#Randomized Controlled Trial

[satoruxx]

i’m in my psych lecture and she’s talking about relational-cultural theory and it’s abbreviated as RCT and all i can think about is stupid jjk……

[religion-is-a-mental-illness]

[teaboot]

What you gotta understand with all this American border stuff kicking up a fuss about “increasing security measures to prevent transportation of fentanyl” is that nobody pushing that agenda gives a shit about Fentanyl. You know why? Because it’s killing addicts, and they don’t give a shit about addicts.

If they gave a shit about addicts, they’d be talking about accessible medical care. They’d be talking about public outreach programs. They’d be talking about safe use sites, and counselling, and housing, and transition programs, and prison reform. And they’re not, because it’s not about drugs, it’s about control.

This is exactly what the American government did when it made pot illegal. You know they said it made you violent? That WEED makes the average same adult into a filthy brainless sex fiend that beats people with hammers and can’t hold down a job?

And then they admitted that it wasn’t true, and that they only targeted weed because they wanted an excuse to destabilize Black and Hispanic communities by stop-and-searching, arresting, breaking up gatherings, and raiding whatever brown homes and groups they wanted whenever?

Now they’ve got a drug that just so happens to actually kill people. And even better, it’s infamous for killing COPS! The heroes of the people! My god, it’s a dream come true!

Or, what, you DON��T want random people at the border to be thrown in prison without trial and abused for slave labour? But that’s how they stop the cartels from getting in! You don’t want DEAD CHILDREN and DEAD COPS and DEAD TEENS, do you?

Like they only just happened to notice Fentanyl was a problem *just* as fascism hit peak popularity. Like you can’t produce that shit anywhere you want with the right resources. Like they ever gave half a crap about drug users, or kids, or poor people. It’s wild

Drug users didn’t just start suddenly dying from drugs yesterday.

The USA-Against-Everybody movement is far more recent

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[crossdreamers]

Real scientists unmask the anti-transgender Cass Review as methodologically flawed and misleading

The Cass Review, a widely cited report on gender-affirming care in the U.K., has been heavily criticized by researchers for its methodological flaws and unsupported claims.

A new peer review published in BMC Medical Research Methodology found that the review lacked statistical rigor, misrepresented evidence, and excluded key studies without justification.

Headed by pediatrician Dr. Hilary Cass, the Cass report dismissed gender-affirming medical care as unreliable, recommending "exploratory therapy," which critics argue is akin to conversion therapy.

The review applied biased analytical methods, misquoted previous studies, and selectively adapted assessment tools to justify anti-trans conclusions.

It also advocated randomized controlled trials (RCTs) for puberty blockers, which experts denounced as unethical. Despite its flaws, the Cass Review influenced policies, leading to a U.K. ban on puberty blockers and contributing to restrictive health measures in the U.S.

Chris Noone and his colleagues write:

Using the ROBIS tool, we identified a high risk of bias in each of the systematic reviews driven by unexplained protocol deviations, ambiguous eligibility criteria, inadequate study identification, and the failure to integrate consideration of these limitations into the conclusions derived from the evidence syntheses. We also identified methodological flaws and unsubstantiated claims in the primary research that suggest a double standard in the quality of evidence produced for the Cass report compared to quality appraisal in the systematic reviews.

Experts urge policymakers to reject the report, calling for research centered on patient autonomy and accurate scientific analysis.

See Them for more.

The science paper can be found here: Critically appraising the cass report: methodological flaws and unsupported claims

[0kurakura0]

Flirts of irritation

Soap x comms operator reader headcanon

this is the correct way to do a headcannon right???

Being soap's main operator for comms would be the true trial of blood pressure control

"SOAP, I SAID TO MAKE A SMALL EXPLOSION, NOT A GOD DAMN GENDER REVEAL NUCLEAR BLAST," you yell through the speaker as you witness the explosion that was meant to just simply cause a small distraction. "aw, but Bonnie just trying to show you my fiery passion"

soap that will start random conversations about planning dates, even during field missions.

"I was thinking," "Wow, that's a first." "Oof, that hurts my wee little heart, Bonnie. Anyway, I was thinking of a nice little cabin getaway you..me." "Can you just focus on not getting shot right now......" "Aaaaa..... too late about that...." "WHAT"

soap who collects rocks for you on missions, and you keep them on your desk as you work as good luck charms

you who get scared when communication gets cut and you can't get through to soap.

"SOAP! SOAP! ARE YOU OKAY?!" "......" "FUCKING HELL SOAP, COME ON! Come on, say something," you say, tearing up. "Don't leave me here we haven't done that stupid date you promised." "..... so is that a yes to that date, Bonnie?" soap breaks through while coughing. "YOU'RE AN ABSOLUTE ASS MACTAVISH," you yell back, crying, but a small smile creeps onto your face. "hehe, but I'm your arse," Soap says weakly as he keeps coughing.

