotional balance.

Lifts brain fog and stabilizes mood swings.

Immune Resilience

B vitamins, zinc, and vitamin C boost immune cells, making your body more resilient during stress or seasonal changes.

Think of it as natural armor against infections.

Detox & Digestion Support

Supports liver methylation pathways, helping remove toxins more efficiently.

Combine with Ayurvedic medicine for constipation like Triphala for smoother digestion.

Heart & Hormone Harmony

Reduces homocysteine, a marker linked to heart disease, and supports hormone metabolism.

Especially beneficial for women dealing with PMS or hormonal imbalances.

Who Needs Methylated Multivitamins the Most?

These are especially beneficial for:

Adults with MTHFR gene mutations (30–40% of people)   Kids needing an immunity booster syrup   Women during pregnancy or PMS   People dealing with fatigue, brain fog, or constipation   Anyone taking Ayurvedic medicine for weight gain or detox  

Even if you’re eating “healthy,” stress, gut issues, and genetics can stop your body from absorbing key nutrients.

How Can You Tell If You Have a Methylation Deficiency?

“You’re fine. Maybe it’s just stress.” How often have you heard that after getting normal blood work?

The truth? Most tests only show what nutrients are present, not if your body can use them.

Data Point:

Around 40% of people have MTHFR gene mutations. This makes it difficult to process synthetic folic acid and B12—leading to nutrient traps, despite a good diet.

Constipation Connection:

Low B vitamins or magnesium can worsen gut motility.

Pairing methylated multivitamins with Ayurvedic medicine for constipation can improve digestion naturally.

Weight Gain Struggles:

If you're underweight or find it hard to build healthy mass, the issue might be poor nutrient absorption.

Combine methylated multivitamins with Namira Churna (Ayurvedic medicine for weight gain) to support metabolism and muscle recovery.

Top 5 Benefits of Methylated Multivitamins

Improved Mental Clarity

Users often report feeling sharper, more focused, and less foggy—especially mid-day.

Boosted Energy Levels

Methylated B12 and folate support cellularenergyproduction, helping you beat that 3 PM slump.

Better Sleep and Mood

Balanced methylation supports serotonin and melatonin production, improving your sleep and emotional well-being.

Fertility Support

Active folate (methylfolate) is crucial for pregnancy and fetal development—safer and more effective than folic acid.

Detox and Immunity

Methylation helps in detoxification and immune function, keeping your system resilient and clean.

Especially Wellness for Every Need

Not all supplements are created equal. Choose what suits your stage of life and health goals:

🔹 For Adults:

Zaocare Multivitamin Tablets – loaded with methyl-B12, folate, and zinc. Ideal for stress, metabolism, and energy.

🔹 For Kids:

Look for methylated multivitamins for kids like Hiya chewables – free from synthetic dyes and designed for young immune systems.

🔹 For Immunity:

Immunoboost Syrup – rich in herbs and vitamins that enhance the immune response, especially during seasonal changes.

Bonus Tip:

Pair your multivitamin with Ayurvedic support:

Triphala for digestion   Namira Churna for healthy weight gain   Mokshkaya Immunity Booster Capsules for all-around wellness   People Also Ask

Are methylated multivitamins safe?

Ans:Yes, especially when taken at recommended doses. They’re just the bioactive form of common nutrients like B9 and B12.

Can kids take them?

Ans:Yes. Look for age-specific products labeled as methylated multivitamin for kids. Always confirm the dosage with your pediatrician.

Will they help with constipation?

Ans:They support digestion and nutrient absorption. For optimal results, combine with Ayurvedic medicine for constipation like Triphala.

Do they support weight gain?

Ans:Yes—by restoring nutrient balance and metabolism. Combine with Ayurvedic medicine for weight gain like Namira Churna.

When will I see results?

Ans:Most people notice improved energy and focus in 2–3 weeks. Immune and mood benefits typically show up in 6–8 weeks.

Summary:

Methylated multivitamins aren’t hype—they’re the future of personalized wellness. Whether you’re an overworked parent, a student dealing with brain fog, or someone exploring Ayurvedic remedies for digestion or immunity, these supplements could be the key to unlocking your vitality.

[jevaajohhnn]

The Ultimate Guide to Gary Brecka 10x Success

In today’s fast-paced world, the pursuit of peak performance—mentally, physically, and professionally—is more important than ever. At the forefront of this movement is Gary Brecka, a man whose name has become synonymous with personal transformation, optimized health, and biological potential. With decades of experience and a revolutionary approach grounded in genetics, Gary Brecka Biologist is not just helping people improve their lives—he’s completely redefining what’s possible.

Welcome to the ultimate guide to Gary Brecka 10x success—a journey that could help you unlock your true potential from the inside out.

Who is Gary Brecka?

Before diving into his 10x system, it’s important to understand the man behind the movement. Gary Brecka is a human biologist with over 20 years of clinical experience in analyzing blood work and DNA to forecast longevity and improve quality of life. He began his career working with life insurance companies, analyzing the data of the sick and the dying. But that work left him unfulfilled—he wasn’t saving lives, just measuring how long people had left.

Determined to change that, Gary Brecka Biologist transitioned to using his expertise to help people take control of their own health destinies. His philosophy? Your body is already telling you everything you need to know—you just need the right tools to listen.

What is Gary Brecka 10x?

At the heart of his methodology lies Gary Brecka 10x, a proprietary health optimization system rooted in functional medicine, epigenetics, and real-time biometric analysis. The “10x” concept is simple: improve every facet of your life—energy, focus, fitness, mood, longevity—tenfold by understanding and hacking your own biology.

Rather than offering generic health advice, Gary Brecka 10x is hyper-personalized. Using DNA testing, blood markers, and lifestyle audits, Brecka and his team create customized wellness protocols designed to optimize the body at the cellular level. Think of it as a blueprint for your best possible self.

The Science Behind the Method

What sets Gary Brecka Biologist apart from others in the health and wellness industry is his scientific rigor. He’s not just promoting a trendy supplement or crash diet; he’s diving deep into the genetic and biochemical makeup of each client.

For example, Gary Brecka focuses on something known as methylation—a biological process that affects everything from mood regulation to detoxification and even DNA repair. Many people have genetic mutations (such as MTHFR) that impair methylation. Without addressing this, even the best health routines can fall flat.

That’s why Gary Brecka 10x includes personalized supplementation based on genetic deficiencies, custom nutrition plans, and guided lifestyle changes. The results? Often dramatic, as detailed in numerous Gary Brecka Reviews from everyday individuals and celebrities alike.

Real Results: What Do the Gary Brecka Reviews Say?

If you're wondering whether this is all hype, the growing library of Gary Brecka Reviews says otherwise. From professional athletes to high-level executives and people simply looking to regain their energy, the testimonials are overwhelmingly positive.

One user reported shedding 30 pounds in four months and reversing chronic fatigue that plagued her for years. Another shared how a tailored protocol allowed them to ditch their antidepressants after discovering key nutrient imbalances in their DNA.

These Gary Brecka Reviews are more than anecdotal—they’re case studies in how understanding your genetic and biological fingerprint can radically change your health and life. It's this track record of tangible, reproducible success that’s turned Gary Brecka Biologist into a trusted name in personal optimization.

The Partnership with Gary Brecka Cardone Venture

The reach and impact of Gary Brecka 10x wouldn’t be what it is today without the strategic partnership with Gary Brecka Cardone Venture. When Gary teamed up with Grant Cardone—real estate mogul and 10x business guru—their combined vision of health and performance took off.

Gary Brecka Cardone Venture bridges science with entrepreneurial spirit. Through this collaboration, the 10x health methodology has been made accessible to a wider audience—from business owners seeking peak mental performance to entire corporate teams looking for a productivity edge.

This venture also paved the way for a multi-platform education system, including masterclasses, live events, and digital programs that integrate both business and biological success strategies.

The 10x Protocol: What to Expect

So what exactly happens when you sign up for Gary Brecka 10x? While the program is customized, the core process generally includes:

1. DNA and Blood Testing

Everything starts with data. Gary Brecka Biologist uses cutting-edge tests to assess your genetic makeup, vitamin levels, hormone balance, and more.

2. Detailed Analysis

Next, a team of experts interprets the results, identifying nutrient deficiencies, inflammation markers, and potential risks.

