#the immune system

[finleycannotdraw]

I don’t have the capacity to be coherent right now but. this movie is so good

[ikiprian]

Ghost Kitchen (brought to you by criminal entrepreneur, Red Hood)

Danny’s got the easiest job in Gotham.

He works as a fry cook at a shoddily-run, independent burger joint. Hardly anyone comes in, despite prices being criminally low, and portions insanely large, and while the manager looks like the average tough-as-nails ex-con, he lets Danny mess around in the kitchen whenever the place is empty. (Which is often. This place has to be the city’s hidden gem or something!)

Mr. Manager’s the only one ever there with Danny, except for sometimes when his buddies come over to smoke and play cards. Danny would find it shady, except part of his job is not to ask questions. Literally, he was told during the interview.

(It was a weird interview. Why would they need to hire someone who’s been in a gunfight before? Like, he has, but Gotham’s idea of “hirable qualities” is so bizarre.)

So instead he whips up some killer burgers with the frozen ingredients, and basks in the praise as the guys tell him he shouldn’t have, he does too much for this joint, ain’t that friendly!

Now, Danny’s a chef on the newer side. As a teen he’d preferred the look of Nasty Burger over anything with Michelin stars, and he only really took up cooking after Jazz moved out for college. But just like ecto-exposure used to turn the groceries sentient, Danny’s low-level ecto signature imbues all his food with something historically haunted Gothamites just love! And Danny’s never been one to half-ass a job when it makes people happy.

With fresher produce, real meat, Danny’s sure he can take his dishes to the next level. It takes a couple months of badgering, but his manager finally agrees to contact the mysterious store owner, who keeps the place going, despite profits Danny knows have to be in the red.

Danny spends the morning prepping. He pours his heart into his food, eager to impress. The big boss will be here soon, and he wants to prove that despite the dangerous location, this place has real potential!

It isn’t until the Red Hood shows up that Danny realizes he’s been working for a money laundering scheme.

[wombywoo]

just checking...

[guooey]

ancient humans were also just some guy, if you got a baby from 60,000 BC and raised him in the 21st century he’d just be another teen boy named logan who tech decks off your arm

[kiksniko]

i am once again sick. have more sketches

[reasonsforhope]

Story from the Washington Post here, non-paywall version here.

Washington Post stop blocking linksharing and shit challenge.

"The young woman was catatonic, stuck at the nurses’ station — unmoving, unblinking and unknowing of where or who she was.

Her name was April Burrell.

Before she became a patient, April had been an outgoing, straight-A student majoring in accounting at the University of Maryland Eastern Shore. But after a traumatic event when she was 21, April suddenly developed psychosis and became lost in a constant state of visual and auditory hallucinations. The former high school valedictorian could no longer communicate, bathe or take care of herself.

April was diagnosed with a severe form of schizophrenia, an often devastating mental illness that affects approximately 1 percent of the global population and can drastically impair how patients behave and perceive reality.

“She was the first person I ever saw as a patient,” said Sander Markx, director of precision psychiatry at Columbia University, who was still a medical student in 2000 when he first encountered April. “She is, to this day, the sickest patient I’ve ever seen.” ...

It would be nearly two decades before their paths crossed again. But in 2018, another chance encounter led to several medical discoveries...

Markx and his colleagues discovered that although April’s illness was clinically indistinguishable from schizophrenia, she also had lupus, an underlying and treatable autoimmune condition that was attacking her brain.

After months of targeted treatments [for lupus] — and more than two decades trapped in her mind — April woke up.

The awakening of April — and the successful treatment of other people with similar conditions — now stand to transform care for some of psychiatry’s sickest patients, many of whom are languishing in mental institutions.

Researchers working with the New York state mental health-care system have identified about 200 patients with autoimmune diseases, some institutionalized for years, who may be helped by the discovery.

And scientists around the world, including Germany and Britain, are conducting similar research, finding that underlying autoimmune and inflammatory processes may be more common in patients with a variety of psychiatric syndromes than previously believed.

Although the current research probably will help only a small subset of patients, the impact of the work is already beginning to reshape the practice of psychiatry and the way many cases of mental illness are diagnosed and treated.