[yey56]

HARLEY SAWYER X PSYCHOLOGIST READER

HEADCANNONS: before Leiths backstabbing

When Pierre Leith first introduced you both when you were working in the project "bigger bodies" he though it would be good to have Sawyer a little bit more controlled. Your personality and insistence on defying authority made you a good match.

Little did he knew that eventually you would actually start getting along with the doctor, which meant that he had two insubordinate pricks to worry about.

Reader does have compassion and some kind of affection towards Doey, but they ignore it in favour of their own ambitions and the project.

Thats the reason they try not to use cold as much with Doey, only when it's really necessary.

Before your friendship/companionship started to develope, the doctor usually appeared more to respond to Pierre's demands or to talk to the executives but since he doesn't really like doing it and does it out of obligation, he often ask you to talk on behalf of both of you.

That's how the scientific team, the specialist, Pierre, Ludwig and other coworkers started getting used to you being basically the voice of Sawyer outside the lab.

You had enough trust on each other to be able to talk in behalf of the other. (Mostly you since Harley doesn't seem to eager to socialise).

At first, when Doey was recently woken up and he still was getting used to their new body. You and Sawyer would go together to the interviews to record the development of the experiment. Some day out of the blue, Doey started to react aggressively to the doctor, only to him so he started to avoid going to the interviews with the mass and stayed in the observation room.

The doctor sometimes gets actually happy about some improvement his experiments may have but he expressed it with a poker face, a raised brow and the slightest change in his voice.

*Yarnaby actually starts listening for once*

Sawyer: ah, that's so interesting-actually glad for once-

(Y/N):are you actually happy or you're just being awfully sarcastic??

You never actually talked about what you guys like in terms of food or drinks so since sometimes you went to the cafeteria in the upper levels to get some food, your started to bring him random stuff for him to try and watch his reaction in order to find out what he liked. Basically using him as a guinea pig with trial and error.

Harley suspects that that's the reason you've been bringing random stuff with you and offering it to him.

I think he has certain favouritism for Yarnaby so sometimes he makes you test him more than usual even though he knows that he won't get a different response from the yarn lion other than animal like reactions. With time it just turned into an excuse to spend time with you. Your company is actually enjoyable after all.

You both are difficult people to deal with in a work environment. You both like control over things and you are both willing to go to any lengths to reach your ends.

This also comes with certain differences that sometimes makes both your works a little bit unbearable. On one hand we have you, you tend to joke and slip sarcastic comments here and there without any filter, you're cunning, more than he initially assumed. Harley is not used to this so it makes him get really irritated when you don't seem to take something seriously, even though he respects your lack of filter in everything you say.

On the other hand, there's him, he's controlling and he gets easily angry. He's used to be in control so he tends to lash out whenever he's not the one in charge, a very self centered man. It never fails to annoy you how sometimes he just forgets that you're working there two. This was more noticeable during your early ages working together.

With time you have learned to adapt to each other in order to obtain better productivity. But still sometimes you get on each others nerves.

When it comes to physical contact, you guys are basically the definition of touch starved. Some more voluntarily than others...

But just there are moments when Sawyer can feel your hands brush against his when your passing him the paperwork about the experiments, or how your knees graze slightly when you're seated next to each other in the observation room.

You can feel sometimes his breath against your neck since the doctor doesn't know the meaning of personal space. You are inspecting the experiments from a footbridge and the doctor just stands right there, behind you, observing in silence.

And his voice, you have catched yourselves zooning out hearing at his smooth silky voice. When he spoke to Yarnaby like a pet or when he named the a list of experiments that he was expected to operate that day. The tone of his voice was like a kiss to your ears.

Once he fell asleep in his chair after days of exhausting procedures and since the air conditioner was to high and you couldn't really afford to keep up with the business rate without the doctor, you decided to put your own jacket on his shoulders and retired his glasses to the side of his desk.

When he woke up, he silently put your jacket back in your shoulders, his touch lingering way to long

Headcannons about the reader and the doctors relationship pre transformation. Part two of the fanfic I made is in progress...

I also redesigned the doctors human form: tell me what do you think??

[wingedwoif94]

Dead by Daylight: Werewolf Killer Concept

POWERS:

Ability 1: Maul

Description: The Beast can grab hold of survivors with its clamping jaws and thrash them around.

Activation: The Beast can use Maul on a survivor within melee range.

Effect: When grabbed, the survivor must complete a difficult skill check.