3. Personalized Protocol

You’ll receive a comprehensive wellness plan. This can include:

Customized supplements

Targeted diet strategies

Sleep and recovery optimization

Biohacking tools (like red light therapy, grounding, or breathwork)

4. Ongoing Support

Many Gary Brecka Reviews highlight the ongoing coaching as a key benefit. You’re not left alone to figure things out—you're guided every step of the way.

Why Now is the Time to 10x Your Health

More than ever, people are searching for sustainable, personalized ways to enhance their well-being. With rising chronic illness rates, skyrocketing stress, and decreasing vitality, the cookie-cutter solutions of the past simply don’t work.

That’s where Gary Brecka Biologist shines. His science-backed approach doesn’t just put a Band-Aid on your symptoms—it goes upstream to fix the root cause. Whether you’re looking to boost your energy, sharpen your focus, or simply feel like yourself again, Gary Brecka 10x offers a proven roadmap.

And thanks to the power of Gary Brecka Cardone Venture, that roadmap is now more accessible and scalable than ever before.

Is Gary Brecka 10x Right for You?

If you’ve tried every diet, supplement, or fitness trend and still feel stuck, it may be time to take a different approach. The magic of Gary Brecka lies in his ability to personalize—there are no one-size-fits-all plans here.

Still not sure? Here are some questions to ask yourself:

Do you often feel fatigued despite “doing everything right”?

Are you taking supplements but not seeing results?

Do you want to prevent disease rather than treat it?

Are you ready to invest in understanding your body?

If you answered yes to any of these, it may be time to explore what Gary Brecka Biologist can do for you.

Final Thoughts: Your Health is Your Edge

In the world of entrepreneurship, business, and even family life, your greatest asset isn’t your money, your time, or even your skills—it’s your health. When your body and mind are firing on all cylinders, everything else becomes easier.

The beauty of Gary Brecka 10x is that it doesn’t just aim to optimize your body—it aims to 10x your life. With the science of Gary Brecka Biologist, the real-life transformations in Gary Brecka Reviews, and the scalable success platform of Gary Brecka Cardone Venture, this is more than a health program. It’s a movement toward human excellence.

[fedorahead]

for a fun follow-up to this post

consider what all of this means for medications; how we digest them, what they actually need to do to be considered food within our body so that we will break them down and achieve the desired results

i learned a few years ago that the majority of supplements and vitamins aren't even bioavailable for the average person. this is largely dependent upon genetics, but an even bigger problem is that since supplements and vitamins are not regulated by the FDA, many (most?) of them are not bioavailable to any person.

chlorophyll supplements, for example, have zero definitive research on whether the human body even processes the chlorophyll. and people pay for this.

meanwhile, people with a homozygous mutation of the mthfr gene (known as the "motherfucker mutation") don't use folate as quickly because their liver cannot process it from many sources. even 90% of folic acid supplements aren't bioavailable at all to people with this gene because they're processed using a pathway their liver doesn't have. i have a heterozygous mthfr, which is a factor in my depression, chronic pain, gut issues, brain fog, and it probably contributed to my mom's hypothyroidism, if she's the one i got it from. people with these mutation have to get extra folate from extra sources because we just don't process most of them.

we know very little about most precription medications. ssris, for instance, aren't even proven to work let alone effect the brain chemistry in the specific ways shared cultural knowledge claims they do.

anything we swallow our body is going to try to digest, which means that medications are being processed the same way as nutrients, at least at first. so maybe we would have better understanding of medications, how they work, and what they really do if we studied them with that understanding from the start.

what medication choices would i have made differently if i knew how my body might break them down and that that might to do different parts of me? i don't mean the "may cause liver damage" nonsense, i mean does it leave a chemical burn? does it process so slowly it backs other important things up? does it bond with random liver molecules and steal them? does it fundamentally alter the way my liver will work every time it goes through it? will it leave residue, forever stuck in my liver, that scientists in the future will cut up and point to and exclaim "aha, z was on ssris, no wonder their liver has this purple spot!"

i've done a lot of drugs, things doctors told me would help xyz problem. interestingly, nobody thought i might be vitamin deficient until adulthood, nobody noticed i had the mthfr gene or a chronic b12 deficiency.

actually, i'm the one who figured out the b12 thing because my blood was always on the lowest acceptable levels* every time i had a blood draw, which is a pretty weird place to be for someone who is consuming b12 enriched energy drinks 3 or 4 times a day, right?

* (acceptable by the computer... if you look up the actual numbers, i was at severe risk of psychosis which answers quite a few questions.)

i would feel our scientific exploration and curiosity in these fields are gatekept to education, but i've been listening to a podcast recently ("Just Eat Normally" with Dr Rachel Evans) where nutritionists and dieticians have come on and talked about how hard it is even in that field of education to get into the details of what our bodies genuinely need without a "weight loss is good, actually" blanketed approach. the classes that cover bigger bodies are specialty and cost more. and so much of it is treated with a one size fits all approach.

as an aside, i have a terrible immune system. i catch every passing cold and flu and have had covid twice, the two times i was really exposed by someone in my house. i've posted on here before, i think, how my bad immune system was part of how i feel so far behind in school i had to test out, because i was missing up to 3 months a year from strep, the flu, rhinovirus, allergies, etc.

i've been trying to eat incredibly healthy recently because i hate having so many disturbances in my life from my weight and all of the nutritional imbalances that got me to this weight. i've been eating as wide a variety of foods as i can manage, in smaller portions but including impulse buying vegetables that look pretty, fruit that's easy to pick at for a few hours, different types of noodles and breads... besides losing nearly 30 lbs, i've had another strange effect.

everyone in my house has covid right now and i'm fine.

maybe i brought it home and didn't feel it, maybe my recent malaise was covid. maybe i'm coming down with it right now. but this is notable and weird because historically, i catch things immediately from exposure, i incubate them pretty quickly, and i'm physically devastated by them. my partner has been out of comission since monday, and this week i've been energetic and feeling fine. i never feel fine, even on good days; i have severe allergies and chronic, disabling illness. even if i get sick, there is no timeline that makes sense based on my norms.

having a wider variety of foods, and more of the macro *and* micronutrients that i've never really had the education to seek out or even realize i needed, purely by accident has changed how my body is responding to exposure to an illness i already know i'm particularly susceptible to.

even while i've been eating less overall.

Why are agriculture classes the first time I've learned extremely basic info about nutrition and how digestion works. Why isn't this stuff in health textbooks or any easily accessible resource about healthy eating.

[openintegrative]

High Homocysteine: How to Manage Levels

Elevated homocysteine can raise the risk of heart disease and other health problems.

Animal-based foods high in B vitamins help reduce homocysteine levels.

Genetics and chronic inflammation may contribute to elevated levels.

A nutrient-rich diet supports balanced homocysteine without the need for supplements.

Regular physical activity and stress management aid in maintaining healthy levels.

What is Homocysteine?

Homocysteine is a sulfur-containing amino acid that occurs naturally in the body. It’s involved in important processes like protein synthesis and cellular metabolism.

While it plays a role in normal metabolic processes, elevated levels in the blood can be dangerous.

High homocysteine is linked to heart disease, cognitive decline, and other health problems. Managing homocysteine levels through diet and lifestyle can help reduce these risks.

Role in the Body

Homocysteine is typically broken down by B vitamins, particularly B6, B12, and folate. These vitamins convert homocysteine into other beneficial compounds, such as methionine, which the body uses for protein production and other functions.

Normal vs. Elevated Levels

While low to moderate levels of homocysteine are normal, high levels (hyperhomocysteinemia) can lead to health problems.

Testing homocysteine levels through a blood test can identify whether someone is at risk for elevated levels. Healthy homocysteine levels generally fall below 15 micromoles per liter.

Causes of High Homocysteine

Several factors can cause homocysteine levels to rise. The most common contributors are poor diet, genetic mutations, and chronic inflammation.

Poor Diet and Nutrient Deficiencies

A diet lacking in key nutrients, especially B vitamins, is a major cause of high homocysteine. Animal foods like meat, eggs, and fish are the richest sources of B6, B12, and folate.

Without enough of these vitamins, the body cannot properly metabolize homocysteine, leading to elevated levels.

Genetic Factors (MTHFR Mutation)

Certain genetic mutations, such as MTHFR, can affect how homocysteine is processed in the body.

People with this mutation may have a reduced ability to break down homocysteine, which can result in higher levels even with an adequate diet.