“These are the forgotten souls,” said Markx. “We’re not just improving the lives of these people, but we’re bringing them back from a place that I didn’t think they could come back from.” ...

Waking up after two decades

The medical team set to work counteracting April’s rampaging immune system and started April on an intensive immunotherapy treatment for neuropsychiatric lupus...

The regimen is grueling, requiring a month-long break between each of the six rounds to allow the immune system to recover. But April started showing signs of improvement almost immediately...

A joyful reunion

“I’ve always wanted my sister to get back to who she was,” Guy Burrell said.

In 2020, April was deemed mentally competent to discharge herself from the psychiatric hospital where she had lived for nearly two decades, and she moved to a rehabilitation center...

Because of visiting restrictions related to covid, the family’s face-to-face reunion with April was delayed until last year. April’s brother, sister-in-law and their kids were finally able to visit her at a rehabilitation center, and the occasion was tearful and joyous.

“When she came in there, you would’ve thought she was a brand-new person,” Guy Burrell said. “She knew all of us, remembered different stuff from back when she was a child.” ...

The family felt as if they’d witnessed a miracle.

“She was hugging me, she was holding my hand,” Guy Burrell said. “You might as well have thrown a parade because we were so happy, because we hadn’t seen her like that in, like, forever.”

“It was like she came home,” Markx said. “We never thought that was possible.”

...After April’s unexpected recovery, the medical team put out an alert to the hospital system to identify any patients with antibody markers for autoimmune disease. A few months later, Anca Askanase, a rheumatologist and director of the Columbia Lupus Center,who had been on April’s treatment team, approached Markx. “I think we found our girl,” she said.

Bringing back Devine

When Devine Cruz was 9, she began to hear voices. At first, the voices fought with one another. But as she grew older, the voices would talk about her, [and over the years, things got worse].

For more than a decade, the young woman moved in and out of hospitals for treatment. Her symptoms included visual and auditory hallucinations, as well as delusions that prevented her from living a normal life.

Devine was eventually diagnosed with schizoaffective disorder, which can result in symptoms of both schizophrenia and bipolar disorder. She also was diagnosed with intellectual disability.

She was on a laundry list of drugs — two antipsychotic medications, lithium, clonazepam, Ativan and benztropine — that came with a litany of side effects but didn’t resolve all her symptoms...

She also had lupus, which she had been diagnosed with when she was about 14, although doctors had never made a connection between the disease and her mental health...

Last August, the medical team prescribed monthly immunosuppressive infusions of corticosteroids and chemotherapy drugs, a regime similar to what April had been given a few years prior. By October, there were already dramatic signs of improvement.

“She was like ‘Yeah, I gotta go,’” Markx said. “‘Like, I’ve been missing out.’”

After several treatments, Devine began developing awareness that the voices in her head were different from real voices, a sign that she was reconnecting with reality. She finished her sixth and final round of infusions in January.

In March, she was well enough to meet with a reporter. “I feel like I’m already better,” Devine said during a conversation in Markx’s office at the New York State Psychiatric Institute, where she was treated. “I feel myself being a person that I was supposed to be my whole entire life.” ...

Her recovery is remarkable for several reasons, her doctors said. The voices and visions have stopped. And she no longer meets the diagnostic criteria for either schizoaffective disorder or intellectual disability, Markx said...

Today, Devine lives with her mother and is leading a more active and engaged life. She helps her mother cook, goes to the grocery store and navigates public transportation to keep her appointments. She is even babysitting her siblings’ young children — listening to music, taking them to the park or watching “Frozen 2” — responsibilities her family never would have entrusted her with before her recovery.

Expanding the search for more patients

While it is likely that only a subset of people diagnosed with schizophrenia and psychotic disorders have an underlying autoimmune condition, Markx and other doctors believe there are probably many more patients whose psychiatric conditions are caused or exacerbated by autoimmune issues...

The cases of April and Devine also helped inspire the development of the SNF Center for Precision Psychiatry and Mental Health at Columbia, which was named for the Stavros Niarchos Foundation, which awarded it a $75 million grant in April. The goal of the center is to develop new treatments based on specific genetic and autoimmune causes of psychiatric illness, said Joseph Gogos, co-director of the SNF Center.