Successful Skill Check: The survivor is thrown a short distance (5 meters) and inflicted with the "Mangled" status effect for 60 seconds, reducing their healing speed by 20%.

Failed Skill Check: The survivor is downed.

Cooldown: After using Maul, there is a 30-second cooldown before it can be used again.

Counterplay: Survivors can attempt to stun the Beast with pallets or flashlights during the grabbing animation to break free.

Ability 2: Deafening Howl

Description: The Beast lets out a terrifying howl, deafening survivors within a 15-meter radius.

Activation: The Beast can use Deafening Howl by pressing the active ability button.

Effect: All survivors within a 15-meter radius are deafened for 15 seconds, silencing all audio cues and the Beast's terror radius.

Additional Effect: Survivors affected by Deafening Howl experience a 10% reduction in movement speed for 5 seconds.

Cooldown: Deafening Howl has a cooldown of 45 seconds.

Counterplay: Survivors can quickly move out of the 15-meter radius upon seeing the Beast preparing to howl, reducing the number of affected players.

------------------------------------------------------------------------------

PERKS: Hex: Delirium:

Effect: Each survivor has their own personal hex totem. While the totem remains active, the survivor’s movement controls are reversed for 10 seconds every 60 seconds. Survivors must cleanse their own totems to remove the effect.

Scourge Hook: Eviscerate:

Effect: At the start of the trial, 4 random hooks are changed into Scourge Hooks. When a survivor is hooked on a Scourge Hook: The killer's basic attack cooldown is reduced by 50% for the time the survivor is hooked. Additionally, the killer gains a 3% increase in movement speed for 20/25/30 seconds.

Ambush Predator:

Effect: For 45 seconds at the start of the trial, and 45 seconds after the last generator is completed, all survivor audio cues are silenced and the killer's terror radius is undetectable. Additional Effect: During these periods, survivors also experience a 10% reduction in vaulting speed. ------------------------------------------------------------------------------ Bio: ???

[orphicsun]

Ellie x reader who’ve been dating a few years, and Ellie tries to propose 5 times but keeps getting interrupted, until for the 6th time, she proposes while in the middle of fucking ?? 💕💕

content: cheesy fluff, 18+ content, scissoring, loser Ellie(ish) content FINALLYYY

Ellie was patient at her best and pacing at her worst. She didn't like rushing things that were most beautiful in development. The process of a fuzzy caterpillar emerging from its cocoon and spreading its wet wings in the midst of the entire sky for it to explore, the beauty of childhood, the process of learning a skill like art or playing the guitar. Good things took time.

Your relationship was inarguably one of the most beautiful things to ever exist. Ellie looked back at the years of change between the two of you. The honeymoon phase never seemed to wear off, still giggling as your lips smushed together in kisses soft like warm, freshly-baked cookies and getting the nervous jitters before a nice date.

You both couldn't get enough of each other through the hardships, the times when you didn't agree with each other and needed space. The challenges of when you had first moved in with Ellie and when you had to adjust to each other's lives. You were no magically perfect couple, and that is what made Ellie love the relationship even more if it were. The disagreements and the road-bumps, the stress over money or things out of your control only brought the two of you closer together, as if Ellie were a red magnet and you were completely blue. Ellie would've taken the worst with you over the best with anyone else, and that thought was what resulted in the purchase of engagement ring.

The thought wasn't on a special date or in one of the moments you were tangled up in bed together, but when she was actually in her solitude. You weren't clocking out 'till 3 pm sharp today, and Ellie was in a state of pathetic yearning. She kept random moments in her brain and stored them for times like these, when you weren't near for her to stare at and wonder how she got so lucky. It was a blurry conjuring in her head, a moment when you were folding the laundry and threw a rag at her head. And suddenly, she thought that thought. She couldn't imagine anyone else throwing a rag at her head. And so, Ellie took it upon herself to find the ring that would shine on your hand like it belonged there, something you'd enjoy looking at while sitting at your desk job 40 miles from home. Ellie wouldn't be like one of the men who bought their wife a ring that she had never shared an interest for.

Then came the 6 trials, as Ellie loved to jokingly call them. The first was a product of her own nerves—sweaty hands and a pricey, velvet box didn't suit well with the girl. She planned a date at a botanical garden and lead you through, but her never-ending adoration for you was what got her. Her inability to say no to you.

Walking up the bridge, she stopped. She tapped your shoulder, humming a small "babe.." for your ears to pick up on the nerves in her tone.