Chronic Inflammation and Health Conditions

Chronic inflammation, whether due to lifestyle or underlying health conditions, can also raise homocysteine levels.

Inflammation affects many of the body’s processes, including how well nutrients are absorbed and utilized, which in turn influences homocysteine metabolism.

Health Risks of High Homocysteine

Elevated homocysteine has been linked to a variety of health risks, particularly concerning cardiovascular health, cognitive function, and bone health.

Cardiovascular Disease

High homocysteine levels damage blood vessels and promote the formation of plaque in arteries, increasing the risk of heart attacks and strokes.

It’s often considered a marker for cardiovascular risk, similar to cholesterol levels.

Cognitive Decline

Elevated homocysteine has been associated with cognitive decline, including memory loss and a higher risk of conditions like dementia and Alzheimer’s disease.

Adequate B vitamin intake helps reduce this risk by maintaining healthy homocysteine levels.

Bone and Joint Health Issues

Increased homocysteine can weaken bones, leading to osteoporosis and fractures. It may also affect joint health, causing inflammation and contributing to conditions like arthritis.

Managing Homocysteine Levels

Lowering homocysteine levels is largely achieved through a nutrient-dense diet, with a focus on B vitamins.

Avoiding synthetic supplements is advisable, as whole foods are more effective and safer for maintaining proper nutrient balance.

Importance of B Vitamins (B6, B12, Folate)

B vitamins play a critical role in breaking down homocysteine. Foods rich in these vitamins are essential to keep homocysteine levels in check.

Grass-fed beef, pasture-raised eggs, and organ meats are excellent sources of B6 and B12.

For folate, liver and leafy greens offer high concentrations, though animal-based sources tend to be more bioavailable.

Foods for Lowering Homocysteine

Animal foods are the best way to lower homocysteine because they provide the most bioavailable forms of B vitamins. Organ meats, red meat, and eggs are particularly effective.

Non Fortified nutritional yeast is another good source that is suitable for everyone including plant-based individuals

Regular consumption of these foods ensures your body has the nutrients needed to maintain healthy homocysteine metabolism.

Avoiding Synthetic Supplements

While synthetic B vitamin supplements may seem like a quick fix, they often lack the same bioavailability as nutrients from whole foods.

Additionally, fortified foods and supplements containing iron can contribute to inflammation.

In some cases, these supplements can even worsen the problem by disrupting the body’s natural balance. Whole, nutrient-dense foods are the best way to manage homocysteine levels.

Lifestyle Changes to Support Healthy Levels

Managing homocysteine isn’t just about diet; lifestyle habits also make a difference. Reducing inflammation, staying active, and managing stress all support lower homocysteine levels.

Reducing Inflammation

Chronic inflammation can raise homocysteine levels. Focusing on an anti-inflammatory lifestyle, including eating nutrient-rich foods, avoiding processed foods, and getting regular sleep, helps keep inflammation under control.

Physical Activity and Its Impact

Exercise helps regulate homocysteine by promoting overall cardiovascular health and reducing inflammation.

Regular, moderate exercise supports better nutrient absorption and metabolic processes that manage homocysteine.

Stress Management

High stress levels affect many areas of health, including homocysteine metabolism. Chronic stress can deplete B vitamins and increase inflammation, so practicing stress-relief techniques like meditation, deep breathing, and regular physical activity is important for managing homocysteine.

Conclusion

Managing homocysteine levels is key to reducing the risk of heart disease, cognitive decline, and other health issues. A diet rich in animal-based foods, regular exercise, and maintaining low levels of inflammation all contribute to keeping homocysteine at healthy levels.

FAQs

What are the symptoms of high homocysteine?

High homocysteine often doesn’t cause noticeable symptoms, but it increases the risk of heart disease, cognitive problems, and bone issues.

How do I test my homocysteine levels?

A simple blood test can measure homocysteine levels. This test is often ordered when there is a risk of cardiovascular disease or other related conditions.

Can diet alone reduce high homocysteine?

Yes, a nutrient-rich diet, particularly with foods high in B vitamins like meat and eggs, can effectively lower homocysteine levels without the need for supplements.

How do genetics influence homocysteine levels?

Certain genetic mutations, like MTHFR, can impair the body’s ability to process homocysteine. In these cases, careful dietary management is crucial.

What foods should I avoid with high homocysteine?

Avoid processed foods, excessive alcohol, and a diet low in animal-based B vitamins, as these can contribute to elevated homocysteine levels

Research

Ambroszkiewicz, J., Klemarczyk, W., Chełchowska, M., Gajewska, J., & Laskowska-Klita, T. (2006). Serum homocysteine, folate, vitamin B12 and total antioxidant status in vegetarian children. Adv Med Sci, 51, 265-268. https://doi.org/10.1016/s0899-9007(03)00158-8

Crider, K. S., Bailey, L. B., & Berry, R. J. (2011). Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions. Nutrients, 3(3), 370-384. https://doi.org/10.3390/nu3030370

Crider, K. S., Zhu, J., Hao, L., Yang, Q., Yang, T. P., Gindler, J., Maneval, D. R., Quinlivan, E. P., Li, Z., Bailey, L. B., & Berry, R. J. (2011). MTHFR 677C→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. The American Journal of Clinical Nutrition, 93(6), 1365-1372. https://doi.org/10.3945/ajcn.110.004671

den Heijer, M., Willems, H.P.J., Blom, H.J., Gerrits, W.B.J., Cattaneo, M., Eichinger, S., Rosendaal, F.R., & Bos, G.M.J. (2006). Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. Blood, 109(1), 139–144. https://doi.org/10.1182/blood-2006-04-014654

Durga, J., van Tits, L.J.H., Schouten, E.G., Kok, F.J., & Verhoef, P. (2005). Effect of Lowering of Homocysteine Levels on Inflammatory Markers. Archives of Internal Medicine, 165(12), 1388. https://doi.org/10.1001/archinte.165.12.1388

Food and Agriculture Organization of the United Nations, World Health Organization. (2004). Joint FAO/WHO Consultation on Human Vitamin and Mineral Requirements. FAO/WHO; Geneva: Vitamin and mineral requirements in human nutrition.

Gallego-Narbón, A., Zapatera, B., Barrios, L., & Vaquero, M.P. (2019). Vitamin B12 and folate status in Spanish lacto-ovo vegetarians and vegans. J Nutr Sci, 8, e7. https://doi.org/10.1017/jns.2019.2

Hao, L., Yang, Q., Li, Z., Bailey, L. B., Zhu, J., Hu, D. J., Zhang, B., Erickson, J. D., Zhang, L., Gindler, J., Li, S., & Berry, R. J. (2008). Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial. The American Journal of Clinical Nutrition, 88(2), 448-457. https://doi.org/10.1093/ajcn/88.2.448

Huang, Y.C., Chang, S.J., Chiu, Y.T., Chang, H.H., & Cheng, C.H. (2003). The status of plasma homocysteine and related B-vitamins in healthy young vegetarians and nonvegetarians. Eur J Nutr, 42(2), 84-90. https://doi.org/10.1007/s00394-003-0387-5

Keser, I., Ilich, J. Z., Vrkić, N., Giljević, Z., & Colić Barić, I. (2013). Folic acid and vitamin B12 supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: A randomized, double-blind, placebo-controlled trial. Nutrition Research, 33(3), 211-219. https://doi.org/10.1016/j.nutres.2013.01.002

Khandanpour, N., Loke, Y., Meyer, F., Jennings, B., & Armon, M. (2009). Homocysteine and Peripheral Arterial Disease: Systematic Review and Meta-analysis. European Journal of Vascular and Endovascular Surgery, 38(3), 316-322. https://doi.org/10.1016/j.ejvs.2009.05.007

Klevay LM. Ischemic heart disease as deficiency disease. Cell Mol Biol (Noisy-le-grand). 2004 Dec;50(8):877-84. PMID: 15704251.