Markx said he has begun care and treatment on about 40 patients since the SNF Center opened. The SNF Center is working with the New York State Office of Mental Health, which oversees one of the largest public mental health systems in America, to conduct whole genome sequencing and autoimmunity screening on inpatients at long-term facilities.

For “the most disabled, the sickest of the sick, even if we can help just a small fraction of them, by doing these detailed analyses, that’s worth something,” said Thomas Smith, chief medical officer for the New York State Office of Mental Health. “You’re helping save someone’s life, get them out of the hospital, have them live in the community, go home.”

Discussions are underway to extend the search to the 20,000 outpatients in the New York state system as well. Serious psychiatric disorders, like schizophrenia, are more likely to be undertreated in underprivileged groups. And autoimmune disorders like lupus disproportionately affect women and people of color with more severity.

Changing psychiatric care

How many people ultimately will be helped by the research remains a subject of debate in the scientific community. But the research has spurred excitement about the potential to better understand what is going on in the brain during serious mental illness...

Emerging research has implicated inflammation and immunological dysfunction as potential players in a variety of neuropsychiatric conditions, including schizophrenia, depression and autism.

“It opens new treatment possibilities to patients that used to be treated very differently,” said Ludger Tebartz van Elst, a professor of psychiatry and psychotherapy at University Medical Clinic Freiburg in Germany.

In one study, published last year in Molecular Psychiatry, Tebartz van Elst and his colleagues identified 91 psychiatric patients with suspected autoimmune diseases, and reported that immunotherapies benefited the majority of them.

Belinda Lennox, head of the psychiatry department at the University of Oxford, is enrolling patients in clinical trials to test the effectiveness of immunotherapy for autoimmune psychosis patients.

As a result of the research, screenings for immunological markers in psychotic patients are already routine in Germany, where psychiatrists regularly collect samples from cerebrospinal fluid.

Markx is also doing similar screening with his patients. He believes highly sensitive and inexpensive blood tests to detect different antibodies should become part of the standard screening protocol for psychosis.

Also on the horizon: more targeted immunotherapy rather than current “sledgehammer approaches” that suppress the immune system on a broad level, said George Yancopoulos, the co-founder and president of the pharmaceutical company Regeneron.

“I think we’re at the dawn of a new era. This is just the beginning,” said Yancopoulos."

-via The Washington Post, June 1, 2023

[macmanx]

There is this idea floating around that what doesn’t kill you, makes you stronger. That surviving a disease leaves you better off. And it seems to make sense because we have all experienced this. When you go through hardship, often you come out more resilient, more ready to face a difficult situation in the future. But it turns out that sometimes, what doesn’t kill you makes you weaker. So, what happens when you get sick?

[dcxdpdabbles]

DCxDP: Immunity system

Danny gets confused for Tim Drake when he stop for gas in Gotham on his way to visit Dan. His clone had set up shop- a literary comic book shop- in Metropolis.

Danny was going for the weekend to help him run the red dot sale and also spend time with his Clone turned older brother.

Dan after being released from his prison and getting a Core Cleanse in the FarFrozen ectoplasm iced pools, had mellowed out greatly.

It turns out Dan had gone mad after suffering a dip in contaminated ectoplasm. He called it "Pit Madness" and Clockwork assured him it was a real medical condition

Much like getting bitten by a rabies-infected animal, Dan's condition was not his fault despite turning him violent.

After the Big Reveal with his parents - who took the news surprisingly well- Team Phantom introduced Elle and Dan to them.

The two clones had been quickly made official Fentons and now Danny had an older brother and a young sister.

Elle lived at home with Danny and his parents, but Jazz and Dan moved out after high school graduation. Danny was thinking of moving in with Dan to go to college.

He wasn't sure, but he still had a whole year to decide.

Danny found a gas station within his GPS map and stopped at the closest one. There weren't a lot of people around, so he assumed that was a slow day.

He was not aware the locals avoided the area due to the danger of feuding gangs. He was also unaware that while pumping the gas, a Scarecrow goon was watching him.