You turned around, and that is when Ellie choked. Your hair swayed in the slight, cool breeze of wind. The sunlight reflected the shine of it in certain areas, and lightened it up in others. Your eyes squinted in avoidance of sun, but your smile was bright. You were looking at her. She stuttered and stumbled like a fool until your eyes suddenly lit up and changed course of direction towards a hibachi truck on the other side of the park.

"Babe! Do you have some cash on you? I really want some california rolls." You tugged at her sleeve and Ellie was already gunning for her leather wallet in the pocket of her jeans.

The last four times were all mostly the same. A nice date like a picnic in a park she drove a while aways from home for, a reservations at a Brazilian steakhouse you rambled on about, the botanical garden (again), and her last desperate attempt was at an art museum both of you were excited for.

Everytime it was something different. The timing wasn't right, or the waiter came back with the appetizers or bill. The second garden trip was because the two of you ran into Jesse and Dina before she could even pat down the box in her pocket and assure herself that she would go through with it. Her nerves only worsened each discouragement.

The sixth trial was accidental. She had initially planned another reservation, this time at a high-end steakhouse in the urban parts of your city. It was a week away, and Ellie was living life just fine.

It was still a week away, and the two of you were in bed together late in the night. Ellie's body was pressed against yours with much intimacy, warm tits pressed together and your legs tangled underneath sweaty sheets Ellie would throw off the bed later.

"Fuck, babe. You feel so good." Ellie murmured against your neck while she indulged herself in the heat that emitted from it. She enjoyed your scent and smothering your softness in loving kisses. Her leg hitched up over yours, aligning your cunts as closely as possible before sinking down.

The moan she tore from your throat made her heart pitter-patter, and her hips jolted forward, her clit catching on yours.

"Mhm.." you mumbled lazily, in your own state of bliss. You'd had another long day of work, but the sleepiness didn't stop you from wanting Ellie like this.

"Can I kiss you, babe?" Ellie requested, already moving her peachy lips from your neck.

Your slow nod lead to the sloppy kisses that got Ellie really wet. You felt it against your own pussy, your girlfriend writhing on top of you and dripping both of you onto the sheets. She humped your pussy as if she were catching a heat, not paying any attention to the shlick sounds that caused a vulnerable red in your cheeks until it became one of those things that really fucked with her.

Her mouth pulled from yours despite your small whine of protest, opting to rant out what she wouldn't normally say. "Fuck..feels so fuckin' good. I need to fuck you like this tomorrow. Can I please, please fuck you just like this tomorrow night?" You didn't get the chance to nod—"You feel so warm, like my own little space heater. I could keep you forever, you know." She gave you earnest, but sloppy movements, making you need more while also getting off on her heightened sense of pleasure.

"Yeah, Els. That's nice-"

"Just marry me already." Ellie blurted from her lips, immediately freezing on top of you. When she went still and rose from your laid form, you tapped her shoulder. You sat up, lifting the blanket over your tits as a reaction to the nerves she caused.

"Ellie..? Did you mean that?"

"Well, yes..I've been meaning to say it for a while." She admitted quietly.

Your heart was racing faster than moments ago, and you cupped her face to turn it towards you. "You really mean that? You wanna marry me, too?"

Ellie didn't miss the implication of that. "You wanna marry me?"

"Yes!" You hugged her, completely missing that Ellie was asking in a different way and not in a proposing way, but nevermind that.

Ellie tugged your hips and you move into her lap, melting in her arms. You both giggled like during the very first kiss back in Ellie's hand-me-down BMW, and she smothered your cheeks in soft, wet kisses while holding you close.

"You know, I was gonna propose on our next date. I made the reservation and everything."

"Celebratory dinner?" You suggested, wrapping your arms around her until they can spread over her bare back.

"Yeah, sure. Or..you could be my celebratory dinner." Ellie grinned at your surprise, and flips you back onto the bed to lay for her, already leaving giddy kisses down your body.

taglist: @witzs, @bewareofmyglock, @ruelezz, @mitskimisfit, @g4ys0n. Taglist form here

[halalchampagnesocialist]

I've probably made a gazillion posts of this iteration over the many years but it bears repeating. What frustrates me about liberal discourses on Palestinian-Israeli violence is the implication that violence is sporadic on both sides. It's frustrating because people will act like the only real issue with Israeli violence towards Palestinians is ones that come solely from extremist settlers or from right-wing governments.

You might argue that perhaps Palestinian violence against Israelis is random, sporadic and so on, but that is not the case with Israeli violence towards Palestinians at all. Israeli violence towards Palestinians is systemic but also is a daily occurrence. Not only does Israel kill Palestinians every single day, even prior to the current war, but it acts as a bystander to settler violence, even actively supports the settler violence. Violence does not even have to be murder but just the sheer control over Palestinian lives. The fact that Israel can cut water, electricity, etc to Palestinians at any time without notice. The way that Israel can come into any city and bulldoze streets like it's been doing in Jenin and Tulkarem in the West Bank. Of course, can't forget to mention the land grabs and that Israel can designate any piece of land a closed military zone whenever it wants. Sometimes there is no rhyme or reason to Israel's actions at all but just does so to play with the lives of Palestinians.