Krajcovicová-Kudlácková, M., Blazícek, P., Babinská, K., Kopcová, J., Klvanová, J., Béderová, A., & Magálová, T. (2000). Traditional and alternative nutrition--levels of homocysteine and lipid parameters in adults. Scand J Clin Lab Invest, 60(8), 657-664. https://doi.org/10.1080/00365510050216385

Majchrzak, D., Singer, I., Männer, M., Rust, P., Genser, D., Wagner, K.-H., & Elmadfa, I. (2006). B-Vitamin Status and Concentrations of Homocysteine in Austrian Omnivores, Vegetarians and Vegans. Annals of Nutrition and Metabolism, 50(6), 485–491. https://doi.org/10.1159/000095828

Mann NJ, Li D, Sinclair AJ, Dudman NP, Guo XW, Elsworth GR, Wilson AK, Kelly FD. The effect of diet on plasma homocysteine concentrations in healthy male subjects. Eur J Clin Nutr. 1999 Nov;53(11):895-9. doi: 10.1038/sj.ejcn.1600874. PMID: 10557004. https://pubmed.ncbi.nlm.nih.gov/10557004/

Mech, A.W., & Farah, A. (2016). Correlation of Clinical Response With Homocysteine Reduction During Therapy With Reduced B Vitamins in Patients With MDD Who Are Positive for MTHFR C677T or A1298C Polymorphism. The Journal of Clinical Psychiatry, 77(05), 668–671. https://doi.org/10.4088/jcp.15m10166

Palchetti, C. Z., Paniz, C., Marchioni, D. M., Colli, C., Steluti, J., Pfeiffer, C. M., Fazili, Z., & Guerra-Shinohara, E. M. Association between serum unmetabolized folic acid concentrations and folic acid from fortified foods. Journal of the American College of Nutrition, 36(7), 572. https://doi.org/10.1080/07315724.2017.1333929

Tovar, A.R., Torres, N., Barrales-Benitez, O., López, A.M., Diaz, M., & Rosado, J.L. (2003). Plasma total homocysteine in Mexican rural and urban women fed typical model diets. Nutrition, 19(10), 826-831. https://doi.org/10.1016/s0899-9007(03)00158-8

Venn, B., Mann, J., Williams, S., Riddell, L., Chisholm, A., Harper, M., Aitken, W., & Rossaak, J. (2002). Assessment of three levels of folic acid on serum folate and plasma homocysteine: A randomized placebo-controlled double-blind dietary intervention trial. European Journal of Clinical Nutrition, 56(8), 748-754. https://doi.org/10.1038/sj.ejcn.1601388

Woodside, J., Yarnell, J., McMaster, D., Young, I., Harmon, D., McCrum, E., Patterson, C., Gey, K., Whitehead, A., & Evans, A. (1998). Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: A double-blind, randomized, factorial-design, controlled trial. The American Journal of Clinical Nutrition, 67(5), 858-866. https://doi.org/10.1093/ajcn/67.5.858

[meditating-dog-lover]

Health update

I am feeling much better and my skin is clearing up

I took a shower this morning and my face didn't turn tomato red. It did itch a bit but nothing that was too bad.

I have a new concerning rash on the back of my neck and my derm said to put steroid cream and antifungal on it for 2 weeks. It should disappear.

My hand was still infected as well, so I'm on oral antibiotics again and that should take care of the issue hopefully. I was also advised to apply antibiotic and steroid creams on my hands for 2 weeks. My hands are much better, and they are less inflamed. But I'm concerned about some infection and some areas that are still inflamed. So the antibiotic and steroid mix can help here.

My face, neck, and ears are much better.

I think my skin got better after my phone call this week as well as my official psych evaluations. It makes me realize that this all happened due to chronic stress.

I think my stress is a big thing that I need to work on because it's making me sick. I will get the support I need, but it will take time. I am still working on my diet and fasting and am doing great. I am working now on hormone balance and liver detoxification. I don't have any major hormone issues besides some minor estrogen dominance. I can manage that by taking DIM. I do want to eat well and drink filtered reverse osmosis water. Minimizing plastic usage and using natural self care and cleaning products helps too (which I already kind of do, I might look into kitchen and laundry and soap options). Also it is impossible to avoid "toxins" 100%, so it helps to do the best you can and to regularly "detox". When I say that I mean to support your key detox organs like the gut, liver, lymphatic system, lungs, skin, and kidneys. I'm not talking about weird and dangerous enemas and teas.

I've been taking a DIM detox supplement for liver support. I think the key ingredient it has that really helps is NAC/glutathione. I might look into that in the future when I finish my supplement bottle. Methylated B vitamins, sulfur, amino acids like taurine, glutamine, cysteine, glycine, NAC/glutathione, magnesium, flavenoids, and antioxidants. I don't know how much of these I'm receiving from diet and supplementation (excluding the DIM Detox supplement I just started) alone, but NAC/glutathione is very important for liver health in general. If I can get that, then that would be great.

Drinking enough water and eating enough fiber helps a lot here. Eating foods rich in sulfur like cruciferous veggies helps too. Dandelion root tea is excellent for liver and kidney health, which in turn helps with detoxification. I actually got some the other day and I like the taste. But I just had 1 cup which isn't going to make a notable difference. I want to drink that combined with an anti-inflammatory diet rich in fiber and drinking 2 L minimum of filtered/reverse osmosis water.

Also there is a key process within phase 2 liver detoxification known as methylation. Some people have a genetic mutation in the MTHFR gene where they are unable to do this efficiently. That's why doctors recommend a methylated B complex. So vitamin B9 (folate) and B12 should be in methylated forms. NAC/glutathione also help here. I've never been tested for this, though. But I do take a multivitamin that has B vitamins.

I'll figure this out as more time passes. At least I'm taking a supplement that helps with both hormone balance and liver detoxification, and I liked the dandelion tea. I'm also drinking aloe juice daily. I need to work on healing psychologically, though.

[understandingfertility]

Exploring the Relationship Between Fertility and MTHFR Gene Mutations

MTHFR gene mutations have gained attention in the field of fertility because increasing evidence points to a possible connection between these genetic variations and reproductive health. At the best IVF center in Indore, we explore the complex relationship between fertility and MTHFR gene mutations, providing information on how genetic factors may impact fertility results and IVF treatment cost in Indore.

Understanding MTHFR Gene Mutations:

Genetic Variants:

The MTHFR gene produces a chemical involved in the methylation process, which is necessary for various bodily functions, including DNA repair and regulation of hormones. Changes in the MTHFR gene, particularly the C677T and A1298C variants, can affect enzyme activity and lead to impaired methylation capacity.

Impact on Fertility:

Research suggests that MTHFR gene mutations could impact fertility by affecting processes like embryo placement, placental development, and hormone metabolism. Women with MTHFR gene changes may be at increased risk of recurrent pregnancy loss, preeclampsia, and other pregnancy complications.

Navigating Fertility Challenges at the Best IVF Center in Indore:

Comprehensive Genetic Testing:

At the best IVF center in Indore, we offer comprehensive genetic testing to identify MTHFR gene mutations and other genetic factors that may impact fertility. Understanding a patient's genetic profile allows us to tailor treatment plans to address individual needs and optimize fertility outcomes.

Personalized Treatment Approach:

Our experienced fertility specialists take a personalized approach to fertility treatment, considering genetic factors such as MTHFR gene mutations in treatment planning. By integrating genetic information into our protocols, we aim to maximize the chances of success for our patients undergoing IVF and minimize IVF treatment cost in Indore.

Conclusion:

As our understanding of the role of genetics in fertility grows, MTHFR gene mutations are now recognized as a possible contributor to reproductive health challenges. By seeking care from the best IVF center in Indore, people can access through genetic testing and personalized therapies that address genetic factors and optimize fertility results. Contact us today to learn more about how we can support you on your journey to becoming parents with skills, compassion, and personalized attention.

[the2amrevolution]

Part of the problem is that CFS/ME is unlikely to be just one pathology. Its a syndrome - a collection of symptoms. Thats part of why I have never been satisfied with that answer and so have tried to keep up with research into its pathology and comparing things I've found to my own symptoms. Following that research is what led to me reading about MTHFR mutations, which led me to taking methylfolate, which led to me discovering I likely have both a methylcobalamin deficiency and pyridoxal-5-phosphate deficiency that are the root of my CFS, POTS, worsening MCAS, hypersomina, and other progressive symptoms.

MTHFR mutations affect between 1 in 3 and 1 in 10 people, depending on race and nationality. They cause a deficiency in methylfolate which raises homocysteine levels and has a similar effect to a B12 or folate deficiency, but with normal B12 and folate levels.

