#fasting and inflammation

[wellhealthhub]

The Ultimate Guide to Fasting with Food: 11 Surprising Benefits You Can't Ignore

Discover the surprising benefits and potential of fasting with food in this ultimate guide. Learn how it can improve your health and unlock new levels of vitality. Table of Contents Introduction to Fasting with Food The Science Behind Fasting with Food Surprising Benefits of Fasting with Food Weight Loss Improved Blood Sugar Control Reduced Inflammation Enhanced Brain Function Lower…

[crimeronan]

multi-day migraine kitkat laying sadly in bed avoiding going to the ER until the last possible second bc it's too bright there while their partners monitor them for signs of stroke. what crimes will they commit

[fictionplumis]

I just LOVE the way my health journey is going right now /s

Rheumatologist: This isn't my department, you need to see a dermatologist.

Dermatologist: This isn't my department, you need to see a cardiologist.

Cardiologist: This isn't my department, you need to see a hematologist.

Hematologist: This isn't my department, you need to see a rheuma-- oh, you already have? Then you need to see a gastroenterologist.

I see a gastroenterologist next Friday, but.

God.

I am tired.

[icewindandboringhorror]

mentally ill people who for whatever reason end up wearing the same exact clothing so many days in a row that it begins to disintegrate and will still not stop wearing it until it’s literally just scraps of fabric VS. those weird shitty rich people who ‘’can’t be seen in the same outfit twice’’ human dichotomy 

[jcmarchi]

Study reveals the benefits and downside of fasting

New Post has been published on https://thedigitalinsider.com/study-reveals-the-benefits-and-downside-of-fasting/

Study reveals the benefits and downside of fasting

Low-calorie diets and intermittent fasting have been shown to have numerous health benefits: They can delay the onset of some age-related diseases and lengthen lifespan, not only in humans but many other organisms.

Many complex mechanisms underlie this phenomenon. Previous work from MIT has shown that one way fasting exerts its beneficial effects is by boosting the regenerative abilities of intestinal stem cells, which helps the intestine recover from injuries or inflammation.

In a study of mice, MIT researchers have now identified the pathway that enables this enhanced regeneration, which is activated once the mice begin “refeeding” after the fast. They also found a downside to this regeneration: When cancerous mutations occurred during the regenerative period, the mice were more likely to develop early-stage intestinal tumors.

“Having more stem cell activity is good for regeneration, but too much of a good thing over time can have less favorable consequences,” says Omer Yilmaz, an MIT associate professor of biology, a member of MIT’s Koch Institute for Integrative Cancer Research, and the senior author of the new study.

Yilmaz adds that further studies are needed before forming any conclusion as to whether fasting has a similar effect in humans.

“We still have a lot to learn, but it is interesting that being in either the state of fasting or refeeding when exposure to mutagen occurs can have a profound impact on the likelihood of developing a cancer in these well-defined mouse models,” he says.

MIT postdocs Shinya Imada and Saleh Khawaled are the lead authors of the paper, which appears today in Nature.

Driving regeneration

For several years, Yilmaz’s lab has been investigating how fasting and low-calorie diets affect intestinal health. In a 2018 study, his team reported that during a fast, intestinal stem cells begin to use lipids as an energy source, instead of carbohydrates. They also showed that fasting led to a significant boost in stem cells’ regenerative ability.

However, unanswered questions remained: How does fasting trigger this boost in regenerative ability, and when does the regeneration begin?

“Since that paper, we’ve really been focused on understanding what is it about fasting that drives regeneration,” Yilmaz says. “Is it fasting itself that’s driving regeneration, or eating after the fast?”

In their new study, the researchers found that stem cell regeneration is suppressed during fasting but then surges during the refeeding period. The researchers followed three groups of mice — one that fasted for 24 hours, another one that fasted for 24 hours and then was allowed to eat whatever they wanted during a 24-hour refeeding period, and a control group that ate whatever they wanted throughout the experiment.

The researchers analyzed intestinal stem cells’ ability to proliferate at different time points and found that the stem cells showed the highest levels of proliferation at the end of the 24-hour refeeding period. These cells were also more proliferative than intestinal stem cells from mice that had not fasted at all.

“We think that fasting and refeeding represent two distinct states,” Imada says. “In the fasted state, the ability of cells to use lipids and fatty acids as an energy source enables them to survive when nutrients are low. And then it’s the postfast refeeding state that really drives the regeneration. When nutrients become available, these stem cells and progenitor cells activate programs that enable them to build cellular mass and repopulate the intestinal lining.”

Further studies revealed that these cells activate a cellular signaling pathway known as mTOR, which is involved in cell growth and metabolism. One of mTOR’s roles is to regulate the translation of messenger RNA into protein, so when it’s activated, cells produce more protein. This protein synthesis is essential for stem cells to proliferate.

The researchers showed that mTOR activation in these stem cells also led to production of large quantities of polyamines — small molecules that help cells to grow and divide.

“In the refed state, you’ve got more proliferation, and you need to build cellular mass. That requires more protein, to build new cells, and those stem cells go on to build more differentiated cells or specialized intestinal cell types that line the intestine,” Khawaled says.

Too much of a good thing

The researchers also found that when stem cells are in this highly regenerative state, they are more prone to become cancerous. Intestinal stem cells are among the most actively dividing cells in the body, as they help the lining of the intestine completely turn over every five to 10 days. Because they divide so frequently, these stem cells are the most common source of precancerous cells in the intestine.

In this study, the researchers discovered that if they turned on a cancer-causing gene in the mice during the refeeding stage, they were much more likely to develop precancerous polyps than if the gene was turned on during the fasting state. Cancer-linked mutations that occurred during the refeeding state were also much more likely to produce polyps than mutations that occurred in mice that did not undergo the cycle of fasting and refeeding.