The Israeli hostages did not deserve to die but you absolutely cannot talk about the tragedy of their deaths or Hamas' 'brutality' in isolation without also mentioning that Gaza has been effectively turned into a death camp or that Israel holds thousands of Palestinians in its prisons without trial. This isn't mentioning that Israel as the occupier can kidnap any person it wants at any time and treats those prisoners very inhumanely.

The worst part about all this is not just the obfuscation of these facts but so many of these same people acting like the violence is sporadic act so nonchalant towards Palestinian deaths in 'normal times.' Or even towards whoever Israel kills as long as Israel gets their wanted guy. It's also this discourse that leads certain people to deny Israeli culpability, minimise Palestinian suffering, etc.

[kakashixhatakesxwhore]

Random NSFW headcanon please? (If you do nsfw...)

alrighty roo, buckaroo, lets discuss kinkage - thank you so much for the request

Random Kinks They Deffo Have

They: Iruka, Kakashi, and Itachi (with additions of Sasuke and Shikamaru) (f!Reader)

Warnings: whew! Swearing, explicit smut, power play, somno/free use, auralism, names of authority, praise kink, spit/blood/cum play, idk just please be 18

Notes: This one is for the freaks, obvi Boruto!Sasuke and Boruto!Shikamaru, I'm begging for everyone's thoughts and opinions - be prepared for Shikamaru's to be nasty

Masterlist💿

Iruka

Power Play

He just fucking loves when you take control

Anything you tell him to do, Iruka will do compulsively, and he's absolutely twitching when you tell him how good he is for doing so

All! About! Your! Pleasure!

Iruka's favourite encounters would be when he's not allowed to touch you, though, funnily enough

You're riding him, and all he can do is watch your sultry smile and feel your pussy hugging him tight - he wants to feel you, to run his hands all over your body - but he can't - or else you'll slow down to a halt and sometimes even pull him out, just to give him a beration of sorts

Now, that said, Iruka does not fuck with demeaning talk - you better love on this motherfucker, he's trying his goddamn best for you, and if you should negate that, it would allow a dark cloud to form over Iruka's mind

You don't want that, right? Exactly. So you keep it sweet, you give him stupid, little commands then fan the flames of his ego when he completes the command in spades

Lowk gets boyfriend-brain when he's with you, so kinda does need to be told what to do

Iruka is a sweetheart!!! He's always going what he can for you, all the time, even if you don't explicitly ask him to every time

Kakashi

Free Use/Somnophilia

When you said you would be okay with giving it a trial run, Kakashi was elated, and fucked you four seperate times that night, and began again before you woke up in the morning

He fucks you slow, almost trying not to wake you up, but the stretch is unmistakable

"Good morning, pretty lady. Have any good dreams?" He would ask, noticing your quickened breath, making you instantly relax into the situation

You love it - you stop sleeping in any amount of pant, just so Kakashi could have you as he pleased

When you got home, he would be pressing you against the door, when you try to start chopping vegetables for dinner, he would bend you over then pop you up on the counter when he just couldn't get enough

Kakashi's condition is that everything spontaneous happens within your shared, lovely, little home

He might sneak you away occasionally while the two of you are out, finding a small cache in the forest, but Kakashi would be asking for permission, assurance, consent at every step of the way - public is just different, but he's not entirely opposed

Kakashi just can't believe he's got you, and every time he looks at you, he needs to have you

Itachi

Auralism

He needs to hear you; the way your voice quakes, the way your nails rake across the skin of his back

Itachi's favourite sound though, is the harmony of your bodies meeting, skin smacking skin, squelches and a slick plunging sound, filling the room

Yeiff - let alone fucking outside - my god - Itachi wants your encounter to be so loud that the whole world knows what's going on

With his shit eyeslight, Itachi would prefer to close his eyes while fucking you, letting your beautifully wanton sounds paint a picture in his mind

In a perfect world, he would totally love to get tied up with a blindfold on - just to be at the mercy of your light touch and the intoxicating sound of your pleasure - Itachi would break the binding eventually, desperate to have his hands on you, needing to fuck you hard enough to hear the smacking and sloshing

Itachi is also the primo dirty talker, insisting you reply to him through your stinted pants, sharp gasps and breathy moans