Cobalamin metabolism disorders are more rare, but they are also very easily missed because total B12 blood tests are normal. The most common cobalamin metabolism disorder causes a deficiency of the usable forms of B12, leading to elevated methylmalonic acid and elevated homocysteine as would be seen in a B12 deficiency from diet or malabsorption. More rare disorders, or currently unknown and so undiagnosed disorders, can cause just a deficiency of methylcobalamin which will have nearly identical symptoms to a methylfolate deficiency.

One research team has hypothesized that an autoimmune disorder affecting the production of adenosylcobalamin may be behind multiple sclerosis. Impaired B12 metabolism leads to defective myelin, which the immune system tries to clear out. Something similar happens with methylcobalamin deficiency. Only genetic cobalamin metabolism disorders are recognized currently, but there could be autoimmune forms as well.

Similarly, some researchers think MTHFR mutations may be behind the trifecta of hEDS, POTS, and MCAS where patients often also fit CFS/ME and fibromyalgia criteria. Methylfolate deficiency can cause methylcobalamin deficiency, and methylcobalamin deficiency also leads to faulty myelin. Methylfolate and methylcobalamin deficiencies also cause problems with how DNA is read to make proteins, leading to faulty collagen, more damaged enzymes, and a variety of other metabolic problems.

The degree of impairment of the enzymes involved would impact the degree of severity of the damage done to the body. A mild deficiency over time would cause a slow, steady increase in platelet count, worsening allergies/MCAS reactions (homocysteine can trigger mast cells), and a wide variety of neurological symptoms as myelin degrades from lack of methylcobalamin and homocysteine causes excitotoxity.

While researching this, I found that there may also be millions of people with a functional pyridoxal phosphate deficiency who have no idea and no doctor is going to know to look for it. The people at risk are those who take B6 supplements and anyone who takes replacement thyroid hormones, both T4 and T3.

Most B6 supplements are a form of the vitamin called pyridoxine hydrochloride. This form can't be used by the body as is, it has to be converted into pyridoxal phosphate first. However, if taken at dosages that overwhelm the conversion to PLP, the pyridoxine itself can bind to PLP receptors on enzymes and block their function.

Free thyroid hormones also bind to PLP receptors, and they do it readily. A study in the 1950s found giving thyroid hormones to rats significantly blocked PLP enzyme function, especially in the liver. Ingested thyroid hormones are free when absorbed by the intestines and sent to the liver, and from there they can bind to carrier proteins which keep them from going places they aren't supposed to. In order to stop the thyroid hormones from interfering with the PLP enzymes, you need to significantly increase how much PLP is in the blood. How much more exactly is unknown, but is likely proportionate to the hormone dosage. Without supplementation or a diet quite high in natural B6 sources (not fortified sources), the body will start to use up the PLP it has stored up in the past. How fast someone depleates their PLP stores depends on how much B6 they get from their diet and thyroid hormone dosage. Functional PLP deficiency has the same symptoms as B6 deficiency, but bloodtests for the vitamin will be "normal." The demand for the vitamin is greater, so standard deficiency screenings aren't going to be useful.

PLP deficiency can also cause elevated homocysteine. Since enzymes in the intestines and liver are the most affected, people may have changes in gastric motility and in liver function tests. Over time, as the stores of PLP run low, people would develop signs of an overall B6 deficiency including neuropathy, dry and cracking skin, mood and sleep changes (PLP is necessary to make serotonin, dopamine, and melatonin), systemic inflammation and oxidative stress (PLP is needed to make the bodies most abundant antioxidant), and liver damage or disease.

Theres also a number of genetic conditions that can affect PLP levels, and, theoretically, there could be an autoimmune impact of PLP metabolism, so people who aren't taking thyroid hormones or pyridoxine can still have a PLP deficiency with normal total B6. PLP levels can be specifically tested and would show low in most of those cases.

The best news about both methylcobalamin and PLP deficiencies is that they are treatable without a prescription. Methylcobalamin lozenges or liquid for sublingual administration (to avoid the first pass effect which would make the supplement useless for the specific conditions that cause low methylcobalamin) and pyridoxal-5-phosphate/P5P/PLP are both available for a fairly low price online. Both are water soluble with limited uptake to storage and no toxicity, so whatever isn't either used or stored will be excreted in urine.

I have had CFS since fall of 2015. I was diagnosed with Hashimoto's and began taking thyroid hormones spring of that year. The onset and progression of all of my symptoms match having either a methylfolate or methylcobalamin deficiency combined with a PLP deficiency.

Taking methylfolate when you dont have a deficiency will increase demand for methylcobalamin, and if you can't meet that demand you will get sicker. Thats what happened to me, even though I was taking a normal B12 supplement and had high serum B12 - thus indicating the methylcobalamin deficiency. I got a methylmalonic acid blood test which indicated no deficiency of adenosylcobalamin, which eliminated the more common cobalamin metabolism disorders. I'd rather be extra rare than have a trio of deficiencies though.

If you take methylcobalamin without a deficiency, nothing changes and you pee it out. If you take it and you have a methylfolate deficiency, nothing changes and you pee it out. If you take pyridoxal phosphate without a deficiency, nothing changes and you pee it out.

These supplements do not interfere with any medications. Thyroid hormones can impair PLP enzymes, but PLP has no effect on thyroid hormone receptors.

This means that methylcobalamin and PLP are easily accessible and safe supplements that people with CFS/ME, fibromyalgia, and/or hEDS trifecta can try even if they don't have access to a helpful doctor.

The remaining question is how long they take to have effect. I can tell you that the PLP helped me in a matter of days. Better energy, better executive function, and some improvement to sleep. The methylcobalamin will take longer to have impact as the major effect of the deficiency is damage to the nervous system.

My neurological symptoms primarily come from the lumbar region of my spinal cord and the reticular formation of my brainstem. I dont know of any way to predict what parts of the nervous system get affected most, but by listing out all of my symptoms and learning the functions of different parts, I was able to trace all of my neurological symptoms to those two places.

Based on other types of B12 deficiency and other adult-onset cobalamin metabolism disorders, treatment has the potential to lead to full healing of damage done in the course of the deficiency. Lasting damage seemed to mostly be in cases where patients presented with strokes, embolism, etc. which caused additional damage. Other patients have full recovery as long as they continue to have the form of B12 they need.

I've so far only been taking the methylcobalamin for less than a week. Thats not enough time to recover from 8 years of damage, unfortunately. Right now I just have to wait and not push my neurological limitations just because I have more energy and focus. I have some very objective symptoms that are what I'll be monitoring most, since others like chronic widespread pain are more easily influenced by other factors. Im hoping that I will be able to point to definite improvement of at least a symptom after a month, but it could take longer. There's honestly no way to know.

Now, disclaimer, I am not a doctor or any other licensed medical professional. I'm a disabled person with the resources to experiment on myself and the ability and education necessary to understand the science enough to connect the dots and weigh the risks. I weighed the risk of taking methylfolate, but I turned out to be an outlier with a 1 in 100 million condition rather than the 1 in 3 for my demographic (granted the 1 in 100 million may be wrong, but thats the approximate current diagnosis rate). However, since what I found indicates zero risk for trialing methylcobalamin and/or PLP, I feel comfortable sharing what I've learned and what I am doing. Its always a good idea to talk to a pharmacist about possible interactions and to talk to a doctor about any other conditions you may have, and taking any supplement is always at your own risk.

I also understand the desperation of people chronic pain, fibromyalgia, and/or CFS/ME for anything that may help their condition, and it is hard for me to keep information to myself while I wait to see how things go, when the information has the potential to start helping someone who may not be able to make it until I have everything in a clear presentation format and my personal results.

As I continue my own treatment trial, I will be reaching out to various doctors and researchers about this and sharing more about my history, research, and how things are going. I will also be working on having cited, edited, clear, and easy to distribute information rather than... this or "look into trying these supplements and just trust me" which sounds about as useful and trustworthy as "try yoga."

even if you did the barest minimum research, the Wikipedia page for chronic fatigue syndrome is so sad. it’s like “this is what we diagnose people with when we can’t find anything else wrong with them. but it’s definitely something physical because there are visible neurological changes seen in neuroimaging and weirdness with the immune system. full recovery rates are less than 5%. the most common treatment is CBT which ignores the fact it is a physical illness and tells sick people they’ll get better if they just stop thinking about being sick.”