That goon knew his boss had been getting a bit bored with his experiments, and he knew it wouldn't be long before his boss turned on his employees to relieve his boredom.

He was just starting to sweat, thinking he would be the new genuine pig until Tim Drake himself rolled out of a beat up car in the bad part of town.

He practically gift-wrapped himself for Scarecrow! The goon grins, creeping up behind the distracted young man.

One of the employees' inside the gas station had clocked Tim Drake too and had been staring at him - how could he not when Tim was a Bi icon?- and sees the moment the goon covers the boy's mouth with a clotch and yank him into a van that speeds away.

For a moment, the employee only gawked after the speeding vehicle, too shook to do anything as it disappears around a corner.

He scrambles for his phone to call 911. He prays that his slow reaction does not cost Drake's life.

(His call's transcript pings on Oracle's program designed to pick up the civilian names of the Bats if ever used in the emergency hotlines)

Sadly it is hours before the Bats have even an idea of where Tim (actually Danny) was taken to.

Danny wakes up in a warehouse, strapped to a table. He only had a brief moment of thinking his worst fear was coming true ,his parents, were going to rip him apart molecular by molecular, despite it being two years since they learn.

Thankfully a man dressed in a ridiculous Halloween costume steps into the light and he knows it's not his parents.

"Lovely expression Mr. Drake. Let's see how lovely that fear truly is," the man says in a raspy voice, holding up a needle. He stabs Danny with it and the boy blanches as the hot liquid enters his blood stream.

A minute goes by.

Two.

Three.

"Ugh was that supposed to do something?" He questioned, moving around his restraints to check his chances of escape without outing himself as Phantom.

The camera pointing at him limits his options.

The man dressed as Scarecrow lets out a gleeful cackle. He doesn't answer Danny, instead turning to the door- from where Danny can lift his head, it looks like he's in a basement of some kind- and shouts, "Bring me experiment six two six!"

A bulky man comes in carrying a tray of tubes. Danny watches as Scarecrow carefully selects a tube and pours it into another needle. "Lets see how you handle this"

The answer is Danny handles it very well. In fact he takes all seven tubes without a single reaction. Honestly it's the needle that's a real bother.

Scarecrow is both impressed and slightly insulted by the end of it. "How did a simpleton chloroform work on you but not my brilliant science!?"

Danny squints at him. "I would call this many things but never science, let alone brilliant, you fruitloop."

He gets knocked out again for his cheek with a new chloroform rag.

He wakes to the same made leaning over him again, but this time, there is also a clown in purple. Danny can only stare as the clown cackles.

"I think you're losing your special touch if Tim Drake is immune to your Fear Gas." The clown says, and Danny wonders if a costume convention exists in town.

Danny is happy to see that besides being knocked out and tied him down they haven't really done anything to him. "Who are you supposed to be?"

The clown face spams before a wide, mad grin breaks across his face. If Danny were to look of the definition of madness in a dictionary he knows this guy would be the example for it.

"I'm just a simple chum who wants to see the world laugh," The clown tells him, holding a squirt flower in Danny's face. "Let's see that smile!"

Danny squeaks as the liquid splashes in his face, some going up his nose. He coughs while the two men stare intensely at him.

After a moment Danny gets himself under control. "Ugh what was that? Is smell nasty"

The clown face freezes, rage bleeding into his eyes as the scarecrow one scoffs "seem you are also losing your touch, chum"

"No no no. Our little friend just needs a higher dosage! I'll have him laughing in no time!"

He doesn't. After a gas tank full of that nasty-smelling stuff is forced onto his face, and five different needles stabbed into his arm the clown is forced to admit Danny is immune.

They still call him "Mr. Drake" even though Danny tells them between needles that's not his name.

After hours of attempting to get a reaction out of him- both by clown and scarecrow- , Danny is knocked out again by the little rag.

When he comes two three people stand over him. The two from before, though clown now looks murderous and scarecrow politely interested, and a women in green with leaves splat across her outfit.

So Danny got kidnapped by a Scarecrow, a clown, and a nymph? Sounds like the beginning of a bad joke.