His whole arousal around the subject of sound is cranked up to ten the second the two of you are in public - your little yips when he squeezes your ass, or the biting 'Itachi' that slips out of your mouth when he corners you to cop a feel

Oh, he fucks with names, you can call him whatever the fuck you want, so long as he's the one you're screaming about - but he likes it when you speak to him with more authoritarian honorifics (sir, daddy, lord)

Sasuke

Praise

Ooh, tell him he's hitting the spot and Sasuke would lose it, only trying to hit the exact same spot again

If you're ever out, singing his tune to another party, about anything, and Sasuke catches wind, he's taking you home immediately to prove he can provide more than you bargained for

Y'all, lets be real, and acknowledge that sweet Sasuke craves praise in any and all capacities, but most fervently in the four walls of your bedroom

Again and again, it doesn't matter how many times you tell him, he wants to hear it again

"Sasuke, your cock is so fucking big," you gasped as he slid in slowly.

"Louder. Tell the neighbours."

Loves, loves, loves to be able to hear the affect he's having on your body, every wave of pleasure, every jolt from your orgasm

Even if it's visibly clear that he's got you like putty in his palm, Sasuke will demand that you tell him how good he is, how deep he can reach, how much your pussy loved him

You're a blabbering mess, and it strokes Sasuke's ego to no end that he can bring you to this point, absolutely drunk with pleasure

Shikamaru

Spit/Blood/Cum Play

Anything Shikamaru can ingest that comes from your body (not excretions, sickos), he will

It's insane when you two hit the trifecta - Shikamaru cumming all over a patch of knicks on your stomach then spitting on the pile of liquid, he would mix it all together with his index finger, on top of you, before he would lean down and lick it all up, shoving the finger covered in the rose-tinted mixture into your mouth

Mm mm mm, and your cum, my good Christ, does he ever love your cum

Nothing brings Shikamaru so much joy as pulling his fingers out of you, being coated in a shiny slick

There's also something about the way your face screws up every time he brings a kunai into the bedroom - Shikamaru goes weak in the knees when he sees your crimson blood, glinting on the tip of the knife, losing it even further when you lick it off without hestitation

He's going to cum on your face, just to see you try to open those pretty eyelashes of yours, beads of white weighing them down

Shikamaru had no clue he was into fluids, until you randomly asked him, one day, to spit in your mouth - it's been a done deal since then, spitting just comes with the territory eventually

He always loved seeing your body get painted with his cum, but it's a whole different ball game to watch you play with it, to watch you lick it all up without wasting a drop like you used to do (honestly, Shikamaru can't even remember why he used to wipe his cum off of you)

[floral-ashes]

Our paper on randomized-controlled trials in trans healthcare was just assigned an issue. Read to learn more about levels of evidence and why RCTs aren’t actually good quality evidence for gender-affirming care!

Read here: https://www.tandfonline.com/doi/full/10.1080/26895269.2023.2218357

[voidsentprinces]

Time for your Daily Roulette

Spin for a randomized dungeon

Spin for a randomized trial

Spin for a randomized raid

Spin for a randomized PvP option/zone

[fight-nights-at-freddys]

MASTER POST OF PROSHIP RESOURCES!!! <3<3

this is just for links (bc i just have No Way of formatting this properly), so for more in-depth stuffs and credits, head to the google doc, or the carrd !! :3c

Fiction ≠ Reality

Violent media -

Does Media Violence Predict Societal Violence? It Depends on What You Look at and When

Video Game Violence Use Among “Vulnerable” Populations: The Impact of Violent Games on Delinquency and Bullying Among Children with Clinically Elevated Depression or Attention Deficit Symptoms

Extreme metal music and anger processing

On the Morality of Immoral Fiction: Reading Newgate Novels, 1830–1848

How gamers manage aggression: Situating skills in collaborative computer games

Examining desensitization using facial electromyography:Violent videogames, gender, and affective responding

'Bad' video game behavior increases players' moral sensitivity

Fiction and Morality: Investigating the Associations Between Reading Exposure, Empathy, Morality, and Moral Judgment

Comfortably Numb or Just Yet Another Movie? Media Violence Exposure Does Not Reduce Viewer Empathy for Victims of Real Violence Among Primarily Hispanic Viewers

Fantasy Crime: The Criminalisation of Fantasy Material Under Australia's Child Abuse Material Legislation

Being able to distinguish fiction from reality -

Effects of context on judgments concerning the reality status of novel entities

Children’s Causal Learning from Fiction: Assessing the Proximity Between Real and Fictional Worlds

Reality/Fiction Distinction and Fiction/Fiction Distinction during Sentence Comprehension

Reality = Relevance? Insights from Spontaneous Modulations of the Brain’s Default Network when Telling Apart Reality from Fiction

How does the brain tell the real from imagined?