[tohealthwiththatmthfr]

MTHFR: The Gene That Can Affect Your Health and How to Optimize It

The MTHFR gene is involved in the methylation process, which is essential for many important bodily functions, including DNA repair, detoxification, and the production of neurotransmitters. About 40% of people have a variation in the MTHFR gene that can interfere with its function. This can lead to a number of health problems, including:

Increased risk of chronic diseases, such as heart disease, stroke, and cancer

Mental health problems, such as depression and anxiety

Fertility problems

Fatigue

Headaches

Sleep problems

There are a number of things that people with the MTHFR gene mutation can do to optimize their genes and improve their health. These include:

Eating a healthy diet that is rich in folate, vitamin B12, and choline.

Taking supplements that contain methyl folate and active B12.

Avoiding processed foods, alcohol, and caffeine.

Getting regular exercise.

Managing stress.

If you are concerned that you may have the MTHFR gene mutation, you can talk to your doctor about getting tested. If you do have the mutation, there are a number of things that you can do to improve your health and well-being.

Here are some additional tips for optimizing your genes with MTHFR:

Get enough sleep. Sleep is essential for methylation, so make sure you are getting at least 7-8 hours of sleep per night.

Manage your stress levels. Stress can interfere with methylation, so find healthy ways to manage your stress levels, such as yoga, meditation, or spending time in nature.

Get regular exercise. Exercise helps to improve circulation and detoxification, which can both support methylation.

Avoid toxins. Exposure to toxins can interfere with methylation, so avoid exposure to environmental toxins, such as pesticides, heavy metals, and cigarette smoke.

By following these tips, you can help to optimize your genes with MTHFR and improve your overall health and well-being.

[thebibliosphere]

Hello Joy! Long time follower and I really enjoy your blog. I just wanted to hope into your asks bc i've had a very frustrating day of doctors appointments and even if you don't have any advice, i was just hoping to rant to someone who'd been around the block with elusive medical illnesses (though please dont feel obligated to respond to this at all), and i apologize in advance for an almost certain lack of coherence.

I've been dealing with quite a lot of doctors appointments over the years, from treating insomnia, my adhd, and depression and anxiety, but long story short we have discovered 2 years ago that I have low b12. I have also been dealing with a chronic cough for 2.5 years. Unfortunately, oral supplements did not work for the b12 and i had to get monthly injections, which stopped when the pandemic hit and, despite doing for 4 months, didnt bring my levels up to normal anyway.

I recently restarted the injections, but my doctor will not approve my request to have more frequent injections, which i think i need, because its not fatally low (its at a 170 based on recent bloodwork). I finally saw a respirologist for my cough, and she has no idea what the cause of it is, even suggested that its psychsomatic, and put me on a different inhaler that i tried before (ive tried a million treatments for it, from post nasal drip meds to ppis for acid reflux to allergy meds, and the inhaler is the only thing that helped a little).

I've gained 20-25 pounds in the past 2 months, when ive been the same weight since i was a teenager (im 22), but my bloodwork continuously come back normal for everything but b12 and vitamin d, so my doctor also has no explanation for that (including normal tsh, and the last time i brought up testing other thyroid factors the doctor told me they dont do that and honestly made me feel silly for asking. Though, granted, my current doctor is a different one). I'm going insane because of how tired i am all the time, and the fact that I feel like a hypochondriac bc all my tests are always normal, and my doctor is only available for appointment once a month.

Sorry for the long block of text, i just feel, when looking at your blog, a sense of hope that eventually i'll have answers and you're just really great. ❤ i hope you had a really good day today ❤

Get a new doctor! Get a new doctor right now!

When you dip below 250 is when you can start to experience chronic fatigue, mood disorders and worsening cognitive function.

170 is when you're on the cusp of things getting seriously bad and depending on your homocysteine levels can start to cause pain and nerve damage. This is also when my hematologist estimates I started to sustain prolonged damage to my nervous system. This was also when I started experiencing the symptoms of early onset dementia.

140 is when my iron and folate levels tanked suddenly and I was so symptomatic my (then) new doctor was worried I had cancer and rushed me through seeing seven specialists in a week. The same day as seeing the hematologist it dipped below 110 and I started hemolyzing and went into medical crisis as my kidneys and heart started to struggle. I owe that hematologist and his team my life.

The good news is the shots you are getting right now are keeping you stable, but your doctor should NOT be waiting for your levels to hit crisis mode to resolve this issue. Please do not give up on this, you deserve better treatment.

Also, what kind of supplements are you taking?

I don't absorb Cyanocobalamin well through my gut, which is the most common type of oral supplement prescribed. What I do absorb through the gut is Methylcobalamin, so if you haven't tried that yet, it might be worth a shot to try and help you manage your levels on your own. Same with folic acid, I don't absorb it for shit, but when I switch to a methylfolate supplement, my numbers start to climb*. If you have tried this and it's been ineffective, then I'm going to emphasize that you need to push your doctor to increase your number of shots to get your levels up because what you are living with is not an acceptable quality of life, and I am so sorry :(

I hope you are able to rest and have better days in store soon. Take care, and if you want to talk about b12 or stuff, hit me up.

---

*Before anyone asks, yeah, I'm aware of the MTHFR gene mutation. I just can't test for it because the procedure is considered to be "investigational" and neither my geneticist nor my insurance wants to run it and I don't want to sell my data to a gene company lol.

[autistic-shaiapouf]

If you don't mind talking about it, are the gene results you've been sharing from a psychiatric genetic test? My psych has suggested i get one to help figure out treatment plans etc. but if it's gonna be all shit like "you're a fire sign- i mean you have the WARRIOR GENE" I'm not wasting my money lol

Okay so here's the thing, they actually were from psychiatric testing, but I'm more making fun of an offhanded interpretation the psychiatrist I was seeing had said, her personal thoughts and observations that I'm completely disregarding lmao. The results themselves are pretty cut and dry, "x gene controls for y and has z result, but your copy is abc which means your body does things differently"

The actual importance of me finding out I have this (comt val/val) gene is that it shows that I'm hypermetabolizing dopamine, my brain basically just burns through the neurotransmitter that helps you feel happy, which in turn is gonna influence the kind of treatment I would receive for anything depression-related

Imo I found it to be helpful bc it did actually reveal that most of my chronic pain was the result of a genetic mutation as well (mthfr) and that's also something that can be treated. Funny little names attached to genes like I was posting about is just kind of a thing I'm betting probably happens so the info can be more appealing to people who don't really know the specifics about how the genes work, also clickbait and all that, but I personally got use out of the testing, so best of luck to you as well anon ✌

[mthfrgenemutation-blog]

MTHFR gene mutation

GeneSight Psychotropic is a pharmacogenomic test which means that it analyzes how your genes may affect medication outcomes. The GeneSight test analyzes clinically important genetic variations in your DNA. Results can inform your doctor about how you may break down or respond to certain medications commonly prescribed to treat depression, anxiety, and other psychiatric conditions. The GeneSight test must be ordered by your doctor or nurse practitioner. The test is a simple cheek swab taken in your healthcare provider’s office or can be sent by your doctor to be taken in the convenience of your home. If you think genetic testing could be helpful for you, talk to your doctor about the GeneSight Psychotropic test. Genesight 6960 Cintas Blvd Mason, OH 45040 866.260.2394 https://genesight.com/genetic-insights/understanding-the-mthfr-gene-mutation Facebook Twitter LinkedIn Instagram YouTub

[jevaajohhnn]

Gary Brecka Biologist Changing Lives with Science

In today’s fast-paced, stress-fueled world, finding a trusted path to optimal health can feel impossible. Amid the noise of health trends, wellness influencers, and conflicting medical advice, one name consistently rises above: Gary Brecka Biologist. With a background rooted deeply in human biology and a mission driven by purpose, Gary Brecka is redefining how we approach wellness through science, not guesswork.

His work is not just about treatment or prevention—it's about transformation. Through the revolutionary Gary Brecka 10x method, he empowers people to reclaim their energy, clarity, and longevity by unlocking the power within their own DNA. In this blog, we’ll explore how his approach is changing lives, what real users have said in Gary Brecka Reviews, and how his partnership with Grant Cardone through Gary Brecka Cardone Venture is scaling science for the masses.

Let’s explore the world of Gary Brecka, the biologist on a mission to heal the world, one DNA strand at a time.

Who Is Gary Brecka?