The gas mask is forced back onto his face and another Danny struggles he can do nothing as he is forced to breath in a new gas.

The woman watches his reaction with a keen eye before nodding "He should be pretty far gone now"

Scarecrow shakes his head. "There isn't a single reaction. He isn't affected by your pheromones."

The woman scoffs, leaning over Danny and fluttering her eyelashes "You're going to kill dear old dad for me"

Danny glares at her. "Like hell, I will."

His voice is muffled by the mask but they hear him and the woman actually looks shocked "He might need a higher dosage "

"By all means, give it a try. Neither Joker or I saw a difference in Mr.Drake even after adjusting his intake."

"How is that possible?"

"Maybe because you all suck!"

The clown slams his hands on the table. "I am one of the best chemists in the world, brat!"

"And the ugliest!"

Danny doesn't see the knife until it's pressed repeatedly into his left leg. He screams around his mask as the Clown spits and swears at him.

The other two only watch, neither seemingly bothered by the man stabbing a teenager.

Then the knife is plunged into his stomach, and he screams as the world almost whites out in agony.

Danny, blinks the white hot pain, and is just barely thinking of going ghost when the door bursts open and a group of people wearing more costumes pour in.

A man dressed as a Bat flings the clown away with an outraged cry. Danny can't see where the clown lands, but he hears fighting all around him.

A boy in a hood and mask appears in his line of sight. There is a worried frown on his face as he quickly picks at the locks keeping Danny down "Do not worry, Drake, we are here."

Danny finally gives in to the pain, running to blissful darkness as a man in a red helmet lifts him off the bed and makes a run for the door.

The kid provided cover for them.

[lotus-pear]

do you guys ever think abt what if mori made chuuya and dazai room together when they became partners instead of just having dazai live in a shipping container? bc i do.

[markscherz]

‘But I am very poorly today & very stupid & hate everyone & everything’

- Charles Darwin. Letter to Charles Lyell, 1 October 1861

[kaogens]

sorry for the inactivity.. im sick Can you guys tell

[bruciemilf]

Bruce who has no idea how terrifying he actually is.

Tim one day decides that his boredom overrides his siblings' need for peace and quiet. So, like the little agent of chaos he is, he brings up the dreaded question.

"In your unbiased opinion, who's the strongest in the family?"

Immediately all of them go, "Cass." She's smiling shyly about it, but there's a silver of assured confidence in there.n

Tim sighs. Fine. Too easy. " Okay, maybe that narrows it down. Who's most dangerous? I vote Dick."

Dick doesn't even need to think about it. "Aw, thanks, Timmy! I think I'm gonna go with Ja--" Damian's holding a dangerously sharp pencil to his windpipe. "Dami. Of course it's Damian."

Jason scoffs, "Clearly, it's me. That's like, my whole thing remember? I'm the violent robin--"

"Todd, we all know you gave stickers and cartoon bandages to every Rogue you had to arrest. You had gumball smoke bombs." Jason's 100% turning red and Tim is so gonna tease later.

"Besides, both you and Grayson are wrong."

Damian? Giving someone else credit? That, they have to hear. "Who is it, then?"

"It's Baba, obviously."

Jason breaks in a fit of laughter, alongside them. "Oh come on! Bruce? Bruce, who bakes awful vegan cupcakes for the PTA? He literally starts crying everytime we watch Toy Story 3."

"Because the unethical treatment within prison complexes and unfair labor laws forced upon inamtes parallels gets to him! Nevertheless. Baba could defeat mother. What makes you think he'd have a hard time with you?"

Dick snorts, " I think you're being a bit biased,--"

Damian throws a batarang at Bruce, slicing through the air with a quickness.

Their dad is reading reports, but not only does he evade it, sends it back with venomous speed. Right next to Damian's cheek. A purposeful missed shot.

Later, after they recovered from that whiplash, they ask Bruce the same question, and he of course goes with the most logical answer, " Alfred. But I think any of you could defeat me easily."

That doesn't make them feel better at all.

[halorvic]

"Do not let anyone convince you that you need to get sick to be healthy."