Meeting George Bush versus Meeting Cinderella: The Neural Response When Telling Apart What is Real from What is Fictional in the Context of Our Reality

loli/shota/kodocon -

If I like lolicon, does it mean I’m a pedophile? A therapist’s view

Virtual Child Pornography, Human Trafficking and Japanese Law: Pop Culture, Harm and Legal Restrains

Lolicon: The Reality of ‘Virtual Child Pornography’ in Japan

Report: cartoon paedophilia harmless

‘The Lolicon Guy:’ Some Observations on Researching Unpopular Topics in Japan

Robot Ghosts And Wired Dreams Japanese Science Fiction From Origins To Anime [pg 227-228]

Australia's "child abuse material' legislation, internet regulation and the juridification of the imaginationjuridification of the imagination [pg 14-15]

Multiple Orientations as Animating Misdelivery: Theoretical Considerations on Sexuality Attracted to Nijigen (Two-Dimensional) Objects

Positive Impact on Mental Health

Art therapy -

The effectiveness of art therapy for anxiety in adults: A systematic review of randomised and non-randomised controlled trials

Efficacy of Art Therapy in Individuals With Personality Disorders Cluster B/C: A Randomized Controlled Trial

Effectiveness of Art Therapy With Adult Clients in 2018 - What Progress Has Been Made?

Benefits of Art Therapy in People Diagnosed With Personality Disorders: A Quantitative Survey

The Effectiveness of Art Therapy in the Treatment of Traumatized Adults: A Systematic Review on Art Therapy and Trauma

The clinical effectiveness and current practice of art therapy for trauma

Writing therapy -

Optimizing the perceived benefits and health outcomes of writing about traumatic life events

Expressive writing and post-traumatic stress disorder: Effects on trauma symptoms, mood states, and cortisol reactivity

Focused expressive writing as self-help for stress and trauma

Putting Stress into Words: The Impact of Writing on Physiological, Absentee, and Self-Reported Emotional Well-Being Measures

The writing cure: How expressive writing promotes health and emotional well-being

Effects of Writing About Traumatic Experiences: The Necessity for Narrative Structuring

Scriptotherapy: The effects of writing about traumatic events

Emotional and physical benefits of expressive writing

Emotional and Cognitive Processing in Sexual Assault Survivors' Narratives

Finding happiness in negative emotions: An experimental test of a novel expressive writing paradigm

An everyday activity as treatment for depression: The benefits of expressive writing for people diagnosed with major depressive disorder

Writing about emotional experiences as a therapeutic process

Effects of expressive writing on sexual dysfunction, depression, and PTSD in women with a history of childhood sexual abuse: Results from a randomized clinical trial

Written Emotional Disclosure: Testing Whether Social Disclosure Matters

Written emotional disclosure: A controlled study of the benefits of expressive writing homework in outpatient psychotherapy

Misc -

Emotional disclosure about traumas and its relation to health: Effects of previous disclosure and trauma severity

Treating complex trauma in adolescents: A phase-based integrative approach for play therapists

Emotional expression and physical health: Revising traumatic memories or fostering self-regulation?

Disclosure of Sexual Victimization: The Effects of Pennebaker's Emotional Disclosure Paradigm on Physical and Psychological Distress

Kink/Porn/Fantasies

Sexual fantasies -

A Critical Microethnographic Examination of Power Exchange, Role Idenity and Agency with Black BDSM Practitioners

Women's Rape Fantasies: An Empirical Evaluation of the Major Explanations

History, culture and practice of puppy play

What Exactly Is an Unusual Sexual Fantasy?

The Psychology of Kink: a Survey Study into the Relationships of Trauma and Attachment Style with BDSM Interests

Punishing Sexual Fantasy

Women's Erotic Rape Fantasies

Sexual Fantasy and Adult Attunement: Differentiating Preying from Playing

What Is So Appealing About Being Spanked, Flogged, Dominated, or Restrained? Answers from Practitioners of Sexual Masochism/Submission

Dark Fantasies, Part 1 - With Dr. Ian Kerner

Why Do Women Have Rape Fantasies

The 7 Most Common Sexual Fantasies and What to Do About Them

Sexual Fantasies

Pornography -

The Effects of Exposure to Virtual Child Pornography on Viewer Cognitions and Attitudes Toward Deviant Sexual Behavior

American Identities and Consumption of Japanese Homoerotica

The differentiation between consumers of hentai pornography and human pornography

Pornography Use and Holistic Sexual Functioning: A Systematic Review of Recent Research

Claiming Public Health Crisis to Regulate Sexual Outlets: A Critique of the State of Utah's Declaration on Pornography

Pornography and Sexual Dysfunction: Is There Any Relationship?