To understand the magnitude of his work, you must first understand the man. Gary Brecka spent more than 20 years in the life insurance industry analyzing human mortality data. He was paid to predict how long someone would live based solely on their health records. While the job may sound clinical, it laid the groundwork for a powerful realization: our bodies provide clues—often hidden in our genetics—that can predict not just disease, but also optimal health.

This realization sparked his transition into functional biology, and from there, he evolved into what he is today: a pioneer in bio-optimization. Gary Brecka Biologist doesn’t just treat symptoms; he decodes the biological blueprint that determines how we function at our core. His goal? Help people unlock the healthiest, most vital version of themselves.

What Is the Gary Brecka 10x Method?

The Gary Brecka 10x method isn’t a diet. It’s not a supplement line. It’s a scientifically driven lifestyle system that uses genetic testing and biological optimization to improve performance, health, and longevity.

Here’s what makes it unique:

Genetic Testing: A simple saliva swab reveals critical data about how your body processes nutrients, detoxifies, and manages inflammation.

Customized Protocols: Based on your DNA, Brecka’s team develops a targeted wellness program.

Lifestyle Integration: The plan includes everything from supplementation and hydration to sleep habits and emotional resilience.

Rapid Results: Many clients report noticeable improvements in energy, focus, and mood within just a few weeks.

The “10x” philosophy stems from the belief that small, precise changes—when aligned with your biology—can yield massive results. That’s the promise behind Gary Brecka 10x: exponential health gains through strategic science.

The Science Behind the Strategy

What sets Gary Brecka Biologist apart is his relentless commitment to hard science. His programs rely heavily on methylation analysis—specifically the way your body converts B vitamins and manages stress at the cellular level.

Your body’s ability to process oxygen, eliminate toxins, and repair itself is deeply influenced by your genetic code. By identifying weak points in your genetic makeup—such as MTHFR mutations or folate conversion issues—Brecka helps people address the root cause of fatigue, brain fog, and chronic illness.

This approach bypasses the traditional "one-size-fits-all" health model. No more trial and error. Instead, your biology becomes your personalized roadmap.

It’s science, simplified—and lives are being transformed as a result.

Real Voices: Gary Brecka Reviews That Speak Volumes

Skeptical? You’re not alone. But one of the most powerful validations of Brecka’s work comes from thousands of firsthand experiences documented in Gary Brecka Reviews.

People from all walks of life—athletes, executives, parents, veterans—report the same thing: radical change.

“After following Gary’s program, I finally have energy again. My sleep is deeper, my focus is sharp, and my depression is gone.” — A 43-year-old entrepreneur

“The DNA testing changed everything. I stopped guessing and started healing.” — A professional triathlete

These Gary Brecka Reviews show a pattern. People are not just improving—they’re reclaiming lives they thought were lost to exhaustion, poor health, or mental burnout.

From clearer skin to balanced hormones, stronger immunity to faster recovery times, the outcomes speak for themselves. This isn’t a miracle cure—it’s biology unleashed.

The Power of Partnership: Gary Brecka Cardone Venture

To take this life-changing model to the world stage, Brecka partnered with entrepreneur Grant Cardone, forming the dynamic Gary Brecka Cardone Venture. Cardone, best known for his business empire and the 10x Growth Conference, saw massive potential in Brecka’s data-driven wellness strategy.

Together, they launched 10x Health System—an ambitious initiative to bring Brecka’s methods to the masses. From executive biohacking programs to corporate wellness packages and public seminars, the Gary Brecka Cardone Venture aims to democratize access to cutting-edge health insights.

Why does this matter?

Because it shows that health isn't just a personal issue—it's an economic one. Healthier leaders make stronger decisions. Healthier employees build better companies. And healthier humans create more vibrant communities.

This partnership is proof that when science and strategy collide, the results can change the world.

5 Ways Gary Brecka Is Transforming Lives

The impact of Gary Brecka Biologist is hard to quantify—but here are five concrete ways his work is changing the health game:

1. Clarity Through Testing

DNA tests remove the guesswork. No more random supplements or fad diets—just targeted, science-backed plans.

2. Rapid Results

Many users see improvements in energy, sleep, and focus within just a few weeks of starting the protocol.

3. Customized Nutrition

Brecka’s approach addresses genetic weaknesses through precise supplementation, restoring natural balance.

4. Empowered Patients

People are no longer passive recipients of care—they become active participants in their own wellness journey.

5. A Community of Transformation

Through programs like 10x Health and the Gary Brecka Cardone Venture, participants gain support, education, and tools to thrive long-term.

It’s not just about preventing illness—it’s about designing a life that feels good to live every single day.

Why Now Is the Time to Take Charge of Your Health

The world has never been more health-conscious—and yet, chronic disease, fatigue, and stress are at all-time highs. Traditional medicine has its strengths, but it often misses one critical component: personalization.

Gary Brecka delivers exactly that. His system taps into your genetic intelligence to create a health strategy that's as unique as you are. And in doing so, he helps people avoid costly trial-and-error cycles that lead to frustration and burnout.

The science is here. The tools are available. All that’s left is the decision to act.

Start Your Transformation

Ready to begin? Here’s how to take the first step into the world of Gary Brecka 10x:

Order a DNA Test Kit – This painless, at-home swab reveals vital information about your body's strengths and weaknesses.

Receive a Personalized Plan – Get a protocol tailored to your exact needs.

Track Your Progress – See improvements in your energy, sleep, mood, and performance.

Join the Community – Whether through online programs, seminars, or the broader Gary Brecka Cardone Venture, surround yourself with others on the same path.

No gimmicks. No hype. Just your body, finally working the way it was meant to.

Final Thoughts: Science Is the New Superpower

In an era filled with quick fixes and empty promises, Gary Brecka Biologist stands out as a beacon of truth, science, and sustainable transformation. His method is built on hard data, deep biological understanding, and a belief that everyone deserves access to optimal health.

The real magic? It's not in some pill or product—it's already inside you.

By aligning your life with your biology, you don’t just survive—you thrive. And thanks to Gary Brecka, countless people are discovering that truth every day.

So, whether you're chasing more energy, deeper sleep, better mood, or just want to feel like you again, remember: real health starts with real science. And real science starts with Gary Brecka.

Read Also: https://medium.com/@jeva4151/gary-brecka-10x-your-health-today-5c68366a96dc

[alluringasteria]

7 Signs From Your Higher Self

1. When you feel like something just isn’t right.

You know in your gut when something just doesn't feel right. I remember after I was suffering miscarriage after miscarriage the doctors couldn't find the physical reason I kept losing the babies. Everything was tested, and everything seemed fine and in good working order. However, on a deep level I felt like because I had worked so hard on the “spiritual reasons” my baby wasn't manifesting there still had to be a “physical reason” why I could only stay pregnant for up to 10 or 11 weeks. It wasn't until I moved states and found a more progressive doctor that she tested me for a gene mutation called MTHFR. Turned out that this was the reason I suffered recurring miscarriages. So I guess the moral of this story is to go with your gut, follow those hunches and keep seeking second and third opinions until your situation “feels right” again. Our intuitive guidance system is such a blessing, we must remember how to use those bullshit detectors to their full capacity.

A message from you higher self: BELIEVE BEYOND WHAT YOU CAN SEE

2. When a little voice whispers a message to you.

Sometimes we hear little voices that give us messages and snippets of wisdom that will help us out in our lives in some way.  To be clear, these are NOT the same types of voices that so-called “crazy” people might be listening to. I'm talking about an intuitive connection to your higher self that is often helping you in your times of need. These could be the voice of your spirit guides or guardian angels etc.

I remember one day when my husband Sean and I were picking up the kids from school. We were running late, so he told me to get out of the car at the stop light and he'd find somewhere to park. I heard a strong voice in my head say “NO” just as I was about to open the car door. As I paused, a school bus went speeding right by us. If I hadn't of taken that pause and listened to the voice I would have been hit by that bus. I was extremely grateful that I listened, otherwise I wouldn't be here to be telling that story.

A message from you higher self: LISTEN

3. When you see signs of alignment and choose to ignore them.

When you are on a spiritual journey and you're living your life by cultivating conscious awareness, signs of alignment from the Universe are frequently presented to you. These signs can be messages from your higher self that you are on the right path. My husband Sean and I see rainbows as a sign of alignment. We saw one on the day we met, the day we got engaged and in various other times when we have launched new ventures within our company.But when you hold and intention dear to your heart and you are then presented with signs that you choose to ignore, then energetic resistance begins to build up. Many of us tend to put our own needs last. We think that because we have children, or because we don't have enough money or other various excuses that we are unable to follow our dreams. This kind of thinking, where we willfully reject the signs of alignment is flawed. You have the power to see and view the world around you as a mirror of your own consciousness. If you see that white rabbit, you need to follow it. It will help your soul to expand and grow in miraculous ways. It's time to stop being fearful of living to your full potential.