“I want to emphasize that this was all done in mice, using very well-defined cancer mutations. In humans it’s going to be a much more complex state,” Yilmaz says. “But it does lead us to the following notion: Fasting is very healthy, but if you’re unlucky and you’re refeeding after a fasting, and you get exposed to a mutagen, like a charred steak or something, you might actually be increasing your chances of developing a lesion that can go on to give rise to cancer.”

Yilmaz also noted that the regenerative benefits of fasting could be significant for people who undergo radiation treatment, which can damage the intestinal lining, or other types of intestinal injury. His lab is now studying whether polyamine supplements could help to stimulate this kind of regeneration, without the need to fast.

“This fascinating study provides insights into the complex interplay between food consumption, stem cell biology, and cancer risk,” says Ophir Klein, a professor of medicine at the University of California at San Francisco and Cedars-Sinai Medical Center, who was not involved in the study. “Their work lays a foundation for testing polyamines as compounds that may augment intestinal repair after injuries, and it suggests that careful consideration is needed when planning diet-based strategies for regeneration to avoid increasing cancer risk.”

The research was funded, in part, by a Pew-Stewart Trust Scholar award, the Marble Center for Cancer Nanomedicine, the Koch Institute-Dana Farber/Harvard Cancer Center Bridge Project, and the MIT Stem Cell Initiative.

[dynamichealthinsights]

Why Many Fast Foods Interfere with Healthy Metabolic Function

The rise of fast food culture has undeniably shaped modern eating habits. With life becoming increasingly fast-paced, convenience often outweighs nutritional value when it comes to food choices. But while fast foods may offer a quick and affordable meal, their long-term impact on metabolic health is far from favorable. Studies have consistently linked frequent consumption of fast foods to various…

[ancientroyalblood]

The Benefits of Intermittent Fasting: How to Start and Maintain It

Intermittent fasting (IF) is a popular eating pattern that alternates between periods of fasting and eating. This approach has gained significant attention due to its potential benefits for weight loss and overall health. In this guide, we will discuss different types of intermittent fasting, how to begin, the benefits for weight loss and health, and tips for maintaining the regimen. Different…

[meditating-dog-lover]

Hiding health stuff from my loved ones

I recently developed hypochondria and started obsessively reading articles online and seeing doctors behind my mom and sister's back.

Honestly it's going to send me down a downward spiral. Me seeing doctors who recommend things that don't even work or are not needed and escalate things and me not having the emotional support I need because I've been hiding things from my mom and sister, so I feel trapped and stressed and feel like I'm so sick but cannot get the support I need. If anything, my mom's pieces of health advice have helped me way more than any doctor I've seen, even the experienced functional ones.

[knowmybio123]

Take control of your health from the comfort of your home with our reliable and convenient blood testing kit. For a limited time, enjoy a special discount on all home blood tests.

[organicbeing]

Unlocking Health: Overcome Carbohydrate Toxicity and Reclaim Your Vitality

Call to Action: Discover the life-changing insights of “The Carbohydrate Toxicity Disease: Healing Begins with a Simple Sentence.” Unlock the secrets to reversing metabolic syndrome and regaining your health through practical, easy-to-follow steps. Don’t wait—take control of your well-being today! Order your copy now and start your journey towards optimal health and vitality. Chapter 1: The…

[anftherapy]

If your body is under cortisol poisoning over a long period of time, it may have other toxic effects besides weight gain.

It can lead not only to osteoporosis, diabetes, or muscle cachexia but also to changes in the central nervous system.

Did you know it?

[agreenroad]

HOURLY BENEFITS OF FASTING

[thunderheadfred]

I never measured my highest weight (and also I’m not here to body shame anybody, including myself) but I did lose a largish amount a while back by changing my habits for the healthier. Knowing I might need roomy pants during pregnancy, I saved a pair of jeans from when I was at my heaviest. Now, nearly at week 30, they’re still too big?? Bodies are wild. For clarity this is not me being like “ewww so fat” about me then or now. More like, amazed that my body is apparently made of silly putty and can just arbitrarily decide to be whatever the fuck size it feels like, just so long as my pants are never, ever comfortable.

[lavandamichelle]

Intermittent Fasting: Your Guide to Time-Restricted Eating

Intermittent fasting (IF) has become a popular buzzword in the health and wellness world, and for good reason. This eating pattern, which focuses on when you eat rather than what you eat, offers a range of potential benefits for both your body and mind. So, what exactly is intermittent fasting? In simple terms, it’s a cyclical eating pattern that involves alternating between periods of eating…

[harmeet-saggi]

What Is Intermittent Fasting? Does It Have Health Benefits?

Intermittent fasting (IF) is an eating pattern that cycles between periods of fasting and eating. It doesn't specify which foods you should eat, but rather when you should eat them.  There are many different types of IF, but the most common is probably the 16/8 method, where you fast for 16 hours and then eat during an 8-hour window. Other popular methods include the 5:2 diet (fasting for two days per week and eating normally for the other five), as well as more extreme versions like the warrior diet (eating only one large meal per day). IF has become popular in recent years because it's a simple way to lose weight without having to count calories.

[gigayak]

Unlocking Uveitis mysteries - History, Examination, or Lab Tests?(Pingu X Indiana Jones X Fast Show)

All three of history, examination and lab tests have important roles to play in diagnosing Uveitis. 

This short (featuring a league of extraordinary defectors including Pingu, the Fast Show tailor, Indiana Jones and Sherlock Holmes) focuses on the importance of uncovering the patient's history to identify potential underlying triggers or associated diseases