Reading and Living Yaoi: Male-Male Fantasy Narratives as Women's Sexual Subculture in Japan

Women's Consumption of Pornograpy: Pleasure, Contestation, and Empowerment

Pornography and Sexual Violence

The Sunny Side of Smut

Other -

Fantasy Sexual Material Use by People with Attractions to Children

Fictosexuality, Fictoromance, and Fictophilia: A Qualitative Study of Love and Desire for Fictional Characters

Exploring the Ownership of Child-Like Sex Dolls

Are Sex and Pornograpy Addiction Valid Disorders? Adding a Leisure Science Perspecive to the Sexological Critique

Littles: Affects and Aesthetics in Sexual Age-Play

An Exploratory Study of a New Kink Activity: "Pup Play"

Jaws Effect

The Jaws Effect: How movie narratives are used to influence policy responses to shark bites in Western Australia

The Shark Attacks That Were the Inspiration for Jaws

The Great White Hope (written by Peter Benchley, writer of Jaws)

The Jaws Myth [not a study BUT is an interesting read and provides some links to articles and studies]

Slenderman Stabbings

Out Came the Girls: Adolescent Girlhood, the Occult, and the Slender Man Phenomenon

Jury in Slender Man case finds Anissa Weier was mentally ill, will not go to prison

2nd teen in 'Slender Man' stabbing case to remain in institutional care for 40 years

Negative effects of online harassment

How stressful is online victimization? Effects of victim's personality and properties of the incident

Prevalence, Psychological Impact, and Coping of Cyberbully Victims Among College Students

Offline Consequences of Online Victimization

The Relative Importance of Online Victimization in Understanding Depression, Delinquency, and Substance Use

Internet trolling and everyday sadism: Parallel effects on pain perception and moral judgement

The MAD Model of Moral Contagion: The Role of Motivation, Attention, and Design in the Spread of Moralized Content Online

Morally Motivated Networked Harassment as Normative Reinforcement

When Online Harassment is Perceived as Justified

Violence on Reddit Support Forums Unique to r/NoFap

"It Makes Me, A Minor, Uncomfortable" Media and Morality in Anti-Shippers' Policing of Online Fandom

[witherby]

Heyyy

Soo this is a random / weird question, so feel free to not answer it.

I was thinking about how kids need to be taught proper hygiene / how not to be stinky and traumatized kids sometimes aren't taught. How do you think the bats would talk to Punchline about hygiene while making her feel comfortable and not being mean? Or would've the Joker taught her?

Sorry this is long

I think the Joker, despite winning World's Worst Dad by a fuckin mile, would at least teach her basic hygiene. Man rocks around in color-coordinated suits and has a theme/image to maintain. A stinky little girl isn't gonna help him with that, and I don't think he'd want to smell her all the time either.

But let's play in the space a minute. Let's pretend he taught her the absolute barest minimum. Punchline will brush her teeth, but not longer than 20 seconds. Punchline will shower, but doesn't use soap, just rinses off and scrubs her body in a half-assed manner. She can kind of style her hair, but any severely tangled/matted sections just get cut away and the remaining hair styled to hide it; she doesn't know about detangling or conditioner or cutting off the split and dead ends. Dirty clothes get dunked in some water and the stains a minimal scrub, then dried and re-worn. So on and so forth.

Alfred notices this first. When he comes by to read to her some more, he watches her take the provided toothbrush, wet it with just water, lightly brush it against her teeth, and then put it down again. He restructures his visits to include little lessons as well as reading. Luckily, she is very receptive to following orders.

Alfred got her teeth situation handled — with no cavities in sight, because she simply doesn't eat enough for it to be a huge risk.

Dick, as the one with the best looks, gets her hair under control. She gets introduced to the magic of clarifying shampoo and hydrating conditioner. He also introduces her to deodorant and perfumes.

Damian, red-faced, is the closest to her in age, so he teaches her what body wash is for and the best application practices for it while he's in a pair of swim trunks.

Bruce reaches her how to do laundry, trim her nails, and how to change the sheets on the bed she doesn't use.

At this point, Jason doesn't see her as worth the effort, and she isn't receptive to Tim being around, so they don't contribute to this stage in her rehabilitation.

It takes a little bit of trial and error — her gums bleed every time she brushes for a few weeks until her mouth acclimates to routine care, and a washing machine had to be replaced entirely because she used way too much laundry soap — but soon Punchline can be found carefully brushing through her emerald hair and changing into a new set of clothes every single day.