A message from you higher self: SEE THE SIGNS AS TIME TO TAKE ACTION TOWARDS YOUR DREAMS

4. When you have recurring dreams or experience recurring synchronicities.

Do you have the same tidal wave dream over and over again? Or do you see the same person showing up in different locations all over your city? When the energetic signature patterns of life are in our awareness there is usually a reason behind it. It's a message… perhaps and instruction and sometimes a warning. Your job is to follow the clues and see if you can make sense of the reason the information is being presented to you on a regular basis.

A message from you higher self: SEEK THE MEANING

5. When your needs aren’t being met in a relationship.

When you don't use your voice in a relationship then the Universe will pick up the pace of your spiritual lessons and speak for you. If you know in your heart that your relationship isn't working and you stay without making an attempt to shine a light on the situation then you are dishonoring yourself at a very deep level. You are worthy of your needs being met. You are worthy to be loved and treated in a way that makes you feeling amazing. If you're currently feeling this way, then see it as a sign that deep transformation needs to take place. Whether you stay or you leave, a decision needs to be made, before it's made for you.

A message from you higher self: YOU ARE WORTHY

6. When you have thoughts that don’t make sense.

Have you ever had a thought about someone that didn't make any sense and then a deep or dark secret was exposed and your intuition was verified? Sometimes when we follow these hunches about people we fall into the trap of judging unfairly. However, there is a really delicate balance to strike where if you have a certain thought about someone then there must be a vibrational match to their energy somehow. The key is to not allow fear to govern your instincts. For instance, you can't constantly be checking your partners phone to see if they're cheating on you because more that likely you will create that experience from your lack of trust. But when you have a random thought or a hunch about someone or something just allow it to be and don't interfere. Send the thoughts love and allow them to play out as they are meant to.

A message from you higher self: SOMETIMES YOU CAN BE WRONG AND IT'S OKAY

7. When you ignore ongoing health issues and pretend they’ll go away.

You might have a pesky cough that doesn't seem to go away, or a mole that keeps changing color, or a weird lump that you are trying to ignore. Whatever it is, you really can't afford to ignore the health symptoms that are being presented to you. My mother-in-law is vigilant at getting a breast examination each year and it literally saved her life when she was diagnosed with breast cancer at an early stage. Our bodies work just like anything else in our lives, if you ignore problems then they will get bigger until you do something about them.

A message from you higher self: PAY ATTENTION TO THE FEEDBACK YOU FEEL IN YOUR BODY

(Not mine)

[healthysimplified-brittneyn]

What is this MTHFR gene 🧬 mutation!? No, I didn’t just curse. 🤣 More than half the world’s population has this mutation and if you or your spouse do then you likely have passed it on to your kids as well, but what is it and how does it affect those who have it and how do you know if you have it? 🤔

WHO HAS IT?

Although it's not a curse word, for the estimated 60% of people affected by this gene mutation, a curse is exactly what it can feel like!! 😳 Most don’t even KNOW that they have this gene mutation that causes an inability to process certain forms of key nutrients and makes it very difficult for their body to detox.

HOW DOES IT AFFECT YOU?

People with the MTHFR mutation are unable to “methylate” ingredients like Folic Acid, as well as certain B vitamins, and instead, these ingredients turn toxic in their body. 🤢Methylation is a very complex thing but simply put, it’s the ability to process toxins and hormones. When the methylation process is inhibited for any reason, glutathione levels drop, making the body more susceptible to oxidative stress, 😩 and far less tolerant to toxins. This lack of detoxification can lead to all kinds of behavioral, mental, and even physical illnesses or disabilities.

WHAT HEALTH ISSUES DOES IT PRESENT:

Here’s a short list of how MTHFR can present health issues:

💥Vascular disease

💥Blood clots

💥Respiratory issues

💥Miscarriages

💥Neural Tube Defects

💥Down Syndrome

💥Anxiety

💥Depression

💥Fatigue

The methylation cycle is tied directly to our serotonin (happy hormone) 😃 and dopamine (reward and pleasure neurotransmitter) 😊 levels. Individuals with MTHFR often need higher doses of Vitamin D as well because they lack the ability to absorb it properly. It’s crucial that they find a good methylated multi-vitamin, as well as a probiotic, and omega 🐟 supplement that have bio-available nutrients they can readily and quickly absorb.

HOW DO YOU KNOW IF YOU HAVE IT?

Super simple and inexpensive DNA 🧬 testing like we have. All you do is take a simple swab in the mouth 👅, send it in the already postmarked envelope, and then you are emailed your very detailed DNA 🧬 results that include everything from vitamin deficiencies to the type of muscle fibers you have which help you to discover the best workouts 🏋🏽‍♂️ for you to how your body metabolizes certain ingredients to whether you have the MTHFR gene mutation and how to combat it and much more.

Here’s some REALLY good news: methylated vitamins and nutrients are beneficial for EVERYONE, even if you DON’T have any form of genetic mutation.... no one is excluded, yet everyone is covered. 🙌🏽 Because of that we make sure our family has fully methylated vitamins going in everyday!!! 😍 #unzipyourgenes #Health #Fitness #Healthy #Health & Fitness #Fitblr #Positive #Positivity #Nutrition #Motivation #Inspiration

[winningmybattle-blog1]

The Answer

These past 8 years of my life I have felt like I’m suffocating. It feels like my body is lost at sea, with every wave my lungs slowly gaining more water, my body getting heavy by each day. Living with chronic pain is debilitating sucking the life right out of me. In the middle of a bad flare up I am stuck mentally and physically. Wishing that I could just “get better” or to “push past the pain.” Year after year with no answer. Doctor after doctor, pill after pill, test after test. At what point do you just give up? You don’t. You keep fighting till you find answers.

I once read an instagram post “Your body is trying to tell you something, listen to it. It’s not trying to fight against you, but for you.” Because of living with chronic inflammation I got into this mindset that my body is fighting against me. This body that God has giving me is failing in every area. As a Mama I want nothing more than to provide the very best for my daughter. Yet when a bad day hits me hard I can’t do anything but blame myself. Mentally I snap way to easily, sometimes physically I can’t even stand without excruciating pain shooting through my body. How do you even take care of another little soul when you can’t even take care of your own?

For years we thought all my inflammation was boiled down to certain foods. After having Serena I eliminated dairy, gluten, any processed foods. It helped calm the havoc in my body but still wasn’t making it go away completely. After a year I started removing any sugars as well (natural and unnatural) changed my skin care, my lotions, my deodorant, my drinks, everything. Again, it helped calm it down for me to have a couple days of sanity. But as soon as it went away something would happen and inflammation spiked. On top of this tormenting pain my anxiety has been debilitating.

I stumbled upon an awesome lady named Tavia who is a certified health, life and wellness coach. Her standpoint is to look at peoples overall health from a holistic and natural approach. The first thing she wanted me to get tested for was Lymes disease. She has put her Lymes disease in remission and is on a mission to help others find the real reason for their pain. The only time I have ever heard of it is through Avril Lavignes testimony. I thought to myself no way in heck do I have that! I’ve never been bitten by a tick. With less money in my pocket and a little blood later, I finally got my results.

Nine years of feeling lost at sea I finally have my answers. After countless nights of feeling like I’m mentally going insane. Truly questioning my own sanity, thinking that I’m just making this all up. I have been battling Lymes Disease. It spreads through any kind of bug bite. Typically people won’t even have a bulls eye rash when they get bitten. Going untreated for years can cause people arthritis and nervous system problems. I also have a gene mutation called MTHFR which doesn’t help my situation. Because of that gene not only is my body not able to properly detox but it can only soak up about 20% of the nutrients I need. The welts that I battle is my body trying to detox.

The next step is to see a specialist in Seattle that can help holistically heal my body from the inside out. With much fear of the unknown and still trying to process this, I would love for you to be a part of my ride. I step out of my comfort zone writing my story. Hoping that it can help someone understand that they can heal. That living with chronic pain is not something that we were created to do.

With much love, Vanessa